REACTIVE & FUNCTIONAL POLYMERS
·
2014
·
IF 2.822
Juan Lv,Li Zhang,Musammir Khan,Xiangkui Ren,Jintang Guo,Yakai Feng
Nowadays, biodegradable amphiphilic block copolymers with stable performance and adjustable structure have attracted the interests of researchers in the field of drug delivery. In this work, the triblock copolymer , P(SBMD- co -PDO)- b -PEG- b -P(SBMD- co -PDO), was successfully synthesized by ring-opening polymerization of 3(S)- sec -butyl-morpholine-2,5-dione (SBMD) and p -dioxanone (PDO) with poly(ethylene glycol) (PEG) as the initiator. In phosphate buffered solution (PBS), these copolymers could self-assemble into nano-sized micelles that have a hydrophobic P(SBMD- co -PDO) core surrounded by a hydrophilic PEG shell. Because of the strong hydrogen bonding and hydrophobic interactions, doxorubicin (DOX) was loaded into the micelles with high loading capacity (LC, up to 28.4%) and encapsulation efficiency (EE, up to 62.5%). The drug-loaded micelles showed sustained-release of DOX along with the hydrolytic degradation of the micelles in PBS. Therefore, these amphiphilic triblock copolymers have potential as drug matrix for controlled release.
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DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 127
·104907-104914
·
IF 3.84
Kunlin Chen,Shuxue Zhou,Limin Wu
Durability of nonfouling coatings is a critical problem to be solved for their practical application. In this paper, self-repairing nonfouling polyurethane (PU) coating was fabricated by spraying of a triblock copolymer of polyethylene glycol (PEG), 2-hydroxyethyl methacrylate (HEMA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) on pre-cured acrylic-based PU coatings. The triblock copolymer was synthesized through living radical polymerization mediated by an atom transfer radical polymerization. Anchoring of the copolymer took place both on the surface and in the interior (namely, 3D-grafting) of PU coatings through the diffusion of the copolymer and subsequently the chemical reaction between the pendent hydroxyl group of the copolymer and the remaining isocyanate groups in the pre-cured PU coatings. This 3D grafting procedure is rather simple and favorable for large-area application. The 3D-grafted PU coating has higher hydrophilicity (water contact angle: 33°). In contrast, if the triblock copolymer was used as an additive in PU coatings, the hydrophilicity of the PU coating did not obviously change. The 3D-grafted PU coating effectively inhibited the adhesion of protein and human platelet cells due to the synergistic effect of PEG and MPC. Moreover, after the coatings were detached and mechanically damaged, the surfaces can restore their hydrophilicity and possess better long-term anti-fouling ability than the control surface-grafted coatings underwater.
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DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 30
·23683-23690
·
IF 3.84
Zhiwei Yu,Kai Xu,Zien Fu,Xin Liu,Youxiong Zhang,Jun Peng,Mingcai Chen
We designed and synthesized a series of amphiphilic copolymers from poly(ethylene glycol) monoacrylate (PEGMA), 2-(dimethylamino) ethyl methacrylate (DMAEMA), styrene (St), and butyl acrylate (BA) via reversible addition–fragmentation chain transfer (RAFT) polymerization. The dispersion capability of carbon nanofibers (CNFs) by these copolymers as well as their stability were investigated using UV-visible spectroscopy, Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TG), transmission electron microscopy (TEM) and dynamic light-scattering (DLS) techniques. The results show that both of the block copolymers PPEGMA-b-P(DMAEMA-co-St-co-BA) and PDMAEMA-b-P(PEGMA-co-PSt-co-PBA) enabled better efficiencies toward dispersion and functionalization of CNFs compared to the random copolymer and P(PEGMA-co-BA)-b-P(DMAEMA-co-St) polymer, which allowed us to evaluate the effect of block sequences on the dispersing properties and understand the structure–property relationship between CNFs and amino-containing block-copolymers.
