Materials
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2025
·Vol. 18
·期 11
·2477
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IF 3.2
Wenjie Wang,Xuan Zhang,Xianchao Wang,Chengwei Gao,Jinling Yin,Qing Wen,Guiling Wang
Natural graphite (NG) is abundant and has a high capacity for lithium-ion storage, but its narrow interlayer spacing and poor cyclic stability limit its use in high-performance lithium-ion batteries (LIBs). To address this, a N/S co-doped micro-expanded graphite composite (BFAC@MEG) was prepared by coating micro-expanded graphite (MEG) with N/S-containing amorphous carbon derived from biochemical fulvic acid (BFAC). This enhanced the electrochemical kinetics of lithium ions, improving charge transfer rates and reducing diffusion resistance. GITT results showed a higher Li+diffusion coefficient than MEG and spherical graphite (SG). BFAC@MEG exhibited excellent rate performance, robust storage capacity and remarkable cycling stability. It had a specific capacity of 333 mAh g−1at 1 C, 205 mAh g−1at 3 C, and retained 81.57% capacity after 500 cycles. Even at 5 C, BFAC@MEG exhibits a high reversible capacity of 98 mAh g−1after 200 cycles. After cycling, SEM and XPS analyses revealed a low expansion rate of 15.96% cross-sectional expansion after 300 cycles at 3 C and a stable solid electrolyte interphase (SEI) film rich in LiF and Li2CO3.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Shuhong Liu,Jiankang Wang,Zhongping Yao,Qixing Xia,Hongbo Xu,Wanqian Guo,Xiaohong Wu
The catalyst employed for activating molecular oxygen to degrade organic pollutants in water environments encounters great challenges, such as facile agglomeration, leaching of metal ions, and a sluggish redox cycle. These factors lead to low catalytic activity and inadequate stability, thereby severely restricting its viability for industrial use. A high-entropy alloy (HEA) catalyst, FeCoNiCuZn@CN, was synthesized via a hydrothermal-pyrolysis method and employed to facilitate the degradation of norfloxacin (NOR) by activating molecular oxygen. The FeCoNiCuZn@CN is a face-centered cubic (FCC) structured FeCoNiCuZn HEA embedded within a nitrogen-doped carbon framework, as proved by XRD, Raman, SEM, XPS, and TEM. The optimized FeCoNiCuZn@CN6–800 demonstrates efficient degradation of NOR, achieving a removal rate exceeding 95 % within 40 min across a broad pH range of 3–11. The catalyst exhibits a maximum mineralization rate of 72.4 %, surpassing recently reported catalysts. Moreover, it exhibits universal degradation properties toward diverse antibiotics and demonstrates strong interference-resistance against prevalent inorganic ions, making it well-suited for treating intricate water matrices. Even after five cycles, the removal efficiency remains at 78.4 %, thanks to the exceptional stability of the HEA and the encapsulation of the carbon skeleton. The intrinsic nature of the synergistic effect caused by the formed HEA and carbon-metal (C-M) bonds between HEA and CN was revealed, which was responsible for the prominent molecular oxygen activation capacity. The reaction mechanism was proposed through reactive oxygen species (ROS) scavenging experiment, electron paramagnetic resonance (EPR), molecular probing experiment, and density functional theory (DFT) calculations. Finally, three degradation pathways were proposed by analyzing degradation intermediates, and the toxicity of intermediate products was predicted by T.E.S.T toxicity estimation software. This study opens new perspectives for the design and preparation of high-entropy-based catalysts that have an excellent ability to activate molecular oxygen in the field of wastewater treatment.
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Microorganisms
·
2025
·Vol. 13
·期 8
·1865
·
IF 4.2
Chenchen Zhao,Yan Qin,Haixin Huang,Yuying Li,Xinyu Zhang,Lin Zhou,Lulu Xie,Yimin Zhou,Yanqing Hu,Wei Chen,Tian Lan,Wen-Chao Sun
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a recently discovered enteric coronavirus that has caused considerable economic losses in the pig industry. SADS-CoV was first reported in 2017 in Guangdong Province, China, and subsequently in Fujian, Guangxi, Henan and Jiangxi Provinces. Bone marrow stromal cell antigen 2 (BST-2), also known as tetherin, acts as an antiviral protein to limit the release of a wide range of enveloped viruses. However, the relationship between BST-2 and SADS-CoV has rarely been studied. Here, we showed that endogenous BST-2 expression is downregulated by SADS-CoV infection in Vero-E6 and ST cells by 2- to 3-fold. The overexpression of BST-2 inhibited SADS-CoV replication, whereas the knockdown of the BST-2 gene in Vero cells restored SADS-CoV replication. Further study revealed that BST-2 targets the SADS-CoV nucleocapsid protein (N) and decreases N protein expression, and that the BST-2 transmembrane (TM) domain is essential for this activity. Moreover, the degradation of the SADS-CoV N protein promoted by BST-2 is mediated by the membrane-associated ring-CH-type finger 8 (MARCHF8)/calcium binding and coiled-coil domain 2 (NDP52) autophagosome pathway. Overall, we found that BST-2 suppresses viral proliferation by inducing the breakdown of the SADS-CoV N protein via the MARCHF8/NDP52 pathway.
