Neural Regeneration Research
·
2026
·
IF 8.5
Zhou Yiyang,Chen Zihao,Chen Keyang,Xiong Fen,Gao Hongchang
Post-stroke cognitive impairment is a severe sequela of cerebral ischemia, with its underlying mechanisms remaining elusive and specific diagnostic biomarkers currently lacking. Growing evidence suggests that secondary neurodegeneration is closely associated with post-stroke cognitive impairment, although its metabolic basis has not been fully elucidated. Therefore, this study aimed to investigate the spatiotemporal changes and metabolic characteristics of secondary neurodegeneration and cognitive function after cortical stroke. We established a photothrombotic mouse model for post-stroke cognitive impairment research and conducted longitudinal assessments with final endpoints at 14, 32, and 84 days postsurgery. Voxel-based morphometry analysis of whole-brain regions using magnetic resonance imaging revealed that only the hippocampus exhibited gray matter alterations consistent with secondary neurodegeneration pathology. Morris water maze and open field tests demonstrated persistent impairments in recent and remote memory, along with anxietylike behaviors in photothrombotic mice. Untargeted metabolomic and lipidomic analyses were established to comprehensively characterize secondary neurodegeneration-related metabolic disturbances in the hippocampus, highlighting pathophysiological mechanisms involving oxidative stress, lipid peroxidation, neurotransmitter dysregulation, and disrupted energy metabolism. These important mechanisms were verified by immunohistochemistry, immunofluorescence staining, and real-time polymerase chain reaction. The screened potential biomarker, N -acetylneuraminic acid, was validated via targeted metabolomics in both photothrombotic mouse serum and 148 clinical samples, showing significant elevation in both cohorts. Receiver operating characteristic curve analysis and decision curve analysis confirmed the clinical utility of N -acetylneuraminic acid in diagnosing post-stroke cognitive impairment (area under the curve = 0.951, 95% confidence interval: 0.903–0.980). Flow cytometry and immunofluorescence staining revealed that N -acetylneuraminic acid activates microglia-driven neuroinflammation and oxidative stress. Our findings elucidate a potential pathological mechanism of post-stroke cognitive impairment: cortical stroke induces hippocampal accumulation of N -acetylneuraminic acid, which promotes microglial oxidative stress and inflammation, thereby triggering hippocampal secondary neurodegeneration and leading to persistent cognitive deficits. Importantly, N -acetylneuraminic acid serves as a dual-functional biomarker capable of predicting post-stroke cognitive impairment progression while dynamically tracking secondary neurodegeneration.
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DOI
PubMed
高影响因子
Nature Energy
·
2026
·
IF 70.1
Zhao Qiangqiang,Zhang Bingqian,Hui Wei,Gao Kun,Ji Hongpei,Sun Xiuhong,Feng Xiaopeng,Peng Cheng,Wang Kaiyu,Gao Caiyun,Zhang Chenyang,Wang Han,Zhang Qi,Su Zhenhuang,Wang Xiao,Wang Li,Pang Shuping,De Wolf Stefaan,Wang Kai
Incorporating two-dimensional (2D) perovskite phases at the interfaces of three-dimensional (3D) perovskite solar cells improves device performance. These 2D structures form in the bulk and at interfaces of the perovskite film by adding long-chain ammonium salts into the perovskite, but achieving them exclusively at the buried interface remains challenging. Here we sequentially graft thioglycolic acid and oleylamine onto SnO 2 nanoparticles. The strong chemical bond between thioglycolic acid and oleylamine ensures that cation exchange with formamidinium iodide, a perovskite precursor, occurs only during thermal annealing, creating a 2D/3D perovskite structure solely at the bottom interface. This localized 2D layer accelerates 3D phase formation, enhances perovskite crystallization and reduces defect concentration at the interface by over tenfold. The resulting solar cells achieve power conversion efficiencies of 26.19% (certified 26.04%, 0.09 cm 2 ), 23.44% (aperture area of 21.54 cm 2 , certified 22.68%) and 22.22% (aperture area of 64.80 cm 2 ), respectively.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Xinxin Wang,Jinping Xu,Mingming Zhang,Qi Yuan,Liwei Jiao,Lihua Zhi
The pursuit of efficient, durable, and cost-effective oxygen evolution reaction (OER) electrocatalysts is of great significance for advancing sustainable energy technologies. Herein, a three-dimensional hierarchical N-doped carbon nanoflower encapsulated with nickel iron selenide (Ni 3 Se 4 /FeSe HNCNF) was fabricated via selenization of the iron salts decorated nickel coordination polymers. The obtained Ni 3 Se 4 /FeSe HNCNF presents abundant heterogenous interfaces, which effectively optimize the electronic configuration, substantially expediting charge-transfer kinetics. Additionally, the hierarchical nanoflower-like N-doped carbon framework maximizes the exposure of catalytic sites and restrains nanoparticle accumulation and erosion. Benefiting from these structural and compositional advantages, Ni 3 Se 4 /FeSe HNCNF delivers remarkable OER performance in alkaline medium (1.0 M KOH), achieving a low overpotential of 280 mV at 10 mA cm -2 , along with excellent durability exceeding 27 h at 10 mA cm -2 and 100 mA cm -2 . This study highlights the potential of heterostructure engineering and three-dimensional hierarchical design in bimetallic selenides, offering new insights into the development of next-generation high-performance OER electrocatalysts.