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高影响因子
Polymer Chemistry
·
2014
·Vol. 5
·期 12
·3824-3830
·
IF 5.368
Yan Zhang,Yujue Chen,Xing Li,Jibo Zhang,Jinlong Chen,Bin Xu,Xueqi Fu,Wenjing Tian
Fluorescent block amphiphilic copolymers are one of the most important bioimaging materials which are highly desirable for early stage cancer diagnosis and treatment. However, sometimes the application of the fluorescent block copolymers is severely limited because of the aggregation-caused quenching (ACQ) effect. In this study, new aggregation induced emission polymer dots (AIE Pdots) were prepared through a self-assembly process by using an AIE-conjugated block copolymer containing an AIE fluorophore, 9,10-bis(4-hydroxystyryl)anthracene, hydrophobic poly(ε-caprolactone) segments, hydrophilic poly(ethylene glycol) segments and folate groups. The AIE Pdots are monodispersed in H2O with an average diameter of 15 nm, and possess strong emission and high solid state fluorescence quantum efficiency (Φ = 27.0%). Furthermore, the AIE Pdots show good stability and little toxicity to living cells and thus can be utilized for targeted HeLa cell imaging. Biological imaging investigation indicated that the folic acid functionalized AIE Pdots can be applied for targeted HeLa intracellular imaging.
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DOI
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2018
·
IF 2.932
Xueqiao Xie,Peng Luo,Juan Han,Tong Chen,Yun Wang,Yunfeng Cai,Qian Liu
In the present study, a novel and efficient immobilization for horseradish peroxidase (HRP) had been developed by using 6-arm magnetic composite microsphere (Fe 3 O 4 @PAA-6-arm-PEG-NH 2 ) containing 6-arm polyethylene glycol (6-arm-PEG-NH 2 ) and Fe 3 O 4 . The morphology and chemical properties of Fe 3 O 4 @PAA-6-arm-PEG-NH 2 were characterized by transmission electron microscopy (TEM), Fourier transform infrared spectra (FTIR), X-ray powder diffraction (XRD), vibrating sample magnetometer (VSM) and thermogravimetric analysis (TGA). The immobilization conditions and loading capacity of the carrier toward HRP were also investigated. According to the results, the optimum immobilization conditions were as follows: glutaraldehyde concentration of 0.10 mol L −1 , the carrier concentration of 7 mg L −1 , the temperature of 35 °C and immobilization time of 180 min. The loading capacity of the immobilized HRP arrived to 139.82 mg g −1 (RSD = 0.87%). Compared with free HRP, the stability of the immobilized HRP had been enhanced in a wide range of temperature and pH. The activity of the immobilized HRP retained 71.05% of its initial activity after 60 days storage. It was also found that the activity of the immobilized HRP retained 61.06% of its initial activity after eight times of successive reuse. The immobilized HRP could hydrolyze phenol to 94.4% within 10 min. It proved that the immobilized HRP could improve the performance of HRP, which had a good prospect in biological application.
研究领域:
生物化学
·
材料科学
·
酶工程
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jingling Gong,Ruirui Jin,Bin Xiang,Fuli Du,Weimin Liu,Jian Li
Membrane technology has become one of the most effective methods for treating oily wastewater, which is harmful to the survival of ecosystems. However, separation membranes often suffer from serious fouling problems. Therefore, in this work, MOF-303 nanoparticles and attapulgites (APT) were loaded on the surface of polyvinylidene fluoride (PVDF) membrane based on the layer-by-layer self-assembly to construct MOF/APT/PEG composite membrane with excellent superhydrophilicity/underwater superoleophobicity, anti-fouling ability and outstanding emulsion separation performance, durability. It should be noted that a unique “absorption-storage” strategy for water molecules has been creatively adopted to realize anti-fouling and promote permeability. The separation efficiency of MOF/APT/PEG composite membrane was as high as 99.6 %, and permeability was above 1316 LMH/bar. Particularly, separation performance still remained stable after 10 cycles and 60 min of cross-flow separation. This study introduces a comprehensive and straightforward methodology for the development of membranes with anti-fouling properties aimed at the highly efficient treatment of oily wastewater.
