International Journal of Nanomedicine
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2024
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IF 6.6
Haishui Sun,Xiao Wang,Zhaoyang Guo,Zhenrong Hu,Yuanchen Yin,Shuhan Duan,Wenwen Jia,Wei Lu,Jingzhou Hu
Introduction Traditional surgical resection, radiotherapy, and chemotherapy have been the treatment options for patients with head and neck squamous cell carcinoma (HNSCC) over the past few decades. Nevertheless, the five-year survival rate for patients has remained essentially unchanged, and research into treatments has been relatively stagnant. The combined application of photothermal therapy (PTT) and immunotherapy for treating HNSCC has considerable potential.Methods Live-dead cell staining and CCK-8 assays proved that Fe3O4 nanoparticles are biocompatible in vitro. In vitro, cellular experiments utilized flow cytometry and immunofluorescence staining to verify the effect of Fe3O4 nanoparticles on the polarisation of tumor-associated macrophages. In vivo, animal experiments were conducted to assess the inhibitory effect of Fe3O4 nanoparticles on tumor proliferation under the photothermal effect in conjunction with BMS-1. Tumour tissue sections were stained to observe the effects of apoptosis and the inhibition of tumor cell proliferation. The histological damage to animal organs was analyzed by hematoxylin and eosin (H&E) staining.Results The stable photothermal properties of Fe3O4 nanoparticles were validated by in vitro cellular and in vivo animal experiments. Fe3O4 photothermal action not only directly triggered immunogenic cell death (ICD) and enhanced the immunogenicity of the tumor microenvironment but also regulated the expression of tumor-associated macrophages (TAMs), up-regulating CD86 and down-regulating CD206 to inhibit tumor growth. The PD-1/PD-L1 inhibitor promoted tumor suppression, and reduced tumor recurrence and metastasis. In vivo studies demonstrated that the photothermal action exhibited a synergistic effect when combined with immunotherapy, resulting in significant suppression of primary tumors and an extension of survival.Conclusion In this study, we applied Fe3O4 photothermolysis in a biomedical context, combining photothermolysis with immunotherapy, exploring a novel pathway for treating HNSCC and providing a new strategy for effectively treating HNSCC.
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jian Wu,Zhiqiang Chen,Haojie Shang,Yonghua Tong,Wen Deng,Yu He,Xiaozhuo Ba,Zichen Zhong,Yongke Bai,Tao Ye,Xiaoqi Yang,Kehua Jiang,Yijing Liu,Kun Tang
Limited lymphocyte infiltration and insufficient tumor immunogenicity remain major challenges for effective immunotherapy in bladder cancer, particularly in immunologically “cold” tumors with a highly suppressive immune microenvironment. Effective activation of the innate immune system is critical for initiating a robust adaptive anti-tumor immune response, primarily mediated by dendritic cells (DCs). Here, we designed genetically engineered hybrid membrane-coated nanoparticles (HM-MPS NPs) with excellent photothermal stability, tumor-targeting capability, and biocompatibility. HM-MPS NPs demonstrated significant tumor-suppressive effects in multiple preclinical models, including murine subcutaneous, orthotopic, and distant bladder tumor models. By combining photothermal therapy (PTT), a STING agonist (SR717), and antigen presentation, HM-MPS NPs achieve triple activation of DCs, leading to enhanced T-cell activation and a remodeled immune microenvironment. Furthermore, HM-MPS NPs synergize effectively with anti-PD-1 therapy, amplifying immunogenic cell death (ICD) and overcoming immune suppression within the tumor microenvironment. This strategy significantly boosts tumor immunogenicity and enhances anti-tumor immune responses, offering a promising approach for bladder cancer treatment.
研究领域:
肿瘤学
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免疫学
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纳米医学
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DOI
高影响因子
JOURNAL OF CHEMICAL RESEARCH
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2011
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IF 0.55
Yong-Rui Pi,Jun Tan,Hui Liu,Jie Chen,Zhu-You Qun,Yan-Bo Zeng,Lei Li
Catalytic cracking reaction of 1,2-dimethyl-1,1,2,2-tetrachlorodisilane with a halobenzene (PhCl, PhBr) to prepare methylphenyldichlorosilane has been investigated. Pd(PPh3)4 exhibited the best catalytic activity among the catalysts used. The activity of chlorobenzene was significantly lower than that of bromobenzene. With the latter and toluene as solvent, in the presence of 0.3 mol % Pd(PPh3)4, the conversion of disilane was 100% with a selectivity to MePhSiCl2 of 97.1%.
