INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 15
·8125
·
IF 4.9
Taoyang Cai,Shangjie Ge-Zhang,Chang Zhang,Pingxuan Mu,Jingang Cui
Transparent films with excellent antibacterial properties and strong mechanical properties are highly sought after in packaging applications. In this study, Ag/SiO2nanoparticles were introduced into a mixed solution of chitosan (CS) and polyvinyl alcohol (PVA) and a Ag/SiO2-CS-PVA transparent film was developed. The excellent properties of the film were confirmed by light transmittance, water contact angle tests and tensile tests. In addition, for the antibacterial test, the antibacterial properties of the sample against Gram-negative bacteria (Escherichia coli) and Gram-positive bacteria (Staphylococcus aureus) were explored, and the average size of the bacteriostatic circle was measured by the cross method. The final results show that Ag/SiO2-CS-PVA transparent film has the advantages of good antibacterial properties, high transparency and high mechanical strength.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2024
·
IF 5.8
Xiaodong Yu,Jihao Fan,Shengquan Zheng,Linlin Ma,Xiaojing Liu,Yue Wu,Chuangqi Zhao,Lei Jiang
High strength/toughness nanocomposites are increasingly in demand due to the development needs of high-end applications. However, the aggregation and random orientation of nanofillers and the weak crosslinking of the polymer matrix lead to the degradation of the mechanical properties of nanocomposites. Here, we present a strategy to prepare chitosan-based nanocomposites with aligned nanosheets via the in situ photo-crosslinking of modified chitosan. The well-dispersed and highly aligned nanosheets, as well as the dense covalently crosslinked network between the modified chitosan chains, effectively improve the mechanical properties of the prepared nanocomposites. For example, the chitosan-based nanocomposite films exhibit a tensile strength of up to 340.6 ± 13.4 MPa, a Young's modulus of 8.2 ± 0.2 GPa and a toughness of 22.0 ± 2.5 MJ m−3, which are 4.2, 4.8 and 1.8 times higher, respectively, than those of pure chitosan films. Moreover, the thermal decomposition temperature of the chitosan-based nanocomposite films reaches 286.8 °C, which is 48.5 °C higher than that of pure chitosan films. We consider that our strategy, which constructs a crosslinked chitosan structure with aligned nanofillers, could lead to the development and application of the bio-based composites with excellent mechanical properties.
研究领域:
材料科学
·
生物工程
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产品关联
DOI
PubMed
高影响因子
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
·
2021
·
IF 3.133
Ya-Wen Zhang,Ling-Lan Tu,Zhan Tang,Qiao Wang,Gao-Li Zheng,Li-Na Yin
Oral absorption of peptides/proteins is usually compromised by various gastrointestinal tract barriers. To improve delivery efficiency, chitosan-conjugated deoxycholic acid (CS-DCA) coupled with sodium alginate (ALG) was prepared to load insulin into pH-sensitive nanoparticles. The insulin-loaded chitosan-deoxycholic acid/alginate nanoparticles (CDA NPs) were characterized by size (143.3 ± 10.8 nm), zeta potential (19.5 ± 1.6 mV), entrapment efficiency (61.14 ± 1.67%), and insulin drug loading (3.36 ± 0.09%). The CDA NPs exhibited pH-triggered release characteristics in vitro and protected the wrapped insulin from gastric degradation. Stability of the CDA NPs in enzyme-containing simulated gastrointestinal fluids suggested that the NPs could partially protect the wrapped insulin from enzymatic degradation. Additionally, CS-DCA-modified NPs promoted the permeability of Caco-2 cells and enhanced intracellular absorption of FITC-labeled insulin by 9.4 and 1.2-folds, when compared to insulin solution and unmodified NPs, respectively. The positively charged NPs increased intestinal villi adhesion and enhanced insulin absorption in the intestines of diabetic rat models. Furthermore, the hypoglycemic test showed that CDA NPs prolonged insulin release in vivo and exerted a remarkable hypoglycemic effect on diabetic rats with an oral bioavailability of 15%. In conclusion, CDA NPs is a potential oral insulin delivery system.
