ADVANCED MATERIALS
·
2025
·
IF 26.8
Yu Zeng,Yong Liu,Tengyao Jiang,Fangyuan Zhao,Likun Wang,Sainan Ma,Guojian Yang,Sijia Han,Guoqiao Lai,Gang Tan,Gaorong Han
Intelligent modulation of solar and thermal radiation for a smart window, including visible, near-infrared (NIR), and long-wave infrared (LWIR) spectral tri-bands (0.38–25 µm), to achieve indoor comfort and energy efficiency is a critical frontier in sustainable building design. However, independent regulations of multi-functional radiation of visible lighting, NIR heating, and LWIR radiative cooling for dynamic operational requirements and weather conditions are not fully solved. A PET/ITO/PB/Pt-NPs electrode featuring separated reactions of ion insertion and metal electrodeposition for dual-band modulation of visible and NIR via precise potential control, enabling multifunctionalities such as illumination, glare reduction, and privacy protection is proposed. A multimodal smart window of lighting-heating-emitting electro-modulation device (LHE-ED), wherein electrochromism and dynamic emittance are delicately manipulated for tri-band modulation, possesses six independent electro-driven states of multi-scene lighting-heating-emitting regulations for the first time, exhibiting excellent wavelength selectivity of △ T Vis = 41.24%, △ T NIR = 53.95%, and Δ ε 8-13 µm = 0.35. Building energy simulations demonstrate the LHE-ED outperforms commercial low-E glass across diverse climate zones, showcasing a maximum reduction in CO 2 emissions of 34.01 kg (m 2 year) −1 and a decrease in heating, ventilation and air conditioning (HVAC) energy consumption by 34.18% annually, which paves the way for next-generation smart window in terms of energy saving and environmental preservation.
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DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Xin Tong,Hongquan Yu,Xiangping Li,Sai Xu,Baojiu Chen
Owing to their environmental friendliness, structural tunability, and ability to emit self-trapped excitons, lead-free halide double perovskites (DPs) have demonstrated significant potential for applications in light-emitting diodes (LEDs) and photodetectors. However, their chemical and thermal stability is generally insufficient. These limitations hinder their practical application in LEDs, as these devices typically generate considerable heat under high operating currents and prolonged usage, particularly in the case of infrared LEDs. In this work, Er 3+ -doped double perovskites (Cs 2 NaYCl 6 and the Cs 2 NaYCl 6 @0.6 KBr composite) were synthesized via a hydrothermal method. The emission intensity of Cs 2 NaYCl 6 :2 % Er 3+ @0.6 KBr is five times greater than that of Cs 2 NaYCl 6 :2 % Er 3+ within the wavelength range of 1400–1600 nm. In the Cs 2 NaYCl 6 :Er 3+ @0.6 KBr composite, the surface defects of Cs 2 NaYCl 6 :Er 3+ were modified by the introduction of KBr, leading to an increase in the external quantum efficiency (EQE) of Cs 2 NaYCl 6 :Er 3+ from 9.5 % to 30.0 %. Under a 150 mA working current, the operating temperatures of the near-infrared (NIR) LED devices based on the Cs 2 NaYCl 6 :2 %Er 3+ and Cs 2 NaYCl 6 :2 %Er 3+ @0.6 KBr composite are 53.2 and 47.4 °C, respectively. After working for 2 h, the temperatures of the NIR LEDs based on Cs 2 NaYCl 6 :2 %Er 3+ and Cs 2 NaYCl 6 :2 %Er 3+ @0.6 KBr were 60.3 °C and 46.0 °C, respectively, under a 100 mA operating current.
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高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Yiwen Xie,Yuwei Shi,Zhihui Li,Sumei Xu,Zhiyun Chen,Xuxia Ye,Wenxi Yan
Introduction Chemotherapy remains the primary treatment modality for advanced and unresectable tumors; however, its antitumor efficacy is limited, and it has significant toxic effects on normal tissues.Methods To address these challenges, cell carrier- and nanomaterial-based strategies were employed in this study to engineer macrophages into functional “Trojan horses” loaded with ICG–CDDP mesoporous silicon nanoparticles, yielding an intelligent cell carrier chemotherapeutic drug delivery system with controlled light responsiveness and “on-demand” nanophotothermolysis capabilities.Results Our findings demonstrate that the intelligent macrophage drug delivery system actively homes to tumor sites and that indocyanine green (ICG) fluorescence can be used to visualize exogenous macrophages at the tumor site. In response irradiation of the delivery area with exogenous near-infrared (NIR) light, ICG generates a thermal effect, resulting in the lysis of macrophages and facilitating spatiotemporally controlled burst release of intracellular cisplatin, thereby precisely targeting tumor cells. Simultaneously, ICG can trigger immunogenic cell death (ICD) under NIR irradiation, transforming “cold tumors” into “hot tumors” and eliciting a prolonged antitumor immune response, thereby overcoming the limitations associated with chemotherapeutic drugs.Conclusion This collaborative trimodal strategy successfully represents a triple breakthrough in precise delivery, spatiotemporally controlled drug release, and immune activation. It is an innovative solution for the precise treatment of advanced tumors and has substantial potential for clinical translation.
