Journal of Cleaner Production
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2022
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IF 11.072
Jinxin Li,Wencheng Ma,Dan Zhong,Kefei Li,Jun Ma,Shaobo Zhang,Xuan Du
Oxygen vacancies (V O ) constructing in metallic compounds have been verified to enhance hydrogen peroxide (H 2 O 2 ) activation for pollutants treatment. However, the interactions between surface V O concentration and H 2 O 2 were still ambiguous. In this study, perovskites with different surface V O concentration were successfully prepared by a simple sol-gel process. Experimental results showed that A-site cation deficient was capable of distorting FeO 6 octahedra in Ca 1−x FeO 3-δ (x = 0, 0.1, 0.2) orthorhombic perovskites for the regulation of surface V O concentration. Afterwards, Ca 0.9 FeO 3-δ exhibited excellent catalytic activity and stability for tetracycline (TC) degradation, which was 4 times higher of catalytic enhancement than that of the raw Ca 1.0 FeO 3-δ . Moreover, up to 9, 17 and 27 times of catalytic enhancement as compared with commercial Fe 3 O 4 , ɑ-FeOOH and Fe 2 O 3 towards TC degradation. Based on electron spin resonance and free radical quenching experiments, the hydroxyl radical (∙OH) was the main active species for the catalytic degradation of TC. Meanwhile, higher or lower surface V O concentration was harmful to the production of ∙OH. Additionally, the toxicity of TC degradation by-products exhibited a decreasing trend according to the results of toxicological simulation. This work provides a new strategy for designing an efficient and promising heterogeneous Fenton-likes catalyst for environmental remediation.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2022
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IF 6.76
Chaochao Jiang,Caihong Qin,Mengke Guo,Jiayu Huang,Dongjie Yan,Xiaoqing Dang
A non-thermal plasma with a wet scrubber (NTP + WS) was used to degrade gaseous toluene. Compared with the NTP + WS/H 2 O system, the toluene and by-product ozone removal efficiencies were increased by 10% and 85% in the NTP + WS/Fe 2+ system, respectively. For 60 ppm toluene degradation, the maximum mineralization rate (MR) of toluene (61%) was obtained, at the optimum Fe 2+ concentration of 50 mg/L. During catalytic oxidation, the removal efficiency of toluene was limited by its solubility in WS systems. In addition, decreased Fe 2+ concentration and accumulation of organics led to the system deactivation. The EPR and quenching experiments verified the presence and contribution of hydroxyl radicals (4.6%) and superoxide radicals (3.8%) to the removal efficiency of toluene. Based on the radicals and intermediates detected in the gas and liquid phases, a degradation mechanism for toluene in the NTP + WS/Fe 2+ system was proposed.
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ACS Nano
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2022
·
IF 18.027
Shikai Liu,Wenting Li,Hengxing Chen,Jialing Zhou,Shuming Dong,Pengyu Zang,Boshi Tian,He Ding,Shili Gai,Piaoping Yang,Yanli Zhao
Nanosystem-mediated tumor radiosensitization strategy combining the features of X-ray with infinite penetration depth and high atomic number elements shows considerable application potential in clinical cancer therapy. However, it is difficult to achieve satisfactory anticancer efficacy using clinical radiotherapy for the majority of solid tumors due to the restrictions brought about by the tumor hypoxia, insufficient DNA damage, and rapid DNA repair during and after treatment. Inspired by the complementary advantages of nitric oxide (NO) and X-ray-induced photodynamic therapy, we herein report a two-dimensional nanoplatform by the integration of the NO donor-modified LiYF4:Ce scintillator and graphitic carbon nitride nanosheets for on-demand generation of highly cytotoxic peroxynitrite (ONOO–). By simply adjusting the Ce3+ doping content, the obtained nanoscintillator can realize high radioluminescence, activating photosensitive materials to simultaneously generate NO and superoxide radical for the formation of ONOO– in the tumor. Obtained ONOO– effectively amplifies therapeutic efficacy of radiotherapy by directly inducing mitochondrial and DNA damage, overcoming hypoxia-associated radiation resistance. The level of glutamine synthetase (GS) is downregulated by ONOO–, and the inhibition of GS delays DNA damage repair, further enhancing radiosensitivity. This work establishes a combinatorial strategy of ONOO– to overcome the major limitations of radiotherapy and provides insightful guidance to clinical radiotherapy.
