CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Ning Yu,Ting Wang,Cheng-Xu Xu,Xue Gou,Ying-Jiao Zhan,Wenli An,Zhi-Cheng Fu,Jinni Deng,Hai-Bo Zhao,Ming-Jun Chen
Rigid polyurethane foam (RPUF), a commonly employed thermal insulation material in buildings, is highly flammable, however, incorporating flame-retardant additives or fillers is significantly limited by their incompatibility, low effectiveness and negative impact on thermal insulation properties. Herein, a novel and simple interfacial bonding and in-situ packing strategy has been proposed to introduce self-intumescent biomass aerogel particles into RPUF. The result aerogel/RPUF composite manifested continuous and “sea-island” pore structures with a firm bonding interface between aerogel and RPUF due to the highly reactive activity between biomass chains (amino and hydroxyl groups) and isocyanate. Benefitting from the intricate thermal conductive paths and enhanced interface resistance, introducing aerogel particles can reduce the thermal conductivity from 36.5 mW·m −1 ·K −1 (RPUF) to 28.6 mW·m −1 ·K −1 , dropped by 21.6 %. Moreover, the aerogel/RPUF composite manifested excellent flame retardancy with a limiting oxygen index of 28 %, a significantly reduced peak heat release rate (−38.0 %) and smoke production (−54.0 %), as well as enhanced compressive strength (+93.7 %). This work provided new insight into fabricating RPUF composites with integrated advantages of high flame-retardant efficiency and outstanding thermal insulation.
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TRIBOLOGY LETTERS
·
2024
·Vol. 73
·期 1
·1-11
·
IF 2.9
Xu Wenya,Yang Guangbin,Zhang Shengmao,Zhang Yujuan,Fan Shuguang,Yu Laigui,Zhang Pingyu
Vegetable oil-based lubricants have a tendency to replace traditional petroleum-based lubricants due to their biodegradability, high flash point, low volatility, and low cost. However, polar molecules such as fatty acids in vegetable oil compete for adsorption with nanoparticles during rubbing process, resulting in imperfect tribological performance of nanoparticles. Magnetic nanoadditives can be adsorbed on the contact surface of iron-based friction materials through magnetic effects, which provides a new idea for solving competitive adsorption problems between additives and base oil. In this study, Ni nanoparticles with a particle size of approximately 15.6 nm were synthesized in-situ in olive oil using nickel acetylacetone as the nickel source and olive oil as the modifier and solvent required for the reaction, which is a simple, efficient, and environmentally friendly in-situ synthesis method. The as-synthesized Ni nanoparticles can significantly improve the antiwear capabilities of olive oil, reducing the wear scar diameter by 30%. The morphology and elemental analysis of wear scar indicated that a composite tribofilm including nickel, nickel oxide, iron oxide, carbon film, and polar fatty acid molecules in olive oil is formed on the rubbing surface, greatly improving the antiwear performance, which opens up an opportunity for the further application of new green nanolubricants.
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Food & Function
·
2024
·Vol. 15
·期 11
·6068-6081
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IF 5.1
Haonan Yu,Zhenyou Lou,Tingbo Wu,Xiaochun Wan,Haitao Huang,Yuanyuan Wu,Bo Li,Youying Tu,Puming He,Junsheng Liu
Epigallocatechin gallate (EGCG), a prominent bioactive compound found in tea, offers numerous health benefits. Previous studies have highlighted its potential in mitigating hyperuricemia. In this study, hyperuricemic mice induced by potassium oxonate (PO) were treated with EGCG or the anti-hyperuricemia medication allopurinol (AP) to investigate the mechanisms underlying their anti-hyperuricemic effects. The results demonstrated that both EGCG and AP significantly reduced serum uric acid (UA) levels. Further analysis revealed that EGCG promoted the expression of UA secretion transporter genes (Oat1 and Oct1) while inhibiting the expression of UA reabsorption transporter genes (Urat1 and Glut9) in the kidney. By 16S rDNA sequencing, EGCG, but not AP, was found to alter the composition of the gut microbiota. Notably, EGCG induced significant changes in the relative abundance of specific bacteria such as Lactobacillus, Faecalibaculum, and Bifidobacterium, which displayed high correlations with serum UA levels and UA-related gene expression. Metabolomic analysis suggested that EGCG-induced modifications in bacterial metabolites might contribute to the alleviation of hyperuricemia. Transcriptomic analysis of the intestinal epithelium identifies 191 differentially expressed genes (DEGs) in EGCG-treated mice, including 8 purine-related genes. This study elucidates the anti-hyperuricemic mechanisms of EGCG, particularly its influence on the gut microbiota and gene expression in the intestinal epithelium.