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INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Wenhan Dai,Yahan Fang,Junfeng Huang,Zhongwei Wang,Jian Li,Mudong Tu,Huijiao Wang,Jun Yang,Cailing Xu,Hua Li
To tackle the pressing issue of nitrate (NO3–) pollution in wastewater and simultaneously convert it into ammonia (NH3), Cu nanocluster-modified Rhodium (Rh) single atoms anchored on N-doped carbon were synthesized via pyrolysis of a zeolitic imidazolate framework-8 (ZIF-8) precursor and applied to the electrochemical reduction of nitrate at a low concentration. Structural characterizations (X-ray powder diffractometer (XRD), high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM), and X-ray photoelectron spectroscopy (XPS)) confirmed the coexistence of Rh single atoms and Cu nanoclusters as well as their strong electronic interactions. Mechanistic investigations revealed that Rh sites enhanced *H generation via water dissociation and promoted NO3– adsorption, thereby facilitating *H transfer and subsequent hydrogenation steps. As a result, the optimized Cu97.5Rh2.5/NC catalyst exhibited outstanding NO3–RR performance, with a Faradaic efficiency (FE) of 84.53%, an NH3 yield rate of 1252.22 μg·h–1 mgcat–1 at −1.0 V vs reversible hydrogen electrode (RHE), an NH3 selectivity of 89.13% at −1.0 V vs RHE, and a NO3– conversion rate of 93.34% at −1.1 V vs RHE. This work presents a rational design for atom-economical catalysts, enabling sustainable NH3 electrosynthesis from nitrate-laden wastewater and reducing effluent NO3––N to meet World Health Organization (WHO) drinking water standards.
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Future Medicinal Chemistry
·
2025
·
IF 3.4
Yan Li,Yajing Xing,Dongxia Huang,Jiuqing Xie,Yangrui Peng,Zhengfang Yi,Yihua Chen
Aim To develop potent B cell lymphoma 6 (BCL6) inhibitors, novel N-phenyl-4-pyrimidine-diamine analogs were designed and synthesized via structure-based and computer-aided drug design.Methods Starting from the hit compound ZB979, we synthesized three series of pyrimidinediamine BCL6 inhibitors (13a-13e, 14a-14c and 15a-15g) and evaluated their inhibitory activities on BCL6-SMRT interaction using homogeneous time-resolved fluorescence (HTRF) assays. The most promising candidate, compound 15d, was further assessed for its anti-proliferative activity and modulation of BCL6 downstream target genes, suppression of germinal center (GC) formation.Results Compound 15d demonstrated significant BCL6-SMRT inhibition with favorable physicochemical properties (Calculated LogP (ClogP) and topological polar surface area (tPSA)).Conclusion These findings highlight the potential of pyrimidinediamine-based scaffolds as novel BCL6 inhibitors, warranting further structural optimization to improve their efficacy.
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NEW JOURNAL OF CHEMISTRY
·
2025
·Vol. 49
·期 39
·17023-17029
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IF 2.5
Shiling Yang,Xuesong Gao,Yang Yu,Zheng Zeng,Jiashang Chen,Wensong Du,Ruiyue Liu,Siqi Li,Bowen Chen,Chonggang Wu
Sulphonated poly(ether ether ketone) (SPEEK) exhibits excellent mechanical properties as a proton exchange membrane. However, its proton conductivity remains insufficient for practical applications. To address this limitation, a covalent incorporation of proton-conductive functional groups into the SPEEK matrix is proposed to establish continuous proton transport channels. Herein, through an iodination reaction of N-iodosuccinimide with SPEEK, we have successfully synthesised iodinated sulphonated poly(ether ether ketone) (I-SPEEK) with an iodination efficiency of 71.0% as confirmed by ion chromatography. This work proposes tentative reactivity positions and mechanistic hypotheses for the sulphonation of poly(ether ether ketone) and the subsequent iodination of SPEEK. Effective introduction of iodine is confirmed by Fourier-transform infrared (FTIR) and nuclear magnetic resonance (NMR) spectroscopies. Meanwhile, I-SPEEK serves as a precursor that provides grafting sites for hydrophilic groups (e.g. vinyl-silanes via the Heck reaction), offering a novel strategy for subsequent studies to introduce proton-conductive moieties.
