METALLURGICAL AND MATERIALS TRANSACTIONS A-PHYSICAL METALLURGY AND MATERIALS SCIENCE
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2026
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IF 3
Kan Xinfeng,Li Wei
The indirect method for fabricating metal components is cost-effective; however, it suffers from issues such as low density and reduced mechanical strength. In this paper, 316L stainless steel components are fabricated by Debinding-Sintering Fused Filament Fabrication (DS-FFF) technology. The effects of copper doping on densification, microstructure, mechanics, antimicrobial, and corrosion resistance of sintered components are studied. It is found that the sintered parts can obtain the maximum tensile strength and elongation when approximately 0.44 wt pct copper is added to the green part. This improvement is mainly because proper copper doping induces a transient liquid phase, promoting particle rearrangement and densification. Copper doping endows sintered parts with excellent antibacterial properties. However, the impact on corrosion resistance is complex; while solid solution copper can improve resistance, the addition of excessive copper (exceeding 2.18 wt pct) leads to the formation of Kirkendall pores and Cu-rich precipitates, which locally destroy the passivation film. The precise optimal levels of copper addition depend on the trade-off between densification and micro-galvanic corrosion. This work indicates that a moderate addition of copper contributes positively to densification, mechanical strength, and corrosion resistance.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 15
Li Menglu,Jiao Zunlong,Lu Yichen,Zou Chenyu,Huang Dian,Zhang Yuwei,Zhu Sha,Li Chao,Feng Ninghan
DNA reactions on solid surfaces often suffer from low efficiency due to limited mass transfer and slow reaction kinetics, which greatly limits their biomedical applications. Here, we report a strategy to construct dynamic DNA biointerfaces based on moveable algal microrobots (AMs), whose autonomous motion-generated micro-hydrodynamics profoundly affects interfacial DNA reactions. After immobilizing DNA strands on the AMs, we uncover that the swimming speed of these microrobots is positively correlated with the kinetics of different DNA reactions from simple hybridization to complex enzymatic/nonenzymatic amplification reactions. This “motion-enhanced” effect mainly stems from the convection and mixing generated around the swimming cells, which greatly improve mass transfer velocity, thereby reducing hybridization times to minutes and enhance reaction efficiency. As a result, this feature is demonstrated to be useful in achieving ultrafast molecular recognition, ultrasensitive nucleic acid detection, and autonomous cell assembly in complex biological media. Our work provides a paradigm shift for overcoming the reaction efficiency bottleneck of DNA interface and paves a new avenue for designing intelligent bio-hybrid systems. Graphical abstract The alternative text for this image may have been generated using AI.
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Nature Communications
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2026
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IF 18.1
Wang Sen,Tang Senxuan,Fu Tianqi,Jiang Yirong,Lin Yun,Fu Lianlian,Wu Ronghui,Lin Youhui
Natural structural tissues achieve exceptional performance through precisely aligned hierarchical architectures that extend across multiple length scales. However, realizing such multiscale long-range alignment in synthetic bulk hydrogels remains challenging because of the difficulty in constructing a uniformly dense and highly oriented structure that extends throughout the full bulk matrix. Here, we introduce a scalable and versatile Layer-by-Layer Shear Densification (LBSD) strategy that integrates flocculation-induced aggregation with shear-driven progressive alignment, precisely driving the architectural evolution toward compact and uniformly ordered lamellar structures across multiscales. The resulting poly(vinyl alcohol) (PVA) hydrogels with a hierarchical network exhibit a Herman’s orientation factor of 0.91, surpassing previously reported values for bulk hydrogels. The structural orientation enables the hydrogel to exhibit excellent mechanical properties, including a tensile strength of 41.29 ± 2.10 MPa and toughness of 159.37 ± 28.15 MJ·m⁻³. To demonstrate the versatility, this strategy is further used to fabricate gelatin hydrogels, resulting in a 32-fold enhancement in toughness. Anisotropic thermal conductivity, another representative physical property originating from molecular-level alignment, is also demonstrated. This work establishes a generalizable technology for developing high-performance bulk polymeric materials through molecular-level engineering, offering substantial potential for applications in load-bearing components, bioelectronic devices, thermal management systems, etc.