研究领域:
药剂学
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生物医学工程
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糖尿病治疗
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DOI
高影响因子
Journal of Applied Spectroscopy
·
2024
·Vol. 91
·期 4
·921-927
·
IF 0.8
Wang Bin,Zhang Xiao,Ma Xiangmei
Exploring new material structures of low photocatalytic degradation activity for ultraviolet screening is one of the important methods for improving polyvinylchloride (PVC) performance. As an important kind of ultraviolet (UV) shielding agent material, nano zinc oxide (ZnO) has been applied extensively in many fields due to its outstanding properties. However, the severe aggregation behavior between nanoparticles (NPs) and photocatalytic activity greatly limits the application. In this work, surface modification of ZnO with hydroxyapatite and chitosan (ZnO–Hap/CS) was fabricated. Then via a solution casting technique dispersed within the PVC matrix. The results demonstrated that the obtained composite exhibited the best ultraviolet screening performance greatly decreasing the photocatalytic degradation activity of ZnO. It is expected that this approach is prospective for the large-scale preparation of nano ZnO with excellent UV-blocking performance and low photocatalytic degradation activity.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
Desalination and Water Treatment
·
2016
·
IF 1.272
Chunxia Ding,Daoxin Gong,Peng Yu,Jihai Shao,Mei-E Zhong
Chitosan–montmorillonite bionanocomposite (CTS–MMT) was prepared for removing the herbicide quinclorac (QC) from aqueous solution. The resulting nanocomposites were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Brunauer–Emmett–Teller (BET) surface area and Barrett–Joyner–Halenda (BJH) pore size distribution analysis. The adsorption of QC onto CTS–MMT as a function of adsorbent dosage, pH, temperature, ionic strength, contact time, and initial QC concentration was investigated by conducting batch adsorption experiments. The results showed that CTS–MMT exhibited higher adsorption affinity and higher adsorption capacity towards QC than the unmodified montmorillonite. The adsorption kinetics data of QC onto CTS–MMT were well described by the pseudo-second-order kinetics model. Adsorption isotherms fitted well with the Freundlich isotherm model in the heterogeneous adsorption process. Adsorption thermodynamics study indicated that the adsorption of QC onto CTS–MMT was a spontaneous and endothermic process. The QC molecules on CTS–MMT could hardly be desorbed by water, but could be desorbed by 0.1 mol/L NaOH solution. QC adsorption on CTS–MMT may involve electrostatic attraction, cation–dipole, hydrogen bonding, and van der Waals interactions. The findings of this study suggest that CTS–MMT is a potential adsorbent for quinclorac pollution remediation.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
Current Nanoscience
·
2013
·Vol. 9
·期 1
·8-13
·
IF 1.356
Du Jing,Li Xueyong,Yang Chen,Li Wei,Huang Weijuan,Huang Rong,Zhou Xue,Deng Hongbing
The chitosan (CS)-organic rectorite (OREC) composites are prepared with the method of solution intercalation. Electrospun nanofibrous mats are made from intercalated CS-OREC composites at different mass ratios. The properties and structure of intercalated CS-OREC can be verified by
small angle X-ray diffraction (SAXRD) and transmission electron microscopy (TEM) micrographs. Energy dispersive X-ray (EDX) spectroscopy and fourier transform infrared (FT-IR) spectra reveal that OREC presents in the composite nanofibrous mats. The MTT assay indicates that the cytotoxicity
of the intercalated CS-OREC nanofibrous mats is low. Besides, the content of OREC in nanofibrous mats has a significant influence on the viability of cells. Antibacterial test confirms that OREC can increase the inhibition rate of the nanofibrous mats against Escherichia coli.
研究领域:
材料科学
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生物学
·
医学
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DOI
高影响因子
FIBERS AND POLYMERS
·
2016
·Vol. 17
·期 11
·1782-1789
·
IF 1.022
Xu QingBo,Wu YongHong,Zhang YanYan,Fu FeiYa,Liu XiangDong
This article focuses on the functional finishing of textiles using silver nanoparticles (AgNPs) and chitosan derivative binder, which was synthesized by a modification of chitosan using α-ketoglutaric acid. The binder covalently linked to cotton fabric via esterification of the hydroxyl groups on the cotton surface, and tightly adhered to surface of the AgNPs by coordination bonds. As a result, the coating of AgNPs on the cotton fabric showed excellent antibacterial property and laundering durability. After 30 consecutive laundering cycles, the Ag content on the fabrics decreased to 37.6 %, but the bacterial reduction rates against both S. aureus and E. coli were maintained over 95 %. It has potential applications in a wide variety of fields such as sportswear, socks, and medical textile.
