Journal of Materials Chemistry A
·
2016
·Vol. 4
·期 36
·13980-13988
·
IF 8.262
Zhibin Fang,Xueyan Huang,Yaozhu Wang,Wenhui Feng,Yan Zhang,Sunxian Weng,Xianzhi Fu,Ping Liu
Defective MoS2 nanosheets have been demonstrated to be a superior catalyst for hydrogen evolution; however, mediocre interfacial contact between the MoS2 cocatalyst and the light harvester still impedes the pursuit of composite photocatalyst systems with highly efficient performance. Herein, we propose a dual-defective assembly methodology following the chemical similarity principle to construct effectively-binding MoS2/In2S3 photocatalysts, in which luxuriant defects on layered In2S3 nanosheets serve as in situ growth sites for defective MoS2 layers with abundant exposed edges. The resulting dual-defective system is endowed with improved separation of electron–hole pairs, beneficial interfacial migration and utilization of electrons, and decreased photocorrosion from holes. By this method, the system achieves dramatically enhanced hydrogen evolution activity as well as considerable stability. The imperfections in both MoS2 and In2S3 are indispensable for desirable performance. The present strategy can not only direct the manufacture of defective MoS2-incorporated photocatalysts but may also contribute to the design of other highly active cocatalyst/light harvester systems with effective interfacial contacts.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2016
·
IF 3.994
Jinli Li,Xudong Cheng,Yan Chen,Weiming He,Li Ni,Peihua Xiong,Minggang Wei
Luteolin (LUT) is an active agent in cancer prevention and a potential candidate for clinical chemotherapy. However, poor water solubility and extensive excretion have limited the clinical use of luteolin. Herein, we attempted to develop vitamin E d-α-tocopherol acid polyethylene glycol 1000 succinate (TPGS) coated liposomes to improve the accumulation of luteolin in lung cancer. Luteolin or coumarin-6 loaded liposomes were prepared using film-dispersion methods and characterized according to their particle size, polydispersity, zeta potential , and drug encapsulation efficiency. Cellular uptake properties and cytotoxicities of luteolin or coumarin-6 loaded liposomes were determined in A549 cells. Optical in vivo imaging was employed as a method of assessing tumor targeting. The antitumor effect was evaluated in mice xenotransplanted with A549 cancer cells. The results showed that TPGS coated liposomes are spherical, and are ∼176.2 nm in size. TPGS coated liposomes enhanced cellular uptake and apoptosis by upregulating the Bax/Bcl-2 ratio, resulting in improved cytotoxicity in A549 cells. TPGS coated liposomes significantly accumulated in tumor tissue and enhanced tumor inhibition without altering the structures of other organs. Thereby, TPGS coated liposomes provide an effective strategy in cancer chemotherapy for model drugs with poor water solubility such as luteolin.
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RSC Advances
·
2016
·Vol. 6
·期 98
·95469-95475
·
IF 3.289
Lingli Bu,Jingdong Peng,Huanjun Peng,Shaopu Liu,Huan Xiao,Dan Liu,Ziyu Pan,Yu Chen,Fang Chen,Yan He
Chromium(VI) is proved to be highly carcinogenic and mutagenic, thus sensitive and rapid sensors for monitoring Cr(VI) are in urgent demand. In this work, a facile fluorescent assay for the sensitive and selective detection of Cr(VI) was proposed based on static quenching combined with inner filter effect (IFE) using phosphate functionalized carbon dots (PCDs) as nanoprobes. A good linear quenching was observed in the range of 1.0–400 μM with a detection limit of 0.24 μM (σ/S = 3) under the optimized conditions. The nanoprobe was employed for detecting Cr(VI) in real water samples including river water and tap water with satisfactory recovery. Moreover, with the addition of Cr(VI), the color changes of PCDs can be easily observed by the naked eye under a UV lamp. Based on this, Cr(VI) test papers were fabricated for spot quick detection of Cr(VI).
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2016
·
IF 2.711
Guocheng Huang,Weixi Cai,Baojun Xu
There is a lack of information on the various components in germinated soybeans. Therefore, this study aimed to further investigate the differences between three-day -germinated and raw (non-germinated) yellow and black soybeans. The results showed that germination increased the contents of beta-carotene and vitamin B 2 significantly. The free amino acids in raw soybeans were not detected but determined in germinated soybeans, which illustrated that the total free amino acids in germinated soybeans were higher than in raw soybeans. Meanwhile, GABA was 10-fold increased in germinated soybeans. The increase of aglycones of isoflavones was significantly high that reached to over 700% in both soybeans. The total saponin content in germinated yellow soybeans was increased two times whereas there was a slight decline in germinated black soybeans. The anthocyanin content was found to be declined in germinated black soybeans. The current study indicates that three-day- germinated soybeans yield higher nutritional values than raw soybeans, suggesting that the germinated soybeans are a good source of various nutrients and other biologically active compounds.