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Nature Communications
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2026
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IF 18.1
Lu Ruihu,Zhu Jiexin,Xia Chenfeng,Li Mengjiao,Yu Ruohan,Chen Xingbao,Dai Yuhang,Zong Wei,Long Yu,Xia Bao Yu,Mai Liqiang,Wang Ziyun
Renewably powered electrochemical CO 2 reduction (CO 2 R) to alcohols presents a promising route to liquid fuels and chemicals. However, protonation of different intermediates often leads to mixed liquid and gas products, complicating separation and reducing economic feasibility. Here, we present a hydroxyl-affinity-tuning strategy that stabilizes hydroxyl-containing CO 2 R intermediates away from interfacial water through constructing nano-metal interfaces, thereby favoring ethanol production. Theory-guided catalyst design directs nano-cobalt/Cu surfaces, delivering CO 2 -to-ethanol Faradaic efficiencies (FE) of 62.17% and 45.32% under alkaline and acidic conditions, respectively, with ethanol partial current densities over ~300 mA cm −2 . In acidic media, the catalyst maintains ethanol production for 235 hours with an average FE of 44.74%. In situ spectroscopy and theoretical calculations reveal that nano-Co/Cu interfaces favor binding hydroxyl groups and thereby enriches C-OH species on the copper surface, redirects CO 2 R pathways toward ethanol. This work provides a catalyst-centered strategy for designing interfacial architectures for selective alcohol synthesis. Future efforts should focus on translating this design principle into scalable systems for practical electrochemical CO 2 utilization.
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高影响因子
MICROCHIMICA ACTA
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2026
·Vol. 193
·期 7
·485
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IF 5.4
Ye Xilei,Zhang Qiaoling,Zhao Yiwei,Huang Lei,Chen Huaixia,Dang Xueping
A Cu 7 Mn 2 bimetallic cluster (Cu 7 Mn 2 ) fiber coating was prepared for headspace solid-phase microextraction (HS-SPME) of 10 phenolic compounds. The fiber coating was characterized by Fourier transform infrared spectroscopy, scanning electron microscopy, nitrogen adsorption–desorption measurement, and thermogravimetric analysis. The adsorption performance was investigated via adsorption isotherm experiments. The results indicated that the adsorption of the Cu 7 Mn 2 fiber coating for 10 phenolic compounds followed the Freundlich isotherm model, suggesting multilayer adsorption. Density functional theory (DFT) calculations revealed that the adsorption mechanism primarily involves hydrogen bonding, π − π stacking and hydrophobic interactions. After the extraction conditions were optimized, an HS-SPME-GC-FID method was established for the determination of 10 phenolic compounds in environmental water samples. The linear ranges were 0.003−500 μg·L −1 for 2-NP, 0.009–500 μg·L −1 for 2-CP, 0.015–500 μg·L −1 for 2,4-DCP and 2,6-DCP, 0.030–500 μg·L −1 for 2,4-DMP, 0.050–500 μg·L −1 for PTBP, 0.100–500 μg·L −1 for phenol and 3-MP, and 0.150–500 μg·L −1 for 2-MP and 4-CP ( R 2 ≥ 0.9908). The limits of detection (LODs, S/N=3) were 0.001−0.045 μg·L −1 . The recoveries of 10 phenolic compounds in water samples ranged from 80.2% to 119.8%. The enrichment factors ranged from 303 to 3435, and the coating could be reused at least 120 times. The established HS-SPME-GC-FID method is reliable for the determination of 10 phenolic compounds in real water samples. Graphical The alternative text for this image may have been generated using AI.
