JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2021
·Vol. 29
·期 10
·3154-3160
·
IF 3.667
Ma Yufeng,Kou Zhimin,Geng Xiang,Gong Xuanang,Cui Juqing,Jia Puyou,Wang Chunpeng
Abstract A series of ethyl cellulose (EC) grafted copolymers were fabricated with methyl methacrylate (MMA), stearyl methacrylate (SMA) and EC grafted 2-bromoisobutyryl bromide(EC-Br) as macroinitiator via atom transfer radical polymerization (ATRP). The chemical structures of EC-Br and EC graft copolymers were identified by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance ( 1 H NMR) spectroscopy. The EC graft copolymers exhibited higher molecular weight and polydispersity index value. With the dosage of SMA increased, EC grafted copolymers exhibited glass transition temperatures in a broad temperature range from 119.1 to 42.3 ℃. And the initial decomposition temperature ( T i ) of EC grafted copolymers were increased (148.2 ℃ to 199.4 ℃). The stresses at break of EC grafted copolymers were decreased with the increase of SMA content. However, the elongation at break of all EC grafted copolymers were increased with the dosage of MMA decreased. These results suggested that the sustainable copolymers with cellulose backbone, acrylate side-chain were potential candidates for service as TPEs in some applications. Graphic Abstract
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高影响因子
BMC CANCER
·
2021
·Vol. 21
·期 1
·1-10
·
IF 4.43
He Ping,Cheng Shihuan,Hu Feng,Ma Zhanchuan,Xia Yan
Background Diacylglycerol-acyltransferase 1 (DGAT1) plays an important role in the energy storage and is involved in cancer progression. A growing number of evidences showed that elevated expression of DGAT1 in cancer tissue indicated a poor outcome in cancer patients. However, the relationship between DGAT1 and gastric cancer is still unclear. Thus, Transcriptomic analysis and in vitro experiments were performed to investigate the role of DGAT1 in gastric cancer, as well as the potential therapy target in gastric cancer treatment.Methods We screened the public cancer datasets to identify the expression and function of DGAT1 in gastric cancer and tumor infiltrating lymphocytes. Then we testified the DGAT1 expression and function after sodium oleate treatment in AGS and MKN45 cell line. Finally, we analyzed ration of apoptosis, necrosis in gastric cancer cells by using flow cytometry after administration of DGAT1 inhibitor.Results Our results showed a highly expression of DGAT1 in gastric cancer tissues (n = 5, p = 0.0004), and tumor-infiltrating macrophages with elevated DGAT1 expression is associated with poor overall survival in gastric cancer patients. In addition, gastric cell lines AGS (n = 3, p < 0.05) and MKN45 (n = 3, p < 0.01) expressed higher level of DGAT1 than human gastric mucosal epithelial cell line GES-1. Administration of DGAT1 inhibitor effectively suppressed functional factors expression and induced cell death in MKN45.Conclusion The findings of this research provide an in-depth insight into the potential role and influences involved in DGAT1 in the gastric cancer patients. And higher expression of DGAT1 leads to lower overall survival (OS) rate in patients with poorly differentiated gastric cancer. Our findings suggest a potential role for DGAT1 in the gastric cancer progression and inhibiting DGAT1 might be a promising strategy in gastric cancer treatment.
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高影响因子
JOURNAL OF POROUS MATERIALS
·
2021
·Vol. 28
·期 4
·1041-1048
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IF 2.496
Wu Zhonghan,He Zhechao,Xu Yinke,Wang Jing,Lu Xinhuan,Xia Qinghua,Zhou Dan
From the view of energy saving and environment protection, green catalysis has become one of the most important goals of chemists, including both the green preparation of catalyst and the highly efficient catalysis under mild reaction condition. Herein, N,N -dimethylaminopropyl-functionalized hybrid zeolite is firstly synthesized by one-step non-templating method, which is characterized by powder X-ray diffraction, Fourier-transform IR, thermogravimetric analysis, element analysis, scanning electron microscope, water contact angle measurements, inductively coupled plasma atomic emission spectrometry, and N 2 adsorption–desorption measurements. The functionalized hybrid zeolite can be directly used as base catalyst without any post modification and achieve high yields of corresponding products in the Knoevenagel condensation of benzaldehyde (or substituted benzaldehyde) with ethyl cyanoacetate at room temperature by using ethanol as solvent. By the comparison with other zeolite catalysts, the unique and excellent catalytic properties of N,N -dimethylaminopropyl-functionalized hybrid zeolite was ascribed to not only the synergic effect of basic property and hydrophobic/lipophilicity of the organic groups, but also the easier accessibility of bulky substrate molecules with highly exposed catalytic active sites over the solid catalyst. The recycling and control experiments show that it owes excellent reusable stability.
