ACS Nano
·
2026
·
IF 17.3
XuanLin Zhao,Tao Wang,QiLong Zhou,ZeLiang Wei,Ying Zhang,XiaoYi Wu,YuDa Zhu,XiuXian Yu,HongLi Jiang,XinRui Xu,Kun Zhang,Guang Xin,Wen Huang
Acute pancreatitis (AP) is a common and potentially fatal inflammatory disorder lacking effective targeted therapies. Mitochondrial dysfunction, marked by ATP depletion and excessive ROS production, lies at the heart of disease initiation and progression. This study presents a hierarchically targeted nanotherapeutic, Cu-CDs/Kyna@RM (RMCK), in which copper-doped, mitochondria-targeting carbon dots (Cu-CDs) are grafted with kynurenic acid (Kyna) and encapsulated within red blood cell-macrophage hybrid membranes. Upon systemic administration, RMCK homes to inflamed pancreatic tissue, where it sequentially releases Cu-CDs to target mitochondria, scavenge ROS, liberate Kyna, and restore mitochondrial function. It markedly improves survival, lowers serum amylase/lipase, attenuates pancreatic edema and necrosis, and prevents secondary lung injury, outperforming free Kyna therapy. In vitro, RMCK significantly reduces sodium taurocholate (STC)-induced acinar cell injury, measured by decreased cell necrosis and LDH release. Mechanistic studies including transcriptomics, immunohistochemistry, and functional assays reveal that RMCK amplifies GPR35-NF-κB inhibition to curb cytokine storms, prevents mtDNA-driven inflammasome activation, and alleviates hypoxia to downregulate HIF-1α and upregulate PPARγ for restored fatty acid oxidation. By integrating organ- and organelle-level targeting with ROS scavenging and mitochondrial energy remodeling, RMCK delivers synergistic, precision therapy for AP and offers a versatile platform for other inflammatory diseases characterized by mitochondrial dysfunction.
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POLYHEDRON
·
2026
·
IF 2.8
Nan Wang,Lei Chen,Wanhe Du,Keying Zhu,Bingyu Zhang,Shengwen Chen,Zhiguo Sun,Jifen Wang
A novel Z -scheme CuWO 4 /Cu/Cu 2 O ternary heterojunction photocatalyst was successfully synthesized via a solvothermal approach, featuring the low-cost metallic copper (Cu) as an efficient electron mediator. This unique structure was designed to enhance Cu 2 O visible light capture capability and accelerate photogenerated charge separation, thereby efficiently degrading the recalcitrant antibiotic Rifampicin (RFP). Comprehensive characterizations (XRD, XPS, SEM, EDS) confirmed the successful construction of the heterojunction, where CuWO 4 and Cu particles are integrated onto the surface of the Cu 2 O. Compared to individual components and binary composites, the optimized CuWO 4 /Cu/Cu 2 O sample demonstrated significantly superior photocatalytic activity, achieving an impressive 88.0% RFP degradation rate within 80 min under visible light. The enhanced performance is primarily ascribed to the successful formation of a Z -scheme charge transfer pathway, where the localized surface plasmon resonance (LSPR) effect of the metallic Cu mediator promotes carrier migration, thereby improving both carrier separation efficiency and redox capacity. Kinetic analysis confirmed a degradation rate constant ( k ) of 0.02743 min −1 , approximately 2.8 times higher than that of pure Cu 2 O. Furthermore, the composite exhibited excellent stability, maintaining a degradation rate above 80% after five recycling runs and demonstrating robust performance across a broad pH range (3.0–7.0). Based on active species trapping and band structure analysis, a Z -scheme mechanism was proposed, highlighting O 2 − as the dominant active species. This study provides a facile and low-cost strategy for constructing highly efficient LSPR-enhanced Z -scheme photocatalysts for environmental remediation.