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产品关联
DOI
高影响因子
Surfaces and Interfaces
·
2026
·
IF 6.3
Ziyu Wang,Yequn Liu,Mingjun Cui,Xinyue Li,Jiate Xue,Siming Ren
Carbon dots have attracted wide interest in corrosion fields due to their superior corrosion inhibition performance, low toxicity and tunable surface functionality. In this work, novel N-doped carbon dots (N-CDs) with dual functionalities—corrosion inhibition and corrosion warning were synthesized via a hydrothermal route and applied to protect carbon steel in strong acid environments. The corrosion inhibition performance of the N-CDs was systematically evaluated using electrochemical measurements, weight loss tests, and surface characterization techniques. Among the synthesized samples, N-CDs derived from L -phenylalanine and L -tryptophan (1:1 molar ratio) exhibited outstanding corrosion inhibition to carbon steel in 1M HCl solution, achieving higher corrosion inhibition efficiency of 96.04% at a concentration of 200 ppm in 1M HCl solution. Mechanistic studies revealed that the inhibition process involved both physisorption and chemisorption, conforming to the Langmuir adsorption isotherm. Moreover, the N-CDs displayed pronounced fluorescence quenching toward Fe³⁺ ions, enabling early-stage detection of corrosion onset. This study presents a multifunctional carbon-based nanomaterial that integrates high-performance corrosion protection with real-time corrosion monitoring, offering new prospects for advanced corrosion control in harsh environments.
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产品关联
DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2020
·
IF 8.247
Wenxin Li,Bo Yu,Yang Hu,Xinqiang Wang,Bin Wang,Xiaojuan Zhang,Dongxu Yang,Zegao Wang,Yuanfu Chen
Exploring highly efficient, stable and nonprecious electrocatalysts for both hydrogen and oxygen evolutions is greatly desirable for sustainable energy conversion, but still a huge challenge. Herein, we construct a unique three-dimensional (3D) porous electrocatalyst with hollow (Co,Fe)P nanoframes encapsulated into N,P-codoped graphene aerogel (CFP NFs@NPGA) through one-step in situ encapsulation and selective etching, followed by phosphorization. Due to its uniqure 3D porous nanoarchitecture, CFP NFs@NPGA displays superior electrocatalytic performance. As a highly efficient catalyst for hydrogen evolution reaction , the CFP NFs@NPGA catalyst only needs low overpotential of 155 mV to afford 10 mA cm −2 under alkaline condition. Meanwhile, the hybrid reveals remarkable oxygen revolution reaction activity with a small overpotential of 278 mV to afford 10 mA cm −2 in alkaline electrolyte . When adopted as both cathode and anode in overall water-splitting cell, the hybrid requires only 1.59 V to achieve 10 mA cm −2 with nearly 100% faradaic efficiency, and the experimentally measured H 2 and O 2 gas genenaration rates are about 0.18 and 0.09 mmol h −1 , respectively, showing outstanding long-term stability even over 48 h. The present results manifest that the combination of hollow nanostructure and hetero-atom-doped carbon matrix is an effective strategy to enhance water-splitting performance of transition metal phosphides.
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DOI
高影响因子
Particuology
·
2018
·
IF 2.785
Xiangyi Deng,Yali Feng,Haoran Li,Zhuwei Du,Qing Teng,Hongjun Wang
To investigate the effect of nitrogen on the photoluminescence properties of carbon quantum dots (CQDs), N-doped carbon quantum dots (N-CQDs) were synthesized by one-step hydrothermal treatment using biomass tar as the carbon precursor. As an inevitable organic pollutant, the unsaturated bonds in biomass tar, such as carboxylic acids, aldehydes, and aromatics, are favorable for formation of the graphitic carbon lattice. The obtained N-CQDs are spherical with an average particle size of 2.64 nm and the crystal lattice spacing is 0.25 nm, corresponding to the (100) facet of graphitic carbon. The N-CQDs emit bright blue photoluminescence under 365 nm ultraviolet light, and they have excellent water solubility and stability with a high quantum yield of 26.1%. Coordination between the functional groups on the N-CQD surface and Fe 3+ ions is promoted because of the improved electronic properties and surface chemical reactivity caused by N atoms, leading to a significant fluorescence quenching effect of the N-CQDs in the presence of Fe 3+ ions with high selectivity and sensitivity. There is a linear relationship between ln ( F 0 / F ) and the Fe 3+ concentration in the N-CQD concentration range 0.06–1400 μmol/L with a detection limit of 60 nmol/L, showing that the N-CQDs have great potential as a fluorescent probe for Fe 3+ detection.
