COLLOID AND POLYMER SCIENCE
·
2023
·Vol. 301
·期 12
·1475-1486
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IF 2.4
Li Yinglu,Zhao Jing,Wang Yurui,Zhao Tianfu,Song Yanan,Liang Fei
Nanoscale metal organic frameworks (NMOFs) have become excellent drug carriers for the treatment of cancer or other diseases, due to the advantages of large surface area, high drug loading, tunable structure and easy functionalization, with potential application in the field of drug delivery. In this paper, UiO-66 NMOF was synthesized using terephthalic acid as organic ligand and zirconium chloride as metal salt, and then biocompatible chitosan (CS) and PEGylated chitosan (CS-g-mPEG)-decorated NMOFs as drug carriers were constructed by surface modification, using 5-FU as the drug model. The structures, size and morphology were characterized by IR, XRD, DLS, SEM and TEM respectively. The results showed that when the concentration was 0.0872 M, the molar ratio was 1:1 and the acetic acid amount was 2.9 mL, the average particle size of NMOFs was 145.60 nm and 171.73 nm, respectively. The drug loading capacity and encapsulation rate could reach 15.7% and 52.8%. The in vitro controlled drug release results indicated that the release rate accelerated with increasing temperature and decreasing initial amount, greatly reduced under acidic conditions, and the coating of CS and CS-g-mPEG on the surface of UiO-66 had the effect of controlling drug release, further improved the bioavailability of 5-FU. The decorated UiO-66 NMOFs show excellent biocompatibility as nanodrug carriers and can avoid rapid degradation under gastric acid, which are more suitable for oral drug delivery.
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Science China-Technological Sciences
·
2023
·Vol. 66
·期 7
·2134-2146
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IF 4.6
Wang ShengLiang,Xu ZhiJun,Chen HaiXu,Wang XiaoLiang,Lin Song,Wang Lei,Liu XiaoMan,Huang Xin
The biointerface engineering of living cells by creating an abiotic shell has important implications for endowing cells with exogenous properties with improved cellular behavior, which then boosts the development of the emerging field of living cell hybrid materials. Herein, we develop a way to perform active nanoencapsulation of single cell, which then endows the encapsulated cells with motion ability that they do not inherently possess. The emerging motion characteristics of the encapsulated cells could be self-regulated in terms of both the motion velocity and orbits by different proliferation modes. Accordingly, by taking advantage of the emergence of differentiated moving abilities, we achieve the self-sorting between mother cells and daughter cells in a proliferated Saccharomyces cerevisiae cell community. Therefore, it is anticipated that our highlighted study could not only serve as a new technique in the field of single-cell biology analysis and sorting such as in studying the aging process in Saccharomyces cerevisiae , but also open up opportunities to manipulate cell functionality by creating biohybrid materials to fill the gap between biological systems and engineering abiotic materials.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2023
·Vol. 33
·期 10
·3237-3246
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IF 4
Zhu Xiaokang,Wang Xiuwu,Zhou Guiyang,Yin Hong,Qi Dongming,Deng Hangjun,Chen Tao
The preparation of polymer-metal complex is an effective way to achieve the bifunctionality of polymer and metal. In this study, temperature-sensitive polymer was synthesized from triethylene glycol methyl ether methacrylate (MEO 2 MA) and methacrylic acid N-hydroxysuccinimide ester (NMS) monomers via reversible addition-fragmentation chain transfer (RAFT) polymerization. 6-Aminohexanoic acid was introduced into the temperature-sensitive polymer using an activated ester strategy to obtain branched carboxyl-containing polymers. The carboxyl group in the polymer was coordinated with Fe(III), resulting in temperature-sensitive polymer-based iron complexes. The obtained iron complexes were used as homogeneous catalysts in the Fenton oxidation. Where, 97% and 96% decolorization of rhodamine B (RhB) and methylene blue (MB) could be achieved within 2 h for P(COOH 10 - co -MEO 2 MA 41 )-Fe 3+ , and the catalytic activities increased with the increase of the COOH content of polymer. In addition, the recycling of the catalyst can be achieved by the heating-centrifugal precipitation method using the temperature-sensitive nature of the polymer. Graphical Abstract
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JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 8
·1-11
·
IF 2.8
Chen Fanfan,Xiao Yao,Yan Sitong,Fang Lin,Wang Zhifen,Liao Jianhe
Modifying natural rubber latex (NRL) and blending it with NRL can improve NRL performance and expand application fields. The performance of co-blended latex will change due to changes in non-rubber components during storage. Therefore, it is important to study the change of properties during the storage of co-blended latexes. In this paper, 30% methyl methacrylate grafted natural rubber (MG30) was synthesized by cumene hydroperoxide/ tetraethylenepentamine (CHPO/TEPA) initiating system, MG30 and NRL were mixed in different proportions to study the morphology and physical and mechanical properties, and the colloidal properties and emulsion properties of co-blended latexes were studied during storage. The results showed that the mechanical stability of NRL and co-blended latexes were high and the viscosity gradually increased during storage. The study of the vulcanization characteristics of the co-blended latexes films and the physical and mechanical properties of the vulcanized latex films showed that the vulcanization time of the co-blended films increased and the torque value increased in comparison to NRL. With the increase of MG30 content, the tensile strength and tear strength of the co-blended latexes vulcanized films showed a trend of increasing and then decreasing, and the co-blended film with 10% MG30 showed the best mechanical properties.
