Nature Communications
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2021
·Vol. 12
·期 1
·1-18
·
IF 14.919
Gao Feng,Shao Tianyi,Yu Yunpeng,Xiong Yujie,Yang Lihua
Acting by producing reactive oxygen species (ROS) in situ, nanozymes are promising as antimicrobials. ROS’ intrinsic inability to distinguish bacteria from mammalian cells, however, deprives nanozymes of the selectivity necessary for an ideal antimicrobial. Here we report that nanozymes that generate surface-bound ROS selectively kill bacteria over mammalian cells. This result is robust across three distinct nanozymes that universally generate surface-bound ROS, with an oxidase-like silver-palladium bimetallic alloy nanocage, AgPd 0.38 , being the lead model. The selectivity is attributable to both the surface-bound nature of ROS these nanozymes generate and an unexpected antidote role of endocytosis. Though surface-bound, the ROS on AgPd 0.38 efficiently eliminated antibiotic-resistant bacteria and effectively delayed the onset of bacterial resistance emergence. When used as coating additives, AgPd 0.38 enabled an inert substrate to inhibit biofilm formation and suppress infection-related immune responses in mouse models. This work opens an avenue toward biocompatible nanozymes and may have implication in our fight against antimicrobial resistance.
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高影响因子
JOURNAL OF MATERIALS SCIENCE
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2020
·Vol. 55
·期 35
·16522-16532
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IF 3.553
Wei Zhiping,Dong Xiaoli,Zheng Nan,Wang Yu,Zhang Xiufang,Ma Hongchao
A series of niobium-doped BiOBr (Nb-BiOBr) were successfully synthesized via hydrothermal method. Moreover, the morphology structure and optical property of BiOBr and Nb-BiOBr samples were determined using various characterization techniques including SEM, TEM, EDS, BET, XRD, XPS and DRS, etc. The photocatalytic performance of Nb-BiOBr was deeply investigated with the rhodamine B and ofloxacin degradation under visible-light irradiation as model reaction. The results showed that Nb-BiOBr samples depicted the outstanding photocatalytic performance, especially for the 1.25Nb-BiOBr. Moreover, its reaction kinetic constant was ca. 6.4 times higher than that of undoped BiOBr. The observed photocatalytic performance could be attributed to the strong light absorption, enhanced separation efficiency of charge carriers as well as high specific surface area. Meanwhile, 1.25Nb-BiOBr demonstrated stability in RhB degradation, thereby facilitating the water treatment application.
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JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 55
·期 35
·16718-16729
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IF 3.553
Wang Chen,Wen Hao,Guo Hailing,Wang Xueyan,Shen Yuhua,Xie Anjian
A novel ferroferric oxide (Fe 3 O 4 )@void@zinc oxide (ZnO) nanocomposite was constructed through a template-assisted selective etching method. The experiment results showed that the magnetic saturation value of nanocomposite could reach to 44.07 emu g −1 , indicating the favorable magnetic targeting function. The presence of the void endowed the nanocomposite with high drug doxorubicin (DOX) loading capacity (85.65 μg mg −1 ). The pH-sensitive drug release was realized due to the gating effect of ZnO, and the DOX release rates were 92.7%, 60.8% and 23.4% at the pH values of 5.0, 6.5 and 7.4, respectively (37 °C). Besides, the Fe 3 O 4 @void@ZnO-DOX exhibited desirable antitumor effects attributed to their cellular uptake and above advantages. Therefore, the Fe 3 O 4 @void@ZnO nanocomposite may serve as a promising drug carrier in cancer therapy and other biomedical applications.
