WATER AIR AND SOIL POLLUTION
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2017
·Vol. 228
·期 11
·1-10
·
IF 1.702
Laipan Minwang,Fu Haoyang,Zhu Runliang,Rivera Linda,Zhu Gangqiang,Zhu Jianxi,He Hongping
Hexavalent chromium (Cr(VI)) and dyes are of particular environmental concern and need to be removed from water urgently due to their high toxicity. Herein, we explored the possibility of electron transferring from dye Orange II (OII) to Cr(VI) under UV and simulated solar light irradiation, expecting to simultaneously decolorize dyes and reduce Cr(VI). Experimental results show that light irradiation can partially decolorize OII but has no ability to reduce Cr(VI) in solution only with OII or Cr(VI). However, both dyes and Cr(VI) can effectively and simultaneously be decolorized and reduced in the solution containing both OII and Cr(VI) under light irradiation, and a low pH level and high OII/Cr(VI) concentration ratio significantly favor the co-removal. Additionally, insoluble organo–Cr(III) complexes identified by FTIR and XPS characterization were generated during the reaction. These complexes are beneficial to the removal of chromium and total organic carbon from water. The possible degradation pathway of OII is further proposed based on the detection of degraded products by GC-MS analysis. The results of this work offer an approach for simultaneously removing multiple contaminants.
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
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2017
·Vol. 22
·期 4
·973-981
·
IF 2.316
Niu Xiaohui,Mo Zunli,Gao Huhu,Wang Ruijuan,Li Zhenliang,Meng Shujuan,Guo Ruibin
A novel electrochemical chiral sensor was reported for recognizing tryptophan enantiomers based on multi-walled carbon nanotubes functionalized by 3,4,9,10-perylenetetracarboxylic acid binding with the l -lysine (MWCNTs-PTCA-PLL) via electropolymerization. The electrochemical behaviors of the proposed sensors were then characterized by cyclic voltammetry (CV). Differential pulse voltammetries (DPVs) were applied to investigate the stereoselective recognition of tryptophan (Trp) enantiomers. d -Trp and l -Trp showed different responses in DPVs, and a larger selectivity was obtained from d -Trp. pH level and the effect of the incubation time on the chiral recognition were also investigated for optimizing experimental parameters. In addition, the results of analyzing percentage composition revealed this sensor was able to determine the enantiomeric mixtures. The novel strategy with high stability, good sensitivity, and selective characteristics had opened up a new avenue to recognize Trp enantiomers.
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Stem Cell Research & Therapy
·
2017
·Vol. 8
·期 1
·1-13
·
IF 4.211
Wang Linli,Chen Yuehua,Guan Chunyan,Zhao Zhiju,Li Qiang,Yang Jianguo,Mo Jian,Wang Bin,Wu Wei,Yang Xiaohui,Song Libing,Li Jun
Background Because the lack of an induced pluripotent stem cell (iPSC) induction system with optimal safety and efficiency limits the application of these cells, development of such a system is important.Methods To create such an induction system, we screened a variety of reprogrammed plasmid combinations and multiple compounds and then verified the system’s feasibility using urine cells from different individuals. We also compared large-scale iPSC chromosomal variations and expression of genes associated with genomic stability between this system and the traditional episomal system using karyotype and quantitative reverse transcription polymerase chain reaction analyses.Results We developed a high-efficiency episomal system, the 6F/BM1-4C system, lacking tumorigenic factors for human urine-derived cell (hUC) reprogramming. This system includes six low-risk factors (6F), Oct4, Glis1, Klf4, Sox2, L-Myc, and the miR-302 cluster. Transfected hUCs were treated with four compounds (4C), inhibitor of lysine-demethylase1, methyl ethyl ketone, glycogen synthase kinase 3 beta, and histone deacetylase, within a short time period. Comparative analysis revealed significantly decreased chromosomal variation in iPSCs and significantly increased Sirt1 expression compared with iPSCs induced using the traditional episomal system.Conclusion The 6F/BM1-4C system effectively induces reprogramming of urine cells in samples obtained from different individuals. iPSCs induced using the 6F/BM1-4C system are more stable at the cytogenetic level and have potential value for clinical application.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 1
·1-11
·
IF 5.3
Zhang Junli,Zhao Yanyan,Hu Haiying,Lv Min,Zhang Hongling
A nano-enzyme sandwich assay (SWzyme assay), a colorimetric system based on a biochip and inorganic nano-enzyme for rapid and simple determination of exosomal Aβ42 in plasma is proposed. Anti-CD63 antibody-modified biochips were prepared for plasma exosome capture and synthesized highly catalytic Ni@Pt nanozymes for detecting exosomal Aβ42. The method was able to detect exosomal Aβ42 with a limit of detection (LOD) as low as 4.2×10 4 particles/mL and a linear range from 10 4 to 10 8 particles/mL. By determination of exosomal Aβ42, the SWzyme assay successfully distinguished plasma from Alzheimer’s desease (AD) and healthy mice. The SWzyme assay holds promise to serve as diagnostic tools for the early detection of AD and supporting the development of personalized medicine. Graphical abstract