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JOURNAL OF HAZARDOUS MATERIALS
·
2026
·
IF 10.6
Zhe Xu,Weilan Zhen,Chengfeng Liu,Jiantong Zhou,Taicheng An
The speciation compatibility of Cu-ligand complexes and catalytic oxidation systems fundamentally governs their decomplexation efficiency, exhibiting pronounced ligand concentration dependence. While contemporary methodologies predominantly focus on stoichiometric Cu(II)-ligand complexes, their efficacy in treating wastewater with ligand excess remains technologically contentious. This study demonstrates the Mn(II)/peroxymonosulfate (PMS) process as a robust solution for the elimination of Cu(II)-ligand complexes even in excessive ligand environments. Using Cu(II)-EDTA as the representative complex, 90% decomplexation was achieved within 1 and 5 min at [EDTA] 0 :[Cu] ratios of 1:1 and 2:1, respectively, surpassing reported decomplexation approaches such as UV/H 2 O 2 , UV/peroxydisulfate (PDS), and Co 2+ /PMS. Mechanistic investigations through oxidation species characterization and product analysis revealed a successive decarboxylation of EDTA by non-radical pathway, i.e., high valence metals and singlet oxygen, enhancing process selectivity while minimizing oxidant consumption ([PMS] 0 :[EDTA] 0 = 30:1). The system exhibits dual mechanistic regimes: (i) instantaneous decomplexation under ligand-deficient conditions via PMS activation by in-situ formed CuO through alkaline precipitation, and (ii) cascade decomplexation for ligand-rich systems involving Mn-Cu synergistic destruction of excessive EDTA prior to CuO-catalyzed degradation of residual ligand. Such synergism is believed to stem from the electron transfer from Cu(II) to Mn(V/VI), forming reactive Cu(III) for decomplexation through intramolecular electron transfer. The Mn(II)/PMS system also exhibited the applicability in treating various Cu(II)-ligand complexes and real wastewater. This work establishes a practical strategy for reliable treatment of industrial wastewater containing non-stoichiometric Cu-ligand complexes.
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Food Bioscience
·
2026
·
IF 6.2
Hongrui Guo,Rui Du,Zijing Dai,Zhidi Xu,Yanqiu Zhu,Xianxiang Wang
Escherichia coli ( E. coli )-induced diarrhea remains a major health challenge in yaks, leading to substantial economic losses in plateau livestock production. Meanwhile, the widespread use of antibiotics has accelerated the emergence of antimicrobial resistance, underscoring the urgent need for green and sustainable antibacterial alternatives. In this study, copper-doped Coptidis Rhizoma -derived carbon dots (Cu-CR-CDs) were successfully synthesized and systematically evaluated for their antibacterial, antioxidant, and intestinal barrier protective effects both in vitro and in vivo . Cu-CR-CDs exhibited a uniform spherical morphology with an average diameter of 3.48 nm, and copper incorporation markedly enhanced its free radical scavenging capacity and conferred with multiple enzyme-like activities, including peroxidase-, superoxide dismutase-, and glutathione peroxidase-like activities. Compared with CR-CDs, Cu-CR-CDs demonstrated significantly enhanced antibacterial activity against E. coli , primarily by disruption of bacterial membrane integrity, increasing permeability, inducing leakage of intracellular biomolecules, inhibiting biofilm formation, and promoting intracellular reactive oxygen species (ROS) generation. In vitro experiments showed that Cu-CR-CDs effectively protected RAW264.7 macrophages and Caco-2 epithelial cells from H 2 O 2 -induced oxidative stress and lipopolysaccharide-induced inflammatory injury through scavenging intracellular ROS, suppressing pro-inflammatory cytokine production, and restoring tight junction protein expression. In vivo , oral administration of Cu-CR-CDs markedly alleviated E. coli –induced diarrhea in mice, reduced intestinal mucosal damage, restored villus structure, mitigated epithelial barrier function, and attenuated systemic inflammation. Moreover, Cu-CR-CDs reshaped gut microbiota composition by decreasing the relative abundance of harmful bacteria (e.g., Proteobacteria, Deferribacteres, and Desulfovibrio ) while increasing beneficial taxa such as Muribaculum, Prevotellaceae, and Akkermansia . Collectively, these results demonstrate that Cu-CR-CDs, as a multifunctional nanozyme with superior performance over CR-CDs, exhibiting potent antibacterial and therapeutic effects against enteric infections, thereby highlighting their potential as a promising nanotherapeutic strategy for the treatment of bacterial diarrhea.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Guanji Chen,Dan Qiu,Li Xu,Guangjie Liang,Peng Xie,Yuewen Huang,Shudong Lin,Bin Wang
