JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 16
·10108-10123
·
IF 4.22
Ma Lingwei,Wang Xuanbo,Wang Jinke,Zhang Juantao,Yin Chengxian,Fan Lei,Zhang Dawei
In this study, graphene oxide–cerium oxide (GO–CeO 2 ) hybrids were synthesized through an in situ hydrothermal approach and were incorporated into epoxy resin to prepare a robust coating for aluminum alloy protection. The mechanical properties of the GO–CeO 2 -loaded coating were characterized by nano-indentation, friction-wear test and pull-off adhesion test, using pristine epoxy coating and GO-loaded epoxy coating for comparison. Results revealed that GO–CeO 2 addition could increase the hardness, elastic modulus and the wear resistance and decrease the friction coefficient of the composite coating. Compared with pristine epoxy coating, the adhesion strength of GO–CeO 2 /epoxy coating increased from 7.3 MPa to 12.2 MPa. Such improvement in the mechanical properties can be explained by the good dispersion of GO–CeO 2 in the composite coating. In addition, salt spray and electrochemical impedance spectroscopy (EIS) measurement results showed that the corrosion resistance of the GO–CeO 2 -loaded coating was significantly enhanced. After 30 days of salt spray test, the coating resistance of the GO–CeO 2 /epoxy coating was 17.8 and 3.5 times higher compared with that of the blank epoxy coating and GO/epoxy coating, respectively. The superior barrier performance of the composite coating was mainly ascribed to the synergistic effects of the prolonged pathway against corrosive media permeation and the corrosion inhibition effect of CeO 2 particles.
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Journal of Ocean University of China
·
2015
·Vol. 14
·期 6
·989-993
·
IF 0.558
Xue Yuejun,Ge Tiantian,Wang Xuchen
Radiocarbon ( 14 C) measurement of dissolved organic carbon (DOC) is a very powerful tool to study the sources, transformation and cycling of carbon in the ocean. The technique, however, remains great challenges for complete and successful oxidation of sufficient DOC with low blanks for high precision carbon isotopic ratio analysis, largely due to the overwhelming proportion of salts and low DOC concentrations in the ocean. In this paper, we report an effective UV-Oxidation method for oxidizing DOC in natural waters for radiocarbon analysis by accelerator mass spectrometry (AMS). The UV-oxidation system and method show 95%±4% oxidation efficiency and high reproducibility for DOC in both river and seawater samples. The blanks associated with the method was also low (about 3 µg C) that is critical for 14 C analysis. As a great advantage of the method, multiple water samples can be oxidized at the same time so it reduces the sample processing time substantially compared with other UV-oxidation method currently being used in other laboratories. We have used the system and method for 14 C studies of DOC in rivers, estuaries, and oceanic environments and have received promise results.
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RESEARCH ON CHEMICAL INTERMEDIATES
·
2012
·Vol. 39
·期 2
·621-629
·
IF 0.697
Li He-ping,Zhang Juan-juan,Qin Long,Zhao Ming-dong
To develop more potential angiotensin converting enzyme (ACE) inhibitors, a series of captopril (Cap) derivatives were synthesized, including Cap-glycine methyl ester, Cap- l -alanine methyl ester, Cap- l -aspartic acid dimethyl ester, Cap- l -lysine methyl ester, Cap- O -acylisourea, acetyl captopril, and benzoyl captopril. The resulting products were characterized by IR and UV–visible spectroscopy and MS, which showed the desired products were successfully synthesized. This could serve as a guide for rational design of highly potent ACE inhibitors.
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BMC Chemistry
·
2019
·Vol. 13
·期 1
·1-15
·
IF 0
Guo J.,Ma Yu L.,Yu Jia Y.,Gao Yu J.,Ma Ning X.,Wu Xiao Y.
