ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2022
·Vol. 30
·期 6
·16156-16165
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IF 5.19
Hou Guangying,Huang Zaihui,Ding Xiaohu,Liu Chunguang
4,4′-Sulfonyl-diphenol (BPS), as a widespread environmental hormone-like micropollutant, is difficult to be degraded in the environment. In this study, the removal of BPS with multi-enzymes extracted from waste sludge and reed sediment was studied at 298 K, 310 K, and 328 K. Results show that BPS could be removed efficiently and was time–temperature dependent, which could involve enzymolysis and bio-flocculation. The mechanism and pathways of the enzymolysis were identified with ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Polymerization of BPS with enzymolysis further improved the removal by bio-flocculation due to the production of BPS oligomers. Furthermore, the interaction mechanism between BPS and multi-enzyme was explored through a series of spectroscopic experiments. Results show that more loose skeletal structure of the multi-enzymes and more hydrophobic microenvironment of the amino acid residues are responsible for the removal of BPS. This research not only provided a method for refractory micropollutants removal but also a way for the utilization of waste sludge and reed sediment.
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JOURNAL OF MATERIALS SCIENCE
·
2022
·Vol. 57
·期 37
·17563-17576
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IF 4.682
He Junjie,He Guo,Wang Panpan,Xu Lurun,Liu Jing,Tao Jingchao
In this work, new high-entropy RE 2 (Ce 0.2 Zr 0.2 Hf 0.2 Sn 0.2 Ti 0.2 ) 2 O 7 (RE 2 HE 2 O 7 , RE = La, Nd, Sm, Eu, Gd, Dy) ceramics were successfully prepared. RE 2 HE 2 O 7 ceramics exhibited a pyrochlore–fluorite dual-phase structure. For Sm 2 HE 2 O 7 ceramic, Ce 4+ with larger ionic radius was enriched in the fluorite phase, Sn 4+ and Ti 4+ with smaller ionic radii were enriched in the pyrochlore phase, while Zr 4+ and Hf 4+ with medium ionic radii existed in both phases. Compared with YSZ materials, RE 2 HE 2 O 7 ceramics exhibited a much lower glass-like thermal conductivity (1.19–1.68 W m −1 K −1 , 100–900 °C) and comparable thermal expansion coefficients (8.67–10.85 × 10 −6 K −1 , 1200 °C). Furthermore, due to grain refinement caused by the competition of two phases, the Vickers hardness (10.29–13.85 GPa) of RE 2 HE 2 O 7 ceramics is improved. The results indicate that dual-phase high-entropy RE 2 HE 2 O 7 ceramics are promising candidate materials for the next generation of thermal barrier coatings.
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JOURNAL OF NANOBIOTECHNOLOGY
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2022
·Vol. 20
·期 1
·1-17
·
IF 9.429
Xu Lihua,Zhang Kaixiang,Ma Xing,Li Yingying,Jin Yajie,Liang Chenglin,Wang Yong,Duan Wendi,Zhang Hongling,Zhang Zhenzhong,Shi Jinjin,Liu Junjie,Wang Yunlong,Li Wentao
Despite many nano-based strategies devoted to delivering cisplatin for tumor therapy, its clinical benefits are compromised by poor tissue penetration and limited DNA adducts formation of the drug. Herein, a cisplatin loading nanomotor based janus structured Ag-polymer is developed for cisplatin delivery of deeper tissue and increased DNA adducts formation. The nanomotor displayed a self‐propelled tumor penetration fueled by hydrogen peroxide (H2O2) in tumor tissues, which is catalytically decomposed into a large amount of oxygen bubbles by Ag nanoparticles (NPs). Notably, cisplatin could elevate the intracellular H2O2 level through cascade reactions, further promote the degradation of Ag NPs accompanied with the Ag+ release, which could downregulate intracellular Cl− through the formation of AgCl precipitate, thereby enhancing cisplatin dechlorination and Pt–DNA formation. Moreover, polymer can also inhibit the activity of ALKBH2 (a Fe2+-dependent DNA repair enzyme) by chelating intracellular Fe2+ to increase the proportion of irreparable Pt–DNA cross-links. It is found that deep tissue penetration, as well as the increased formation and maintenance of Pt–DNA adducts induced by the nanomotor afford 80% of tumor growth inhibition with negligible toxicity. This work provides an important perspective of resolving chemotherapeutic barriers for boosting cisplatin therapy.Graphical Abstract
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-10
·
IF 17.694
Chen Jiadong,Chen Chunhong,Qin Minkai,Li Ben,Lin Binbin,Mao Qing,Yang Hongbin,Liu Bin,Wang Yong
Noble metal electrocatalysts (e.g., Pt, Ru, etc.) suffer from sluggish kinetics of water dissociation for the electrochemical reduction of water to molecular hydrogen in alkaline and neutral pH environments. Herein, we found that an integration of Ru nanoparticles (NPs) on oxygen-deficient WO 3-x manifested a 24.0-fold increase in hydrogen evolution reaction (HER) activity compared with commercial Ru/C electrocatalyst in neutral electrolyte. Oxygen-deficient WO 3-x is shown to possess large capacity for storing protons, which could be transferred to the Ru NPs under cathodic potential. This significantly increases the hydrogen coverage on the surface of Ru NPs in HER and thus changes the rate-determining step of HER on Ru from water dissociation to hydrogen recombination.