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 2
·1-11
·
IF 5.3
Li Kaiwei,Jiang Han,Wang Liying,Wang Rui,Zhang Xuewei,Yang Libin,Jiang Xin,Song Wei,Zhao Bing
Semiconductor materials have become a competitive candidate for surface-enhanced Raman scattering (SERS) substrate. However, powdered semiconductors are difficult to execute a fast in situ detection for trace analytes. Here, we developed a new flexible semiconductor SERS substrate by in situ densely growing anatase TiO 2 nanoparticles on the surface of cotton fabric through a filtration-hydrothermal method, in which TiO 2 exhibits excellent controllability in size and distribution by regulating the ratio of water to alcohol in synthesis and the number of filtration-hydrothermal repetitive cycle. Cotton fabric/TiO 2 (Cot/TiO 2 ) substrate exhibits a high SERS activity and excellent spectral repeatability. The developed substrate has an ultra-high stability that can withstand long-term preservation; it can even resist the corrosions of strong acid and alkali, as well as high temperature up to 100 °C and low temperature down to − 20 °C. The flexible substrate can be used to carry out a rapid in situ detection for quinolone antibiotic (enrofloxacin and enoxacin) residues on the fish body surface by using a simple swabbing method, with high quantitative detection potential (up to an order of magnitude of 10 −7 M), and even for the simultaneous detection of both drug residues. The flexible substrate also exhibits an excellent recyclability up to 6 recycles in the actual SERS detection. Graphical Abstract
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ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
·
2024
·Vol. 46
·期 9
·1-20
·
IF 3.2
Yang Yonghao,Luo Zhihao,Wei Zuoan,Zhao Junkang,Lu Ting,Fu Tianbao,Tang Shuang
Tailings dust can negatively affect the surrounding environment and communities because the tailings are vulnerable to wind erosion. In this study, the effects of halides (sodium chloride [NaCl], calcium chloride [CaCl 2 ], and magnesium chloride hexahydrate [MgCl 2 ·6H 2 O]), and polymer materials (polyacrylamide [PAM], polyvinyl alcohol [PVA], and calcium lignosulfonate [LS]) were investigated for the stabilization of tailings for dust control. Erect milkvetch ( Astragalus adsurgens ), ryegrass ( Lolium perenne L.), and Bermuda grass ( Cynodon dactylon ) were planted in the tailings and sprayed with chemical dust suppressants. The growth status of the plants and their effects on the mechanical properties of tailings were also studied. The results show that the weight loss of tailings was stabilized by halides and polymers, and decreased with increasing concentration and spraying amount of the solutions. The penetration resistance of tailings stabilized by halides and polymers increased with increasing concentration and spraying amount of the solutions. Among the halides and polymers tested, the use of CaCl 2 and PAM resulted in the best control of tailings dust, respectively. CaCl 2 solution reduces the adaptability of plants and therefore makes it difficult for grass seeds to germinate normally. PAM solutions are beneficial for the development of herbaceous plants. Among the three herbaceous species, ryegrass exhibited the best degree of development and was more suitable for growth in the tailings. The ryegrass plants planted in the tailings sprayed with PAM grew the best, and the root-soil complex that formed increased the shear strength of the tailings.
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IONICS
·
2024
·
IF 2.4
Gu Chengyang,Zhang Zhenzhong,zhang Xiaomin,Zhao Fangxia,Chen Haoyi,Tang Xingfeng
In order to determine the optimal crystalline form of manganese-based catalysts for zinc-air battery cathodes, in this paper nano-α-MnO 2 and amorphous manganese dioxide (AMO) materials were successfully synthesised by hydrothermal and liquid-phase co-precipitation methods, respectively. The results show that the spherical AMO material has larger specific surface area and more mesopores than the rod-like α-MnO 2 . Moreover, AMO has abundant structural defects and short-range ordered atomic arrangements that can enhance the ion diffusion kinetics and improve the catalytic performance of the materials. Through electrochemical tests, it is found that the AMO materials have better catalytic properties compared to α-MnO 2 . At a current of 10 mA/cm 2 , its discharge-specific capacity reached 575.2 mAh/g, which is 11.1% higher than that of 517.8 mAh/g for α-MnO 2 . And AMO have higher peak power density and smaller charge/discharge voltage gaps. In the long-cycle test, the initial round-trip efficiency of the electrode prepared of AMO is also better than that of α-MnO 2 . However, when the AMO electrodes are charged and discharged for a long time, part of the AMO will be converted to α-MnO 2 , which lead to a gradual decrease in the cycling stability of the AMO electrodes. Therefore, this paper concludes that AMO materials are superior to α-MnO 2 as catalysts for zinc-air batteries.