研究领域:
有机化学
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催化化学
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DOI
高影响因子
HYDROMETALLURGY
·
2023
·
IF 4.7
Shaoping Feng,Kun Huang
Dialkylsulfide is considered as the most promising extractant for separating Pd(II) and Pt(IV) in industrial processes. However, the slow kinetics for Pd(II) extraction limits its extensive application. The development of new extractants with faster kinetics, high extraction efficiency, and exceptional Pd(II) separation selectivity has been a persisting goal over the past few decades. In this study, a new functionalized extractant, 1-methyl-2-(nonylthio)-1H-imidazole (MNI) containing both N and S atoms, was synthesized and employed to separate Pd(II) from mixed hydrochloric acid solutions with different initial Pd(II)/Pt(IV) concentration ratios. Experimental results revealed that MNI not only has a high selectivity for Pd(II) over Pt(IV) but also has faster kinetics for Pd(II) extraction than diisopentylsulfide (S201) under similar extraction conditions. In contrast to traditional dialkylsulfide extractants, MNI coordinates with Pd(II) ions via the N(5) atom in its imidazole ring to form Pd(MNI) 2 Cl 2 complexes, instead of using the S atom as with dialkylsulfide. The extraction mechanism involving the coordination between Pd(II) and MNI was demonstrated using the slope analysis method and ultraviolet (UV), Fourier-transform infrared (FT-IR), 1 H NMR, and 13 C NMR spectroscopic methods. The fast extraction kinetics between MNI and Pd(II) was possibly attributed to the high charge density of the N(5) atom in the imidazole ring, whereas the outstanding separation selectivity for Pd(II) was due to the strong affinity of the N(5) atom. The facile synthesis, high saturation capacity, excellent Pd(II) selectivity, and remarkable reusability endow MNI with potential applications in Pd(II) recovery from leach solutions of waste automotive catalysts and other secondary resources.
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高影响因子
JOURNAL OF ORAL PATHOLOGY & MEDICINE
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2021
·Vol. 51
·期 1
·74-85
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IF 4.253
Jing-Ya Yang,Fang Wang,Gang Zhou
Background Oral lichen planus (OLP) is a T-cell-mediated chronic inflammatory disease with uncertain aetiology. Mucosal-associated invariant T (MAIT) cells and γδT cells are unconventional, innate-like T cells with immunoregulatory capacity. This study aimed to investigate the potential effects of MAIT and γδT cells on the pathogenesis of OLP. Methods Circulating MAIT cells and γδT cells were identified using flow cytometry. Surface proteins including CD4, CD8, CD69, CD103, CD49d, programmed death-1 (PD-1) and its ligand PD-L1 were assessed. Cytokines containing interleukin (IL)-4, IL-17, interferon (IFN)-γ, granzyme B and tumour necrosis factor (TNF)-α released by MAIT and γδT cells were measured following PMA and ionomycin stimulation. Results Circulating MAIT and γδT cells were deficient in OLP. The percentage of CD4 + , CD69 + , CD103 + and PD-1 + MAIT cells was increased in OLP, while that of CD8 + and CD49d + MAIT cells was decreased. The percentage of CD103 + , PD-1 + and PD-L1 + γδT cells was upregulated in OLP. Both the MAIT and γδT cells in OLP produced less IL-4 than controls. The granzyme B-producing MAIT cells were increased, while γδT cells secreting granzyme B and TNF-α were reduced in OLP. IL-17 and IFN-γ in OLP MAIT and γδT cells were not significantly different from that in controls. The frequency of OLP MAIT cells and the MAIT/γδT rate were positively associated with the disease severity. Conclusion The deficient MAIT and γδT cells expressing functional proteins and releasing cytokines may play an immunoregulatory role in the pathogenesis of OLP.