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JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-14
·
IF 10.2
Yang Wen,Wang Ning,Yang Jin,Liu Chao,Ma Shuang,Wang Xiye,Li Wenzhen,Shen Meiling,Wu Qinjie,Gong Changyang
Background Photothermal therapy (PTT) is taken as a promising strategy for cancer therapy, however, its applicability is hampered by cellular thermoresistance of heat shock response and insufficient accumulation of photothermal transduction agents in the tumor region. In consideration of those limitations, a multifunctional “Golden Cicada” nanoplatform (MGCN) with efficient gene delivery ability and excellent photothermal effects is constructed, overcoming the thermoresistance of tumor cells and improving the accumulation of indocyanine green (ICG). Results Down-regulation of heat shock protein 70 (HSP70) makes tumor cells more susceptible to PTT, and a better therapeutic effect is achieved through such cascade augmented synergistic effects. MGCN has attractive features with prolonged circulation in blood, dual-targeting capability of CD44 and sialic acid (SA) receptors, and agile responsiveness of enzyme achieving size and charge double-variable transformation. It proves that, on the one hand, MGCN performs excellent capability for HSP70-shRNA delivery, resulting in breaking the cellular thermoresistance mechanism, on the other hand, ICG enriches in tumor site specifically and possesses a great thermal property to promoted PTT. Conclusions In short, MGCN breaks the protective mechanism of cellular heat stress response by downregulating the expression of HSP70 proteins and significantly augments synergistic effects of photothermal/gene therapy via cascade augmented synergistic effects.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 28
·11631-11646
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IF 4.5
Li Peihang,Ran Hongshun,Pan Yaoyu,Xu Ziqiang,Chen Xueqin,Li Cao,Jiang Bingbing
Membrane separation is one of the most effective ways to remove organic dyes in wastewater. Rationally regulating the pore size of separation membranes would contribute to great performance. However, membranes with a uniform pore structure make it difficult to simultaneously realize high flux and excellent rejection ratio. Herein, functional composite nanoporous fiber membrane material with visible-light-driven self-cleaning performance was constructed by spinning hypercrosslinked polystyrene nanoparticles (HCPNPs) and TiO 2 -based catalysts into the electrospun membrane of polyvinylidene fluoride (PVDF). The composited fiber membrane with a hierarchical pore structure exhibits unique performances: excellent adsorption capacity for organic dyes, reaching 12 mg·g −1 (methylene blue), respectively, extraordinary high photocatalytic degradation rate (up to 99%) and gorgeous cycle degradation performance for MB (degradation rate is maintained at 95% after five cycles), and excellent comprehensive performance for the removal of extensive pollutant library including organic dye, and antibiotic pollutant. Therefore, coupled with facile and economical synthesis, we provide a novel idea for advanced membrane construction, which has the potential to be widely used for organic pollutants’ removal in sewage treatment. Graphical abstract
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Journal of Coatings Technology and Research
·
2023
·
IF 2.3
Meng Fangfei,Wang Wenjin,Yu Yijia,Xia Wenjuan,Wang Ling,Wu Zhaoqiang,Chen Hong
A simple and convenient strategy for fabricating superhydrophilic multifunctional antifogging coatings was developed by hydrolyzing triethoxysilyl-terminated poly( N -vinylpyrrolidone) (TRES-PVP) with tetraethyl orthosilicate (TEOS) under acidic conditions. These antifogging coatings can be easily obtained by coating TRES-PVP hydrolysates on substrates at room temperature and then curing by thermal treatment. The superhydrophilic transparent coatings exhibited excellent antifogging, self-cleaning and antifouling properties. Additionally, the coatings also have good adhesion against the cross-cut test and remain stable after exposure to the laboratory environment for five months or immersion in water at room temperature for 20 days. Therefore, the present TRES-PVP hydrolysate coatings are promising for practical multifunctional antifogging applications.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Chen Zhigang,Zhang Yi,Li Wenlu,Gao Chenyi,Huang Fengbo,Cheng Lu,Jin Menglei,Xu Xiaoming,Huang Jian