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JOURNAL OF POLYMER RESEARCH
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2022
·Vol. 29
·期 10
·1-8
·
IF 3.061
Yang Zhaokun,Yu Zhangyong,Zhang Tao,Shi Dongjian,Qin Liyan,Liu Shirong,Chen Mingqing
Inverse opal of molecularly imprinted photonic hydrogels (MIPHs) represents an important colorimetric sensing platform, where the order and connectivity of inverse-opal structure is critical. However, MIPHs constructed by conventional approaches generally bear many cracks and merely presents order in short range. Herein, we report a facile approach to overcome these challenges by integrating evaporative co-deposition of colloids suspended within a hydrogel precursor and polymerization of monomers in single step. Co-deposition of colloids, imprinted molecules, and polymeric monomers as well as concurrent polymerization is firstly studied in detail. As-prepared inverse opal of MIPHs presents high order in long range and almost no crack. Different parameters affecting sensing performance were optimized in detail. MIPHs present high selectivity, sensitivity, and rapid response due to highly ordered inverse-opal structure and molecular recognition sites which are situated either at surface or in proximity to surface. Additionally, a mathematic relationship between Bragg diffraction wavelength shift of MIPHs and analyte concentration is proposed, enabling that MIPHs can not only be used in qualitative detection by visually perceptible color, but could quantitatively infer analyte concentration based on fitted equation. This work would provide an important inspiration for future construction of molecularly imprinted photonic hydrogels.
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FIRE TECHNOLOGY
·
2022
·Vol. 59
·期 3
·1181-1197
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IF 3.605
Cheng Siyuan,Hu Yuhang,Jiang Lihua,Dang Hongbin,Ding Yibin,Duan Qiangling,Xiao Huahua,Sun Jinhua,Wang Qingsong
Semi-solid lithium slurry battery is an important development direction of lithium battery. It combines the advantages of traditional lithium-ion battery with high energy density and the flexibility and expandability of liquid flow battery, and has unique application advantages in the field of energy storage. In this study, the thermal stability of semi-solid lithium slurry battery material system was investigated for the first time employing C80 micro-calorimeter. In this new electrode material system, the heat generation of the electrolyte is the decisive factor for its thermal stability. Then, the measurement of in-situ dynamic cycle heat generation of semi-solid lithium slurry battery indicated a lower heat generation than traditional lithium-ion battery. What’s more commendable is that its electrochemical performance is basically the same as traditional lithium-ion battery. In addition, through the HPPC test, the mechanism of semi-solid lithium slurry battery cycle heat generation was explained. So, in this work, a preliminary evaluation on the safety and cycling stability of semi-solid lithium slurry battery is carried out. The electrochemical performance test affirms the application prospects of semi-solid lithium slurry battery, and the evaluation on the fire safety provides a reference for the future industrial applications of semi-solid lithium slurry battery.
