JOURNAL OF MOLECULAR STRUCTURE
·
2023
·
IF 3.8
Chenglu Zhang,Shiru Nie,Libo Shang,Chang Liu,Yanpeng Zhang,Yang Zhang,Jinghao Guo
A dual responsive and “turn-on” fluorescent probe NapL with large Stokes shift (115 nm) and large fluorescence emission (585 nm) was designed, synthesized and investigated. NapL has high selective and suitable sensitive (LOD = 82.6 nM) towards Cu 2+ over a wide pH range (7.4–12.1) through a fluorescence “turn-on” mechanism and with rapid response to Cu 2+ (30 s) in complex environments. Furthermore, NapL is sensitive toward pH changes within range (7.4–2.1) with obvious "turn - on" effect (about 37- fold). The sensitive detection characteristics of Cu 2+ can be ascribed to the coordination performance of N and O atoms to Cu 2+ , whereas pH responsiveness is ascribed to the protonation of imino group. NapL has been made into convenient and low-cost pH test strip for detecting pH range (7.4–2.1), and it has also been successfully used for the detection of Cu 2+ in MCF-7 breast cancer cells under neutral conditions.
研究领域:
分析化学
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生物医学
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材料科学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Xinqiang Cao,Yan Gu,Hailin Tian,Yanfen Fang,David Johnson,Zhiyong Ren,Chuncheng Chen,Yingping Huang
In this work, BiVO 4 composites, containing the tetragonal zircon phase ( tz -BiVO 4 ), and monoclinic scheelite phase ( ms -BiVO 4 ), were synthesized using the microemulsion method. The effect of pH on phase composition and photocatalytic activity were investigated. Based on X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), a ms/tz -BiVO 4 composite forms at pH = 1.0 and pure ms -BiVO 4 is obtained in the pH range 4.0–10.0. The three primary steps in preparing BiVO 4 were monitored by optical microscopy and the role played by the microemulsion on the phase composition of BiVO 4 is explained. Photoluminescence spectroscopy (PL), UV–visible diffuse reflectance spectroscopy (UV-DRS), Brunauer-Emmett-Teller (BET), linear sweep voltammetry (LSV) and electrochemical impedance spectroscopy (EIS) were employed to characterize the physical and chemical properties of BiVO 4 composites. The composite formed at pH = 1 exhibited the lowest hole-electron ( h + - e - ) recombination rate, resulting in the highest photocatalytic activity towards microcystin-LR (MC-LR), with near 100% removal of MC-LR in 5 h. ESR and trapping experiments indicated that MC-LR degradation was mediated primarily by hydroxyl radicals (•OH), superoxide radicals (O 2 •− ) and photogenerated holes ( h + ).
研究领域:
材料科学
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环境科学
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化学工程
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Naiyong Xiao,Qiang Zhang,Yantao Yin,Wen Xia,Qinxiu Sun,Zongyuan Han,Qiuyu Xia,Shucheng Liu,Wenzheng Shi
The interactions between grass carp myofibrillar proteins (MPs) and selected aldehydes under different pH conditions were analyzed. The results showed that the binding capacity of MPs to the aldehydes followed the order: nonanal > octanal > hexanal, and their binding capacity increased with rising pH (5–9). MPs-aldehyde interactions exhibited static and dynamic quenching, predominantly mediated by hydrophobic forces, with pH exerting no effect on the quenching mode. With the increase of pH, the imolecular quenching constant, binding constant, and binding sites number of MP and aldehyde gradually increased. Meanwhile, MPs-aldehyde interactions modulated the microenvironment of tryptophan and tyrosine residues, with elevated pH levels amplifying this effect. The presence of aldehydes significantly and differentially reduced the secondary structure in MPs at different pH conditions. Besides, molecular docking result revealed that pH affected the interaction between grass carp proteins and aldehydes by thier altering the binding sites and binding free energy.
