POLYMER
·
2016
·
IF 3.586
Meng-meng Zhu,Fei Song,Wu-cheng Nie,Xiu-li Wang,Yu-zhong Wang
Miktoarm star copolymers , which are in the simplest form of branching, are particularly of interest to biomedical applications. Nevertheless, their synthesis is facing troubles of seeking inner cores with heterogeneous functional groups as well as tedious protection and deprotection. Herein, ethyl-β- d -glucopyranoside, a sugar molecule containing homogeneous groups, was directly employed as a core to synthesize an amphiphilic miktoarm star copolymer via a chemoenzymatic approach without complicated decoration and protection of the core. Because of the high regioselectivity originated from enzymatic catalysis, the resultant copolymers with well-regulated molecular architecture were synthesized, which can self-assemble into highly-stable nanoaggregates in aqueous media. The copolymers were nontoxic in preliminary in vitro cytotoxicity assays and able to carry doxorubicin into tumor cells, indicating their promising application as a new biocompatible platform for drug delivery.
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JOURNAL OF NANOPARTICLE RESEARCH
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2016
·Vol. 18
·期 5
·1-9
·
IF 2.101
Chen Jiucun,Li Junzhi,Liu Jianhua,Weng Bo,Xu Liqun
Abstract A novel well-defined four-armed star poly(ethylene brassylate)- b -poly(poly(ethylene glycol)methyl ether methacrylate) (s-PEB- b -P(PEGMA)) was synthesized and self-assembled via the combination of ring-opening polymerization and reversible addition-fragmentation chain transfer polymerization (RAFT) in this work. It proceeded firstly with the synthesis of hydrophobic four-armed star homopolymer of ethylene brassylate (EB) via ROP with organic catalyst, followed by the esterification reaction of s-PEB with chain transfer agent. Afterward, RAFT polymerization of PEGMA monomer was initialed using PEB-based macro-RAFT agent, resulting in the target amphiphilic four-armed star copolymer. The obtained s-PEB- b -P(PEGMA) can assemble into micelles with PEB segments as core and P(PEGMA) segments as shell in aqueous solution. The self-assembly behavior was studied by dynamic light scattering and transmission electron microscope. The micelles of s-PEB- b -P(PEGMA) exhibited higher loading capacity of the anticancer drug doxorubicin (DOX). The investigation of DOX release from the micelles demonstrated that the release rate of the hydrophobic drug could be effectively controlled. Graphical Abstract
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Frontiers of Materials Science
·
2017
·Vol. 11
·期 3
·223-232
·
IF 1.471
Wei Lulu,Lu Beibei,Li Lei,Wu Jianning,Liu Zhiyong,Guo Xuhong
A novel β-cyclodextrin-poly(2-(2-methoxyethoxy)ethyl methacrylate)- co -poly(ethylene glycol) methacrylate (abbreviated as: β-CD-(P(MEO 2 MA- co -PEGMA)) 21 ) was prepared by using the one-step strategy, and then the star-shaped copolymers were used in the atom transfer radical polymerization (ATRP). The structure of star-shaped β-CD-(P(MEO 2 MA- co -PEGMA)) 21 copolymers were studied by FTIR, 1 H NMR and gel permeation chromatography (GPC). The star-shaped copolymers could self-assembled into micelles in aqueous solution owing to the outer amphiphilic β-CD as a core and the hydrophilic P(MEO 2 MA- co -PEGMA) segments as a shell. These thermo-responsive starshaped copolymers micelles exhibited lower critical solution temperature (LCST) in water, which could be finely tuned by changing the feed ratio of MEO 2 MA to PEGMA. The LCST of star-shaped β-CD-(P(MEO 2 MA- co -PEGMA)) 21 copolymer micelles were increased from 35°C to 58°C with the increasing content of PEGMA. The results were investigated by DLS and TEM. When the temperature was higher than corresponding LCSTs, the micelles started to associate and form spherical nanoparticles. Therefore, β-CD-(P(MEO 2 MA- co -PEGMA)) 21 star-shaped copolymer micelles could be potentially applied in nano-carrier, nano-reactor, smart materials and biomedical fields.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 31
·
IF 1.768
Xiongfa Yang,Cheng Cao,Zhonghong Chen,Jia Liu,Alan R. Bassindale,Guoqiao Lai
Combination of the organic–inorganic hybrid such as silsesquioxane with ε-caprolactone will lead to materials expected to be environmentally friendly and applicable to biomedical usages. A ladder-like poly(phenyl silsesquioxane) based hybrid star-shaped copolymer of ε-caprolactone was prepared by ring opening polymerization of ε-caprolactone catalyzed by Sn(Oct) 2 with hydroxyl terminated ladder-like poly(phenyl silsesquioxane) as initiator. The copolymers were characterized by proton nuclear magnetic resonance ( 1 H-NMR), silicon nuclear magnetic resonance ( 29 Si-NMR), Fourier-transform infrared spectrometer (FT-IR), size exclusion chromatography (SEC), thermo gravimetric analysis (TGA), and differential scanning calorimetry (DSC) in detail. Furthermore, the enzymatic degradation property of the copolymers was also investigated. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 42335.