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Advanced Healthcare Materials
·
2022
·Vol. 11
·期 16
·2200571
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IF 11.092
Jinjie Cui,Xingge Yu,Bin Yu,Xiuyi Yang,Zeyu Fu,Jianyu Wan,Min Zhu,Xudong Wang,Kaili Lin
In clinical treatment, the bone regeneration of critical-size defects is desiderated to be solved, and the regeneration of large bone segment defects depends on early vascularization. Therefore, overcoming insufficient vascularization in artificial bone grafts may be a promising strategy for critical-size bone regeneration. Herein, a novel dual-drug programmed releasing electrospinning fibrous mat (EFM) with a deferoxamine (DFO)-loaded shell layer and a dexamethasone (DEX)-loaded core layer is fabricated using coaxial electrospinning technology, considering the temporal sequence of vascularization and bone repair. DFO acts as an angiogenesis promoter and DEX is used as an osteogenesis inducer. The results demonstrate that the early and rapid release of DFO promotes angiogenesis in human umbilical vascular endothelial cells and the sustained release of DEX enhances the osteogenic differentiation of rat bone mesenchymal stem cells. DFO and DEX exert synergetic effects on osteogenic differentiation via the Wnt/ β -catenin signaling pathway, and the dual-drug programmed releasing EFM acquired perfect vascularized bone regeneration ability in a rat calvarial defect model. Overall, the study suggests a low-cost strategy to enhance vascularized bone regeneration by adjusting the behavior of angiogenesis and osteogenesis in time dimension.
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CARBOHYDRATE POLYMERS
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2022
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IF 10.723
Ruhe Zhang,Xinru You,Moucheng Luo,Xinyu Zhang,Yifen Fang,Hai Huang,Yang Kang,Jun Wu
The use of cisplatin is restricted by systemic toxicity and drug resistance. Supramolecular nano-drug delivery systems involving drugs as building blocks circumvent these limitations promisingly. Herein, we describe a novel supramolecular system [Pt(IV)-SSNPs] based on poly(β-cyclodextrin), which was synthesized for efficient loading of adamantly-functionalized platinum(IV) prodrug [Pt(IV)-ADA 2 ] via the host-guest interaction between β-cyclodextrin and adamantyl. Pt(IV)-ADA 2 can be converted to active cisplatin in reducing environment in cancer cells, which further reduces systemic toxicity. The introduction of the adamantane group-tethered mPEG 2k endowed the Pt(IV)-SSNPs with a longer blood circulation time. In vitro assays exhibited that the Pt(IV)-SSNPs could be uptaken by CT26 cells, resulting in cell cycle arrest in the G2/M and S phases, together with apoptosis. Furthermore, the Pt(IV)-SSNPs showed effective tumor accumulation, better antitumor effect , and negligible cytotoxicity to major organs. These results indicate that supramolecular nanoparticles are a promising platform for efficient cisplatin delivery and cancer treatment.
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Gels
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2022
·Vol. 8
·期 8
·508
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IF 4.432
Shuwen Zhou,Xinmeng Zheng,Ke Yi,Xuancheng Du,Cheng Wang,Pengfei Cui,Pengju Jiang,Xinye Ni,Lin Qiu,Jianhao Wang
Background: Promising cancer chemotherapy requires the development of suitable drug delivery systems (DDSs). Previous research has indicated that a hydrogel is a powerful DDS for tumor therapy and holds great potential to offer a feasible method for cancer management. Methods: In this study, glutathione-gellan gum conjugate (GSH-GG) was synthesized through chemical reaction. Doxorubicin hydrochloride (DOX) was loaded into GSH-GG to accomplish DOX-loaded GSH-GG. The properties, injectability, drug release, and in vitro and in vivo anticancer effects of DOX-loaded GSH-GG were tested. Results: DOX-loaded GSH-GG showed a temperature-ion dual responsive gelling property with good viscosity, strength, and injectability at an optimized gel concentration of 1.5%. In addition, lower drug release was found under acidic conditions, offering beneficial long-acting drug release in the tumor microenvironment. DOX-loaded GSH-GG presented selective action by exerting substantially higher cytotoxicity on cancer cells (4T1) than on normal epithelial cells (L929), signifying the potential of complete inhibition of tumor progression, without affecting the health quality of the subjects. Conclusions: GSH-GG can be applied as a responsive gelling material for delivering DOX for promising cancer therapy.Keywords:hydrogel;responsive;gellan gum;doxorubicin;cancer