研究领域:
纺织科学
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材料科学
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生物学
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DOI
高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2025
·
IF 8.4
Jin-Hyuk Choi,Mingi Ko,Soyeong Yoon,Narae Kim,Taesoon Jang,Myeongsong Lee,Jeong-Ann Park
A three-dimensional porous graphene oxide/chitosan (GO/CS) sponge (average pore size = 21.67 μm; pore size distribution = 0.75–319.26 μm, total pore area = 1.84 m 2 /g; and pH pzc = 5.76) was evaluated for the polystyrene (PS) NPs (hydrodynamic diameter = 31.1 ± 0.4 nm) removal from aqueous solutions. The adsorption kinetics followed a pseudo-second-order model, and intra-particle diffusion occurred in three distinct stages: film diffusion, pore diffusion, and surface sorption. Adsorption isotherms aligned best with the Langmuir model, indicating a maximum adsorption capacity of 33.30 mg/g. Thermodynamic analysis showed that PS NPs adsorption was spontaneous (ΔG° < 0) and endothermic (ΔH° > 0) within the temperature range of 283–293 K. FT-IR and XPS analyses confirmed that adsorption occurred through multiple mechanisms, including electrostatic attraction, hydrogen bonding, and π–π stacking. The adsorption behavior was significantly affected by pH, salinity, and competing ions. The highest adsorption capacity (17.99 mg/g) was observed at pH 5.5, which is close to the pH PZC (5.76) of the sponge, due to favorable electrostatic and hydrophobic interactions. As NaCl concentration increased, adsorption capacity remained stable up to 20 mM, but declined sharply above 100 mM due to PS NPs aggregation. Divalent cations, particularly Ca 2+ , significantly reduced adsorption by compressing the electrical double layer and enhancing aggregation, while monovalent cations and anions had minimal impact. The sponge was reusable after a simple squeeze-wash regeneration, achieving 83.12 % removal efficiency after 12 consecutive adsorption–desorption cycles. Compared to deionized water, real water samples exhibited similar or improved adsorption capacities, with the highest capacity observed in seawater (15.78 mg/g).
研究领域:
环境科学
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材料科学
·
水污染控制
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纳米毒理学
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环境化学
·
可持续技术
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Gao Yang,Gao Shan,Zhang Yunhua,Lyu Shaoyi,Wang Feijun
Reuse of dye-containing wastewater for valuable products offers significant potential. Chitosan, a natural high-molecular-weight porous material, served as an effective carrier for dye molecules. This study uses chitosan to adsorb Congo Red, preparing hierarchical porous carbon materials, which are then applied in supercapacitors. The findings reveal that chitosan achieves an impressive adsorption capacity of 1450 mg g −1 for Congo Red. When the chitosan–Congo Red composite material-based carbon is used as the electrode material, it shows an outstanding specific capacitance of 318 F g −1 at a current density of 1 A g −1 . Furthermore, due to its high content of heteroatoms such as N, O, and S, the double-layer supercapacitor fabricated with this electrode material demonstrates a specific capacitance of 149.49 F g −1 at 1 A g −1 , with an energy density of 8.77 Wh kg −1 at a power density of 335.35 W kg −1 . These results highlight the considerable potential of this material after adsorption of dye-containing wastewater for applications in the energy storage field.