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AMB Express
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2021
·Vol. 11
·期 1
·1-10
·
IF 3.298
Yao Jian,Gui Lun,Yin Shaocheng
A novel esterase gene was isolated from a soil metagenomic library. The gene encoded a protein of 520 amino acids which contained a 21 aa signal peptide. Primary structure analysis of the protein sequence revealed that it contained a conserved active site motif (SxSxG) and a structural motif (CS-D-HC). Then the esterase gene was cloned and expressed in Escherichia coli BL21(DE3). SDS-PAGE analysis of the purified esterase showed that it was expressed in a highly soluble form and its molecular mass was estimated to be 55 kDa. Characterization of the esterase revealed that it exhibited high activity toward p-nitrophenyl esters with short acyl chains and especially p-nitrophenyl acetate, suggesting that it was a typical carboxylesterase rather than a lipase. With p-nitrophenyl acetate as substrate, the enzyme showed its optimal activity at pH 7.0 and 30 °C, and it was stable at a broad pH range from 4.5 to 10.0 and temperature not higher than 50 °C. Furthermore, the enzyme showed different substrate specificity from known esterase, it was not only hydrolyzing against p-nitrophenyl esters, but also hydrolyzing all hydroxybenzoic esters and hydroxycinnamic ester assayed. As it was an enzyme active on a broad range of phenolic esters, simultaneously possessing feruloyl esterase, chlorogenate esterase and tannase activities, it could serve as a valuable candidate for applications in biotechnology.
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高影响因子
MICROCHIMICA ACTA
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2021
·Vol. 188
·期 8
·1-8
·
IF 5.833
Hu Cong Yi,Jiang Zhong Wei,Huang Cheng Zhi,Li Yuan Fang
Based on the laccase-mimicking activity of Cu 2+ -modified University of Oslo (UiO) metal–organic framework (UiO-67-Cu 2+ ), we developed a colorimetric sensor array for distinguishing a series of phenols with different number and position of substituted hydroxyl group (-OH) and different substituent group on the benzene ring, including phenol, catechol, quinol, resorcinol, pyrogallol, phloroglucinol, o -chlorophenol, o -aminophenol, and o -nitrophenol. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of phenolic compounds were obtained by theoretical calculation. The results show that the lower the LUMO energy level, the easier the chromogenic reaction occurs. The UiO-67-Cu 2+ -catalyzed phenol chromogenic reaction showed a good linearity in the range from 0.1 to 200 μM with limit of detection approximately 61 nM. Through the detection of phenol in tap water and river water, the recovery rate and RSD ( n = 3) were calculated as 94.1~103% and 1.0~3.3, respectively, showing good recovery, reliable results, and outstanding stability. Therefore, the proposed colorimetric sensor array will have a great potential for the detection of phenols in the environment. Graphical abstract
Schematic presentation of a simple and sensitive colorimetric strategy based on the laccase-mimicking activity of Cu 2+ -modified UiO-type metal–organic framework (MOFs, Uio-67-Cu 2+ ) to distinguish phenols with analogous structures.
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Advanced Composites and Hybrid Materials
·
2021
·Vol. 4
·期 3
·716-724
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IF 5.693
Yan Zhaoqian,Sun Zhihao,Li Anran,Liu Hongshou,Guo Zihao,Qian Lei
Traditional Fe-based oxide with poor intrinsic conductivity, severe volume expansion, and structure destruction exhibits the poor cyclic performance for anode materials of lithium ion batteries (LIBs). Heteroatomic doping Fe-based oxide with nanoarchitectures is deemed to settle the above problems effectively. Herein, with sulfur (S) doping, three-dimensional porous flower-like Fe 2 O 3 (denoted as S- Fe 2 O 3 ) prepared via ordinary solvothermal reaction and calcining process was ingeniously designed as anode materials for LIBs. The S doping changed the morphology, improved the electrical conductivity, and provided more active sites for lithium storage. The flower-like S-Fe 2 O 3 made up of plentiful carbon encapsulated nanoparticles not only relieved the volume expansion but also provided the connected conductive network. The as-prepared flower-like S-Fe 2 O 3 electrode delivered a high discharge/charge capacity (1570.8 mAh g −1 at 0.1 A g −1 after 100 cycles) and the excellent long-cycle performance (521.3 mAh g −1 at 2.0 A g −1 after 1000 cycles). S doping and nanoarchitectures engineering in this work provide rational preparation strategies for composites containing transition metal oxides toward energy storage system. Graphical abstract Three-dimensional porous flower-like S-Fe 2 O 3 from ordinary solvothermal reaction and calcining process is ingeniously designed as anode materials for LIBs.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-20