Efficient removal and rapid in situ monitoring of Cu(II) in wastewater are of great importance for aquatic environmental remediation, yet conventional adsorbents generally fail to simultaneously achieve high adsorption capacity and quantitative detection. In this study, a N-doped carbon dot composite hydrogel strategy integrating adsorption and fluorescence sensing was proposed. A three-dimensional hydrogel network rich in N/O-containing functional groups was constructed using gelatin methacryloyl (GelMA), acrylic acid (AAc), acrylamide (AAm), and nitrogen-doped carbon dots (NCDs) were further introduced to fabricate the bifunctional fluorescent composite hydrogel NCDs-GA 1 A 2 gel. This structure not only provided abundant coordination and electrostatic adsorption sites for Cu(II), but also endowed the material with optical responsiveness for fluorescence detection. Batch adsorption experiments showed that the Cu(II) adsorption process followed the pseudo-second-order kinetic model and the Langmuir isotherm model, indicating monolayer chemisorption, with a maximum theoretical adsorption capacity of 203.1 mg·g −1 . After ten adsorption-desorption cycles, the hydrogel retained 86.7% of its initial adsorption capacity, demonstrating favorable regeneration stability. Meanwhile, NCDs-GA 1 A 2 gel could serve as a fluorescent probe for Cu(II), showing a good linear fluorescence response to Cu(II) concentration and a low detection limit of 0.65 μM. Coexisting ion interference experiments further confirmed its excellent selectivity and anti-interference capability. This work provides a facile strategy for developing multifunctional biomass-derived fluorescent hydrogel adsorbents and demonstrates promising application potential for Cu(II) removal and in situ detection in wastewater
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Zihao Cheng,Xixi Zhu,Tao Wu,Bo Gong,Jingjing Zhao,Zhongzheng Gao,Hui Zhao,Qingyun Liu
A Cu single-atom nanozyme Cu/phen-NC is synthesized. • Cu/phen-NC is introduced to a hydrogel to construct a portable colorimetric sensor. • Smartphone-assisted colorimetric sensor for ascorbic acid detection is developed. The rapid and on-site monitoring of ascorbic acid (AA, vitamin C) is crucial for assessing the nutritional quality and freshness of food products. In this work, a portable colorimetric sensor is developed by embedding a Cu single-atom nanozyme (Cu/phen-NC) within a polyacrylamide-gelatin hydrogel for smartphone-assisted detection of ascorbic acid (AA) in foods. Cu/phen-NC, synthesized using 1,10-phenanthroline and urea dual-ligands, exhibits enhanced peroxidase-like activity. The nanozyme-hydrogel catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H₂O₂, generating a blue color that fades upon AA addition. Smartphone-captured images are analyzed via ImageJ, establishing a linear relationship between grayscale and AA concentration. The platform achieves detection limits of 0.12 μM and 0.44 μM, with high selectivity and stability. Application to vitamin beverages and oranges yields recoveries of 97.07%–101.32% (RSD ≤ 6.49%). This integrated sensing system offers a cost-effective, user-friendly approach for on-site AA detection, with promising applications in food quality control and nutritional assessment. Schematic illustration of ascorbic acid colorimetric sensing using Cu/phen-NC nanozyme encapsulated in hydrogel versus traditional UV–Vis spectroscopic detection. Download: Download high-res image (112KB) Download: Download full-size image
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Small
·
2026
·
IF 11.8
Na Hong,Yanping Song,Zhao Li,Wenjie Shao,Jun Kang,Shuai Han,Shihao Wang,Zhiyuan Yang,Zhuang Miao,Shudong Zhang,Cui Liu,Min Xi,Nian Li,Zhenyang Wang
Silicon-based anodes are limited by severe volume fluctuations and sluggish charge-transfer kinetics. Although metallic coatings can improve electronic conductivity, continuous dense coatings may impede electrolyte access, and lithium-ion transport. Herein, a soft-hard synergistic bicontinuous conductive network strategy is proposed to fabricate a SiO x /nitrogen-doped laser-induced graphene/Cu (SiO x /NLIG/Cu) composite. Deep eutectic solvent (DES)-derived nitrogen-doped active sites combine with super-lyophilic NLIG matrix to spatially guide the electrodeposition of an interconnected percolation network, rather than an ionic blocking layer. This bicontinuous configuration decouples electronic