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2013
·
IF 3.535
Yu Zhang,Yurong Tang,Xing Liu,Lichun Zhang,Yi Lv
At present, glutathione (GSH) is a very important biomarker in vivo. However, the sensitive and selective assay for the detection of GSH in biological matrix still keeps challenging due to the high complexity of samples. Lanthanide-doped upconverting phosphors (UCPs) which exhibit unique near-infrared (NIR) excitation nature are able to overcome interferences from complex samples. In this study, a novel probe based on the linkage of UCPs and dopamine-quinone through hydrogen bonding and electrostatic interaction has been designed for rapid, economic, sensitive and selective detection of GSH in aqueous solution and human blood serum . Here, dopamine-quinone served as an efficient quencher for upconverting fluorescence, while GSH as a strong reducing agent chemically reduced the dopamine-quinone turning on the fluorescence. The fluorescence recovery was found to be proportional to GSH concentration within the range from 1 to 75 μM. The detection limit of this sensor was 0.29 μM, which was quite competitive for GSH detection. The simple, sensitive and selective fluorescence method took full advantages of UCPs properties of low interferences and broadened the application scope of UCPs in complex biological detection.
研究领域:
分析化学
·
生物分析化学
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生物传感器
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纳米技术
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荧光光谱学
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DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Chao Li,Ying Li,Yi Xu,Jiyou Zhong
Near-infrared (NIR) phosphors as crucial components of NIR light sources have multifunctional and smart spectroscopy applications, prompting an increasing research interest in developing efficient and stable NIR materials. Focusing on this issue, the present study explored the luminescent properties of Cr 3+ -doped Ca 3 ZnMGe 3 O 12 (M = Zr, Hf, Sn and Ti) garnet family. These materials exhibit an emission peak falls within the range of 785–805 nm with a full width at half maximum (FWHM) varying from 114 to 123 nm. Among them, the Ca 3 ZnZrGe 3 O 12 :Cr 3+ phosphor shows the highest photoluminescence quantum yield (PLQY = 60.3 %) and an excellent thermal stability ( I 423K / I 298K = 77.51 %). Moreover, the performance of a prototype Ca 3 ZnZrGe 3 O 12 :Cr 3+ -containing NIR pc-LED device was estimated, which achieves an NIR output of 23.46 mW and a photonic efficiency of 14.09 % under 100 mA driving current. Non-destructive examination can be realized using this light source, demonstrating the good potential of the material in NIR spectroscopy applications.
研究领域:
材料科学
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光电技术
·
光子学
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DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2018
·Vol. 28
·期 51
·1803815
·
IF 13.325
Lingyu Zhang,Shengnan Li,Xiangjun Chen,Tingting Wang,Lu Li,Zhongmin Su,Chungang Wang
The development of novel Janus nanostructure with desired compositions and functionalities is essential for various applications, especially as drug delivery system to deliver multiple payloads with total different solubility. Here, a unidentified flying object (UFO)-like cyclodextrin–palladium nanosheet/zeolitic imidazolate framework-8 Janus nanoparticle (CD–PdNS/ZIF-8 JNP) prepared via a selective coating of polyacrylic acid (PAA) on one of the flat surfaces of 2D PdNS followed by further formation of ZIF-8 on a PAA template, and alternative modification of CDs on exposed PdNS surface is reported. The CD-PdNS and PAA-ZIF-8 parts are designed to load hydrophobic10-hydroxycamptothecin (HCPT) and hydrophilic doxorubicin (Dox) independently for synergistic chemotherapy (combination index = 0.65). Because of the broad near-infrared (NIR) absorption band of PdNSs, the photothermal effect of UFO-like CD-PdNS/ZIF-8 JNPs in NIR-II biowindow is studied. The in vitro and in vivo results show that the dual-drug loaded JNPs under a laser-irradiation group present highest cancer therapeutic efficiency. The good performance is due to the synergistic chemotherapy and photothermal therapy in NIR-II biowindow. This work significantly broadens the application prospects of metal–metal organic framework JNPs by rationally designing their compositions and discovering related physiochemical properties.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
药物递送系统