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POLYMER JOURNAL
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2022
·Vol. 55
·期 1
·13-25
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IF 3.135
Hongbo Tang,Manxin Wang,Yanping Li,Xiaojun Liu
Octenyl succinate hydroxypropyl acidolysis tamarind gum (OSA-HATG) with a high substitution degree of ester groups was first synthesized using hydroxypropyl acidolysis tamarind gum (HATG) as a raw material, 1-butyl-3-methylimidazolium chloride (ionic liquid) as a solvent, octenyl succinic anhydride (OSA) as an acylating agent, and 4-dimethylamino pyridine (DMAP) as a catalyst. The results showed that OSA-HATG, as a new emulsifier, has good emulsification capacity and stability. The emulsifying capacity of OSA-HATG increased with increasing substitution degree. Acidolysis (acid hydrolysis) and hydroxypropylation were mainly conducted on the large particles of TG. The stretching vibration peaks of the C=O bonds at 1735 cm −1 and C=C bonds at 1654 cm −1 indicated that the acylation of HATG by OSA was successfully accomplished. TG was almost amorphous. The acylation resulted in a reduction in the thermal stability of OSA-HATG but obviously increased the contact angle of OSA-HATG (102.7°). The addition of TG and its derivatives did not improve the setback of potato starch. The acidolysis and hydroxypropylation could swell the TG particles.
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BRITISH JOURNAL OF CANCER
·
2022
·Vol. 128
·期 2
·219-231
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IF 9.075
Yang Bingxue,Xie Xinran,Lv Dazhao,Hu Jiajun,Chen Yuyun,Wu Zhaoyu,Luo Shuyue,Zhang Shiyi
Background Hand-foot syndrome (HFS) is a serious dose-limiting cutaneous toxicity of capecitabine-containing chemotherapy, leading to a deteriorated quality of life and negative impacts on chemotherapy treatment. The symptoms of HFS have been widely reported, but the precise molecular and cellular mechanisms remain unknown. The metabolic enzyme of capecitabine, thymidine phosphorylase (TP) may be related to HFS. Here, we investigated whether TP contributes to the HFS and the molecular basis of cellular toxicity of capecitabine. Methods TP-/- mice were generated to assess the relevance of TP and HFS. Cellular toxicity and signalling mechanisms were assessed by in vitro and in vivo experiments. Results TP-/- significantly reduced capecitabine-induced HFS, indicating that the activity of TP plays a critical role in the development of HFS. Further investigations into the cellular mechanisms revealed that the cytotoxicity of the active metabolite of capecitabine, 5-DFUR, was attributed to the cleavage of GSDME-mediated pyroptosis. Finally, we demonstrated that capecitabine-induced HFS could be reversed by local application of the TP inhibitor tipiracil. Conclusion Our findings reveal that the presence of elevated TP expression in the palm and sole aggravates local cell cytotoxicity, further explaining the molecular basis underlying 5-DFUR-induced cellular toxicity and providing a promising approach to the therapeutic management of HFS.
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PHARMACEUTICAL RESEARCH
·
2022
·Vol. 40
·期 2
·567-577
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IF 4.58
Chen An,Cai Peishan,Luo Minqian,Guo Minshan,Cai Ting
Purpose The fixed-dose combination drug products have been increasingly used to treat some complex diseases. A cocrystal containing two therapeutic components, named as a drug-drug cocrystal, is an ideal solid form to formulate as a fixed-dose combination product. The aim of the study is to prepare celecoxib-carbamazepine (CEL-CBZ) cocrystals by melt crystallization to achieve the synchronized release of drugs. Method The crystal structure of the CEL-CBZ cocrystal was determined from the cocrystals harvested from melt by single crystal X-ray diffraction. The binary phase diagram and crystal growth kinetics of the CEL-CBZ cocrystal from melt were studied to optimize the process parameters of hot-melt extrusion for manufacturing large-scale cocrystals. The intrinsic dissolution rate studies were conducted to compare the dissolution profiles of drugs in the cocrystal and their individual forms. Result The CEL-CBZ cocrystal crystallized in the triclinic space group with one CEL and one CBZ molecule in the asymmetric unit. The crystallization of CEL-CBZ cocrystals were observed both in the supercooled liquid and glassy state. The formation of drug-drug cocrystals significantly alter the intrinsic dissolution rates of the parent drugs to favor the synchronized release. Conclusion Melt crystallization is an alternative, efficient and eco-friendly approach for preparing drug-drug cocrystals on a large scale. The synchronized drug release by drug-drug cocrystals can be used to modulate the release profiles of parent drugs in the fixed-dose combination products.