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ANALYST
·
2017
·Vol. 142
·期 9
·1452-1458
·
IF 3.885
Li Liu,Limin Zhang,Zhihui Dai,Yang Tian
Nitric oxide (NO) is key free-radical messenger and neuronal signal which is closely related to many brain diseases. It is a challenge to develop a sensitive and reliable biosensor for in vivo monitoring of NO in the brain. In this research, a simple ratiometric electrochemical biosensor for NO monitoring in rat brain following cerebral ischemia was developed using a carbon nanotube fiber (CNF) modified with hemin, in which the CNF not only served as a platform to assemble the hemin molecule, but greatly facilitated the electron transfer of hemin on to the electrode surface. Additionally, the hemin molecule was found to play dual roles: as a stable catalyst for the reduction of NO for selective detection of NO at −0.67 V versus silver/silver chloride, as well as an inner reference element to provide a built-in correction, to avoid the interference from the complicated brain environment. The developed ratiometric biosensor can detect NO with a linear range from 25 to 1000 nM, with a low limit of detection down to 10 nM, which fulfills the requirements for in vivo measurement of NO. The remarkable analytical performance of the present biosensor, as well as the long-term stability and good reproducibility established this as a reliable approach for in vivo monitoring of NO in the hippocampus of rat brains following cerebral ischemia. This is the first report that the average level of NO increased from 61 ± 23 nM to 141 ± 18 nM after cerebral ischemia for 15 min.
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RSC Advances
·
2017
·Vol. 7
·期 10
·6114-6122
·
IF 3.108
Bingzhi Liu,Huaili Zheng,Xiangrui Deng,Bincheng Xu,Yongjun Sun,Yongzhi Liu,Jianjun Liang
A template assembly method was introduced to obtain a cationic hydrophobic micro-block structure based amphiphilic electrolyte poly(acrylamide-co-2-methacryloxyethyltrimethyl ammonium chloride) P(AM-DMC) in this work, thereby increasing charge density and enhancing charge neutralization ability at the same charge density. The alteration of copolymerization or homo-polymerization was evaluated by the changes in reactivity ratios, so as to unravel the mechanism of template assembly. The micro-blocks generated by the new distribution of sequences were demonstrated by 1H nuclear magnetic resonance spectroscopy (1H NMR) and differential thermal-thermogravimetric analysis (DSC-TGA). Two negative controls were employed in sludge dewatering experiments to further evaluate the advanced properties of the template-assembled polymer. The results further verified that the positive effect of template assembly on flocculation performance of the polymer was achieved mainly through two ways: improving charge density and generating the micro-block structure. It can be concluded that the introduction of template assembly into polymerization can improve the performance of the polymer.
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ULTRASONICS SONOCHEMISTRY
·
2016
·
IF 4.556
Guanshu Li,Hongbo Zhang,Chunsheng Wei,Yingying Huang,Xuekai Dou,Yidi Wang,Jun Wang,Youtao Song
(5.0%)Er 3+ :Y 3 Al 5 O 12 /Pt-(TiO 2 -Ta 2 O 5 ) powder, as a high effective sonocatalyst, was prepared using sol-gel and calcination method. Then it was characterized by X-ray diffractometer (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive X-ray spectroscopy (EDX). In order to evaluate the sonocatalytic activity of the prepared (5.0%)Er 3+ :Y 3 Al 5 O 12 /Pt-(TiO 2 -Ta 2 O 5 ) powder, the sonocatalytic decomposition of ametryn was studied. In addition, some influencing factors such as different Ti/Ta molar ratios on the sonocatalytic activity of the prepared (5.0%)Er 3+ :Y 3 Al 5 O 12 /Pt-(TiO 2 -Ta 2 O 5 ) powder, catalyst added amount with ultrasonic irradiation time and used times on the sonocatalytic decomposition efficiency were examined by using ion chromatogram determination. The experimental results showed that the best sonocatalytic decomposition ratio of ametryn were 77.50% based on the N atom calculation and 95.00% based on the S atom calculation, respectively, when the conditions of 10.00 mg/L initial concentration, 1.00 g/L prepared (5.0%)Er 3+ :Y 3 Al 5 O 12 /Pt-(TiO 2 -Ta 2 O 5 ) powder (Ti/Ta = 1.00:0.25 heat-treated at 550 °C for 3.0 h) added amount, 150 min ultrasonic irradiation (40 kHz frequency and 300 W output power), 100 mL total volume and 25–28 °C temperature were adopted. Therefore, the (5.0%)Er 3+ :Y 3 Al 5 O 12 /Pt-(TiO 2 -Ta 2 O 5 ) composite nanoparticles could be considered as an effective sonocatalyst for decomposition of ametryn in aqueous solution.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6
Xuwen Chen,Zhengli Luo,Zongjing Hu,Donghui Sun,YingYing He,Jiani Lu,Lili Chen,Shunying Liu