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DOI
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Jujun Yuan,Meiqi Mu,Xijun Xu,Yunfei Gan,Haishan He,Xianke Zhang,Xiaokang Li,Fanguang Kuang,Haixia Li,Jun Liu
The three-dimensional (3D) FeS@N doped Carbon (NC) nanosheets are successfully synthesized using a simple sol-gel method followed by a solid sulfidation process. As SIBs anode, the 3D FeS@NC nanosheets exhibit a maintainable capacity (254 mAh g −1 at 1.5 A g −1 upon 1100 cycles) and outstanding rate behaviour. As PIBs anode, the 3D FeS@NC nanosheets also exhibit a maintainable capacity (120 mAh g −1 at 1 A g −1 upon 1100 cycles) and outstanding rate behaviour. The excellent electrochemical performance can be attributed to the distinctive 3D porous FeS@NC nanosheets, which can inhibit the aggregation and pulverization of FeS, enhance electronic/ionic conductivity, firmly immobilize the dissolved polysulfides , and provide a larger contact area between active materials and electrolytes. Moreover, the N-doped carbon framework can also provide substantial active sites for Na + (K + ) storage. Our synthesizing strategy can be potentially utilized for fabricating other 3D metal sulfide@C composites for SIB (PIB) anodes.
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DOI
高影响因子
APPLIED THERMAL ENGINEERING
·
2019
·
IF 4.026
Jun Li,Lisi Jia,Ying Chen,Longjian Li,Songping Mo,Jiacheng Wang,Chao Wang
An easy two-stage approach was proposed to prepare microencapsulated phase-change materials (MEPCMs) with n-heptadecane as the core and hexanediol diacrylate (HDDA) polymer as the shell in a co-flowing microfluidic device. The micromorphology and chemical compositions of the MEPCMs were investigated by scanning electron microscopy and Fourier transform infrared spectroscopy, respectively. The results showed that the shell of HDDA polymer was successfully fabricated upon n-heptadecane core. The obtained MEPCMs had regular spherical shape, smooth surface, and uniform particle size. The coefficient of variation in size was within the 2% limit. The thermal energy storage properties of the MEPCMs were investigated by differential scanning calorimetry. The results revealed that the MEPCMs with HDDA shell had good phase-change performance, high thermal-storage capability. The thermogravimetric analysis and thermal cycling test consisted with 100 heating/cooling processes were conducted to investigate the thermal stability of the MEPCMs. The results showed that the HDDA shell of MEPCMs was able to provide good protection for the core material of n-heptadecane. The excellent thermal stability of the MEPMCs was confirmed by the absence of n-heptadecane leakage. These advantageous properties make the MEPCMs with HDDA shell potential materials for thermal energy storage applications.
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DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·Vol. 15
·期 3
·2528-2538
·
IF 1.5
Wenhui Geng,Mengmeng Zheng,Dan Chen,Xianwen Wang,Zekai Zhang,Yishan Lin,Dongqin Cai,Huiqin Li,Guobo Huang,Yanxian Jin Yu,Binbin Yus
Palladium catalyst (Pd) are made attention to application in alcohol fuel cells due to unique performance, as well as the resource abundance and low cost, but the catalyst performance and stability of the catalysts are still not satisfied. In this article, the novel PdFe/B-N-G catalysts with the double element alloying and dual-doping for ethanol electro-oxidation are successfully prepared and determined by XRD, TEM and XPS. TEM results reveal a relatively uniform and high dispersion of Pd particles is observed on PdFe/B-N-G catalyst. The XPS analysis indicates that Pd(0) contents of the PdFe/B-N-G catalyst are increased on account of the B, N-doping effect. Being explored as the catalyst to the ethanol oxidation reactions, the PdFe/B-N-G catalysts exhibit the better electrocatalytic activity with higher current densities and catalyst stability compared to those of PdFe/G and Pd/B-N-G, which can be attributed to the synergistic effect of the enhanced PdFe alloying and the B, N-doping, that can produce more activity sites dispersing on the surface of graphene. Thus, the novel PdFe/B-N-G catalysts can be the potential alternate in alcohol fuel cells.