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MOLECULAR NEUROBIOLOGY
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2026
·Vol. 63
·期 1
·697
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IF 5.5
Wang Ya-Han,Ding Peng-Li,Qin Hao,Zhang Kai-Xin,Ge Jin-Wen,Wu Da-Hua,Xie Le,Liang Kun
Abnormal glucose metabolism in the central nervous system is a major cause of sporadic Alzheimer's disease (SAD). We hypothesize that glycogen synthase kinase 3β (GSK3β) mediates cognitive impairment by inhibiting the Wnt/β-catenin pathway, which in turn induces abnormal glucose metabolism, synaptic damage, and mitochondrial dysfunction. To test this hypothesis, we injected streptozotocin bilaterally into the lateral ventricles of 100 male C57BL/6 J mice to establish in vivo models of SAD, and into HT22 cells to establish in vitro models of SAD. GSK3β expression was knocked down via adeno-associated virus (AAV) injection into the hippocampal CA1 region in vivo and via lentiviral transfection in vitro. We assessed cognitive function using the Morris water maze, Y-maze, and novel object recognition tests ( n = 10). Glucose metabolism was evaluated by 18F-FDG PET imaging ( n = 3), while synaptic and myelin sheath ultrastructure was examined using transmission electron microscopy ( n = 6). Cell viability, mitochondrial function, and key protein expression were measured using CCK-8 assays, Seahorse analysis, and molecular biology techniques, respectively ( n = 3, n = 6). In both in vivo and in vitro STZ-induced SAD models, GSK3β knockdown significantly reduced amyloid-β (1–42) deposition and tau hyperphosphorylation, activated the Wnt/β-catenin pathway, enhanced glucose metabolism, reversed glycolytic inhibition and mitochondrial dysfunction, and repaired synaptic and myelin sheath damage, ultimately improving cognitive deficits. Our findings demonstrate that GSK3β knockdown ameliorates STZ-induced SAD-like pathologies by restoring Wnt/β-catenin signaling and normalizing glucose metabolism, highlighting GSK3β as a potential therapeutic target for SAD. Graphical
The alternative text for this image may have been generated using AI.
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Translational Cancer Research
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2026
·Vol. 15
·期 5
·378
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IF 2.1
Zhongshun He,Aiping Huang,Jing Lv,Jing Zhou,Wenrong Lou,Biao Xu,Xuesong Wu
Background Malignant melanoma is among the most aggressive and life-threatening forms of skin cancer, and effective therapeutic treatment options remain limited. Thus, there is an urgent need to develop efficient and broadly applicable anti-melanoma drugs. Growing evidence suggests that baicalin (BAI) possesses anti-cancer potential; however, its anti-tumor mechanisms in melanoma cells remain to be fully elucidated. Therefore, this study aimed to investigate whether BAI exerts anti-melanoma effects. Methods A375 melanoma cells were treated with varying concentrations of BAI to assess its effects on cell proliferation, migration, invasion, and apoptosis. Network pharmacology analysis was then employed to predict potential molecular targets of BAI in melanoma treatment. Molecular docking was used to evaluate the binding interactions between BAI and the predicted targets. Finally, in vitro experiments were performed to investigate the regulatory effects of the potential targets on A375 cell functions. Results BAI significantly inhibited A375 cell proliferation, invasion, and migration, as well as inducing apoptosis of A375 cells in a dose-dependent manner (all P<0.05). Subsequent network pharmacology analysis identified three potential therapeutic targets of BAI, among which epidermal growth factor receptor (EGFR) exhibited strong binding affinity with BAI. Further in vitro experiments demonstrated that BAI suppressed EGFR-mediated PI3K/AKT pathway activation in a dose-dependent manner. Consistent with previous findings, EGFR overexpression exerted oncogenic effects in melanoma cells by inhibiting apoptosis. Mechanistically, BAI induced apoptosis in melanoma cells by targeting the EGFR-mediated PI3K/AKT signaling pathway. Conclusions This study demonstrates that BAI exerted cytotoxic effects on melanoma cells by targeting EGFR and inhibiting the PI3K/AKT pathway, thereby inducing apoptosis. These findings suggest that BAI may serve as a promising therapeutic candidate for the treatment of malignant melanoma.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