and ionic transport. The porous NLIG framework serves as a strain buffer and a low-tortuosity ion conduit, while the interpenetrating Cu network maintains electrical continuity and structural integrity. This conductive framework is associated with the formation of a stable, LiF-rich solid electrolyte interphase, enhancing the lithium-ion diffusion coefficient by one order of magnitude. The binder-free anode delivers an initial lithiation capacity of 1820.6 mAh g −1 with an initial Coulombic efficiency of 86.3% at 0.1 A g −1 . It also exhibits enhanced durability, achieving 86.4% capacity retention after 1000 cycles at 2.0 A g −1 . Full cells assembled with LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathodes achieve an active-material-level gravimetric energy density of 614.7 Wh kg −1 . This soft-hard synergy strategy provides a versatile solution to high-performance lithium-ion batteries.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Bao Zien,Ren Xiaohong,Rong Zeming
The selective upgrading of lignin-derived compounds into
high-value
chemicals remains a critical challenge. In this study, a series of
Ni-based catalysts supported on Hβ zeolite and modified with
secondary metals (Zn, Fe, and Cu) were synthesized and systematically
evaluated for the catalytic conversion of 4-propylguaiacol in aqueous
phase under hydrogen-free conditions. Among the catalysts studied
at 220 ° C for 2 h, Ni/Hβ delivered a conversion of 36.1%
and a phenolic selectivity of 89.6%. By comparison, NiZn/Hβ
exhibited the highest catalytic activity, achieving a conversion of
82.9% with a selectivity of 96.5%, indicating the promotional effect
of Zn incorporation. NiFe/Hβ showed a moderate conversion of
45.5% but maintained a high phenolic selectivity of 97.6%. However,
NiCu/Hβ showed almost no catalytic activity, with a conversion
of only 2.0%. Structural characterization by XRD, XPS, N 2 physisorption, H 2 -TPR, SEM, and TEM revealed that the
introduction of Zn significantly improved the dispersion of Ni species
and reduced Ni crystallite size, thereby increasing the number of
accessible active sites. In contrast, Fe incorporation altered the
catalyst structure and reduced catalytic activity, while Cu addition
induced metal aggregation and markedly suppressed catalytic performance.
The results indicate that appropriate second-metal modification can
effectively regulate the metal dispersion, microstructure, and metal–support
interactions in Ni/Hβ catalysts, thereby influencing the hydrogen
activation ability and the cleavage of Ar–CO 3 bonds.
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Energy Materials
·
2026
·Vol. 6
·期 3
·N
·
IF 11.9
Jie Zhang\u003Csup\u003E1,\u003C\u002Fsup\u003E,Xiao-Lei Shi\u003Csup\u003E2,\u003C\u002Fsup\u003E,Li Zhang\u003Csup\u003E1,*\u003C\u002Fsup\u003E,Meng Li\u003Csup\u003E2\u003C\u002Fsup\u003E,Wenyi Chen\u003Csup\u003E2\u003C\u002Fsup\u003E,Jianfeng Zhu\u003Csup\u003E1\u003C\u002Fsup\u003E,Yanling Yang\u003Csup\u003E1,*\u003C\u002Fsup\u003E,Zhi-Gang Chen\u003Csup\u003E2,*\u003C\u002Fsup\u003E
p-Type Mg3Sb2 possesses strong thermoelectric potential, yet effective strategies to further enhance its performance remain underexplored. In this study, we investigated the p-type Zintl-phase compound Mg3Sb2 and proposed a Zn/Cu co-doping strategy to synergistically optimize carrier transport and lattice thermal conductivity. Mg3.1-xZnxSb2 (x = 0, 0.4, 0.6, and 0.8) and Mg2.3-yZn0.8CuySb2 (y = 0, 0.075, 0.100, and 0.125) series samples were prepared via high-energy ball milling followed by hot pressing. First-principles calculations reveal that substituting Mg sites with Zn and Cu induces pronounced band-structure modulation, shifting the Fermi level into the valence band and narrowing the bandgap. These effects collectively increase hole concentration and enhance electrical conductivity. Meanwhile, the mass fluctuation and local lattice distortion introduced by co-doping intensify phonon scattering, resulting in a substantial reduction in lattice thermal conductivity. Experimentally, Zn/Cu co-doping delivers a well-balanced optimization of thermoelectric transport properties. The Mg2.2Zn0.8Cu0.1Sb2 sample achieves a power factor of 351.99 μW cm-1 K-2 and a peak figure of merit (ZT) of 0.42 at 735 K, corresponding to a 147% improvement compared with the undoped sample. This work elucidates the synergistic effects of Zn/Cu co-doping in electronic band engineering and phonon modulation, offering a promising strategy for the rational design of high-performance p-type Mg3Sb2 and other Zintl-phase thermoelectric materials.