研究领域:
食品化学
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水产科学
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蛋白质科学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BMC Oral Health
·
2025
·Vol. 25
·期 1
·1-16
·
IF 3.1
Ge Yongcheng,Zhao Ting,Liu Yuguang,Fan Sizheng,Liu Pengyuan,Zhao Chengji,Liu Xiaoqiu
ObjectiveEnhancing the mechanical properties of composite resins and promoting dentin remineralization are effective strategies for extending the longevity of restorations. In this study, we developed a pH-responsive composite resin reinforced with phosphorylated chitosan (Pchi)/amorphous calcium phosphate (ACP) and amino-functionalized mesoporous silica nanoparticles (MSNs) (Pchi/ACP@A-MSN complexes).Methods MSNs and Pchi/ACP were synthesized, and the resulting composite resins were classified into five groups based on the filler compositions: Group A (45wt.% A-MSNs + 15wt.% Pchi/ACP + 40wt.% resin matrix), Group B (22.5wt.% A-MSNs + 37.5wt.% Pchi/ACP@A-MSNs + 40wt.% resin matrix), Group C (45wt.% nonporous silica + 15wt.% Pchi/ACP + 40wt.% resin matrix), Group D (15wt.% Pchi/ACP + 85wt.% resin matrix), and Group E (100wt.% resin matrix). The degree of double-bond conversion and mechanical properties (Flexural modulus, flexural strength, and Vickers hardness) of each group were measured. The remineralization performance and calcium ion (Ca²⁺) release performance were observed. Cell viability was evaluated by CCK-8 assay.Results Group A exhibited the highest mechanical performance, with flexural strength of 115 ± 9.68 MPa, flexural modulus of 5.99 ± 0.44 GPa, and Vickers hardness of 31.73 ± 2.39 HV. All groups achieved double-bond conversion rates > 50% after 60 s of light curing (P > 0.05). At pH 4.0, Group B exhibited the highest Ca²⁺ release (276 µg/mL), while Group D had the highest release at pH 7.4 (128 µg/mL). SEM and EDS analyses indicated that Group D achieved the most substantial dentin remineralization, followed by Groups C and A. All groups maintained cell viability above 75% throughout the 7-day assay, with no significant cytotoxicity observed.Conclusion A composite formulation containing 45 wt% A-MSNs and 15 wt% Pchi/ACP (Group A) significantly enhanced mechanical strength. The 15 wt% Pchi/ACP formulation (Group D) demonstrated the greatest remineralization effect. Group B, combining A-MSNs and Pchi/ACP@A-MSNs, provided pH-responsive Ca²⁺ release with a favorable balance of mechanical performance and remineralization potential. All formulations met the biocompatibility requirements for dental applications.
研究领域:
牙科材料
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纳米技术
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生物材料
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修复牙科
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Wenyan Zhou,Tong Wang,Yanan Pu,Lin Cao,Wen Li,Jiaxin Huang,Huimeng Feng,Shougang Chen
The research on intelligent corrosion inhibition and repair protective coatings is currently underway, with a particular focus on the intricate microstructure failure process of these coatings due to the inherent complexity of their fillers (functionality, interfacial compatibility, etc.). Herein, we developed corrosion inhibition nanocontainers with enhanced photothermal and pH-responsive properties. The incorporation of chitosan facilitated the acidic environment responsiveness of the nanocontainers, while MoS 2 nanocontainers enabled light-triggered release. The electrochemical results show that after 60 days, the impedance modulus of epoxy coating with 1 % nanocontainers is 4.35 × 10 8 Ω·cm 2 , while that of pure epoxy coating is 2.09 × 10 6 Ω·cm 2 . And it can achieve 300 h of salt spray resistance. In addition, the mechanical properties show that the adhesion and tensile properties of the coating are improved, and the saturated water absorption of the coating is decreased. In addition, the evolution of its electrochemical structure was comprehensively studied using relaxation time analysis. The research results indicate that the coating exhibits multiple electrochemical processes, and the controlled release and formation of a protective layer effectively hinder the formation of corrosion products and reduce internal electrochemical reactions. This study provides a potential method for studying the structural evolution of composite coatings.
研究领域:
材料科学
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电化学
·
防腐蚀工程
✓ 已验证
DOI
高影响因子
RENEWABLE ENERGY
·
2024
·
IF 9
Xiangjun Guo,Yun Huang,Yunheng Tang,Ao Xia,Xianqing Zhu,Xun Zhu,Qiang Liao
Mixed bacterial syngas fermentation is a promising carbon-neutral method for producing acetic acid and ethanol. However, the bacterial community and metabolic pathways were different in the growth and ethanol production stages, whereas the activity of the bacterial community greatly depended on the pH of the culture. In this study, the effect of pH on syngas fermentation performance and microbial community composition under continuous gas supply was investigated. The mixed bacteria grew fastest at a pH of 7, while a constant pH of 6 led to the highest ethanol concentration of 5.15 g L −1 , which was 160 % higher than that at pH 7. Based on this, a two-step pH regulation method was proposed in this study to improve the ethanol production. Initially, the culture pH was maintained at 7 to create optimal growth conditions. Once bacterial density stabilized, it was then changed to a pH 6 to promote ethanol production. By doing this, compared with the control group, the maximum ethanol concentration (5.85 g L −1 ) increased by 148.9 %, the ethanol production rate (2.41 g L −1 d −1 ) increased by more than 8 times. This two-step pH regulation method ensured a high bacterial density and effectively stimulated ethanol production during syngas fermentation.