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Food Production Processing and Nutrition
·
2024
·Vol. 6
·期 1
·1-15
·
IF 4
Zhou Zheng,Jiang Haonan,Sun Haoyuan,Huang Xu-Hui,Cui Shuang,Zhou Dayong,Qin Lei
After thermal treatment, quail eggs pruduce an attractive flavor that is favored by consumers. In this study, the key aroma volatiles and their lipid precursors during thermal treatment were investigated by the electronic nose, GC-MS, GC-O-MS and UPLC-Q-Exactive HF-X. The results exhibited that the raw and fresh flavor of raw egg yolks came from 1-Octen-3-ol, 2-Ethyl-1-hexanol, 1-Decene, and 1-Undecene. 2-Methyl-3-octanone, Toluene, and some aromatic compounds worked synergistically to contribute to the aroma profile of boiled eggs. (+)-2-Bornanone, Octanal, 2-Methyl-butanal, Nonanal, (.+Dihydro-3-hydroxy-4,4-dimethyl-2(3 H)-furanone, 6,7-Dihydro-2,5-dimethyl-5 H-cyclopentapyrazine, (E)-2-methyl-6-(1-propenyl)-pyrazine, 2-Ethyl-3,5-dimethyl-pyrazine, 3,5-Diethyl-2-methyl-pyrazine, 2,5-Dimethyl-pyrazine were the key flavor compounds in the fried egg and gave it the popcorn and roasted flavors. The statistical analysis of the lipid profile revealed that brief, high-temperature heating (100 or 200 °C for 10 min) in typical boiled and fried quail eggs had minor effects on the lipid nutritional value. PE-related lipids, particularly those containing 18-carbon fatty acids, contributed to the aroma formation of fried quail eggs. Graphical Abstract
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Ren Yuqi,Fu Yiwei,Li Naixu,You Changjun,Huang Jie,Huang Kai,Sun Zhenkun,Zhou Jiancheng,Si Yitao,Zhu Yuanhao,Chen Wenshuai,Duan Lunbo,Liu Maochang
H 2 O dissociation plays a crucial role in solar-driven catalytic CO 2 methanation, demanding high temperature even for solar-to-chemical conversion efficiencies <1% with modest product selectivity. Herein, we report an oxygen-vacancy (V o ) rich CeO 2 catalyst with single-atom Ni anchored around its surface V o sites by replacing Ce atoms to promote H 2 O dissociation and achieve effective photothermal CO 2 reduction under concentrated light irradiation. The high photon flux reduces the apparent activation energy for CH 4 production and prevents V o from depletion. The defects coordinated with single-atom Ni, significantly promote the capture of charges and local phonons at the Ni d -impurity orbitals, thereby inducing more effective H 2 O activation. The catalyst presents a CH 4 yield of 192.75 µmol/cm 2 /h, with a solar-to-chemical efficiency of 1.14% and a selectivity ~100%. The mechanistic insights uncovered in this study should help further the development of H 2 O-activating catalysts for CO 2 reduction and thereby expedite the practical utilization of solar-to-chemical technologies.
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Journal of Natural Medicines
·
2024
·
IF 2.5
Gao Chong,Hu Zhong-He,Cui Zhen-Yu,Jiang Yu-Chen,Dou Jia-Yi,Li Zhao-Xu,Lian Li-Hua,Nan Ji-Xing,Wu Yan-Ling
Angelica dahurica (A. dahurica) has a wide range of pharmacological effects, including analgesic, anti-inflammatory and hepatoprotective effects. In this study, we investigated the effect of A. dahurica extract (AD) and its effective component bergapten (BG) on hepatic fibrosis and potential mechanisms. Hepatic fibrosis was induced by intraperitoneal injection with carbon tetrachloride (CCl 4 ) for 1 week, and mice were administrated with AD or BG by gavage for 1 week before CCl 4 injection. Hepatic stellate cells (HSCs) were stimulated by transforming growth factor-β (TGF-β) and cultured with AD, BG, GW4064 (FXR agonist) or Guggulsterone (FXR inhibitor). In CCl 4 -induced mice, AD significantly decreased serum aminotransferase, reduced excess accumulation of extracellular matrix (ECM), inhibited caspase-1 and IL-1β, and increased FXR expressions. In activated HSCs, AD suppressed the expressions of α-SMA, collagen I, and TIMP-1/MMP-13 ratio and inflammatory factors, functioning as FXR agonist. In CCl 4 -induced mice, BG significantly improved serum transaminase and histopathological changes, reduced ECM excessive deposition, inflammatory response, and activated FXR expression. BG increased FXR expression and inhibited α-SMA and IL-1β expressions in activated HSCs, functioning as GW4064. FXR deficiency significantly attenuated the decreasing effect of BG on α-SMA and IL-1β expressions in LX-2 cells. In conclusion, AD could regulate hepatic fibrosis by regulating ECM excessive deposition and inflammation. Activating FXR signaling by BG might be the potential mechanism of AD against hepatic fibrosis.