Herein, 2-(2-methoxyphenoxy)-1-phenylethanol (β- O -4), 2-methoxyphenyl anisole (α- O -4) and 4-phenoxyphenol (4- O -5) were selected as typical lignin model compounds. Given the effectiveness of traditional acid–base catalysts for lignin depolymerisation, a novel Ni/CaO–H-ZSM-5(60) catalyst was prepared to investigate the difficulty level of C–O bond of three model compounds cleavage in ethanol. It was observed that Ni/CaO–H-ZSM-5(60) had prominent performance on the C–O bond cleavage at very mild conditions (140 °C, 1 MPa H 2 ). Among them, the C–O bond of α- O -4 and β- O -4 could be completely cleaved within 60 min. Although the C–O bond of 4- O -5 had high bond energy, 41.2% of conversion was occurred in 60 min. The introduction of CaO could regulate the acidity of H-ZSM-5 to enhance the ability to break C–O bonds. Moreover, the possible pathways of C–O ether bonds in three lignin model compounds cleavage were proposed in order to selectively obtain target products from the raw lignin degradation.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-15
·
IF 15.7
Xie Chang,Li Wenyue,Yao Xudong,Wu Boxuan,Fang Jinghua,Mao Renwei,Yan Yiyang,Meng Hongxu,Wu Yan,Zhang Xianzhu,Li Rui,Zhang Jie,Duan Wangping,Dai Xuesong,Wang Xiaozhao,Ouyang Hongwei
Growth plate (GP), a critical cartilaginous structure in amniotes, underpins longitudinal bone growth, yet the intricate mechanisms behind its polarized mineralization during evolution remain unclear. Herein, employing high-resolution analytical techniques, we reveal that the GP-epiphysis interface displays a sharp transition in tissue modulus, acting as a protective shell for the underlying GP, whereas the GP-metaphysis interface exhibits a gradual modulus increase, enabling efficient load redistribution to the metaphysis. This mechanical microenvironment contributes to unique microstructural and compositional transformations from GP to epiphysis and metaphysis. Notably, the GP-epiphysis interface acts as a mineralization inhibition zone while the GP-metaphysis serves as a mineralization promotion zone, orchestrated by a complex network of proteins. Proteins such as secreted phosphoprotein 1 (SPP1) and alpha-2-HS-glycoprotein (AHSG) at the GP-epiphysis interface inhibit mineralization, forming a defense line; while ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) and alkaline phosphatase, biomineralization associated (ALPL), coexisting with SPP1 and AHSG, promote a sequential nucleation and assembly of calcium phosphate minerals at the GP-metaphysis. Such polarized mineralization patterns maintain the homeostasis of GPs and drive polarized bone elongation. Replicating this process in vitro, we synthesize stable amorphous calcium phosphate which shows highly controlled transformation into hydroxyapatite. This work provides a more comprehensive view of the structural integrity of human bone in development and offers strategies for controlled biomineralization.
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PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-8
·
IF 15.7
Li Yajing,Meng Na,Xu Yutian,Yu Bufan,Liu Junhao,Cui Yuanhao,Wang Ziqiang,Ke Xinwu,Pan Tengfei,Min Xue,Chen Jiangshan,Ma Dongge,Chao Lingfeng,Hu Zhelu,Xia Yingdong,Guo Qingxun,Chen Yonghua,Huang Wei
Thermal-evaporated perovskite light-emitting diodes are highly promising for future display and lighting. However, multi-source co-evaporation faces challenges such as difficulty in regulating crystallinity, especially for red perovskite light-emitting diodes, whose external quantum efficiencies are still less than 2%. Here, we demonstrate a facile layer-by-layer thermal-evaporation strategy to fabricate high-quality perovskite-emitting films with tunable emission wavelengths. 5-Aminovaleric acid is introduced to regulate interfacial reactions during deposition, slow down crystallization during post-annealing, and passivate defects through coordination interactions. This approach yields perovskite emitting layers with high uniformity and luminance efficiency. As a result, red (670 nm) and deep-red (730 nm) perovskite light-emitting diodes achieve maximum external quantum efficiencies of 9% and 7.27%, and luminance of over 1500 cd m -2 and 200 W s -1 m -2 , respectively. Furthermore, large-area (2500 mm²) and patterned perovskite thin films and light-emitting diodes with outstanding uniformity are successfully demonstrated.