研究领域:
微生物学
·
生物技术
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yuan-Ju Tang,Shu-Jie Zhang,Zi-Tao Zhong,Bin Zhang,Wen-Ming Su,Guo-Ping Wang,Yuan-Di Zhao
The construction of porous ion channels with ion current rectification (ICR) at the submicron scale has great significance for the development of large-area bionic ion channel devices. In this manuscript, one kind of heterogeneous membrane with asymmetric composition, geometry and wettability was prepared by simple drop-coating of the neutral hydrophobic conducting polymer precursor and in-situ thermal polymerization on cylindrical submicron scale anodic aluminum oxide channels (D≈269 nm) at 150 °C. ICR in the submicrochannel heterogeneous membrane was successfully achieved due to the asymmetric charge distribution induced by asymmetric pH gradient. Furthermore, the rectification ratio ( R ic : 1.6 ∼ 42.8) could be effectively regulated by multiple drop-coating, the electrolyte concentration (0.01 mM ∼ 1 M) and pH gradient (3 ∼ 11). Finally, through the permeation experiment of anionic dye and cationic dye, the mechanism of the synergistic effect of surface charge and electrophoresis on the ion selectivity and ICR was discussed, and it was successfully applied to the directional and on-demand transport of anionic and cationic ions under the regulation of pH gradient and voltage driving. It has important potential applications in the treatment of pollutants, the purification of water and energy conversion etc.
研究领域:
生物物理学
·
材料科学
·
仿生学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Ruoyu Dai,Xipao Chen,Ning Ouyang,Yaoping Hu
Carbon dots (CDs) with tunable photoluminescence (PL), especially with long wavelength PL , offer great potential for various applications including sensing, bioimaging, photomedicine, and optoelectronic devices. Here, we use 2,3-diaminopyridine as a single precursor to synthesize colorful CDs in different pH conditions. By simply regulating the reaction media from alkali to neutral to acid, bright CDs emitting violet, green, and orange fluorescence are prepared, respectively. Detailed characterizations reveal that the red-shift of PL is caused by the growing size of sp 2 conjugated domain and increasing content of graphite nitrogen. We embed CDs in starch to suppress self-quenching and enhance the PL quantum yields. The CD/starch composites, possessing efficient solid-state fluorescence, can be coated on the ultraviolet chips (365 nm) to fabricate multicolor light-emitting diodes toward indoor illumination. This work presents a new strategy to adjust the PL wavelength of CDs in a wide range, and clarifies the emission mechanism.