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
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2018
·Vol. 56
·期 22
·2574-2583
·
IF 2.588
Zhangxin Chen,Chang Su,Xiaogang Zhu,Ruoteng Xu,Lihuan Xu,Cheng Zhang
A novel organic conjugated polymer based on star-shaped triazine-functional triphenylamine framework poly[1,3,5-tris(4-diphenylamino-phenyl)triazine] (PTDAPTz) is designed and synthesized successfully by FeCl 3 -catalysted chemical oxidative polymerization. The polymer PTDAPTz powder exhibits a compactly packed pleated skirt shape-like morphology with a high surface area (~930 m 2 g −1 ) and a bimodal pore size distribution ranging from micropores (~0.55 nm) to small diameter mesopores (~2–6 nm). As explored as the cathode material, the obtained PTDAPTz presents the double charge–discharge process characteristics of both the free radical redox of triphenylamine unit and the bipolar redox of triazine unit in the polymer and a well-defined multistage charge/discharge voltage plateau (~3.8 V for p-doped and ~2.0 V for n-doped) during the charge–discharge process. Also, the PTDAPTz demonstrates an improved capacity (stabilized at 123 mA h g −1 until 50th cycle) and the enhanced rate performance compared to polytriphenylamine (PTPAn). Specially, the discharge curve for the part of triphenylamine unit presents an obviously improved discharge plateau (~3.8 V for PTDAPTz compared to ~3.6 V for PTPAn) due to the electron-withdrawing effect of the triazine unit to triphenylamine. The elaborate structural design and created micro-/mesoporous morphology with the double charge–discharge process make PTDAPTz a potential candidate as the performance-improved cathode of Li-organic battery. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56, 2574–2583
研究领域:
材料科学
·
电化学
·
有机合成
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Soft Matter
·
2018
·Vol. 14
·期 36
·7420-7428
·
IF 3.709
Dinglei Zhao,Quan Tang,Qiang Zhou,Kang Peng,Haiyang Yang,Xingyuan Zhang
As one of the most promising biomaterials, injectable self-healing hydrogels have found broad applications in a number of fields such as local drug delivery. However, controlled release of drugs in hydrogels is still difficult to realize up to now. Here, we report a novel photo-degradable injectable self-healing hydrogel based on the hydrophobic interaction of a biocompatible four-arms star polymer, poly(ethylene glycol)-b-poly(γ-o-nitrobenzyl-L-glutamate). The hydrophobic interaction between poly(γ-o-nitrobenzyl-L-glutamate) not only connects poly(ethylene glycol)-b-poly(γ-o-nitrobenzyl-L-glutamate) together with a crosslink but also provides a hydrophobic domain to encapsulate hydrophobic pharmaceuticals such as doxorubicin (DOX). Due to the dynamic character of the hydrophobic interaction, the hydrogel exhibits excellent injectable and self-healing ability. In particular, the photolabile o-nitribenzyl ester group is cleaved under UV irradiation. As a result, the hydrophobic domain transforms into the hydrophilic one and the embedded DOX is released effectively. An increasing release ratio of DOX dramatically enhances the apoptosis ratio of HeLa cells. We expect these attractive properties may be beneficial to practical applications of the hydrogel as an effective local drug delivery means in a truly physiological environment.
研究领域:
生物医学工程
·
药学
·
材料科学
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ACS Applied Polymer Materials
·
2025
·
IF 4.7
Yunpeng Zhang,Peng Gao,Rui Guan,Haoran Zheng,Chuanren He,Longxiang Tao,Bingjie Zhao,Jun Yin
Shape-color dual-responsive polymers triggered by thermal stimuli have garnered significant attention due to their potential to impart a variety of functionalities within a single material. Nevertheless, developing a nontoxic and durable color-shape dual-responsive polymer system through a cost-effective and feasible strategy remained a challenge. In this study, a star-shaped poly(ε-caprolactone) modified by diacetylene (s-DA-PCL31) was synthesized and blended with poly(vinyl chloride) (PVC) via solution casting followed by in situ photopolymerization, resulting in a nontoxic, reversible shape-color dual-responsive flexible PVC-based composite film. The s-PDA-PCL31@PVC composite film exhibited enhanced mechanical properties, including an elongation at break of approximately 447.1% and toughness of 67.1 MJ/m3, which were ∼94 and ∼60 times greater than those of pure PVC, respectively. Furthermore, the composite film demonstrated excellent durability, with only ∼10.1% volatility and ∼2.0% degree of migration. The PVC-based composite film also displayed shape-memory properties, which can be attributed to the formation of stable physical cross-links through hydrogen bonding interactions and chain entanglements. Due to the feasible conformational transition of PDA enabled by the star-shaped PCL with symmetrical chains, the composite film exhibited reversible thermochromism, with an obvious color transition from blue–purple–red–purple–blue with a temperature cycle from 25–80–120–80–25 °C. More importantly, by fine-tuning the appropriate shape transfer temperature (Ttr), the composite exhibited both shape recovery and color change in response to thermal stimuli within a temperature range of 0 to 80 °C. This dual-responsive smart material demonstrated great potential for a variety of applications, including camouflage, anti-counterfeiting, and temperature monitoring.