研究领域:
免疫学
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炎症
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口腔疾病
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细胞生物学
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DOI
PubMed
高影响因子
Nanoscale
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2025
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IF 5.1
Shaonan Tian,Zhenya Hu,Mengyuan Ma,Hui Liu,Jun Yang
Developing high-performance electrocatalysts is essential for the commercialization of fuel cells, but the commercial catalyst is still far from satisfactory in terms of catalytic activity and stability. Herein, we report a convenient solid-phase synthesis strategy that couples ball milling and rapid Joule-heating to prepare fine palladium nanoparticles supported on carbon substrate (Pd/C). The as-synthesized Pd/C catalyst shows excellent catalytic performance for typical electrochemical reactions, e.g., oxygen reduction reaction (ORR), ethanol oxidation reaction (EOR) and formic acid oxidation reaction (FAOR), compared to commercial Pd/C catalyst. We emphasize the multi-dimensional comparison of the obtained Pd/C product and commercial catalysts to illustrate the potential advantages of the synthesis method in industrial applications.
研究领域:
材料科学
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电化学
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能量转换
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纳米技术
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DOI
PubMed
高影响因子
Applied Sciences-Basel
·
2019
·Vol. 9
·期 9
·1792
·
IF 2.217
Anqiu Liu,Xiaochen Wang,Daming Gao,Le Wang,Junjie Cheng,An Wang,Zehui Zhang
Chemoselective hydrogenation of aldehydes with heterogeneous catalysts under mild conditions is of great importance but remains a major challenge. Herein, an efficient strategy was developed for low temperature chemoselective hydrogenation of aldehydes with broad substrate scope over a magnetic material supported palladium catalyst (γ-Fe2O3@HAP-Pd). Aldehydes bearing various reducible functional groups readily underwent hydrogenation to give the corresponding primary alcohols with moderate to excellent yield at room temperature in aqueous solutions. The Hammett equation revealed that the hydrogenation of aromatic aldehydes proceeded via an anionic intermediate. Additionally, when the temperature increased to 70 °C, toluene was obtained by the deoxygenation of benzaldehyde in excellent yield. Furthermore, the γ-Fe2O3@HAP-Pd could be recycled up to six times without loss of activity and metal leaching.Keywords:selective hydrogenation;aldehydes;Pd catalysts;mild conditions
研究领域:
催化化学
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材料科学
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DOI
高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2018
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IF 4.841
Chanjuan Liao,Xixi Liu,Yongshen Ren,Daoxin Gong,Zehui Zhang
A sustainable method was developed for the upgrade of biomass derived vanillin (a typical model compound of lignin) into the potential liquid biofuels over a layered double hydroxide supported Pd catalyst (abbreviated as CoAl–LDH/Pd). The CoAl–LDH/Pd catalyst showed high catalytic activity towards the hydrodeoxygenation of vanillin into 2-methoxy-4-methylphenol (MMP) under mild conditions in aqueous media. High MMP yield up to 86% was produced at 120 °C after 4 h. Kinetic studies revealed that the rate-determining step for the hydrodeoxygenation of vanillin was the hydrogenolysis of vanillyl alcohol. More importantly, the CoAl–LDH/Pd catalyst was highly stable without the loss of activity.