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Nano Research
·
2024
·
IF 9.5
Song Kai-Zheng,He Xiao-Hang,Chen Zhe-Yong,Tang Ge,Huang Jin-Zhao,Jiang Feng-Lei
Environment-friendly indium phosphide (InP)-based quantum dots (QDs) with efficient red-emitting properties are sufficiently needed to satisfy the requirement of burgeoning display and lighting technology. Currently, the syntheses of InP QDs using tris(trimethylsilyl)phosphine as the precursor are highly toxic and expensive. Herein, we successfully introduced gallium (Ga) ions into tris(dimethylamino)phosphine-based red InP cores through thermally-promoted cation exchange, and the obtained Ga-doped InP cores exhibited significantly increased photoluminescence quantum yields (PLQY) of up to 26%. The existence of Ga was directly confirmed by energy-dispersive X-ray spectroscopy and X-ray photoelectron spectroscopy, and the functions of Ga were systematically studied. After subsequent coating of Ga-doped InP cores with ZnSeS and ZnS shells, the resulting Ga-InP/ZnSeS/ZnS QDs achieved a high PLQY of 62% with an emission maximum at 640 nm. In contrast, without Ga-doping, the PLQY only attained 36% using the same synthetic approach. This indicated an approximate 1.7-fold increase in PLQY. The enhancement of photoluminescence was related to the Ga 3+ , as it not only passivated surface defects of InP cores but also reduced core-shell interface stress. The Ga-InP/ZnSeS/ZnS QDs exhibited good stability towards heat treatment and ultraviolet (UV) irradiation. Moreover, the red light-emitting diode (LED) based on Ga-InP/ZnSeS/ZnS QDs performed well in a wide injected current range of 2 to 200 mA, with a maximum power efficiency of 0.68 lm/W. This work showcases Ga-doping through cation exchange as a promising strategy for enhancing the efficiency of InP-based red emitters.
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Journal of Translational Medicine
·
2024
·Vol. 22
·期 1
·1-9
·
IF 6.1
Zheng Rongji,Guan Tian,Hong Chaoqun,Yao Yao,Fang Yutong,Huang Wei,Chen Chunfa,Zeng Huancheng,Huang Jiman,Lin Hui,Chen Bingfeng,Zhang Rendong,Chen Dongmei,Ding Zhechun,Zeng Haoyu,Wu Jundong
ObjectivesSTAT3 is a transcriptional activator of breast cancer oncogenes, suggesting that it could be a potential therapeutic target for breast cancer. Therefore, this study investigated the potential application of C188-9, a STAT3 signal pathway inhibitor, in the treatment of breast cancer through a novel pre-clinical platform with patient-specific primary cells (PSPCs).Methods PSPCs were isolated from breast cancer samples obtained via biopsy or surgery from fifteen patient donors with their full acknowledgements. PSPCs were treated with C188-9 or other chemotherapeutic agents, and then analyzed with cell viability assay. Western blot assay and real-time quantitative PCR were also used to determine the expression and activity of STAT3 signaling pathway of corresponding PSPCs.Results C188-9 treatment at normal (experimental) concentration had valid inhibition on PSPCs proliferation. Meanwhile, treatment at a low (clinic-relevant) concentration of C188-9 for an extended period reduced cell viability of PSPCs still more than some of other traditional chemotherapy drugs. In addition, C188-9 decreased expression level of pSTAT3 in PSPCs from some, but not all patient samples. The treatment of C188-9 reduced cell viability of the breast cancer samples through inhibiting the STAT3 to C-myc signaling pathway.Conclusion sIn this study, we tested a novel drug C188-9 at a low, clinic-relevant concentration, together with several traditional chemotherapy agents. PSPCs from ten out of fifteen patient donors were sensitive to C188-9, while some of traditional chemotherapy agents failed. This finding suggested that C188-9 could have treatment effects only on those ten PSPC patient donors, indicating the future personalized utilization of PSPCs.
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