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DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2018
·
IF 4.432
Mengmeng Hou,Ruihao Yang,Lei Zhang,Leiyang Zhang,Gang Liu,Zhigang Xu,Yuejun Kang,Peng Xue
The injection of theranostic drug-laden hydrogels into subcutaneous tumors has proven to be a promising strategy to achieve precise local tumor eradication. Humic acid, a natural product of biochemical decomposition of animal and plant residues, abundantly exists in soils, peats, oceans, etc. In this study, a robust injectable thermoresponsive agarose hydrogel incorporating sodium humate (SH) and doxorubicin (DOX) was constructed as a unique agent for tumor management based on the combined chemo-photothermal therapeutic effect. SH, which strongly absorbs near-infrared (NIR) light, can efficiently convert light energy into thermal energy, induce local hyperthermia and subsequently trigger sustained drug release from the complex of the SH/DOX@hydrogel through a typical gel–sol transition, resulting in enhanced cellular uptake of therapeutic drugs. Moreover, intratumoral injection of the SH/DOX@hydrogel resulted in a simultaneous chemo-photothermal therapeutic effect against solid tumors under NIR laser irradiation, which may collectively prevent tumor recurrence. In addition, the SH/DOX@hydrogel exhibited ultralow systemic toxicity as demonstrated using an animal model. This work provides a promising attempt to develop a low-cost, light-responsive hydrogel for precise tumor therapy, which may also incorporate extra theranostic modules as an advanced platform for the treatment of cancer or other critical diseases.
研究领域:
生物医学工程
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材料科学
·
肿瘤学
·
药剂学
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DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Yue Wang,Aofeng Yang,Lihao Xiong,Jiayi Song,Sihan Chen,Huang Zhou,Le Li,Deshuai Zhen
Uranium, a radioactive element, exists in aqueous environments primarily as uranyl ions (UO22+), posing significant risks to human health and the environment. Detecting UO22+ in such environments remains challenging. Here, an upconversion fluorescent sensor (UCDM) for the detection of UO22+ in an aqueous environment was constructed based on the fluorescence resonance energy transfer (FRET) principle. This sensor utilizes upconversion nanoparticles loaded with DNAzyme (UCDA) as energy donors and molybdenum disulfide (MoS2) as energy acceptors. MoS2 exhibits a high affinity for single-stranded DNA (ssDNA), enabling the sensor to function effectively. In the presence of UO22+, DNAzyme catalyzes substrate cleavage at the rA site, releasing ssDNA that binds to MoS2. This interaction leads to a decrease in UCDA upconversion luminescence. The unique upconversion luminescence property of an upconversion nanoparticle minimizes background autofluorescence, enhancing sensitivity. The sensor achieves a low detection limit of 5.81 nM and demonstrates robust recoveries (98.7%–102.7%) in complex aqueous matrices such as Xiangjiang water, uranium mine wastewater, human serum, and urine samples, underscoring its practical applicability.
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Xin Du,Liping Yin,Lixia Lu,Congcong Zhang,Mingshuang Zheng,Shuo Zhang,Fangping Yuan,Hua Li,Zhenguo Zhang
Photodynamic therapy (PDT) is a promising non-invasive anticancer approach that relies on photosensitizers (PSs) activated by specific light wavelengths to generate cytotoxic reactive oxygen species, particularly singlet oxygen (¹O₂), selectively destroying tumor cells. However, conventional PDT faces challenges due to the poor bioavailability of hydrophobic PSs and the limited tissue penetration of UV/visible light, hindering its efficacy for deep-seated or large tumors. To address these limitations, we developed a novel nanoplatform integrating up-conversion nanoparticles (UCNPs) with dual photosensitizers-5-aminolevulinic acid and Rose Bengal-encapsulated in a mesoporous silica-folic acid (FA) coating. Upon 980 nm near-infrared (NIR) irradiation, the UCNPs emit two kinds visible light, simultaneously activating both PSs to enhance ¹O₂ production, thereby inducing synergistic apoptosis and autophagy in cancer cells. Furthermore, cyanine 5 (CY5)-modified UCNPs enable imaging-guided tumor targeting via FA receptor-mediated uptake. In vitro and in vivo studies demonstrate significantly improved PDT efficacy with the dual-PSs system compared to single-PS modalities. This strategy offers a potent solution for deep-tumor PDT, showcasing substantial potential for clinical translation.