研究领域:
催化化学
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生物质能
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绿色化学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
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2020
·Vol. 44
·期 46
·20367-20374
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IF 3.288
Dan Zhang,Bowei Wang,Lijuan Yan,Ruixiao Gao,Lu Liu,Ziyi Xia,Xilong Yan,Yang Li,Ligong Chen
Synthesis of an easily separable and efficient catalyst is of great significance for selective hydrogenation of unsaturated functional groups. In this work, novel magnetic flower-like carbonaceous Pd catalysts are constructed for the selective reduction of the CC bond. According to the characterization results, a flower-like architecture is observed in the catalysts containing both Fe3O4 and Pd NPs, which is constructed by the secondary self-assembly in the preparation process due to the interaction between Pd and magnetic nitrogen-doped graphene (Fe3O4-NG). More flower-like structures are formed by increasing the Pd loading amount, further enhancing the specific surface area of the catalyst. The specific surface area of Pd-FONG-3 is the highest (521.17 m2 g−1). Combining the results of characterization and experiments, it is found that the catalytic activity is positively related to the flower-like architecture and the interaction between Pd NPs (6.0 nm) and Fe3O4 NPs (6.7 nm). Fe3O4 is not only beneficial to the magnetic recovery of the catalyst, but also acts as a cocatalyst, which can significantly improve the reactant conversion. Moreover, N species play an important role in protecting the CO bond, resulting in the selective hydrogenation of the CC group. Herein, Pd-FONG-3 exhibits excellent activity in the selective hydrogenation of cinnamaldehyde (CAL) with 99.5% conversion and 96.5% hydrocinnamaldehyde (HCAL) selectivity, and its catalytic performance is much better than that of the commercial 5% Pd/C catalyst (100% conversion and 69.1% HCAL selectivity). This work provides a new strategy to construct highly active catalysts with magnetic recovery properties for selective hydrogenation of CC bonds, and Pd-FONG-3 shows tremendous application foreground.
研究领域:
催化化学
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材料科学
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纳米技术
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DOI
高影响因子
Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 12
·4485-4489
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IF 8.262
Wei Hong,Peiyan Bi,Changshuai Shang,Jin Wang,Erkang Wang
A simple one-pot synthesis of multi-walled carbon nanotube supported Pd nanocubes is described in this work. Pd nanocubes were in situ grown on carbon nanotubes. The Pd nanocubes show a single-crystal nanostructure and an average diameter of about 9.6 nm. The use of KBr is essential for the formation of Pd nanocubes; without KBr, only irregular Pd nanoparticles can be generated. The structural properties and electronic states of the prepared Pd nanocubes were studied by transmission electron microscopy and X-ray photoelectron spectroscopy, respectively. The developed nanomaterials present enhanced electrocatalytic activity which is 1.3 times and 1.75 times higher than that of their counterpart multi-walled carbon nanotube supported Pd nanoparticles and a commercial Pd/C reagent, respectively, for formic acid electrooxidation.
研究领域:
材料科学
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电化学
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DOI
高影响因子
Catalysis Science & Technology
·
2013
·Vol. 3
·期 10
·2620-2626
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IF 3.753
Chunhui Chen,Ensheng Zhan,Na Ta,Yong Li,Wenjie Shen
Pd nanocubes of 6–19 nm in size were synthesized using a seeded growth method and examined for enantioselective hydrogenation of α,β-unsaturated carboxylic acids. It was found that the Pd nanocubes had two types of active sites on the planes and at the edges, respectively. Small nanocubes having a higher edge/plane ratio were more active in enantioselective hydrogenation of α,β-unsaturated carboxylic acids, but afforded a lower enantioselectivity because their sharp edges could not offer stable adsorption of the chiral modifier and the reaction intermediates. In contrast, large nanocubes with a higher fraction of flat planes provided a higher enantioselectivity but a much lower activity.
研究领域:
化学
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纳米材料科学
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催化反应
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DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·Vol. 10
·期 9
·7783-7793
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IF 1.5
Fen Wang,Xian Jing Yang,Qi Guo Chen,Mei Chao,Chun An
Pd/Ag/Cu electrode was successfully prepared on Ag dendrites with Cu substrate (Ag/Cu) by galvanic replacement reactions, and was characterized by scanning electron microscopy, X-ray diffraction and transmission electron microscopy. The electroreductive dechlorination reaction of 2,3-dichlorophenol on Pd/Ag/Cu electrode was investigated by cyclic voltammetry and in situ FTIR techniques. Compared with Pd/Cu, Ag/Cu and Cu electrodes, Pd/Ag/Cu electrode exhibited the highest electrocatalytic activity for electroreductive reaction of 2,3-dichlorophenol. C-Cl bond was broken by reaction of adsorbed 2,3-dichlorophenolate with (H) ads Pd on Pd/Ag/Cu electrode surface. The main intermediate was 2-chlorophenolate, and the final product was phenolate.
研究领域:
环境化学
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电催化
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材料科学
·
分析化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）