Chemotherapy combining with surgical treatment has been the main strategy for osteosarcoma treatment in clinical. Due to unclear pathogenesis and unidentified drug targets, significant progress has not been made in the development of targeted drugs for osteosarcoma during the past 50 years. Our previous discovery reported compound R - 8i with a high potency for the treatment of osteosarcoma by phenotypic screening. However, both the metabolic stability and bioavailability of R - 8i are poor (T 1/2 = 5.36 min, mouse liver microsome; and bioavailability in vivo F = 52.1 %, intraperitoneal administration) which limits it use for further drug development. Here, we described an extensive structure−activity relationship study of thiazolidine-4-one sulfone inhibitors from R - 8i , which led to the discovery of compound 68 . Compound 68 had a potent cellular activity with an IC 50 value of 0.217 μM, much higher half-life (T 1/2 = 73.8 min, mouse liver microsome) and an excellent pharmacokinetic profile ( in vivo bioavailability F = 115 %, intraperitoneal administration). Compound 68 also showed good antitumor effects and low toxicity in a xenograft model (44.6 % inhibition osteosarcoma growth in BALB/c mice). These results suggest that compound 68 is a potential drug candidate for the treatment of osteosarcoma.
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JOURNAL OF FOOD SCIENCE
·
2024
·Vol. 89
·期 6
·3469-3483
·
IF 3.2
Yan Wang,Qiju Shao,Xijin Yang,Ke Su,Zhirong Li,Yuyao Yang,Xiaoyan Yuan,Rongxiang Chen
Pyracantha fortuneana ( P. fortuneana ) fruit is a wild fruit that is popular because of its delicious taste and numerous nutrients, and phenolic compounds are considered to be the main bioactive components in P. fortuneana fruits. However, the relationship between phenolic compounds and their antioxidant and tyrosinase (TYR) inhibitory activities during the ripening process is still unclear. The study compared the influence of the five developmental stages on the accumulation of phenolic compounds, antioxidant activity, and TYR inhibitory activity in the fruits of P. fortuneana . The compounds were identified by offline two-dimensional liquid chromatography-electrochemical detection (2D-LC-ECD) combined with liquid chromatography–tandem mass spectrometry, and the main active ingredients were quantified. The results showed that stage II had higher total phenolic and flavonoid content, as well as higher antioxidant and TYR inhibitory activity, but the total anthocyanin content was lowest at this stage. A total of 30 compounds were identified by 2D-LC-ECD. Orthogonal partial least squares discriminant analysis screened out six major potential markers, including phenolic acids, procyanidins, and flavonoids. In addition, it was found that caffeoylquinic acids, procyanidins, and flavonoids were higher in stage II than in stages I, III, IV, and V, whereas anthocyanins accumulated gradually from stages III to V. Therefore, this study suggests that the changes in antioxidant and TYR inhibitory activities of P. fortuneana during the five developmental stages may be due to the transformation of procyanidins, caffeoylquinic acids, and phenolic glycosides into other forms during the fruit maturation process. Practical Application : Differences in chemical constituents, antioxidant, and tyrosinase inhibitory activities in fruit maturity stages of P. fortuneana were elucidated to provide reference for rational harvesting and utilization of the fruits and their bioactive components. These findings are expected to provide a comprehensive assessment of the bioactive profile and guide the food industrial production.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-11
·
IF 3.8
Cai Xiao-Shi,Jiang Hao,Xiao Jie,Yan Xiangmin,Xie Penggui,Yu Wenjie,Lv Wen-fa,Wang Jun,Meng Xiangyu,Chen Cheng-zhen,Zhang Mingjun,Zhang Yang,Yuan Bao,Zhang Jia-Bao
It is important to study the bacteria that cause endometritis to identify effective therapeutic drugs for dairy cows. In this study, 20% oxytetracycline was used to treat Holstein cows (n = 6) with severe endometritis. Additional 10 Holstein cows (5 for healthy cows, 5 for cows with mild endometritis) were also selected. At the same time, changes in bacterial communities were monitored by high-throughput sequencing. The results show that Escherichia coli, Staphylococcus aureus and other common pathogenic bacteria could be detected by traditional methods in cows both with and without endometritis. However, 16S sequencing results show that changes in the abundance of these bacteria were not significant. Endometritis is often caused by mixed infections in the uterus. Oxytetracycline did not completely remove existing bacteria. However, oxytetracycline could effectively inhibit endometritis and had a significant inhibitory effect on the genera Bacteroides , Trueperella , Peptoniphilus , Parvimonas , Porphyromonas , and Fusobacterium but had no significant inhibitory effect on the bacterial genera Marinospirillum , Erysipelothrix , and Enteractinococcus . During oxytetracycline treatment, the cell motility, endocrine system, exogenous system, glycan biosynthesis and metabolism, lipid metabolism, metabolism of terpenoids, polyketides, cofactors and vitamins, signal transduction, and transport and catabolism pathways were affected.