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Translational Andrology and Urology
·
2024
·Vol. 13
·期 9
·2055
·
IF 1.9
Shoubin Li,Chunhong Yu,Helong Xiao,Qingle Xu,Bo Gao,Liuxiong Guo,Zhanxin Sun,Junjiang Liu
Background Benign prostatic hyperplasia (BPH) is a common disease among older men characterized by non-malignant proliferation of epithelial cells and inflammation. Nitric oxide synthase traffic inducer (NOSTRIN) is a pleiotropic regulator of endothelial cell function and signaling and exerts anti-inflammatory, anti-proliferation, and modulating nuclear factor-kappa B (NF-κB) signaling effects. Its expression and function in BPH tissues and prostate epithelial cells are unknown. The study aims to investigate the expression and functions of NOSTRIN in BPH, and its possible molecular mechanism. Methods The BPH model was constructed in male Institute of Cancer Research (ICR) mice using 5 mg/kg/day testosterone propionate (TP) for 30 days, and the model was evaluated by detecting prostate index, prostate epithelial thickness, and prostate-specific antigen (PSA) expression. Dihydrotestosterone (DHT, 10 nM)-induced in vitro model of human prostate epithelial cells (RWPE-1) was established. We generated lentivirus-harboring human NOSTRIN . The mRNA expression was detected by real-time quantitative polymerase chain reaction (PCR) assay; the protein expression or localization was detected by western blot assay, immunohistochemistry, or immunofluorescence staining. Cell proliferation was assayed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and 5-ethynyl-2'-deoxyuridine (EdU) staining. Reactive oxygen species (ROS) production was observed by dihydroethidium staining. Nitric oxide (NO) and malondialdehyde (MDA) levels and superoxide dismutase (SOD) activity were detected using commercial kits. Enzyme-linked immunosorbent assay (ELISA) was used to determine levels of interleukin 1 beta (IL1B), interleukin 6 (IL6), interferon gamma (IFNG), and tumor necrosis factor (TNF). Results NOSTRIN expression was significantly inhibited in the TP-induced ICR mouse BPH model and DHT-induced model of RWPE-1 proliferation. Protein expression of the BPH-related and proliferation markers PSA and proliferating cell nuclear antigen (PCNA) was suppressed in NOSTRIN-overexpressing RWPE-1 cells exposed to DHT. NOSTRIN overexpression notably inhibited the RWPE-1 cell proliferation in vitro , as evidenced by MTT and EdU staining. NOSTRIN overexpression significantly decreased the expression of cell cycle-related proteins cyclin dependent kinase 4 (CDK4) and cyclin D1 (CCND1) in vitro . The production of ROS, NO, and lipid peroxidation products MDA was inhibited by NOSTRIN overexpression in vitro , while the SOD activity was increased. NOSTRIN overexpression reduced the mRNA expression of inflammatory mediator nitric oxide synthase 2 (NOS2) and inhibited the mRNA expression and secretion of pro-inflammatory cytokines IL1B, IL6, IFNG, and TNF in vitro . The mechanistic studies revealed an increased phosphorylation of NF-κB p65 in vivo and in vitro . Remarkably, NOSTRIN overexpression notably inhibited the protein expression of phospho-NF-κB p65 in vitro . Conclusions NOSTRIN is involved in BPH by inhibiting proliferation, oxidative stress, and inflammation in prostate epithelial cells. These functions may act through the inhibition of NF-κB signaling.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Juan Zhai,Zihan Li,Hengyang Mao,Xiuyang Zou,Shouyong Zhou,Meisheng Li,Minghui Qiu,Yan Zhang,Shanshan Xia,Yijiang Zhao