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Molecular Catalysis
·
2026
·
IF 4.3
Xiaofei Ma,Shijiao Hao,Hui Jiang,Weiqian Qi,Hefang Wang
Cu-Al mixed oxide catalysts (CxA-LDO), prepared via calcination of layered double hydroxides (LDHs) precursors, were investigated for the transesterification of propylene carbonate (PC) with methanol to dimethyl carbonate (DMC). Characterization demonstrated that calcination temperature and the Cu/Al molar ratio critically influence the surface basicity properties and structural stability. Under optimized conditions (80 °C, 2 h, 2.0 wt% loading, MeOH/PC = 10:1), the C 0.5 A-400-LDO catalyst achieved 57.93% PC conversion and 57.29% DMC yield (TON = 28.94). Surface basicity was identified as the key governing factor for the reaction. This conclusion is supported by a strong correlation observed between the reaction rate and the number of total basic sites. However, the catalyst deactivated significantly over six cycles (PC conversion dropped from 57.93% to 47.2%), which ICP-AES analysis unambiguously attributed to significant copper leaching (8.1 wt.% net loss) rather than sintering. Kinetic analysis revealed a complex reaction mechanism that could be simplified to pseudo-first-order reaction behavior. The activation energies were determined to be Ea( k + ) = 51.61 kJ·mol -1 for the forward reaction and Ea(k - ) = 55.34 kJ·mol -1 for the reverse reaction. Concurrently, a hybrid genetic algorithm-optimized backpropagation (GA-BP) neural network was developed. Compared to conventional BP, the GA-BP model demonstrated superior predictive accuracy (R 2 = 0.997 for training set and 0.977 for testing set) and exhibited significantly reduced error metrics. This study not only contributes to the fundamental understanding of base-catalyzed transesterification but also introduces a synergistic experimental-computational strategy applicable to rational catalyst design.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Siyi Liu,Mingqin Kang,Zhongping Dong,Shuyan Xiao
Single-atom nanozymes exhibit high catalytic efficiency, which is strongly determined by the coordination environment of metal centers and the structure of the supporting carbon matrix. Herein, a series of sulfur-coordinated copper single-atom nanozymes with atomically dispersed Cu-N x sites was synthesized via pyrolysis of zeolitic imidazolate framework-8 precursors co-encapsulating sodium copper chlorophyllin (SCC) and L -cysteine. SCC provided Cu-N 4 motifs, stabilizing atomically dispersed Cu sites during pyrolysis. L -cysteine plays a multifaceted role by introducing Cu-S coordination, regulating carbon framework size, and generating defect-rich structures, collectively enhancing oxidase-like activity. The optimized nanozyme exhibited a Michaelis-Menten constant of 0.28 mM and a maximum reaction rate of 6.73 × 10⁻ 8 M·s⁻ 1 , indicating strong substrate affinity and rapid catalytic turnover. Using this nanozyme, a colorimetric sensor for D -penicillamine ( D -PA) was developed, achieving an ultra-wide detection range from 0.5 to 3000 μM through a segmented detection strategy, with a low detection limit of 0.279 μM and recoveries of 92.7–107.4% in river water samples. This work demonstrates a robust sulfur-coordination strategy for high-performance single-atom nanozymes and provides a practical platform for monitoring pharmaceutical pollutants over an ultra-wide concentration range.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Xunxun Li,Lei Jing,Shiwei Wang,Hexin Li,Yijia Li,Yaru Wang,Shouying Huang,Hongbo Yu,Jing Lv,Xinbin Ma
Copper-based catalysts suffer from sintering and excessive oxidation during the methanol oxidation carbonylation process to produce dimethyl carbonate (DMC), which leads to their easy deactivation and thus are restricted in industrial applications. In this work, we designed and fabricated a series of nitrogen-doped carbon-supported copper-cobalt nanoparticles (CuxCo-NC). A distinctive volcano-type dependence of catalytic activity on the Cu/Co molar ratio was revealed, and a remarkable DMC space-time yield (STY) of 5.35 g g-1 cat·h-1 was delivered by the optimal composition (Cu/Co = 3). There was a strong metal-support interaction between the Cu-Co nanoparticles and the N-doped carbon matrix, promoting the dispersion of the metal. This study has demonstrated the role of ZIF-derived nitrogen-doped carbon materials in the liquid-phase oxidation and carbonylation of methanol, providing a foundation for subsequent research.
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