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JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
·
2026
·Vol. 82
·期 1
·108
·
IF 5.1
Xu Hongwei,Liu Chunlin,Wang Dajun,Zhang Lu,Peng Yanan,Wang Liang
Pancreatic acinar cell pyroptosis played a key role in acute pancreatitis (AP), while the underlying molecular mechanisms were unclear. In this study, hyperlipidemic acute pancreatitis (HLAP) model mice and primary acinar cells were employed for the in vivo and in vitro experiments, respectively. Western blot was employed to assess Gasdermin D-N-terminal pore-forming domain (GSDMD-N) oligomerization; Flow cytometry was employed to assess cell pyroptosis; Immunofluorescence was performed to assess GSDMD-N location in the cytoplasm; HE and TUNEL staining were employed to assess the pathological changes and cell apoptosis of pancreatic tissues. Palmitic acid levels were elevated in serum and pancreatic tissues of HLAP mice, palmitoyltransferase Zinc Finger DHHC Domain-Containing Protein 13 (ZDHHC13) and ZDHHC15 expression levels were markedly increased in primary acinar cells of HLAP mice. Acinar cells of HLAP mice exhibited the increased pyroptosis, which was evidenced by the increased cleaved-caspase-1 and GSDMD-N protein levels, Interleukin (IL)-1β, IL-18, and lactate dehydrogenase (LDH) release, GSDMD-N oligomerization, and caspase-1 + PI + cells. Mechanistically, palmitic acid induced GSDMD palmitoylation. ZDHHC15 interacted with GSDMD, and ZDHHC15 knockdown reduced GSDMD-N oligomerization and thereby suppressed pyroptosis in palmitic acid-treated acinar cells. The in vivo experiments further revealed that AAV-sh-ZDHHC15 reduced cell apoptosis and GSDMD-N oligomerization in pancreatic tissues of HLAP mice. In conclusion, this study identified a potential regulatory pathway of HLAP involving ZDHHC15-dependent modulation of GSDMD palmitoylation and subsequent GSDMD-N oligomerization.
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ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Lihong Su,Tingjun Chen,Tianxiang Xue,Anzhi Sheng,Liangfen Cheng,Juan Zhang
In this work, the boronic acid–aptamer conjugate (BAAC) is elaborately designed and explored as a recognition unit. The admirable properties of the pH-dependent boronic acid ester are integrated with the specific capturing capability of the modified aptamer; thus, BAAC can efficiently and selectively bind with the target by adjusting the pH values. An electrochemical biosensor based on pH-adjusted BAAC has been further developed for the analysis of CNeu5Gc, an important biomarker of different kinds of cancer. The boronic acid moiety in BAAC can react with CNeu5Gc to form a BAAC–CNeu5Gc complex under acidic conditions, followed by the release of CNeu5Gc from the complex and subsequent capture by the aptamer moiety with the adjustment of the pH value to alkalinity. With simplicity, high specificity, and efficiency, the biosensor exhibits a wide linear range from 2.816 to 3603.960 ng/mL with a low detection limit of 1.224 ng/mL and can be applied to analyze CNeu5Gc in animal food samples. Besides, this work can also provide a kind of modified aptamer, i.e., the chemical capturing group-modified aptamer, to give a new viewpoint for the exploration of other functionalized aptamers.
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Journal of Materials Chemistry A
·
2020
·Vol. 8
·期 33
·17257-17265
·
IF 11.301
Yi Yang,Yu-xin Liu,Yan Li,Bo-wen Deng,Bo Yin,Ming-bo Yang
Nowadays, carbon nanomaterials are considered as the most important supercapacitor electrode materials. But it's still a great challenge to design rational structures of carbon materials at both nano and micro scales to endow carbon electrode materials with outstanding electrochemical performance. Herein, a well-designed compressible and elastic N-doped porous carbon nanofiber aerogel (N-PCNFA) with hierarchical cellular structures in both the PAN/ZIF-8-based carbon nanofibers and the 3D carbon monolith was prepared by a simple method. A large specific surface area was obtained for the construction of abundant pore structures and a robust architecture was built by the introduction of mechanically reinforced structures, which would endow the N-PCNFA electrode material with a vast surface area for ion adsorption/desorption, plenty of short channels for electrolyte diffusion and stable frameworks during the charge/discharge process. N heteroatoms were also incorporated into the carbon material as active sites for faradaic redox reactions. Thus, the N-PCNFA electrodes exhibited superior electrochemical performance, with a high specific capacitance of 279 F g−1 at 0.5 A g−1, consisting of pseudocapacitance (∼46%) and electrochemical double-layer capacitance (∼54%), remarkable rate performance of 59% at 20 A g−1 and excellent long-term durability. Moreover, the simple and general strategy for construction of compressible and elastic porous carbon nanofiber aerogels with delicate microstructures is also applicable to other advanced functional materials for a wide range of applications.