研究领域:
环境科学
·
材料科学
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DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Shuqun Zhang,Yiyuan He,Peng Xiang,Jun Li,Yunfei Zhi,Yunfei He,Shaoyun Shan
Water-based inks offer a sustainable alternative to solvent-based systems, yet their performance remains limited by particle sedimentation, poor dispersion, and insufficient film adhesion. In this study, multifunctional hybrid microspheres (SiO 2 -g-R-P) were synthesized by sequentially grafting rosin-derived acrylates and polyethylene glycol (PEG) onto silica particles. The rosin shell enhances compatibility with polyurethane–acrylic binders, while PEG chains provide steric stabilization and hydrophilicity. When incorporated at 1.5 wt% into water-based inks, the modified microspheres markedly improved dispersion stability (ζ potential = −51.6 mV), suppressed sedimentation for over 60 days, and enhanced low-shear viscosity by forming a weak reversible 3D particle network, with the formation of this network demonstrated via oscillatory rheometry (average G″ = 0.35 Pa, average G′ = 7.82 Pa). The resulting inks achieved high-resolution image transfer and strong substrate adhesion (ASTM D3359 rating 2B to 5B) on both paper and steel substrates, outperforming the unmodified formulation. These improvements stem from the synergistic effects of hydrogen bonding, steric hindrance, and particle–matrix interactions at the ink–film interface. This surface-engineering strategy provides a scalable and environmentally friendly approach for developing high-performance inks with enhanced print fidelity, mechanical durability, and colloidal stability across various substrate types.
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高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Weijing Chu,Yanjuan Huang,Chanzhen Yang,Yunhui Liao,Xuefei Zhang,Mina Yan,Shengmiao Cui,Chunshun Zhao
Because of the peculiarity of the bone microstructure, the uptake of chemotherapeutics often happens at non-targeted sites, which induces side effects. In order to solve this problem, we designed a bone-targeting drug delivery system that can release drug exclusively in the nidus of the bone. Alendronate (ALN), which has a high ability to target to hydroxyapatite , was used to fabricate double ALN-conjugated poly (ethylene glycol) 2000 material (ALN-PEG 2k -ALN). The ALN-PEG 2k -ALN was characterized using 1 H NMR and 31 P NMR and FTIR. ALN-PEG 2k -ALN-modified calcium phosphate nanoparticles (APA-CPNPs) with an ALN targeting moiety and hydrophilic poly (ethylene glycol) arms tiled on the surface was prepared for bone-targeted drug delivery. The distribution of ALN-PEG 2k -ALN was tested by X-ray photoelectron spectroscopy. Isothermal titration calorimetry data indicated that similar to free ALN, both ALN-PEG 2k -ALN and APA-CPNPs can bind to calcium ions. The bone-binding ability of APA-CPNPs was verified via ex vivo imaging of bone fragments. An in vitro release experiment demonstrated that APA-CPNPs can release drug faster in an acid environment than a neutral environment. Cell viability experiments indicated that blank APA-CPNPs possessed excellent biocompatibility with normal cells. Methotrexate (MTX) loaded APA-CPNPs have the same ability to inhibit cancer cells as free drug at high concentrations, while they are slightly weaker at low concentrations. All of these experiments verified the prospective application of APA-CPNPs as a bone-targeting drug delivery system.
研究领域:
药学
·
生物医学工程
·
肿瘤学
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DOI
PubMed
高影响因子
Polymer Chemistry
·
2012
·Vol. 4
·期 1
·156-165
·
IF 5.321
Lejiao Jia,Zhenyu Li,Dianrui Zhang,Qiang Zhang,Jingyi Shen,Hejian Guo,Xiaona Tian,Guangpu Liu,Dandan Zheng,Lisi Qi
The chitosan oligosaccharide-based disulfide-containing polyethylenimine derivative PEG-ss-COS-ss-PEI was synthesized and evaluated as a nonviral gene delivery carrier. The structure of the obtained polymers was confirmed by 1H NMR and FTIR. PEG-ss-COS-ss-PEI copolymers could effectively condense DNA into small particles with average diameters less than 120 nm and the zeta potential of +15.7 mV at the N/P ratio of 15/1. Additionally, the resultant polyplexes showed excellent colloidal stability against 150 mM NaCl and had a better buffering capacity of ∼44%, which was more than double the buffering capacity of PEI1.8k (∼20%). In the presence of 10 mM glutathione (GSH), however, polyplexes of PEG-ss-COS-ss-PEI were rapidly unpacked, as revealed by significant increase of particle sizes to over 800 nm. In vitro experiments revealed that the PEG-ss-COS-ss-PEI copolymers not only had much lower cytotoxicity, but also displayed high transfection efficiency as compared to the control branch 25 kDa PEI. This study indicates that a reducibly degradable copolymer PEG-ss-COS-ss-PEI composed of low molecular weight PEI, chitosan oligosaccharide and PEG via disulfide-containing linkages can be a promising gene delivery carrier.