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Nature Communications
·
2022
·Vol. 13
·期 1
·1-22
·
IF 17.694
Zhou Tian,Li Yuxin,Li Xiaoyu,Zeng Fanzhuo,Rao Yanxia,He Yang,Wang Yafei,Liu Meizhen,Li Dali,Xu Zhen,Zhou Xin,Du Siling,Niu Fugui,Peng Jiyun,Mei Xifan,Ji Sheng-Jian,Shu Yousheng,Lu Wei,Guo Feifan,Wu Tianzhun,Yuan Ti-Fei,Mao Ying,Peng Bo
Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout the lifespan. If microglial debris is not removed in a timely manner, accumulated debris may influence CNS function. Clearance of microglial debris is crucial for CNS homeostasis. However, underlying mechanisms remain obscure. We here investigate how dead microglia are removed. We find that although microglia can phagocytose microglial debris in vitro, the territory-dependent competition hinders the microglia-to-microglial debris engulfment in vivo. In contrast, microglial debris is mainly phagocytosed by astrocytes in the brain, facilitated by C4b opsonization. The engulfed microglial fragments are then degraded in astrocytes via RUBICON-dependent LC3-associated phagocytosis (LAP), a form of noncanonical autophagy. Interference with C4b-mediated engulfment and subsequent LAP disrupt the removal and degradation of microglial debris, respectively. Together, we elucidate the cellular and molecular mechanisms of microglial debris removal in mice, extending the knowledge on the maintenance of CNS homeostasis.
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Journal of Inorganic and Organometallic Polymers and Materials
·
2022
·Vol. 33
·期 2
·328-336
·
IF 3.518
Gao Feifei,Wu Feiyang,Zhang Xianyang,Jiang Bowen,Li Qizhong
In this paper, zirconium-based MOF (Zr-MOFs) materials, namely UIO-66, UIO-66-NH 2 , GMA-UIO-66 and NB-UIO-66, were selected as fillers to enhance the mechanical properties of polydicyclopentadiene (PDCPD) nanocomposites, and Zr-MOFs/PDCPD nanocomposites were prepared by in situ polymerization. The functional groups and morphology of Zr-MOFs were characterized by Fourier transform infrared (FT-IR), X-ray diffraction (XRD) and field emission scanning electron microscopy (SEM). The mechanical properties of Zr-MOFs/PDCPD composites were studied by tensile toughness, notched impact strength and bending strength test. Furthermore, the optimum Zr-MOFs loading was determined. The results show that when the mass fraction of NB-UIO-66 is 0.4%, the composites’ tensile toughness, flexural strength, impact strength and heat distortion temperature (HDT) are simultaneously increased by 47.3%, 37.5%, 119.4%, and 59.2% respectively, compared with the pure PDCPD, which synergistically enhances the mechanical properties. Graphical Abstract
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2022
·Vol. 39
·期 2
·290-295
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IF 2.726
Qin Chang,Dong Jing,Xie Beibei,Wang Hongkun,Zhang Na,Zhao Chunhua,Qiao Congde,Liu Mingxia,Yang Xiaodeng,Li Tianduo
Poly(lactic-co-glycolic acid)(PLGA) is one of the most representative degradable copolymers and promising drug carriers. In the current paper, the PLGAs with a lactic acid/glycolic acid(LA/GA) molar ratio of 52/48 and various molecular weights were prepared by a melting method. The molecular weight, molecular weight distribution, and thermal stability were determined by 1 H NMR and thermogravimetric analysis methods. The results demonstrated that PLGAs with the fixed LA/GA molar ratio(52/48), different molecular weights, and narrow molecular weight distribution could be obtained by solely altering the reaction time. The PLGA films were prepared, and their properties including micro-structure, mechanical property, in-vitro cytotoxicity, and biodegradability were characterized. In combination with the homogeneous microstructures and mechanical properties, the drug-loading and releasing properties of PLGA 3.2 films were investigated. The results show that PLGA 3.2 film with an LA/GA molar ratio of 52/48 is a promising curcumin carrier.
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