Fibroadenomas (FAs) are the most common breast tumors in women. No pharmacological agents are currently approved for FA intervention owing to its unclear mechanisms and a shortage of reproducible human models. Here, using single-cell RNA sequencing of human FAs and normal breast tissues, we observe distinct cellular composition and epithelial structural changes in FAs. Interestingly, epithelial cells exhibit hormone-responsive functional signatures and synchronous activation of estrogen-sensitive and hormone-resistant mechanisms ( ERBB2 , BCL2 and CCND1 pathways). We develop a human expandable FA organoid system and observe that most organoids seem to be resistant to tamoxifen. Individualized combinations of tamoxifen with ERBB2, BCL2 or CCND1 inhibitors could significantly suppress the viability of tamoxifen-resistant organoids. Thus, our study presents an overview of human FA at single-cell resolution that outlines the structural and functional differences between FA and normal breast epithelium and, in particular, provides a potential therapeutic strategy for breast FAs.
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高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·Vol. 30
·期 40
·91997-92006
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IF 5.8
Ran
Chunmei,Liu Yubin,Li Ke,Wang Chenye,Pu Jian,Sun Hongwen,Wang Lei
Although the combined effect of organic ligands and heavy metals in the environment on plants have been frequently reported, their complexed interaction in plants and the physiological effects remain to be revealed. Metal complexing agent benzotriazole (BTR) has extensive environmental pollution. In this study, root-splitting experiments were designed to identify the in vivo and in vitro effects of BTR on the accumulation and translocation of Cu in rice ( Oryza sativa L . ), and the concentrations and translocation factor (TF) of Cu and BTR in different parts of rice were measured. In the in vitro interaction treatments, low BTR concentrations enhanced Cu uptake and lateral transport in rice, while higher levels of BTR’s exposure (i.e., ≥ 100 μM) resulted in opposite effects. Differently, significant increase in the lateral transport of Cu and vertical translocation of BTR in rice presented in the in vivo interaction treatments. TF of Cu from root A to root B (TF RA-RB ) increased from 0.05 to 0.272 with the BTR concentration increasing from 0 to 100 μM, and higher TF of BTR from root to shoot (TF R-S ), ranging from 1.00 to 1.75, compared with single BTR exposure treatments was observed. The phytotoxicity of BTR expressed by the catalase activity was significantly alleviated by the in vivo accumulated Cu in rice.
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JOURNAL OF BIOMEDICAL SCIENCE
·
2023
·Vol. 30
·期 1
·1-14
·
IF 11
Shen Weiyi,Shao Wentao,Wang Qihan,Wang Bo,Zhao Gang,Gu Aihua,Jiang Zhaoyan,Hu Hai
Background Cholesterol gallstone disease is a common disease. Reducing cholesterol burden is important to prevent/treat gallstone. In this study, we investigated the application of diosgenin (DG) to prevent the formation of gallstone in mice.Methods Adult male C57BL/6J mice were fed with the lithogenic diet (LD) only or LD supplemented with DG or ezetimibe for 8 weeks. Incidences of gallstone formation were documented. Intestine and liver tissues were collected to measure the lipid contents and expression of genes in cholesterol metabolism. Caco2 cells were treated with DG to monitor the regulation on cholesterol absorption and the transcriptional regulation of Npc1l1 gene. Changes of gut microbiota by DG was analyzed. Intraperitoneal injection of LPS on mice was performed to verify its effects on STAT3 activation and Npc1l1 expression in the small intestine.Results LD led to 100% formation of gallstones in mice. In comparison, dietary DG or ezetimibe supplementary completely prevents gallstones formation. DG inhibited intestinal cholesterol absorption in mice as well as in Caco2 cells by down-regulation of Npc1l1 expression. DG could directly inhibit phosphorylation of STAT3 and its transcriptional regulation of Npc1l1 expression. Furthermore, DG could modulate gut microbiota profiles and LPS mediated STAT3 activation and Npc1l1 expression.Conclusion Our results demonstrated that dietary DG could inhibit intestinal cholesterol absorption through decreasing NPC1L1 expression to prevent cholesterol gallstone formation.