研究领域:
生物材料学
·
基因治疗
·
药剂学
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DOI
高影响因子
POLYMER
·
2017
·
IF 3.684
Ya-Ping Xiao,Ji Zhang,Yan-Hong Liu,Xiao-Chuan Chen,Qing-Ying Yu,Chao-Ran Luan,Ju-Hui Zhang,Xi Wei,Xiao-Qi Yu
Gene therapy has shown great potential in the treatment of various diseases, and the development of low-toxic and efficient gene carriers is still one of the burning issues for gene therapy. PEGylation is generally regarded as an efficient strategy to improve the biocompatibility of non-viral vectors. However, PEGylation also led to several problems such as lower cellular uptake, difficult endosomal escape and much reduced transfection efficiency, which was described as “PEG dilemma”. We herein devote to the development of polymeric gene vectors that can overcome such dilemma via diepoxide ring-opening polymerization (DEROP) of low molecular weight PEI, and unmodified PEI and PEG-grafted PEI were used for comparison. Transfection experiments with various concentrations of serum revealed that the DEROP polymers gave much higher transfection efficiency together with better serum tolerance than PEI and PEGylated ones. Protein adsorption and flow cytometry assays further proved their better serum resistance. Besides, confocal microscopy suggested that the polyplexes formed from these polymers could escape from endosome/lysosome more efficiently than those derived from PEGylated material. In vivo biochemical studies also reflect good biocompatibility of the DEROP polymers. Results demonstrate that such polymer construction strategy gave cationic materials with both high transfection efficiency and improved biocompatibility, and afforded an effective way to overcome PEG dilemma.
研究领域:
生物医学工程
·
基因治疗
·
材料科学
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DOI
高影响因子
NANOTECHNOLOGY
·
2021
·Vol. 32
·期 22
·225706
·
IF 3.874
Yanqi Wang,Yao Wang,Miaorong Zhang,Jixian Liu,Linjun Huang,Yanxin Wang,Tian Hao,Jie Li,Jianguo Tang
The composite particles composed of quantum dots coated with silica and grafted with copolymer of polyethylene glycol and low molecular weight polyethylene terephthalate (QDs@SiO2-PEG-LMPET) are synthesized. The internal QDs provide luminescent performance and combine with SiO2 to form QDs@SiO2 with good dispersion to solve the defect that small-sized SiO2 is prone to agglomerate. The block polymer LMPET-PEG grafted on the surface can make the composite particles better compatible with the PET matrix. In summary, QDs@SiO2-PEG-LMPET not only play the same role as SiO2 to enhance the crystallization performance of PET matrix, but also provide stable luminescence performance, which is multifunctional additive with broad application prospects.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
International Journal of Nanomedicine
·
2023
·
IF 8
Liting Guo,Haijun Zhang,Fei Wang,Ping Liu,Yonglu Wang,Guohua Xia,Ran Liu,Xueming Li,Haixiang Yin,Hulin Jiang,Baoan Chen
The study investigated the reversal of multidrug resistance (MDR) and the biodistribution of nanoparticles (NPs) that target leukemia cells in a nude mice model via a surface-bound transferrin (Tf). The cytotoxic cargo of daunorubicin (DNR) and tetrandrine (Tet) was protected in the NPs by an outer coat composed of polyethylene glycol (PEG)-poly-l-lysine (PLL)-poly(lactic-co-glycolic acid) (PLGA) NPs. Injection of DNR-Tet-Tf-PEG-PLL-PLGA NPs into nude mice bearing MDR leukemia cell K562/A02 xenografts was shown to inhibit tumor growth, and contemporaneous immunohistochemical analysis of tumor tissue showed the targeted NPs induced apoptosis in tumor cells. Targeted tumor cells exhibited a marked increase in Tf receptor expression, with noticeable decreases in P-glycoprotein, MDR protein, and nuclear factor κB, as assessed by quantitative real-time polymerase chain reaction and Western blot analysis. Moreover, the concentration of DNR was shown to increase in plasma, tumor tissue, and major organs. Flow cytometry analysis with a near-infrared fluorescent (NIRF) dye, NIR797, was used to study the effectiveness of Tf as a targeting group for leukemia cells, a finding that was supported by NIRF imaging in tumor-bearing nude mice. In summary, our studies show that DNR-Tet-Tf-PEG-PLL-PLGA NPs provide a specific and effective means to target cytotoxic drugs to MDR tumor cells.
研究领域:
药学
·
肿瘤学
·
纳米技术
·
分子生物学
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DOI
PubMed
高影响因子
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