·Vol. 24
·期 1
·491
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IF 15
Wang Pinkai,Ai Fanrong,Huang Guanfeng,Shen Yunfeng,Cui Fengyang,Deng Hui,Liang Chengzhi,Xie Jiajun,Kang Jiawei,Zhu Yudan,Xiong Weixiang,Tao Jun
Chronic diabetic wounds complicated by biofilm infections resist healing because persistent bacterial colonization coexists with microenvironmental imbalances, including oxidative stress and inflammation. Conventional pharmacotherapy and wound care are limited by impaired local perfusion, which hinders both effective biofilm eradication and reversal of the pathological wound microenvironment. We developed an ultrasound-activated core–shell microneedle platform (CCA&Lut@MN) that combines sonodynamic gas cascade antimicrobial therapy with a ROS-responsive microenvironment modulation strategy. Upon ultrasonic stimulation, L-arginine–modified copper–cysteine nanoparticles (CCA) in the microneedle shell generate reactive oxygen species (ROS) and catalyze NO release from L-Arg, producing synergistic oxidative and nitrative stress that yields rapid bactericidal activity and effective biofilm eradication. The microneedle core consists of an ROS-responsive PVA-HP-luteolin hydrogel that degrades in response to elevated ROS in the microenvironment, releasing luteolin. Luteolin scavenges excess ROS and promotes macrophage polarization to the M2 phenotype, thereby enhancing angiogenesis and cell migration. In a diabetic rat wound model infected with MRSA , CCA&Lut@MN markedly reduced wound bacterial load, alleviated local inflammation and improved blood supply, and thereby accelerated wound healing. This microneedle platform produces synergistic antibacterial effects via sonodynamic therapy (SDT)–gas cascade reactions, modulates the pathological microenvironment, and improves local blood supply, offering a promising strategy for treating complex and refractory wounds. Graphical The alternative text for this image may have been generated using AI.
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Nature Communications
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2026
·
IF 18.1
Hu Honglu,Zhang Zhen,Sun Mingzi,Kim So Yeon,Kim Se Young,Yang Xinru,Mei Liang,Yan Ruixin,Zheng Weikang,Zhang Yue,Gu M. Danny,Fang Guozhao,Chao Dongliang,Liao Hong-Gang,Lee Joon Sang,Huang Bolong,Li Ju,Zeng Zhiyuan
Lithium metal batteries are considered promising candidates for next-generation energy storage due to the high capacity and low redox potential of lithium negative electrodes. However, dendritic Li growth and unstable solid-electrolyte interphase formation remain critical bottlenecks for practical implementation. While electrolyte anion chemistry critically governs solid-electrolyte interphase formation, nanoscale observations of anion-regulated Li nucleation and growth mechanisms remain limited in tracking dynamic interfacial processes. Here, we employ in situ liquid-phase transmission electron microscopy combined with cryogenic spectroscopy and computational modelling to unravel anion-specific Li nucleation and growth in three distinct electrolytes: LiClO 4 , LiPF 6 , and LiTFSI-based electrolytes. Real-time tracking reveals that ClO 4 − drives dendritic Li growth with organic dominated solid-electrolyte interphase, whereas PF 6 − stabilizes moss-like Li nucleation through LiF-organic hybrid interphases. Notably, TFSI⁻ forms a bilayer SEI with LiF/Li 2 CO 3 -rich inner layers, enabling Li lateral growth and fusion. Molecular dynamics simulations correlate anion-induced interface architectures with Li + transport and surface potential distributions, demonstrating that TFSI − suppresses dendrites via balanced mechanical confinement and ion-flux regulation. These anion-mediated interface engineering observations offers principles for electrolyte design toward stable lithium metal batteries.