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3 Biotech
·
2025
·Vol. 15
·期 12
·412
·
IF 2.9
Fang Zhiruo,Zhu Haojun,Gao Jiancao,Cao Liping,Yao Yu,Li Quanjie,Dai Fei,Yang Xiwei,Du Jinliang,Xu Gangchun
Silymarin has proven antioxidant activity and hepatoprotective effects, but no study to date has investigated the potential protective effect on deltamethrin-induced hepatopancreas injury in Chinese mitten crabs Eriocheir sinensis . This study investigated the protective effect of silymarin pretreatment on deltamethrin-induced hepatopancreas injury in E.sinensis . Healthy crabs (n = 150) were randomly divided into five experimental groups: the control, a deltamethrin exposure group (Basal feed without silymarin), and three silymarin groups (addition of 0.1, 0.5, or 1.0 g/kg diet to the basal feed). After 6 weeks of feeding (no deltamethrin exposure), the crabs were exposed to a deltamethrin concentration of 4.317 μg/L for 48 h. Histopathological results showed that the hepatopancreas remained relatively intact in the silymarin pretreatment groups. Furthermore, metabolites annotated by LC–MS were mainly enriched in signaling pathways related to cytochrome P450, terpenoid alkaloid biosynthesis and phospholipid metabolism. Silymarin at 0.1, 1.0 and/or 0.5 g/kg were significantly increased AKP, ACP, GSH activities and T-AOC levels, and significantly decreased AST, ALT, TNF-α, IL-6, NO, TC, MDA, CYP3A and CYP2E1 levels ( P < 0.05). Silymarin at the concentation of 0.1, 0.5 and 1.0 g/kg could significantly up-regulated the expressions of immune-related genes ( propo , alf3 , crustin1 , hsp70 , hsp90 , relish ), anti-apoptotic gene ( bcl-2 ), and significantly down-regulated the lipid metabolism-related genes ( cpt1 , srebp , acc ) and apoptosis-related genes ( caspase3 , caspase8 , p53 , cyt-c ) ( P < 0.05). Silymarin at 0.5 and/or 1.0 g/kg significantly down-regulated the mRNA expression of inflammation-related genes ( tnf-α , il-16 ) and drug metabolism-related genes ( cyp2a , cyp2e1 , cyp3a ) ( P < 0.05). The results demonstrate a good protective effect of 1.0 g/kg silymarin on deltamethrin-induced hepatopancreas injury induced by deltamethrin in a crustacean species.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·40525
·
IF 3.9
Ma Chunli,Wang Linghong,Cao Lili,Zhao Linyun,Zhang Xin,Ma Chengyou,Lian Hua,Bao Xiufang,Eerde Mutu,Buren Qiqige,Tong He,Dai Lili,Amu Guleng,Bao Yulong,Hong Mei,Wang Li
Acute liver injury (ALI) is a prevalent hepatic condition that poses significant risks to both life and overall health. Traditional Mongolian medicine utilizes Honghua Qinggan Thirteen-Flavor Pills (HHQG) as a primary formula for dispelling liver heat, illustrating both an extensive application in clinical settings and notable therapeutic effectiveness for treating liver ailments such as hepatitis and liver failure. Nevertheless, the molecular mechanisms underpinning the hepatoprotective properties of HHQG remain inadequately understood.We employed a CCl 4 -induced mouse model of liver injury alongside network pharmacology analysis, molecular docking studies, and cellular assays to dissect the effects and mechanisms of action of HHQG. Our findings demonstrated that HHQG significantly improved CCl 4 -induced liver injury in mice, reducing pathological damage and inflammatory factors. Network pharmacology identified 184 overlapping targets, 6 key genes, and 5 key active components in HHQG. Molecular docking confirmed the binding affinity of these components to RASD1. Gene expression analysis in liver tissue revealed a positive correlation between mRNA expression of RASD1 and NLRP3. Cell experiments demonstrated the role of RASD1 in regulating NLRP3 inflammasome and inflammatory factors. Pretreatment of HHQG attenuated LPS-induced inflammatory response and the activation of PKCδ-NF-κB signaling pathway. In the CCl 4 -induced liver injury model, HHQG significantly reduced NLRP3, RASD1, and PKCδ-NF-κB expression.This study revealed that HHQG effectively mitigates CCl 4 -induced liver injury by inhibiting the activation of NLRP3 inflammasome by regulating the PKCδ-NF-κB signaling pathway via RASD1. These findings provide novel theoretical support for the rational application of HHQG as a potential hepatoprotective agent.
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2025
·Vol. 47
·期 12
·568
·
IF 3.8
Xie Hongguan,Gong Lian,Lei Shiwei,Li Shida,Feng Yuxin,Liao Lin,Wang Yue,Wang Kongxi
Polycyclic aromatic hydrocarbons (PAHs) pose a significant threat to the ecological environment, and plant–microbe remediation represents a promising strategy for the treatment of contaminated soils. This study aimed to evaluate the effects of foliar application of selenite or selenium nanoparticles (SeNPs) on the remediation efficiency of pyrene by Alfalfa ( Medicago sativa L.) and Bacillus subtilis PSL-1. A pot experiment was conducted with foliar selenium treatments at different concentrations (5–15 mg kg −1 ), and the effects were comparatively analyzed in terms of plant physiological parameters (chlorophyll content, biomass, and antioxidant enzyme activity), soil enzyme activities (dehydrogenase and catalase), soil pyrene speciation, and microbial community structure. The results showed that low-concentration foliar selenium application (5 mg