研究领域:
电化学
·
纳米催化
·
能源材料
·
燃料电池
·
表面科学
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DOI
高影响因子
DYES AND PIGMENTS
·
2021
·
IF 4.889
You Liu,Fang Liu,Jungan Wang,Hongyan Huang,Suhao Yan,Song Gao,Lin Wang,Wei Huang,Tianshi Qin
Wide-bandgap photovoltaics (WBPV) could not only provide electrical energy by photoelectronic conversion of the invisible part of the solar spectrum, but also usually had the unique advantage of high open circuit voltage ( V oc). In this work, we reported a novel HTM based on tetrakis (N-phenothiazine) Spirobifluorene (Spiro-PT), its HOMO energy level could be well matched with MAPbBr 3 perovskite HOMO energy level. This HTM could effectively suppress nonradiative recombination, which leads to an increase in the photovoltage of WBPV to more than 1.41 V. As a result, the n-i-p mesoscopic structured WBPV achieved a champion PCE of 7.36% as well as excellent operational stability exhibiting 91% of initial efficiency after 500 h continuous illumination without encapsulation. Based on the high V oc of the MAPbBr 3 /Spiro-PT device, the photovoltaic electrochromic device showed a response speed (the average coloring time was 40 s and the bleaching time was 272 s) and high average visible light transmittance contrast (about 37% in 450–780 nm), the corresponding electrochromic device with maximum dynamic contrast up to 46% at 600 nm between bleached and colored states. This WBPV-powered electrochromic system could provide a pathway towards stand-alone smart window technique for future energy-saving buildings.
研究领域:
材料科学
·
光伏技术
·
纳米能源
·
智能窗技术
·
器件物理
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DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2021
·
IF 5.316
Xiaoyan Yuan,Aiming Sha,Shengyan Huang,Hui Zhao,Xu Chen,Yi Zhang,Shouwu Guo
Carbon nanofibers are widely used for electromagnetic wave (EMW) absorption. However, it is still worthy attention for rationally optimizing their permittivity. Herein, a satisfactory EMW absorber of few-layer BN nanosheets decorated N-doped carbon nanofibers (BNNS-CNFs) was successfully prepared by electrospinning-assisted synthetic technology. The permittivity of CNFs can be adjusted by introducing of BNNS and N-doped in carbon matrix. As a EMW absorber, BNNS-CNFs/paraffin hybrid with a low filling ratio of 10 wt% shows excellent absorption performances. The minimum reflection loss (RL) is about −58.41 dB at a thickness of 1.6 mm and the widest absorption bandwidth (RL<−10 dB) of 5.76 GHz can be obtained at 1.75 mm. The significant enhancement of EMW absorption performance is mainly attributed to the improvement of impedance match and multiple polarizations after introduction of BNNS and more defects by N-doped. Thus, BNNS-CNFs with lightweight and wide-band at low load content would be utilized as a high-efficiency EMW absorber.
研究领域:
材料科学
·
电磁功能材料
·
纳米复合材料
·
能量吸收
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Xinxin Lin,Peng Peng,Jianing Guo,Zhonghua Xiang
This study exploits an effective mechanochemical process (termed as reaction milling) to conduct Schiff-based coupling reaction with melamine and terephthalaldehyde for the synthesis of covalent organic polymer (RM-COP) as the carbon skeleton and the derivative phosphorus doped material (RM-COP-PA). Comparing with the tradition solvothermal method with reaction time of 3 days under 120 °C, the newly developed reaction milling method significantly shorten the reaction time of the synthesis to 3 h under room temperature as well as bypassing the usage for hazardous solvents. The space-time yield of the developed reaction milling method for synthesis of the bifunctional electrocatalytic precursor reaches 189 kg m −3 day −1 . Significantly, the optimal products followed by further carbonization (RM-COP-PA-900) demonstrated excellent bifunctional electrocatalytic activities for an efficient ORR performance with similar commercialized Pt/C half-potential of 841 mV vs RHE as well as an IrO 2 -like OER activity with a potential of 1.69 V at 10 mA cm −2 in alkaline media, which is better than most metal-free bifunctional catalysts. Moreover, the obtained RM-COP-PA-900 exhibits much better durability and resistance to crossover effect even than the commercial 20 wt% Pt/C catalysts. Therefore, this work will open up a rapid, solvent-free and scalable approach for, but not limit to, highly efficient electrocatalysts.
研究领域:
材料科学
·
电化学
·
可持续化学
·
能源材料
·
纳米技术
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DOI
高影响因子
危险品化学品经营许可证（带存储）