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3 Biotech
·
2022
·Vol. 12
·期 9
·1-15
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IF 2.893
Weng Chunyue,Mi Zheyan,Li Meijing,Qin Haibin,Hu Zhongce,Liu Zhiqiang,Zheng Yuguo,Wang Yuanshan
To improve S-Adenosyl-L-methionine (a compound with important physiological functions, SAM) production, atmospheric and room temperature plasma and ultraviolet-LiCl mutagenesis were carried out with Saccharomyces cerevisiae strain ZY 1–5. The mutants were screened with ethionine, L-methionine, nystatin and cordycepin as screening agents. Adaptive evolution of a positive mutant UV6-69 was further performed by droplet microfluidics cultivation with ethionine as screening pressure. After adaptation, mutant T11-1 was obtained. Its SAM titer in shake flask fermentation reached 1.31 g/L, which was 191% higher than that of strain ZY 1–5. Under optimal conditions, the SAM titer and biomass of mutant T11-1 in 5 L bioreactor reached 10.72 g/L and 105.9 g dcw/L (142.86% and 34.22% higher than those of strain ZY 1–5), respectively. Comparative transcriptome analysis between strain ZY 1–5 and mutant T11-1 revealed the enhancements in TCA cycle and gluconeogenesis/glycolysis pathways as well as the inhibitions in serine and ergosterol synthesis of mutant T11-1. The elevated SAM synthesis of mutant T11-1 may attribute to the above changes. Taken together, this study is helpful for industrial production of SAM.
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Analytical Methods
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2022
·Vol. 14
·期 37
·3632-3637
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IF 3.532
Zhi-Ang Liu,Ya-Nan Zuo,Yinghui Xia,Jing Sun,Shuyun Zhu
An innovative strategy with target-triggered cascade fluorescence recovery of a dual-nanoquencher system was developed to detect ascorbic acid (AA). Herein, manganese dioxide (MnO2) nanosheets and gold nanoparticles (AuNPs) were used as nanoquenchers simultaneously. Owing to their synergistic effects, the fluorescence of 2,3-diaminophenazine (DAP) was decreased efficiently, thus minimizing the background fluorescence. The introduction of AA triggered the decomposition of MnO2 into Mn2+, which induced the aggregation of AuNPs. Both the decomposed MnO2 and aggregated AuNPs possess weak quenching abilities towards DAP. Such a cascade amplification strategy enhanced the detection sensitivity for AA with a LOD as low as 6.7 nM, which was two orders of magnitude lower than that of MnO2-based fluorescence assay. Furthermore, this amplification strategy was successfully applied to detect AA in food samples.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
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IF 8.025
Zhengqi Zha,Yinghua Miao,Huiling Tang,Daniela D. Herrera-Balandrano,Hongping Yin,Su-Yan Wang
Zinc(II) phthalocyanine (ZnPc) is a promising photosensitizer in photodynamic therapy (PDT) for melanoma treatment. However, the poor solubility of ZnPc limits its application. To overcome this limitation, heparosan (HP)-based nanoparticles were prepared by anchoring the l -lysine-linked α-linolenic acid branch to the carboxylic acid group to produce amphiphilic conjugates named heparosan with an l -lysine-linked α-linolenic acid branch (HLA). HLA conjugates could self-assemble into spherical nanoparticles in aqueous media and encapsulate ZnPc to form HLA-ZnPc nanoparticles. The cellular uptake of ZnPc could be improved by HLA carriers. These nanoparticles presented excellent photodynamic-mediated toxicity against mouse melanoma cells (B16) by markedly upregulating the intracellular reactive oxygen species (ROS) levels while showing no cytotoxicity to either B16 or normal cells (L02 and HK-2 cells) in the dark. Furthermore, HLA-ZnPc displayed excellent stability in both powder and Roswell Park Memorial Institute (RPMI) 1640 medium, indicating its promise for application in drug delivery and PDT. These results revealed a strategy for HP-based enhancement of ZnPc in PDT efficacy.