L −1 ) enhanced antioxidant defense, alleviated oxidative stress, and promoted chlorophyll synthesis and growth of Alfalfa, thereby stimulating soil enzyme activity and enriching pyrene-degrading microorganisms. Consequently, the pyrene degradation rate increased from 62.07% to 67.83–71.91%. In contrast, high selenite concentration (15 mg L −1 ) induced phytotoxicity and weakened the stimulation of soil enzyme and microbial activities. Compared with selenite, SeNPs consistently enhanced the remediation efficiency across all tested concentrations, demonstrating a broader safe concentration range. Overall, foliar selenium application effectively promoted plant–microbe remediation of pyrene-contaminated soil, and SeNPs exhibiting a superior promoting effect and higher application potential than selenite.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 25
·1-14
·
IF 2.8
Zhang Simin,Ning Suiting,Zhao Wenzeng,Yang Xuanye,Chen Zhiquan,Wu Yichu
CuAlO \(_{2}\) as an oxide thermoelectric material has attracted researchers’ attention because of its low-cost and high-temperature stability. In this work, CuAl \(_{1-x}\) O \(_{2}\) + Gd \(_{x}\) ( x =0, 0.01, 0.03, 0.04, 0.06, 0.1) samples were synthesized by solid-state reaction and spark plasma sintering. Positron annihilation measurements showed that doping with a small amount of Gd ( \(x \le\) 0.03) inhibits the growth of Cu vacancy and vacancy cluster size, which improves the carrier mobility of the sample and optimizes the electrical conductivity and power factor of the sample. With further increase of Gd content, both the vacancy cluster size and concentration shows increase, which leads to fast decrease of the mobility. Finally, the sample CuAl \(_{0.97}\) O \(_{2}\) +Gd \(_{0.03}\) exhibits the best thermoelectric performance at 773 K, with the highest zT value of 5.824 \(\times\) 10 \(^{-3}\) , which is 40.39% higher than that of the intrinsic CuAlO \(_{2}\) . The average zT of CuAl \(_{0.97}\) O \(_{2}\) +Gd \(_{0.03}\) between 303 K and 773 K is also 38.9% higher than that of the intrinsic sample.
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ARCHIVES OF DERMATOLOGICAL RESEARCH
·
2025
·Vol. 317
·期 1
·942
·
IF 2.1
Yang Mingmei,Wang Huiying,Huang Zeyu,Zhang Ruzhi
Mesenchymal stem cell-derived exosomes (MSC-Exos) have been shown to protect melanocytes from oxidative injury, suggesting their potential contribution to therapeutic strategies for vitiligo. Multilineage-differentiating stress-enduring (Muse) cells are a unique subpopulation of mesenchymal stem cells (MSCs) that can tolerate stress and differentiate into multiple cell types. However, the effects of Muse cell-derived exosomes (Muse-Exos) on melanocyte injury are not well understood. In this study, we investigated whether Muse-Exos could protect human epidermal melanocytes (HEMs) from hydrogen peroxide (H 2 O 2 )-induced oxidative stress injury in vitro. Muse cells were isolated from MSCs via magnetic-activated cell sorting (MACS), and the exosomes were collected by ultracentrifugation. The exosomes were characterized using transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA) and Western blotting. HEMs were pretreated with either MSC-Exos or Muse-Exos at concentrations of 5, 10–20 µg/mL for 48 h, after which they were exposed to H 2 O 2 to induce oxidative stress. Functional assays were conducted to assess cell viability, apoptosis, reactive oxygen species (ROS) accumulation and autophagy-related markers (LC3B-II, Beclin-1 and p62). Both MSC-Exos and Muse-Exos reduced H 2 O 2 -induced cytotoxicity and promoted cell survival. Muse-Exos were found to have relatively stronger effects in reducing ROS levels, inhibiting apoptosis, and enhancing autophagic activity. These results suggest that Muse-Exos may protect melanocytes against oxidative stress in vitro and could inform new approaches to treating vitiligo using exosomes.
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Nature Communications
·
2025
·Vol. 16
·期 1
·10322
·
IF 15.7
Li Xuan,Jiang Xiao,He Ye,Xiong Hongwei,Huang Qian,Xu Kun,Luo Xin-Xin,Li Kai,Tao Bailong,Zha Kangkang,Wu Jing,Liu Peng,Cai Kaiyong
The elimination of senescent cells can enhance the osteointegration of implants in elderly patients. However, achieving specific clearance of senescent cells without adversely affecting the function of normal cells remains challenging. Here we show an implant surface modification technique to achieve specific clearance of locally senescent cells by modulating their metabolism. Our method involve modifying implants with BPTES, a glutaminase 1 (GLS1) inhibitor, through π-π stacking with dopamine. This modification effectively induces intracellular acidosis in senescent mesenchymal stem cells (MSCs) through suppression of glutaminolysis. Simultaneously, poly(γ-glutamate) (PGA), modified by a layer-by-layer method, serve as a high-density carbon source coating, continuously supporting glutamine metabolism in MSCs without ammonia production. Our results show that modified implants significantly reduce the senescence level around implants and promote osteointegration in aged rats. These findings provide promising insights into the design and application of orthopedic implants for elderly patients.
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