·
IF 10.435
Deng Xuanru,Liu Hongxing,Xu Yuan,Chan Leung,Xie Jun,Xiong Zushuang,Tang Zheng,Yang Fang,Chen Tianfeng
Background The design of stable and biocompatible black phosphorus-based theranostic agents with high photothermal conversion efficiency and clear mechanism to realize MRI-guided precision photothermal therapy (PTT) is imminent.Results Herein, black phosphorus nanosheets (BPs) covalently with mono-dispersed and superparamagnetic ferrous selenide (FeSe2) to construct heteronanostructure nanoparticles modified with methoxy poly (Ethylene Glycol) (mPEG-NH2) to obtain good water solubility for MRI-guided photothermal tumor therapy is successfully designed. The mechanism reveals that the enhanced photothermal conversion achieved by BPs-FeSe2-PEG heteronanostructure is attributed to the effective separation of photoinduced carriers. Besides, through the formation of the P-Se bond, the oxidation degree of FeSe2 is weakened. The lone pair electrons on the surface of BPs are occupied, which reduces the exposure of lone pair electrons in air, leading to excellent stability of BPs-FeSe2-PEG. Furthermore, the BPs-FeSe2-PEG heteronanostructure could realize enhanced T2-weighted imaging due to the aggregation of FeSe2 on BPs and the formation of hydrogen bonds, thus providing accurate PTT guidance and generating hyperthermia to inhabit tumor growth under NIR laser with negligible toxicity in vivo.Conclusion sCollectively, this work offers an opportunity for fabricating BPs-based heteronanostructure nanomaterials that could simultaneously enhance photothermal conversion efficiency and photostability to realize MRI-guided cancer therapy.Graphic abstract
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 37
·期 4
·900-905
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IF 1.307
Liu Xiaoyan,Zhou Yan,Zheng Tingting,Tian Yang
W ith the advancement of nanomaterials for surface-enhanced Raman scattering(SERS) detection, a deeper understanding of the chemical mechanism(CM) and further applications has been achieved. Herein, we prepared a porous tungsten trioxide(WO 3 ) film by the pulse electrodeposition method, and constructed a WO 3 film SERS aptasensor. With methylene blue(MB) as the adsorption molecule, the developed WO 3 film SERS aptasensor revealed remarkable Raman activity. Through experimental data and theoretical calculations, we found that the significant SERS enhancement[enhancement factor(EF)=1.5× 10 6 ] was due to the CM based on charge transfer and molecular resonance. Utilizing the Raman response of MB on the WO 3 film and specific aptamers, we successfully developed the aptamer sensor by covalently attaching the MB modified aptamer to the WO 3 film. The sensor realized the specific and sensitive determination of vascular endothelial growth factor(VEGF) with the detection limit down to 8.7 pg/mL. In addition, the developed aptasensor indicated the excellent selectivity among other interferences, such as metal ions, reactive oxygen species(ROS), and proteins. This WO 3 film SERS aptasensor not only contributed to the study of the enhancement mechanism of semiconductor material, but also provided a powerful platform for the sensitive detection of VEGF, possessing a great potential in the real-time monitoring of biomarkers of glioblastoma in vitro .
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COLLOID AND POLYMER SCIENCE
·
2021
·Vol. 299
·期 8
·1327-1335
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IF 1.931
Wu Shu,Zhang Xueqin,Sun Ying,Yang Hong,Lin Baoping,Han Xuelian,Chen Ping
Abstract To investigate the influence of crosslinking density and free polysiloxane chain length on oxygen permeability and hydrophilicity of multicomponent silicone hydrogels, two kinds of silicone macromonomers, single methacrylate terminated silicone macromonomers (PDMS-1) and double methacrylate terminated silicone macromonomers (PDMS-2), were synthetized, respectively. Then, a series of multicomponent silicone hydrogels with different crosslinking densities and free polysiloxane chain lengths were prepared by copolymerization of obtained silicone macromonomers, silicone monomer tris(trimethylsiloxy)-3-methacryloxpropylsilane (TRIS), and hydrophilic monomers. The oxygen permeability coefficient (Dk), equilibrium water content (EWC), light transmittance, and mechanical properties of silicone hydrogels were characterized. The results indicated that the longer free polysiloxane chain was beneficial to the increase of Dk values and EWC of silicone hydrogels. With the increase of crosslinking density, the Dk values and EWC of the silicone hydrogels decreased. This work provided a new idea for the preparation of high-permeability silicone hydrogels in the future. Graphical abstract
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PHARMACEUTICAL RESEARCH
·
2021
·Vol. 38
·期 4
·669-680
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IF 4.2