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JOURNAL OF NANOBIOTECHNOLOGY
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2020
·Vol. 18
·期 1
·1-13
·
IF 6.518
Zhu Guanchen,Wang Kaikai,Qin Haixiang,Zhao Xiaozhi,Chen Wei,Xu Linfeng,Cao Wenmin,Guo Hongqian
Background Chemotherapy is a standard cancer treatment which uses anti-cancer drugs to destroy or slow the growth of cancer cells. However, chemotherapy has limited therapeutic effects in bladder cancer. One of the reasons of this resistance to chemotherapy is that higher levels of glutathione in invasive bladder cancer cells. We have fabricated nanoparticles that respond to high concentrations of glutathione and near-infrared laser irradiation in order to increase the drug accumulation at the tumor sites and combine chemotherapy with photothermal therapy to overcome the challenges of bladder cancer treatment. Methods The DOX&IR780@PEG-PCL-SS NPs were prepared by co-precipitation method. We investigated the tumor targeting capability of NPs in vitro and in vivo. The orthotopic bladder cancer model in C57BL/6 mice was established for in vivo study and the photothermal effects and therapeutic efficacy of NPs were evaluated. Results The DOX&IR780@PEG-PCL-SS NPs were synthesized using internal cross-linking strategy to increase the stability of nanoparticles. Nanoparticles can be ingested by tumor cells in a short time. The DOX&IR780@PEG-PCL-SS NPs have dual sensitivity to high levels of glutathione in bladder cancer cells and near-infrared laser irradiation. Glutathione triggers chemical structural changes of nanoparticles and preliminarily releases drugs, Near-infrared laser irradiation can promote the complete release of the drugs from the nanoparticles and induce a photothermal effect, leading to destroying the tumor cells. Given the excellent tumor-targeting ability and negligible toxicity to normal tissue, DOX&IR780@PEG-PCL-SS NPs can greatly increase the concentration of the anti-cancer drugs in tumor cells. The mice treated with DOX&IR780@PEG-PCL-SS NPs have a significant reduction in tumor volume. The DOX&IR780@PEG-PCL-SS NPs can be tracked by in vivo imaging system and have good tumor targeting ability, to facilitate our assessment during the experiment. Conclusion A nanoparticle delivery system with dual sensitivity to glutathione and near-infrared laser irradiation was developed for delivering IR780 and DOX. Chemo-photothermal synergistic therapy of both primary bladder cancer and their metastases was achieved using this advanced delivery system.
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高影响因子
JOURNAL OF FLUORESCENCE
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2020
·Vol. 30
·期 3
·463-470
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IF 2.093
Chen Hongxia,Peng Junxiang,Yu Long,Chen Hui,Sun Mingtai,Sun Zhenli,Ni Runyan,Alamry Khalid A.,Marwani Hadi M.,Wang Suhua
Herein, we report an interesting finding about the new application of oxytetracycline (OTC), as a fluorescent probe for the detection of calcium ion (Ca 2+ ), which proved that it can offer an expeditious, highly sensitive, and selective detection method for Ca 2+ . Upon the addition of Ca 2+ , the fluorescence of OTC could be significantly enhanced with rapid response and high sensitivity, and achieved a good limit of detection as low as 125 nM in aqueous solution. The complex formed via Ca 2+ coordinating to the hydroxyl group of OTC contributes to the fluorescence enhancement, which has been proved by several characterization methods including UV-vis analysis, binding constant determination, and fluorescence titration. The method avoided complexity for EDTA measurement of Ca 2+ in running water as proposed previously. Taking advantage of good availability, stability and operability, the OTC was further successfully applied to the detection of Ca 2+ in a real environment.
Graphical Abstract
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高影响因子
BMC Complementary Medicine and Therapies
·
2020
·Vol. 20
·期 1
·1-17
·
IF 0
Wang Le,Tan Nana,Wang Huan,Hu Jingbo,Diwu Wenbo,Wang Xiaoling
Background Flavonoids from plant medicines are supposed to be viable alternatives for the treatment of type 2 diabetes (T2D) as less toxicity and side effects. Radix scutellariae ( RS ) is a widely used traditional medicine in Asia. It has shown great potential in the research of T2D. However, the pharmacological actions remain obscured due to the complex chemical nature of plant medicines. Methods In the present study, a systematic method combining ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology was developed to screen α -glucosidase inhibitors from flavonoids of RS , and explore the underlying mechanism for the treatment of T2D. Results The n -butanol part of ethanol extract from RS showed a strong α -glucosidase inhibition activity (90.55%, IC 50 0.551 mg/mL) against positive control acarbose (90.59%, IC 50 1.079 mg/mL). A total of 32 kinds of flavonoids were identified from the extract, and their ESI-MS/MS behaviors were elucidated. Thirteen compounds were screened as α -glucosidase inhibitors, including viscidulin III, 2′,3,5,6′,7-pentahydroxyflavanone, and so on. A compound-target-pathway (CTP) network was constructed by integrating these α -glucosidase inhibitors, target proteins, and related pathways. This network exhibited an uneven distribution and approximate scale-free property. Chrysin ( k = 87), 5,8,2′-trihydroxy-7-methoxyflavone ( k = 21) and wogonin ( k = 20) were selected as the main active constituents with much higher degree values. A protein-protein interaction (PPI) weighted network was built for target proteins of these α -glucosidase inhibitors and drug targets of T2D. PPARG ( C d = 0.165, C b = 0.232, C c = 0.401), ACACB ( C d = 0.155, C b = 0.184, C c = 0.318), NFKB1 ( C d = 0.233, C b = 0.161, C c = 0.431), and PGH2 ( C d = 0.194, C b = 0.157, C c = 0.427) exhibited as key targets with the highest scores of centrality indices. Furthermore, a core subnetwork was extracted from the CTP and PPI weighted network. Type II diabetes mellitus (hsa04930) and PPAR signaling pathway (hsa03320) were confirmed as the critical pathways. Conclusions These results improved current understanding of natural flavonoids on the treatment of T2D. The combination of ultrafiltration UPLC-TripleTOF-MS/MS and network pharmacology provides a novel strategy for the research of plant medicines and complex diseases.