研究领域:
纳米医学
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癌症治疗
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光动力治疗
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生物医学成像
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药物递送
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Ke Zhan,Yuting Zhao,Haiying Li,Shan Jiang
The persistent threat of bacterial infections, which contribute to significant global morbidity and mortality, highlights the urgent demand for developing advanced antimicrobial materials. Herein, octopod-shaped silver-gold alloy nanostructures (Ag-Au octopods) were synthesized through a controlled deposition of gold onto silver octopods. Ag-Au octopods can convert near-infrared (NIR) light into thermal energy with photothermal conversion efficiency of 41.5 %. They also exhibited peroxidase-like nanozyme activity, catalysing the decomposition of trace amounts of H 2 O 2 to produce significant levels of reactive oxygen species (ROS). Notably, this catalytic activity was further enhanced upon exposure to NIR light. During in vitro antibacterial tests, a dose of 32 µg mL −1 of Ag–Au octopods, together with H 2 O 2 and 10 min of NIR irradiation, achieved a bactericidal rate greater than 99.0 %. Mechanistic investigations revealed that the antimicrobial effect arises from the disruption of bacterial membrane integrity, leakage of intracellular nucleic acids, a rise in intracellular ROS, and subsequent oxidative stress. The results present an effective and synergistic antibacterial strategy using the combined photothermal and nanozyme activities, offering a promising direction for next-generation antibacterial applications.
研究领域:
纳米材料
·
抗菌治疗
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光热治疗
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纳米酶
·
活性氧
·
感染性疾病
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DOI
PubMed
高影响因子
Nanoscale
·
2017
·Vol. 9
·期 29
·10367-10374
·
IF 7.367
Shanyue Guan,Yangziwan Weng,Mengnan Li,Ruizheng Liang,Chenghua Sun,Xiaozhong Qu,Shuyun Zhou
A supramolecular nanovehicle, denoted as ICG-DOX/Gd-LDH, was synthesized by the co-intercalation of indocyanine green (ICG) and doxorubicin hydrochloride (DOX) into a gallery of Gd3+-doped-layered double hydroxide (Gd-LDH) such that to achieve a chemo-photothermal synergistic therapeutic agent. The unique structure of Gd-LDH can not only stabilize the photothermal agent ICG to enhance the photothermal efficiency, but also hamper the recombination between electron and holes, leading to the generation of more reactive oxygen species (ROS) under irradiation in the NIR range. Together with the loading capacity of DOX, ICG-DOX/Gd-LDH exhibited excellent combinatorial effects on tumor growth inhibition in both in vitro studies on HeLa cell line and in vivo tests over tumor-bearing mouse models. Moreover, it showed ideal ability for long-term tracing of the carrier distribution via either MRI or fluorescence imaging. Thus, this study indicates that Gd-LDH is a promising platform for the construction of multifunctional formulations, especially theranostic nano-systems for cancer treatment.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
·
材料科学
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DOI
PubMed
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Yiyu Wang,Wenlong Yu,Chunqing Niu,Guiting Yu,Xin Huang,Jian Shi,Da Ma,Xuezheng Lin,Kai Zhao
Microspheres produced from biodegradable poly (D, L-lactic-co-glycolic acid) (PLGA) have been studied widely as drug delivery carriers for therapeutics. This study aimed to develop a near-infrared (NIR) light-activated PLGA microsphere loaded with two kinds of drugs with different molecular weights respectively or simultaneously by the double emulsion method (bovine serum albumin (BSA) and tetracycline hydrochloride (TH) as the drug model agents, indocyanine green (ICG) as the NIR responsive component). To optimize the incorporation of drugs and particle size for PLGA microspheres loaded single drug, the effect of three processing parameters, including the amount of polymer, initial ICG content, and initial BSA or TH content on the drug entrapment efficiency (EE), drug loading and the particle size were investigated. The PLGA microspheres were spherical and ranged from 5 to 10 μm in diameter. The EE of ICG and BSA in PLGA@ICG-BSA was 78.41 ± 0.71% and 69.88 ± 5.14%, respectively. The EE of ICG and TH in PLGA@ICG-TH was 71.52 ± 5.07% and 28.39 ± 3.39%. The PLGA microspheres exhibited desirable biodegradability and low cytotoxicity. Based on the optimized processing of single drug-loaded microspheres, dual-drug-loaded microspheres containing both large and small molecule drugs were further prepared. The EE of ICG, BSA, and TH was 83.37 ± 0.59%, 52.65 ± 3.48%, and 12.88 ± 2.53%; the particle size was ∼7.21 μm. All the NIR-responsive PLGA microspheres exhibited an efficient photothermal property and enhanced photothermal stability under multiple NIR irradiation cycles. The drugs from the different PLGA microspheres were released continuously over 18 days, mainly determined by Fick's diffusion. Furthermore, the drugs can be controlled released through a NIR light trigger, resulting in a dosage increase at a specific time point.
研究领域:
生物医学工程
·
药剂学
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DOI
高影响因子
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