The surge in oil-in-water (O/W) emulsions poses a threat to the ecological environment. Membrane separation technology can achieve complete O/W emulsion separation through size sieving; however, its efficiency is limited by membrane fouling. In this study, an efficient O/W separation membrane with passive and positive anti-fouling properties was fabricated using Fe 3 O 4 functionalized attapulgite (ATP) nanofibers. The anti-fouling mechanism of the multifunctional membranes for the separation of various O/W emulsions was studied. During separation process, a hydration layer, which mitigates oil adhesion with binding energy as low as −169 kcal·mol −1 , forms on the interface of Fe 3 O 4 -ATP. When a cationic surfactant is present, positively charged oil droplets are attracted to the membrane surface, where they compress against each other, leading to demulsification and escape. Synergistic effects including electrostatic shielding, interaction energy, and steric hindrance were demonstrated through characterization and simulation. Our findings showed that the membrane exhibited a high filtration efficiency with an oil rejection of over 99 % and a steady flux of over 73 % of its initial value. After filtration, oil fouling degraded into smaller sizes and escaped from the membrane structure through the Fenton-like catalytic function of Fe 3 O 4 , resulting in a flux recovery ratio of up to 90 %. This study provides a reference for the construction of multifunctional membranes for efficient separation processes and advancing anti-fouling research on membrane interfaces.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Ying Liang,Zi Wang,Deyang Huo,Jun-nan Hu,Lingjie Song,Xiaochi Ma,Shuang Jiang,Wei Li
In recent years, there has been a growing concern regarding health issues arising from exposure to nanoplastics (Nps) in the natural environment. The Nps bioaccumulate within the body via the circulatory system and accumulate in the liver, resulting in damage. Previous studies have demonstrated that maltol, derived from red ginseng (Panax ginseng C.A. Meyer) as a Maillard product, exhibits hepatoprotective effects by alleviating liver damage caused by carbon tetrachloride or cisplatin. In order to explore the specific mechanism of maltol in improving hepatotoxicity induced by Nps, mice exposed to 100 mg/kg Nps were given maltol at doses of 50 and 100 mg/kg, respectively. The results showed that Nps induced an increase in the levels of liver apoptotic factors BAX and cytochrome c, a decrease in the levels of the autophagy key gene LC3 II/I, and an increase in P62. It also caused oxidative stress by affecting the Nrf2/HO-1 pathway, and a decrease in GPX4 protein expression suggested the occurrence of ferroptosis. However, treatment with maltol significantly improved these changes. In addition, maltol (2, 4, and 8 μM) also protected human normal liver L02 cells from Np (400 μg/mL)-induced damage. Our data suggest that maltol could ameliorate Np-induced L02 cytotoxicity by reducing autophagy-dependent oxidative stress, exhibiting similar protective effects in vitro as in vivo. This study helps shed light on the specific molecular mechanism of Np-induced hepatotoxicity. For the first time, we studied the protective effect of maltol on Np-induced liver injury from multiple perspectives, expanding the possibility of treatment for diseases caused by environmental pollutants.