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JOURNAL OF MOLECULAR LIQUIDS
·
2021
·
IF 6.165
Yannan Du,Hongjun Zang,Yimo Feng,Kai Wang,Yaxin Lv,Zhipeng Liu
This paper briefs the emerging strategies for the designing of catalytic systems, which direct conversion of chitin biomass monomer N -acetyl- d -glucosamine (NAG) to 3-acetylamino-5-acetylfuran was studied systemically. Twelve catalysts were investigated, and pyrazine hydrochloride ([Pyz]Cl) ionic liquid exhibited the good performance-achieving 3A5AF with yields of 36.94% from NAG . Further adding boric acid and CaCl 2 , treating at 190 °C for 60 min, the conversion rate of NAG is 100%, and the yield of 3A5AF can be increased to 69.54% in DMA. Furthermore, functional group changes before and after the reaction have been characterized by FTIR, HPLC-MS and 13 C NMR were applied to monitor the reaction process with [Pyz]Cl as the catalyst. The reactive intermediate was clearly detected by these techniques. Accordingly, a possible reaction pathway was proposed. The results of this experiment provide a mild and efficient reaction route for the degradation of biomass, and enrich the theoretical research of quaternary amine catalysts in the conversion of biomass waste into high value-added chemicals.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Jinlong Hu,Qingqing Chen,Qi Xia,Lingzhi Zhang
Heteroatom-doped hollow carbon nanostructures are one of the most promising sulfur hosts for high-performance lithium-sulfur (Li-S) batteries. However, finding a facile and controllable synthesis and enhancing their immobilization effect on polysulfides have been challenging. Herein, we propose a one-step in-situ reaction approach to synthesize N/F dual-doped hollow micro/mesoporous carbon nanospheres (NFHCs) as multifunctional sulfur host, which integrates the physical confinement of hollow porous structure and chemical adsorption/catalytic ability of N/F active sites to realize strong anchoring and accelerated conversion of polysulfides. This sulfur cathode based on NFHCs host with a high sulfur content of 80 wt% enables a superior high-rate capacity of 689 mAh g −1 at 3C, accompanied by outstanding cycle life over 500 cycles at 2C with a capacity decay of only 0.05% per cycle and nearly 100% Coulombic efficiency. This work opens up new horizons to design nanostructured functional hollow carbons for advanced Li-S batteries.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Qingqing Jiang,Lin Wang,Yan Wang,Meihua Qin,Rui Wu,Zhengxi Huang,Hai-Jian Yang,Yongxiu Li,Tengfei Zhou,Juncheng Hu
For potassium-ion battery (PIB), it remains a huge challenge to develop an appropriate anode material to compensate the large radius of K + . MoSe 2 shows great potential for efficient K + insertion/extraction due to its unique lamellar structures with an interlayer spacing of 6.46 Å. However, pure MoSe 2 has low electronic conductivity and agglomerates during long-term cycling. In the present work, MoSe 2 nanosheets were fabricated on the N -doped porous carbon polyhedron (NPCP). The obtained product was designated as NPCP@MoSe 2 and functioned as anode materials for PIBs. NPCP@MoSe 2 displayed a promising reversible capacity (325 mAh/g at 100 mA/g after 80 cycles), long-term cycling performance (128 mAh/g at 500 mA/g after 800 cycles), and superior rate property at 5000 mA/g. The enhanced electrochemical performance of NPCP@MoSe 2 could be attributed to the rational design of hybrid structures. Notably, the hollow NPCP provide a large contact area for the interactions among the electrolytes and electro-active materials as well as partly buffer the volume expansion. The synergistic effects between MoSe 2 and NPCP could mitigate the agglomeration of MoSe 2 nanosheets. Besides, the uniformly doping N elements enhanced the conductivity of the carbon matrix, and the N -group also provided potential binding active sites for K-ion accommodation. This work paves the ideas for the design of novel anode materials with high specific capacity, good cycling stability and outstanding rate capability for PIBs.
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