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Science China-Life Sciences
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2026
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IF 9.6
Cao Zheng,Yu Zongyu,Wang Xin,Jiang Dongqi,Yuan Yafei,Shu Ze,Yang Yiting,Zhang Yunfang
Emerging evidence highlights the pivotal roles of RNA modifications in affecting male fertility and offspring health. However, the dynamic landscapes of RNA modification during spermatogenesis and sperm maturation are still incompletely characterized. Here, we profiled 27 RNA modifications across total RNA, tRNA-enriched fractions, and small RNA fractions in developing mouse testes (P7–P56), isolated spermatogenic cells, and epididymal sperm by applying a liquid chromatography-tandem mass spectrometry-based RNA modification quantification platform, deciphered the developmental dynamics of RNA modification signature and coordinative inter-modification cross-talk. Through integrative analyses of RNA modification signatures among spermatogenic cells in the testis and spermatids at different maturation stages in the epididymis, we found that most RNA modifications were gradually reprogrammed from the testis to the epididymis, and finally declined in mature sperm. Specifically, some RNA modifications (e.g., m 6 A and m 5 U) were enriched in meiotic prophase II spermatocytes and round spermatids, while others (e.g., m 5 C and m 2 G) exhibited high abundance in caput sperm. Additionally, using a type 2 diabetes mellitus mouse model, we found that sperm RNA modification signatures are dynamically reprogrammed during epididymal maturation in response to diabetes, leading to a remarkable alteration in sperm RNA modification signatures and inter-modification correlation networks. Collectively, our study delineates the dynamic landscape of RNA modifications during spermatogenesis and maturation, uncovering its origins and trajectory alterations in the type 2 diabetes mellitus mouse model. This provides novel insights into both the underpinned regulatory mechanisms of RNA modification-dependent spermatogenesis and epigenetic remodeling of sperm during epididymal maturation.
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Nature Communications
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2026
·
IF 18.1
Sha Zongnuo,Chen Fang,Hu Cheng,Huang Hongwei
Upcycling of various plastic wastes and their mixtures into clean fuels at ambient conditions holds great potential, but challenging the mild catalytic technologies in terms of product selectivity. Herein, we propose constructing mechanically-driven piezocatalytic reforming system as a universal plastic reforming platform, based on [PO 4 ] unit-substituted BiOIO 3 nanorods. The [PO 4 ] tetrahedra acting as polarization vacancies disrupt the symmetric dipole alignment of [IO 3 ] units to beak the see-saw effect between effective active sites and piezoelectric polarization intensity, achieving polarization reorientation and constructing I ⋅ ⋅ ⋅ O P frustrated Lewis acid-base pairs, which undergo kinetically-favorable dynamic transformation under periodic stress. This system successfully produces H 2 and CO from typical plastic including polyester, polylactic acid, polyethylene, and their mixtures with selectivity beyond 87% in gas. Especially, methanol and ethanol with the total yield of 91.84 mmol ⋅ g −1 ⋅ h −1 can be directly obtained from polyester in liquid, setting a mechanical-to-chemical conversion efficiency of 4.96%.
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Science China-Chemistry
·
2026
·
IF 9.8
Cheng Baijie,Wang Ruixue,Xu Peipei,Wu Xueying,Xia Zhenhao,Jin Yexi,Xu Hongyao,Guang Shanyi
Conductive gel-based flexible wearable devices have emerged as transformative platforms for emerging applications in human-machine interaction. However, environmental humidity fluctuations can impair material performance through mechanisms such as water uptake-induced swelling/dehydration-induced embrittlement, as well as signal baseline drift. In this study, inspired by the strong hydration mechanism of natural moisturizing factors (NMF) and the sebum barrier in the skin, a biomimetic heterophase liquid-locking (BHL) design is proposed. This design precisely recapitulates the dual protective characteristics of skin. An internal hydrophilic phase, formed by zwitterionic polymers, achieves NMF-like high moisturization via hydrogen bonding/ion-dipole interactions. Meanwhile, a stable hydrophobic phase, mimicking the sebum barrier, is constructed on the surface through the covalent grafting of nanoscale hydrophobic polyhedral oligomeric silsesquioxane (POSS). The resulting gel exhibits ultra-stable mechanical and sensing performance over an ultra-wide humidity range (RH = 10%–90%), with less than 5% variation over 108 days. Furthermore, the eutectogel possesses softness, self-healing capability, high transparency, a wide temperature operating window, and ionic conductivity. By integrating gel-based electrode arrays and devices, human-machine collaboration and virtual reality (VR)-based human-machine interaction are realized. Moreover, an intelligent human-machine interaction system developed by further incorporating deep learning technology achieves a recognition rate of up to 99.68% for various gesture signals.
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