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Nature Catalysis
·
2020
·Vol. 3
·期 2
·170-178
·
IF 30.471
Huang Zhipeng,Zhao Zhitong,Zhang Chaofeng,Lu Jianmin,Liu Huifang,Luo Nengchao,Zhang Jian,Wang Feng
The decarboxylation of bio-derived fatty acids provides a sustainable pathway for the production of alkane products under mild conditions; however, products are generally obtained in low selectivity due to the uncontrollable reactivity of radical intermediates. Here we demonstrate that photogenerated radicals can be rapidly terminated by surface hydrogen species during photocatalytic decarboxylation of fatty acids on a hydrogen-rich surface that is constructed by the interactions between H 2 and Pt/TiO 2 catalyst, thereby greatly inhibiting oligomerization; C n – 1 alkanes can therefore be obtained from bio-derived C 12 –C 18 fatty acids in high yields (≥90%) under mild conditions (30 °C, H 2 pressure ≤0.2 MPa) and 365 nm light-emitting dode irradiation. Industrial low-value fatty acid mixtures (namely, soybean and tall oil fatty acids) can be transformed into alkane products in high yields (up to 95%). Our research introduces an efficient biomass-upgrading approach that is enabled by subtle control of the radical intermediate conversion on a heterogeneous surface.
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CELLULOSE
·
2020
·Vol. 27
·期 7
·3971-3988
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IF 4.21
Deng Yudi,Chen Jinyuan,Huang Jinyu,Yang Xushan,Zhang Xudong,Yuan Sijie,Liao Wenzhen
Abstract The composite hydrogel was prepared with cellulose and flaxseed gum and characterized by fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Brunauer–Emmitt–Teller (BET) and thermogravimetric analysis (TGA). The swelling property, drug adsorption, biocompatibility and hemostatic function of composite hydrogel were investigated. The composite hydrogel had the pore structure and exhibited high stability with a thermal decomposition temperature of 332.66 °C. And the composite hydrogel showed excellent swelling capability with a moisture expansivity of over 200%, and with a drug adsorption capacity of 7.27 ± 0.15 mg/g. Mechanical properties tests showed that as the proportion of flaxseed gum increased, the ability to withstand pressure of hydrogel was improved. In addition, MTT assay, flow cytometry analysis, and in vivo toxicological evaluation suggested that composite hydrogel had good biocompatibility. Moreover, hemostatic potential assay and wound healing were made in order to evaluate the effect of hemostasis and wound healing of composite hydrogel and our results indicated that the composite hydrogel with cellulose and flaxseed gum could be effective to promote hemostatic and wound healing function. All in all, the great properties exhibited by the composite hydrogel could make it a potential candidate as biomaterial in bleeding and wound treatment. Graphic abstract
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Nano-Micro Letters
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2020
·Vol. 12
·期 1
·1-15
·
IF 12.264
Zhai Xian-Zhi,Qu Jin,Hao Shu-Meng,Jing Ya-Qiong,Chang Wei,Wang Juan,Li Wei,Abdelkrim Yasmine,Yuan Hongfu,Yu Zhong-Zhen
A layered sodium-ion/crystal water co-intercalated Na 0.55 Mn 2 O 4 ·0.57H 2 O (NMOH) cathode is synthesized successfully with a selectively etching method for zinc-ion batteries.
A displacement/intercalation mechanism is confirmed in the Mn-based cathode for the first time.
The NMOH cathode delivers a competitive reversible capacity of 201.6 mA h g −1 at 500 mA g −1 after 400 cycles.