Wang Yeying,Li Qilong,Zhou Jing-e,Tan Jingwen,Li Minghao,Xu Nan,Qu Feng,Chen Jian,Li Ji,Wang Jing,Liang Zhiqiang,Yu Lei,Wang Yiting,Yan Zhiqiang
Purpose To address the issue of local drug delivery in tumor treatment, a novel nanoparticle-hydrogel superstructure, namely semi-interpenetrating polymer networks (semi-IPNs) hydrogel composed of poly (ethylene glycol) diacrylate (PEGDA) and hyaluronic acid (HA) and incorporated with paclitaxel (PTX) loaded PLGA nanoparticles (PEGDA-HA/PLGA-PTX), was prepared by in situ UV photopolymerization for the use of local drug delivery. Methods Using the gelation time, swelling rate and degradation rate as indicators, the optimal proportion of Irgacure 2959 initiator and the concentration of HA was screened and obtained for preparing hydrogels. Next, paclitaxel (PTX) loaded PLGA nanoparticles (PLGA-PTX NPs) were prepared by the emulsion solvent evaporation method. Results The mass ratio of the initiator was 1%, and the best concentration of HA was 5 mg/mL in PEGDA-HA hydrogel. In vitro experiments showed that PLGA-PTX NPs had similar cytotoxicity to free PTX, and the cell uptake ratio on NCI-H460 cells was up to 96% by laser confocal microscopy and flow cytometry. The drug release of the PEGDA-HA/PLGA-PTX hydrogel local drug delivery system could last for 13 days. In vivo experiments proved that PEGDAHA/PLGA-PTX hydrogel could effectively inhibit the tumor growth without causing toxic effects in mice. Conclusions This study demonstrated that the PEGDA-HA/PLGA-PTX hydrogel is a promising local drug delivery system in future clinical applications for tumor therapy. Graphical abstract
A photopolymerized semi-interpenetrating polymer networks-based hydrogel incorporated with paclitaxel-loaded nanoparticles was fabricated by in situ UV photopolymerization, providing a promised nanoplatform for local chemotherapy of tumors.
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MACROMOLECULAR RESEARCH
·
2021
·Vol. 29
·期 3
·199-210
·
IF 2.227
Wu Zhihui,Shen Chunhui,Gao Shanjun,Zhu Xi,Zhang Mingliang,Ding Ao
A series of proton exchange membranes were prepared by incorporating phosphonic functionalized siloxane into sulfonic poly(2,6-dimethyl-1,4-phenyleneoxide) (SPPO) and imidazole functionalized poly(2,6-dimethyl-1,4-phenyleneoxide) grafted with siloxane (IPPO-Si). Phosphonic acid functionalized siloxane was synthesized from amino trimethyl phosphonic acid (ATMP) and (3-aminopropyl)triethoxysilane (APTES). FTIR results showed that 1-methylimidazole and APTES were successfully grafted onto polyphenylene oxide, and APTES successfully formed Si-O-Si crosslinked networks through hydrolytic crosslinking. The membranes were thermally stable up to 220 °C and exhibited excellent oxidative stability and mechanical performance. We also measured the proton conductivity of the membranes. The results showed that the proton conductivities of the composite membranes increased with the increasing of SPPO content at different degrees under high (100 °C–160 °C) and low (25 °C–80 °C) temperature conditions. Furthermore, the IPPO-SI-P/SPPO-30 has the best conductivity, reaching to 0.1131 S cm −1 at 80 °C, 100%RH and 0.1049 S cm −1 at 160 °C, 5%RH, respectively. Therefore, this novel membrane acts as a potential candidate for proton exchange membranes with a wider applicable temperature (25 °C–160 °C).
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FIBERS AND POLYMERS
·
2021
·Vol. 22
·期 5
·1208-1217
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IF 2.153
Zhao Chenyu,Wang Guangshu,Sun Mengtao,Cai Zewei,Yin Zichu,Cai Yurong
As one of the most important parameters to characterize the organic pollution of water, biochemical oxygen demand (BOD) determined through a rapid, in situ and on line method is very attractive. In this paper, a new BOD biosensor has been developed, which are composed of the ecofriendly precursor of Saccharomyces cerevisiae ( S. cerevisiae ) embedded in bacterial cellulose (BC) matrix and the Ketjen Black (KB) modified glassy-carbon electrode. Furthermore, a doublemediator system is constructed using potassium ferricyanide and menadione in reaction cell to transfer electron from the microbe to electrode. The responses of glucose glutamic acid (GGA) standard solutions are amperomertrically measured with an applied potential of 0.25 V versus Hg/Hg 2 Cl 2 in a three-electrode system. Under the optimum conditions, the (BC/ S. cerevisiae -menadione)/KB modified electrode shows a high operational stability with relative standard deviation (RSD) of 4.16% (fourteen assays), a good repeatability (RSD=3.10%), a fast response time (in 20 minutes) and a wide linear range (from 10–220 mg O 2 l −1 ). The BOD values measured by this method have been highly correlated with the standard BOD 5-day method for wastewater samples (R 2 =0.9859, n=3), indicating that it can meet the requirement of BOD rapid measurement.
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