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BIOLOGY AND FERTILITY OF SOILS
·
2017
·Vol. 53
·期 6
·663-675
·
IF 3.683
Zhao Hai-Ming,Hu Rui-Wen,Huang He-Biao,Wen Hong-Fei,Du Huan,Li Yan-Wen,Li Hui,Cai Quan-Ying,Mo Ce-Hui,Liu Jie-Sheng,Wong Ming-Hung
The widely used plastic film containing di(2-ethylhexyl) phthalate (DEHP) in agriculture has caused serious soil pollution and poses risks to human health through the food chain. An effective DEHP degradation bacteria, Microbacterium sp. J-1, was newly isolated from landfill soil. Response surface methodology was successfully employed for optimization resulting in 96% degradation of DEHP (200 mg L −1 ) within 5 days. This strain degraded DEHP by hydrolysis of the ester bond and hydroxylation of the aromatic ring to form 2-ethyl hexanol, mono-(2-ethylhexyl) phthalate, phthalate acid, and protocatechuic acid, and subsequently transformed these compounds with a maximum specific degradation rate ( q
max ), half-saturation constant ( K
s
), and inhibition constant ( K
i
) of 1.46 day −1 , 180.2 mg L −1 , and 332.8 mg L −1 , respectively. Bioaugmentation of DEHP-contaminated soils with the strain J-1 greatly enhanced the DEHP dissipation rate (~88%). Moreover, this strain could efficiently colonize the rhizosphere soil of inoculated vegetables and further enhanced DEHP degradation (~97%), leading to a significant decrease (>70%) in DEHP accumulation in shoots and roots of the inoculated vegetables compared to uninoculated vegetables. The results highlighted the roles of the inoculated exogenous bacteria in simultaneously bioremediating contaminated soils and reducing bioaccumulation of DEHP in the edible part of the vegetable for food safety.
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ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Qian Zhang,Ting Yin,Guo Gao,Joseph G. Shapter,Weien Lai,Peng Huang,Wen Qi,Jie Song,Daxiang Cui
Core@shell magnetic nanoparticles (core@shell MNPs) are attracting widespread attention due to their enhancement properties for potential applications in hyperthermia treatment, magnetic resonance imaging (MRI), diagnostics, and so forth. Herein, we developed a facile thermal decomposition method for controllable synthesis of a superparamagnetic, monodispersed core@shell structure (Co@Mn = CoFe2O4@MnFe2O4) with uniform size distribution (σ < 5%, dc ≈ 15 nm). The CoFe2O4 core could enhance magnetic anisotropy, and the MnFe2O4 shell could improve the magnetization value. The Co@Mn MNPs were transferred into aqueous solution with an amphiphilic polymer (labeled 2% TAMRA) and functionalized with PEG2k and target molecules (folic acid, FA) to fabricate multifunctional PMATAMRA-Co@Mn-PEG2k-FA nanoprobes. The obtained PMATAMRA-Co@Mn-PEG2k-FA nanoprobes exhibit good biocompatibility, high T2 relaxation values, and long-term fluorescence stability (at least 6 months). Our results demonstrate that the synthesized PMATAMRA-Co@Mn-PEG2k-FA nanoprobes can effectively enhance the targeted MRI and fluorescent labeling in vitro and in vivo. The research outcomes will contribute to the rational design of new nanoprobes and provide a promising pathway to promote core@shell nanoprobes for further clinical contrast MRI and photodynamic therapy in the near future.
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