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高影响因子
International Journal of Environmental Science and Technology
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2020
·Vol. 17
·期 5
·3055-3064
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IF 2.54
Liu S.-S.,Luo D.-M.,Yang X.,Tong C.-X.,Tao L.-G.,Ding H.-P.,Zhang J.
A series of graphitic carbon nitrides (g-C 3 N 4 ) were prepared using different precursors; these g-C 3 N 4 -supported CoOx catalysts exhibited different catalytic performances in toluene catalytic combustion reaction. The structure of samples was detected by XRD, TEM, SEM, XPS, H 2 -TPR, nitrogen adsorption and desorption technique, to build up the structure–performance relationship and uncover the key property of g-C 3 N 4 that mostly influences the catalytic performance of CoOx/g-C 3 N 4 . CoOx with average particle size of 12.7 nm supported on g-C 3 N 4 prepared by dicyandiamide showed better catalytic performance than on other supports, 100% toluene conversion could be achieved at ~ 285 °C, characterization results showed that Co was directly connected with N, and the integrity of g-C 3 N 4 sheet affects the dispersion of CoOx; the content of sp 2 -N (within C=N–C structure) determines the interaction between g-C 3 N 4 and CoOx; these two factors together affect the performance of CoOx/g-C 3 N 4 catalysts in the catalytic combustion of toluene.
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SN Applied Sciences
·
2020
·Vol. 2
·期 3
·1-10
·
IF 0
Jia Shuyue,Wang Qidong,Peng Jing,Gao Jingru,Tang Dongyan
ZnO nanomaterials have been widely studied in medical and biological fields owing to their better biocompatibility, pH-responsibility and higher photocatalytic ability as drug carriers and disease therapy agent. However, the unstability of ZnO nanomaterials within aqueous solution restricts the applications of it to some extent. In this work, ZnO nanofibers with relative higher porosity were fabricated by electrospinning to improve the load capacity as carriers, and then were modified by hydrophobic poly(methyl methacrylate) (PMMA) through graft polymerization on the surface to improve their stability in aqueous solution. Observations on the morphologies of the nanofibers by SEM showed that the surface modification of PMMA well enhanced the water-stability of ZnO nanofibers. Moreover, the photocatalytic degradation of Rhodamine B was investigated, and pH sensitive release behaviors were studied in details under different pH values, by taking Nifedipine as drug model. The results indicated that PMMA modified ZnO nanofibers showed obvious photocatalytic performances and maintained relative excellent pH-response properties. These findings all suggested that the modified ZnO nanofibers might be one kind of excellent material as medical carrier or therapy agents.
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Silicon
·
2020
·Vol. 12
·期 12
·3005-3013
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IF 1.499
Pan Zhaoqun,Zeng Kelin,Huang Bingsheng,Zhu Liqiang
The oligosiloxane resins were synthesized through hydrolytic sol-gel reaction and remained many hydroxyl groups, which did great harm to the curing process and resulted in poor performance of the cured products. In previous works, epoxy-modified silicone resins were synthesized by dealcoholization, a reaction between 3-glycidoxypropylmethyldimethoxysilane and terminal hydroxyl groups in phenyl silicone resins. Although this method eliminated the hydroxyl groups, it caused a large loss of vinyl groups inevitably and a poor stability of cured products. In this study, methyltrimethoxysilane (MTMS) was used to eliminate hydroxyl groups containing in vinyl methyl phenyl silicone resins, which were synthesized through hydrolytic sol-gel reaction. Most of residual hydroxyl groups were deleted effectively and the great loss of vinyl groups were avoided in the dealcoholization reaction. Then, the methyl phenyl silicone materials were fabricated by hydrosilylation reaction between the synthesized vinyl methyl phenyl silicone resins and hydrogen-containing ones. The cured silicone materials showed excellent optical performance (~ 89.1% at 450 nm) and good adhesion performance. In addition, due to less vinyl loss in the vinyl methyl phenyl silicone resins, the cured methyl phenyl silicone materials exhibited higher cross-linking density, better thermal resistance (5% mass loss at 435 °C) and better mechanical properties (50 shore D) compared with the epoxy-modified phenyl silicone materials. The lumen depreciation (working 168 h at 50 mA) and reflow soldering tests further demonstrated the methyl phenyl silicone materials possessed good thermal stability. These results indicated that the methyl phenyl silicone materials could be used as a LED encapsulant with a good performance.
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