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ELECTROCHIMICA ACTA
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2022
·
IF 7.336
Xing Chen,Di Chen,Guofu Li,Pengfei Sha,Jianhua Yu,Liyan Yu,Lifeng Dong
The ingenious design and synthesis of low-cost, non-precious metal bifunctional catalysts for oxygen reduction reactions (ORR) and oxygen evolution reactions (OER) is a pressing demand to solve energy crisis and to promote the development of zinc-air batteries. Herein, a simple strategy was developed to derive FeNi incorporated N-doped carbon nanotube (denoted as glu-NiFe) from glucosamine. Extensive metal-nitrogen-carbon (M-N-C) and FeNi alloys act as electrocatalytic active sites for ORR and OER, respectively, together with highly graphitized carbon nanotubes for facilitating electron transport. And the combinations endow glu-NiFe with an ORR half-wave potential of 0.85 V and an OER potential of 1.67 V at 10 mA cm −2 , which exceed commercial catalysts of Pt/C and RuO 2 . Furthermore, the rechargeable Zn-air battery based on glu-NiFe delivers a high peak power density of 127 mW cm −2 and superior cycling stability (over 240 h). Moreover, a favorable performance is exhibited by glu-NiFe based all solid-state Zn-air battery. This work will provide some assistance in designing efficient and low-cost bifunctional catalysts for high performance rechargeable Zn-air batteries.
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ChemistrySelect
·
2022
·Vol. 7
·期 29
·e202201596
·
IF 2.307
Yunlong Zhou,Dongyao Lin,Xiaoyuan Ye,Bo Sun
Graphical We propose a strategy for photocatalytic H 2 production using acid-treated corn straw and its extracts as sacrificial agent. Results show that cellobiose and xylose, which are extracted from corn straw, significantly improve the H 2 production performance. The optimal H 2 generation rates is 72 times greater than that using pure water, 2 times greater than that using raw corn straw, and 4.5 times greater than that using acid-treated corn straw. Using natural biomass as sacrificial agent for photocatalytic hydrogen production is a current topic of interest in the field of new energy research because it has widely available resources, is economical, and has environmental benefits. In this study, we propose a strategy for photocatalytic hydrogen production using acid-treated corn straw and its extracts as a sacrificial agent. Furthermore, the important factors that affect the photocatalytic performance of hydrogen production are also studied. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) are employed to characterize the composition, structure, and morphology of the corn straw. High-performance liquid chromatography (HPLC) is employed to characterize the composition of extracts in the filtrate obtained from acid treatment. The results from the above analyses show that cellobiose and xylose, which are extracted from corn straw, significantly improve the hydrogen production performance. The optimal hydrogen generation rates in this study reach 30.583 μmol/h in 100 mL of water; this is 72 times greater than that using pure water, 2 times greater than that using raw corn straw, and 4.5 times greater than that using acid-treated corn straw. Also, from these characterizations and analyses, the possible photocatalytic mechanism of this system is also proposed in this paper.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Mingzhe Li,Wenli Yao,Min Yu,Changduo Sun,Xinquan Deng,Fengjuan Chen,Lei Zhou,Yian Zheng
Hydrogels possess 3D network with abundant reactive groups, and can bind with active metal ions within their confined 3D structure for fabricating functional materials . In this study, a chitosan grafted polyacrylic acid (CTS-g-PAA) hydrogel was prepared for loading Fe 2+ , which was then converted into magnetic Fe@C via subsequent pyrolysis process . In Fe@C activated peroxymonosulfate (PMS) (Fe@C/PMS) system, the degradation behaviors of ciprofloxacin (CIP) were systematically investigated, including influencing parameters, reactive oxygen species (ROSs), degradation mechanism and potential eco-toxicity of degradation intermediates. The results showed that CTS-g-PAA supported, in-situ derived magnetic Fe@C had not only stable catalytic ability at pH 3.0–9.0, but also high degradation efficiency in the presence of inorganic Cl − and HCO 3 − (5–20 mM) as well as organic humid acid (10 and 20 mg/L). Under the optimized conditions, the degradation efficiency of CIP could reach to 96.84 % within 1 h. In Fe@C/PMS system, the main ROSs involved free radicals SO 4 •− , •OH, O 2 •− and non-free radical 1 O 2 . Through free radical quantitative experiments, the concentration of SO 4 •− and •OH at 60 min was determined respectively to be 11.84 µM and 0.14 µM, proving the dominant role of SO 4 •− . By HPLC-MS analysis, the degradation products were proposed via four degradation pathways, including hydroxylation, defluorination and decarboxylation, as well as the ring opening of quinolone and piperazine. Finally, the potential eco-toxicity of CIP and its degradation intermediates was evaluated by using ECOSAR method based on quantitative structure–activity relationships analysis.
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