研究领域:
材料科学
·
高分子化学
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JOURNAL OF CATALYSIS
·
2025
·
IF 6.5
Shan Wu,Jian Shi,Qian Duan,Ludan Shang,Xiaodong Zhang,Yuhan Duan
Porphyrins and phthalocyanines are considered as visible light catalysts with great development potential due to their unique π-conjugated structure, strong visible light absorption and structural tunability. However, they are easy to aggregate and difficult to dissolve, and their application in the field of photocatalysis is limited. Based on the above problems, in this study, three four-arms star-shaped thermosensitive copolymers (PcZn-(PNIPAM n -co-PUMPP m ) 4 ) photocatalysts with zinc phthalocyanine as the core and porphyrin thermosensitive copolymer as the arms was constructed by using RAFT polymerization technology and the ’core first’ route. The visible light catalytic activity of the prepared star-shaped copolymers was evaluated by using 1,5-dihydroxynaphthalene (DHN) and methylene blue (MB) as model pollutants. The three copolymers were found to be effective in oxidizing DHN to juglone and degrading MB. Among them, PcZn-(PNIPAM 33.5 -co-PUMPP 1.6 ) 4 (P3) showed the highest DHN conversion efficiency (100.0 %), reaction yield (70.0 %) and MB degradation (96.9 %). 1 O 2 and O 2 · - are the main active substances in the visible photocatalytic process. Based on UV–vis absorption spectra, Fluorescence spectra, EIS Nyquist plots and transient photocurrents, it is confirmed that P3 has a wider range of visible light absorption, and there is effective energy and electron transfer between TTPcZn and UMPP units in P3, which makes it have higher catalytic activity. More importantly, the lower critical solution temperature (32.6 ∼ 32.9 °C) of P3 makes it possible to achieve homogeneous catalysis and heterogeneous recovery through simple temperature regulation in the catalytic process, which makes P3 have good reusability. This work paves a way for the construction of high-performance and recyclable visible polymer photocatalyst.
研究领域:
材料科学
·
环境科学
·
化学工程
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ACS Applied Polymer Materials
·
2026
·
IF 5.2
Jakkree Intranuwong,Arin Kim,Nutcha Nongyai,Seong Kyu Shin,Yong Ku Kwon
Porous polymeric biodegradable monoliths (PHIPEn, where n denotes the number of arms of the PLA macroinitiator) based on poly(δ-valerolactone-co-l-lactide) were prepared via bulk ring-opening polymerization of a δ-valerolactone/l-lactide (VL/LA) eutectic mixture (80/20) using various PLA macroinitiators. Linear (one- and two-arm) or star-shaped (four- and six-arm) PLA macroinitiators were employed to investigate the effect of initiator functionality on the morphology and properties of PHIPEns. The variation in initiator functionality strongly affected the pore morphology, cross-link density, and overall physical properties of the materials. Increasing the number of arms resulted in smaller pore size, higher cross-link density, greater crystallinity, and improved compressive strength and modulus. Thermal analysis revealed that PHIPEns prepared from star-shaped macroinitiators exhibited improved thermal stability and higher PVL crystallinity compared with those derived from linear macroinitiators. Hydrolytic degradation in phosphate-buffered saline at 37 °C showed that PHIPEns synthesized from star-shaped macroinitiators degraded more slowly, absorbed less water, and maintained a more stable pH than those derived from linear ones. These results demonstrate that combining star-shaped macroinitiators with a VL/LA eutectic mixture provides an effective strategy for designing biodegradable porous materials with tunable properties.