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高影响因子
BMC Complementary Medicine and Therapies
·
2023
·Vol. 23
·期 1
·1-14
·
IF 3.9
Zhang Ke,Ji Xiawei,Song Zhengyang,Song Wenjing,Huang Qunjia,Yu Tiantian,Shi Dibang,Wang Fangyan,Xue Xiangyang,Guo Junping
Background Cervical cancer (CC) is a common gynecological malignancy with high morbidity worldwide. Butyrate, a short-chain fatty acid produced by intestinal flora, has been reported to inhibit cervical carcinogenesis. This study aimed to investigate the pro-apoptotic effects of butyrate on CC and the underlying mechanisms. Methods Human HeLa and Ca Ski cells were used in this study. Cell proliferation, cell migration and invasion were detected by CCK-8 and EdU staining, transwell and wound healing assay, respectively. Cell cycle, mitochondrial membrane potential and apoptosis were evaluated by flow cytometry. Western blot and RT-qPCR were carried out to examine the related genes and proteins to the mitochondrial complex Ι and apoptosis. Metabolite changes were analyzed by energy metabolomics and assay kits. The association between G protein-coupled receptor 41, 43, 109a and CC prognosis was analyzed using data from The Cancer Genome Atlas (TCGA). Results CCK-8 results showed significant inhibition of CC cell proliferation induced by butyrate treatment, which was confirmed by EdU staining and cell cycle detection. Data from the transwell and wound healing assay revealed that CC cell migration was dramatically reduced following butyrate treatment. Additionally, invasiveness was also decreased by butyrate. Western blot analysis showed that cleaved Caspase 3 and cleaved PARP, the enforcers of apoptosis, were increased by butyrate treatment. The results of Annexin V/PI staining and TUNEL also showed an increase in butyrate-induced apoptotic cells. Expression of Cytochrome C (Cytc), Caspase 9, Bax, but not Caspase 12 or 8, were up-regulated under butyrate exposure. Mechanistically, the decrease in mitochondrial NADH and NAD + levels after treatment with butyrate was observed by energy metabolomics and the NAD+/NADH Assay Kit, similar to the effects of the complex Ι inhibitor rotenone. Western blot results also demonstrated that the constituent proteins of mitochondrial complex Ι were reduced by butyrate. Furthermore, mitochondria-dependent apoptosis has been shown to be initiated by inhibition of the complex Ι. Conclusion Collectively, our results revealed that butyrate inhibited the proliferation, migration and invasion of CC cells, and induced mitochondrial-dependent apoptosis by inhibiting mitochondrial complex Ι.
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International Journal of Minerals Metallurgy and Materials
·
2023
·Vol. 30
·期 9
·1705-1715
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IF 4.8
Zhou Guotao,Wang Yilin,Qi Tiangui,Zhou Qiusheng,Liu Guihua,Peng Zhihong,Li Xiaobin
Goethitic bauxite is a widely used raw material in the alumina industry. It is an essential prerequisite to clarify the effect of Ti- and Si-containing minerals on goethite transformation in the Bayer digestion process, which could efficiently utilize the Fe- and Al-containing minerals present in goethitic bauxite. In this work, the interactions between anatase or kaolinite with goethite during various Bayer digestion processes were investigated using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM). The results showed that anatase and kaolinite hindered the transformation of goethite. Anatase exerted more significant effects than kaolinite due to the dense sodium titanate layer on the goethite surface after reacting with the sodium aluminate solution. Adding the reductant hydrazine hydrate could eliminate the retarding effect by inducing the transformation of goethite into magnetite. In this process, titanium was embedded into the magnetite lattice to form Ti-containing magnetite. Furthermore, the weakening of the interaction between magnetite and sodium aluminosilicate hydrate reduced the influence of kaolinite. As a validation of the above results, the reductive Bayer method resulted in the transformation of goethite into goethitic bauxite with 98.87% relative alumina digestion rate. The obtained red mud with 72.99wt% Fe 2 O 3 could be further utilized in the steel industry. This work provides a clear understanding of the transformative effects of Ti- and Si-containing minerals on iron mineral transformation and aids the comprehensive use of iron and aluminum in goethitic bauxite subjected to the reductive Bayer method.
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