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产品关联
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2016
·Vol. 23
·期 16
·3850-3862
·
IF 5.771
Tuan-Wei Sun,Ying-Jie Zhu,Feng Chen
Graphical Highly flexible multifunctional biopaper with superior mechanical properties, comprising chitosan and high-weight-fraction ultralong hydroxyapatite nanowires (UHANWs/CS) is reported. This material is promising for various biomedical applications such as wound dressing, bone-fracture fixation, and bone-defect repair. Highly flexible multifunctional biopaper comprising ultralong hydroxyapatite nanowires and chitosan (UHANWs/CS), with high weight fractions of ultralong hydroxyapatite nanowires (UHANWs) up to 100 wt. %, is reported. The as-prepared UHANWs/CS composite biopaper has high flexibility and superior mechanical properties even when the weight fraction of UHANWs is as high as 90 wt. %. In contrast, the control samples consisting of hydroxyapatite nanorods and chitosan (HANRs/CS) with weight fractions of HANRs higher than 66.7 wt.% cannot be obtained in the form of the flexible membrane. The ultimate tensile strength and Young's modulus of the UHANWs/CS composite biopaper are about 3.2 times and 4.3 times those of the HANRs/CS membrane with the same weight fraction of HAP, respectively. In addition, the UHANWs/CS composite biopaper (90 wt. % UHANWs) can be used for color printing using a commercial ink-jet printer. The surface wettability, swelling ratio, and water vapor transmission rate of the UHANWs/CS composite biopaper are adjustable by changing the addition amount of UHANWs. In vitro experiments indicate that the UHANWs/CS composite biopaper has good degradability, high acellular bioactivity and high biocompatibility. The as-prepared UHANWs/CS composite biopaper is therefore promising for various biomedical applications such as wound dressing, bone-fracture fixation, and bone-defect repair.
研究领域:
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2021
·
IF 4.089
Jie Zhang,Zihuayuan Yang,Yan-Hong Li,Samran Durrani,Ai-Ping Pang,Yichen Gao,Fu-Gen Wu,Fengming Lin
Establishing antimicrobial photodynamic therapy (PDT) approaches to enhance antimicrobial activities of insoluble photosensitizers in terms of their solubility, stability, and safety is highly desirable yet challenging. Here, we reported super-stable carboxymethyl chitosan-polyethyleneimine-protoporphyrin IX nanoparticles (CMCS-PEI-PpIX NPs) for effective photodynamic inactivation of bacteria and fungi with excellent biocompatibility. CMCS-PEI-PpIX self-assembled into NPs in solution with significantly improved singlet oxygen generation. Consequently, NPs exhibited exceptional photoinactivation toward a broad range of microbes with record low minimal bactericidal concentrations. NPs were highly stable after 28 days of storage. Furthermore, NPs exhibited negligible cytotoxicity without hemolysis on red blood cells. NPs can efficiently attach to the microbial cell through electrostatic interaction to generate singlet oxygen with light irradiation, which caused severe damage to the cell membrane, causing microbial cell death. Overall, the development of CMCS-PEI-PpIX NPs provides a route for improving the microbicidal PDT efficacy, benefiting the clinic treatment of microbial infections.
研究领域:
药剂学
·
微生物学
·
纳米技术
·
治疗学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Min Mu,Xiaoyan Liang,Di Chuan,Shasha Zhao,Wei Yu,Rangrang Fan,Aiping Tong,Na Zhao,Bo Han,Gang Guo
The safe and effective drug delivery system is important for cancer therapy. Here in, we first constructed a delivery system Cabazitaxel(Cab)@MPN/CS between metal-polyphenol (MPN) and chitosan (CS) to deliver Cab for melanoma therapy. The preparation process is simple, green, and controllable. After introducing CS coating, the drug loading was improved from 7.56 % to 9.28 %. [email protected] /CS NPs released Cab continuously under acid tumor microenvironment. The zeta potential of [email protected] /CS NPs could be controlled by changing the ratio of [email protected] and CS solutions. The positively charged [email protected] /CS accelerate B16F10 cell internalization. After internalized, [email protected] /CS NPs could escape from lysosomes via the proton sponge effect. The permeability of CS promotes the penetration of [email protected] /CS to the deeper B16F10 tumor spheroids. In vivo results showed that [email protected] /CS NPs have a longer retention time in tumor tissues and significantly inhibit tumor growth by up-regulating TUNEL expression and down-regulating KI67 and CD31 expression. Thus, this delivery system provides a promising strategy for the tumor therapy in clinic.
研究领域:
药学
·
肿瘤学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
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