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THERIOGENOLOGY
·
2026
·
IF 2.9
Jiahao Zhao,Xiangyu Zhou,Baoyi You,Bowen Cheng,Jiashuo Hu,Yuxuan Lu,Dianrui Xu,Xiwei Zhang,Chunlong Yan,Qingshan Gao,Haixing Liu,Qingguo Jin
Florfenicol (FLO) is widely used to treat bacterial respiratory diseases and hoof rot in cattle at various physiological stages. However, residues of FLO that accumulate in cattle may have adverse effects on animal health. Although FLO has been reported to exhibit embryotoxic and cytotoxic properties, the mechanism underlying its effects on bovine granulosa cells (GCs) remains poorly understood. In this study, we treated GCs with FLO at concentrations of 0, 10, and 100 μg/mL for 48 h to evaluate the effects of FLO on cell viability, mitochondrial function, and steroid hormone synthesis. The results showed that FLO treatment was associated with increased apoptosis, reduced GC proliferation, and impaired mitochondrial function. In addition, FLO treatment was accompanied by decreased ATP levels and increased intracellular reactive oxygen species (ROS). Furthermore, FLO exposure was associated with changes in PROG and E2 production, decreased protein expression of StAR and CYP11A1, and reduced levels of adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA). The antioxidant N-acetyl-L-cysteine (NAC) partially attenuated these changes. In conclusion, our findings suggest that FLO exposure is associated with GC dysfunction and impaired steroidogenesis. These effects may be related to oxidative stress, mitochondrial dysfunction, and alterations in the cAMP/PKA/StAR signaling pathway, although direct causal relationships remain to be further elucidated.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yu Ding,Liya Chen,Xiao Wang,Puyan Huang,Guorong Chen,Jifang Fu
High-performance lithium metal batteries demand polymer electrolytes materials possessing excellent electrochemical performance, mechanical properties and interfacial compatibility. However, the low ionic conductivity, significant polarization and parasitic side reactions observed in conventional polymer electrolytes hinder their practical application. In this work, novel POSS-based single-ion conducting hybrid electrolytes (PSCHEs) with a star -crosslinked network were synthesized by introducing multifunctional POSS into single-ion conducting polymer chains through epoxy ring-opening polymerization. These PSCHEs exhibit a high porosity exceeding 90 %, a room-temperature ionic conductivity of 1.15 × 10 −4 S cm −1 , a high lithium-ion transference number of 0.80 and a wide electrochemical window of 4.8 V. Furthermore, the formation of a stable LiF and Li x SiO y -rich SEI layer at the lithium metal anode interface and excellent interfacial compatibility between the electrolytes and the electrodes were demonstrated, enabling stable lithium plating/stripping for over 1400 h at a current density of 0.1 mA cm −2 . The Li|PSCHEs|LiFePO 4 cells exhibit good cycling and rate performance at room temperature. This work offers a promising strategy for designing polymer electrolytes with a range of desirable properties for high-performance lithium metal batteries.
研究领域:
材料科学
·
电化学
·
高分子科学
·
储能技术
·
纳米技术
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.7
Xiaofei Sun,Ning Chen,Shujun Wang,Yushu Lin,Jie Zhang,Shuo Xing,Qing Liu,Yueyun Li,Daopeng Zhang,Kai Feng,Jongnam Park,Feng Tang
Cardiac troponin I (cTnI), recognized as the gold-standard biomarker for acute myocardial infarction (AMI), plays a crucial role in the early diagnosis and clinical management. Herein, we present a rationally designed multiple signal enhancement strategy for an ultrasensitive electrochemical immunoassay of cTnI. This work integrates the superior catalytic activity of a wrinkled MoS 2 -supported PtAgCu ternary alloy (PtAgCu/MoS 2 ) with the excellent conductivity of hexagonal star-like nitrogen-doped carbon (HS-NC) modified by gold nanoparticles (Au@HS-NC). The PtAgCu alloy, featuring maximized atomic utilization and optimized d-orbital coupling, exhibits outstanding hydrogen peroxide (H 2 O 2 ) electroreduction activity and a large electrochemically active surface area, thereby effectively amplifying the sensing signal. Meanwhile, the precisely designed MoS 2 carrier not only offers abundant anchoring sites and facilitates charge transfer but also enriches H 2 O 2 reactant, thereby promoting the catalytic performance of the PtAgCu alloy. Furthermore, as an ideal substrate, the morphologically engineered HS-NC, enriched with nitrogen functionalities, offers a highly conductive framework with ultralarge surface area (1121.80 m 2 g −1 ), enabling efficient immobilization of primary antibodies (Ab 1 ) and stable, accelerated charge transfer, thereby synergistically amplifies the signal output. Benefiting from this multiple amplification strategy, the proposed immunosensor achieves a remarkably low limit of detection of 0.51 fg mL −1 , and an exceptionally broad dynamic range (from 10 fg mL −1 to 100 ng mL −1 ), while exhibits excellent selectivity in complex matrices, maintaining high reproducibility and stability. This work demonstrates a rational multi-amplification design paradigm for constructing high-performance immunosensors and highlights its promising application in AMI early diagnosis.
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