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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
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2024
·
IF 3
Zou Yanyan,Pau Dennis,Yi Linlin,Li Yaoqiang,Li Kaiyuan
13X zeolite–calcium oxide (CaO) composite capture agent application in the pyrolysis recovery of polyvinyl chloride (PVC)-based waste cables was investigated in this research to elucidate the agent’s efficiency in capturing chlorine (Cl) and carbon (C) during pyrolysis. The 13X zeolite–CaO mixture is subjected to separate pyrolysis of the PVC-based cable outer sheath in experimental furnaces of simulated solar-powered and thermogravimetry. Subsequently, a range of spectroscopic techniques are employed to quantitatively analyze the gaseous and solid products resulting from the pyrolysis process. Through X-ray fluorescence, total carbon, and other analyses, the research outcomes demonstrated that the capture agent exhibits superior Cl and C capture performance compared to using a single agent for plastic pyrolysis. The yield of Cl element in the solid residue has increased significantly by 130–140% under the presence of optimized composite capture agent. By determining the dynamic changes of gaseous and solid products during the cable outer sheath pyrolysis, the influence of the capture agent on the redistribution and transformation mechanisms of Cl and C elements was identified, and it was found that contaminating volatiles were well immobilized in the solid residue. This research provides a new solution for efficient Cl and C capture in the pyrolysis recovery of waste cables and determines the fixation and transformation mechanisms of Cl and C elements by the composite capture agent, indicating a potential for feasible and sustainable resource utilization of waste cables.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yao Chen,Xin Chen,Kaicheng Zhang,Yong Liu,Gaorong Han,Gang Xu
Rechargeable aqueous zinc-ion batteries (RAZIBs) have attracted considerable attention for application in large-scale energy storage systems. However, the progress of RAZIBs has been hindered by the sluggish reaction kinetics and poor structural stability, which are closely associated with the desolvation process of hydrated Zn 2+ . To overcome these issues, an in situ interfacial polymerization strategy is proposed to uniformly germinate a polyaniline (PANI) layer on α-MnO 2 and form an organic–inorganic hybrid cathode (MnO 2 @PANI). Theoretical calculations and experimental characterizations disclose that the polyaniline layer equipped with hydrophilic functional groups can effectively trap the active water molecules to break the strong attraction between H 2 O and Zn 2+ , thereby facilitating the desolvation process of hydrated Zn 2+ , and regulating the Zn 2+ diffusion kinetics and electrode reaction kinetics on the cathode/electrolyte surface. Meanwhile, the irreversible phase evolution and dissolution of active species are largely suppressed due to the PANI shell protecting the α-MnO 2 from the attack of active water molecules. As a consequence, the organic–inorganic hybrid cathode exhibits 401.9 mAh/g after 200 cycles at a current density of 0.5 A/g and long-term durability over 1000 cycles at a current density of 2.0 A/g without irreversible phase transformation. This work provides insight into the regulation of the desolvation process for high performance aqueous energy storage systems.
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TOXICOLOGY AND APPLIED PHARMACOLOGY
·
2018
·
IF 3.616
Linlin Zhang,Huizong Su,Yue Li,Yujuan Fan,Qian Wang,Jian Jiang,Yiyang Hu,Gaofeng Chen,Bo Tan,Furong Qiu
The aim of this study was to determine the effect of ursodeoxycholic acid (UDCA) on the alpha-naphthylisothiocyanate (ANIT)-induced acute and recovery stage of cholestasis model mice. In the acute stage of model mice, pretreatment with UDCA (25, 50, and 100 mg·kg −1 , ig) for 12 days prior to ANIT administration (50 mg·kg −1 , ig) resulted in the dramatic increase in serum biochemistry, with aggrevation of bile infarcts and hepatocyte necrosis. The elevation of beta-muricholic acid (β-MCA), cholic acid (CA), and taurocholic acid (TCA) in serum and liver, and reduction of these bile acids (BAs) in bile was observed. In contrast, in the recovery stage of model mice, treatment with UDCA (25, 50, and 100 mg·kg −1 , ig) for 7 days after ANIT administration (50 mg·kg −1 , ig) resulted in the significant decrease in levels of serum alanine aminotransferase (ALT) and total bile acid (TBA). Liver injury was attenuated, and the levels of TBA, CA, TCA, and β-MCA in the liver were significantly decreased. Additionally, UDCA can upregulate expression of BSEP, but it cannot upregulate expression of AE2. UDCA, which induced BSEP to increase bile acid-dependent bile flow, aggravated cholestasis and liver injury when the bile duct was obstructed in the acute stage of injury in model mice. In contrast, UDCA alleviated cholestasis and liver injury induced by ANIT when the obstruction was improved in the recovery stage.