研究领域:
材料科学
·
光学
·
化学
✓ 已验证
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2016
·
IF 2.725
Guiyou Wang,Lingmei Zhang
In this study, well-defined double-hydrophilic triblock copolymers , consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly( N , N -diethylamino-2-ethylmethacrylate) (PDEAEMA), were synthesized and characterized. The molecular weights of the copolymers were controllable. In the basic environments, the copolymers can self-assemble into the PDEAEMA core and PEG corona micelles in aqueous solution with an average size of 40–180 nm. The low critical micelle concentration (CMC, about 10 − 3 mg mL − 1 ) of copolymers investigated in pH 7.4 aqueous solution confirmed the adequate thermodynamic stability of their self-assembly. As shown in the cytotoxicity assay, the copolymers have good biocompatibility. Doxorubicin (DOX) was encapsulated into the triblock copolymer micelles . The drug loading efficiency and entrapment efficiency values of DOX-loaded micelles reached 8.14% and 88.6%, respectively. The DOX release of the drug-loaded micelles depends on the pH values. These phenomena indicated that the double-hydrophilic PDEAEMA – PEG – PDEAEMA triblock copolymers have a potential application in the drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Ziqi Zhou,Liyan Zhang,Muyan Qin,Xu Cui,Deping Wang
Chronic wound healing is often compromised by bacterial infection, and wound pH changes strongly correlate with infection. Therefore, the development of wound dressings capable of real-time pH monitoring, antimicrobial activity, and tissue repair is crucial for the effective management of infected chronic wounds. This study reports a novel multifunctional composite hydrogel (GM-C-mBG@P) synthesized by incorporating microwave-synthesized carbon quantum dots (CQDs) and polydopamine-modified mesoporous bioactive glass nanoparticles (mBG@P) into modified gelatin methacryloyl (GelMA). The incorporated polydopamine (PDA) confers excellent photothermal properties to the hydrogel, enabling effective antimicrobial activity. Under 360 nm UV excitation, the fluorescence intensity of CQDs in GM-C-mBG@P exhibits a strong linear correlation with pH, enabling real-time wound pH monitoring. Furthermore, mBG@P can gradually dissolve calcium, silicon, boron, and other functional ions to enhance the bioactivity and functionality of the hydrogel and accelerate wound healing. These findings suggest that the GM-C-mBG@P hydrogel has the potential to serve as a promising wound dressing for the treatment of infected chronic wounds.
研究领域:
生物材料学
·
医学工程
·
组织修复与再生
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Da Feng,Li Guo,Yihan Zhao,Fang Yuan,Lulu Ning,Yuan Guo,Jianjian Zhang
Real-time monitoring of the lysosomal microenvironment using small-molecule probes is critical for understanding the complex interactions between organelles and diseases associated with lysosomal dysfunction. Most traditional fluorescent-dye-based lysosome probes rely on the protonation of the nitrogen atom in the morpholine unit to visualize the lysosomal microenvironment by inhibiting the photoinduced electron transfer (PET) effect. However, these probes often face selectivity issues within the complex cellular microenvironment. For instance, classic hemicyanine dyes (HD) show nonspecific fluorescence responses in the liver due to inappropriate pKa value, leading to low imaging contrast and the risk of false positives. Herein, a series of novel pH/viscosity-activatable, lysosomal-targeted near-infrared (NIR) fluorescent probes were developed by incorporating naphthalimide dye with hemicyanine dyes. These probes exhibit no fluorescence at physiological pH and weak fluorescence under acidic conditions (key 1), with substantial fluorescence activation triggered by abnormal viscosity in pathological tissues (key 2). Notably, NpCy-4 demonstrated a superior signal-to-background ratio (SBR) for cellular imaging and proved effective for real-time in situ diagnosis of acute gastritis.
研究领域:
生物化学
·
医学影像学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2025
·
IF 6.3
Rui Xu,Jingqi Bao,Ningru Xuan,Bingxin Zhou,Lingshan Liao,Qiusheng Zhou,Di Wu,Linfang Lu
The template sacrifice method is a pivotal strategy for synthesizing noble metal-based nanocrystals with enhanced catalytic properties. A critical limitation of this method lies in the challenges associated with regulating the morphology of the resultant nanocrystals. This study demonstrates that the morphology of PtCu nanocrystals can be effectively modulated by adjusting the pH in the Cu 2 O template sacrifice method. Various PtCu nanocrystals, including PtCu hollow nanoboxes and PtCu nanodendrites of differing sizes, have been successfully synthesized. Mechanistic investigations reveal that reduced pH corresponds to a lower electrode potential of Cu 2 O, which enhances its reducing capacity, thereby intensifying the galvanic replacement reaction with the Pt precursor. The driving force of Kirkendall effect during this process can be systematically manipulated via pH adjustments, leading to the generation of PtCu nanocrystals with diverse morphologies. The synthesized PtCu nanocrystals demonstrate significantly improved methanol oxidation reaction activity compared to commercial Pt/C. Specifically, the PtCu hollow nanoboxes exhibit a methanol oxidation reaction (MOR) activity of 1.93 A mg⁻¹, which is 5.4 times greater than that of the commercial Pt/C. Physical characterizations suggest that the superior catalytic performance of PtCu hollow nanoboxes catalyst is attributed to its increased surface electronic density of Pt resulting from the special hollow and porous morphology. The pH control strategy outlined in this research holds promise for the synthesis of other Cu-based nanoalloys with varying morphologies, and may be applicable to other catalytic systems.
研究领域:
材料科学
·
催化化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）