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RSC Advances
·
2018
·Vol. 8
·期 16
·8805-8812
·
IF 2.936
Pengfei Wu,Yuanyuan Tang,Zongwei Cai
Coal fly ash is usually used as a cost-effective adsorbent for heavy metal removal, accumulating large amounts of spent coal fly ash that requires further disposal. In this study, fly ash that adsorbs copper with a maximum copper adsorption capacity of 48.8 mg g−1 was further sintered at 900–1050 °C, and it was found that the copper is thermally incorporated in a spinel structure in aluminum- and iron-containing ceramic matrices provided by the fly ash. To further explore the immobilization mechanisms of copper in both aluminum- and iron-containing ceramic matrices like those in fly ash, two systems were prepared from CuO + Fe2O3 + kaolinite and CuO + Fe2O3 + Al2O3. A CuAlxFe2−xO4 spinel solid solution was formed, the peak intensity of which was found to increase upon an increase in the sintering temperature until a maximum amount was reached at 1150 °C. In the CuO + Fe2O3 + Al2O3 system, the 2θ value of the CuAlxFe2−xO4 peaks was found to increase due to the continuous engagement of aluminum in the spinel structure. However, iron was found to be more likely to react with the copper in CuO + Fe2O3 + kaolinite during the formation of CuAlxFe2−xO4. Through effective adsorption of copper on coal fly ash and the subsequent copper stabilization in the spinel, this study found a dual role for fly ash in copper immobilization and further confirmed the potential to recycle waste coal fly ash as a marketable ceramic material.
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ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Xilin Bai,Suying Xu,Leyu Wang
The sensitive and selective detection of hydrogen sulfide is of great importance due to its crucial role in pathological and physiological processes. Herein, we report a novel fluorescent platform, AuNCs@GC, for selective detection of hydrogen sulfide in living cells by impregnating the Au nanoclusters (AuNCs) into a biocompatible cationic polymer matrix, glycol-chitosan (GC) nanogel. The confinement effect significantly increased the emissive Au(I) units, resulting in a 6-fold enhancement of quantum yield (from 6.38% to 36.42%). In addition, the prepared positively charged AuNCs@GC nanogel exhibits excellent selectivity and improved sensitivity to aqueous sulfides. Moreover, the as-fabricated AuNCs@GC showed very good biocompatibility and super fluorescence stability across the full pH range and good salt tolerance, which demonstrated excellent adaptability toward intracellular sulfide imaging.
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Biomaterials Science
·
2017
·Vol. 6
·期 2
·340-349
·
IF 4.21
Luyao Sun,Wendong Gao,Xiaoling Fu,Miao Shi,Weihan Xie,Wen Zhang,Fujian Zhao,Xiaofeng Chen
Nanofibrous scaffolds that offer proper microenvironmental cues to promote the healing process are highly desirable for patients with chronic wounds. Although studies have shown that fiber organization regulates cell behaviors in vitro, little is known about its effects on the wound healing process in vivo. Most of the nanofibrous scaffolds currently used in skin repair are randomly oriented. Herein, inspired by the basketweave-like pattern of collagen fibrils in native skin, we fabricated biomimetic nanofibrous scaffolds with crossed fiber organization via electrospinning. The regulation of crossed nanofibrous scaffolds on fibroblasts was compared with that of aligned and random nanofibrous scaffolds. Unexpectedly, crossed nanofibrous scaffolds induced different cellular responses in fibroblasts, including differences in cellular morphology, migration and wound healing related gene expression, in comparison to either aligned or random nanofibrous scaffolds. More importantly, the regulation of nanofibrous scaffolds with different fiber organizations on wound repair was systematically investigated in diabetic rats. While the healing processes were enhanced by all nanofibrous scaffolds, wounds treated with crossed nanofibrous scaffolds achieved the best healing outcome, which was evidenced by the resolution of inflammation, the accelerated migration of fibroblasts and keratinocytes, and the promotion of angiogenesis. These findings helped reveal the role of fiber organization in regulating the wound healing process in vivo and suggest the potential utility of biomimetic crossed nanofibrous scaffolds for the repair of chronic wounds.
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