Nature Nanotechnology
·
2019
·Vol. 14
·期 4
·379-387
·
IF 33.407
Gong Ningqiang,Ma Xiaowei,Ye Xiaoxia,Zhou Qunfang,Chen Xiaoai,Tan Xiaoli,Yao Shengkun,Huo Shuaidong,Zhang Tingbin,Chen Shizhu,Teng Xucong,Hu Xixue,Yu Jie,Gan Yaling,Jiang Huaidong,Li Jinghong,Liang Xing-Jie
Mitochondrial redox homeostasis, the balance between reactive oxygen species and antioxidants such as glutathione, plays critical roles in many biological processes, including biosynthesis and apoptosis, and thus is a potential target for cancer treatment. Here, we report a mitochondrial oxidative stress amplifier, MitoCAT-g, which consists of carbon-dot-supported atomically dispersed gold (CAT-g) with further surface modifications of triphenylphosphine and cinnamaldehyde. We find that the MitoCAT-g particles specifically target mitochondria and deplete mitochondrial glutathione with atomic economy, thus amplifying the reactive oxygen species damage caused by cinnamaldehyde and finally leading to apoptosis in cancer cells. We show that imaging-guided interventional injection of these particles potently inhibits tumour growth in subcutaneous and orthotopic patient-derived xenograft hepatocellular carcinoma models without adverse effects. Our study demonstrates that MitoCAT-g amplifies the oxidative stress in mitochondria and suppresses tumour growth in vivo, representing a promising agent for anticancer applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NATURE METHODS
·
2025
·
IF 32.1
Cao Ruijie,Li Yaning,Zhou Yao,Li Meiqi,Lin Fangrui,Wang Wenyi,Zhang Guoxun,Wang Gang,Jin Boya,Ren Wei,Sun Yu,Zhao Zhifeng,Zhang Wei,Sun Jing,Hou Yiwei,Xu Xinzhu,Hu Jiakui,Shi Wei,Fu Shuang,Liang Qianxi,Lu Yanye,Li Changhui,Zhao Yuxuan,Li Yiming,Kuang Dong,Wu Jiamin,Fei Peng,Qu Junle,Xi Peng
In fluorescence microscopy, a persistent challenge is the defocused background that obscures cellular details and introduces artifacts. Here, we introduce Dark sectioning, a method inspired by natural image dehazing for removing backgrounds that leverages dark channel prior and dual frequency separation to provide single-frame optical sectioning. Unlike denoising or deconvolution, Dark sectioning specifically targets and removes out-of-focus backgrounds, stably improving the signal-to-background ratio by nearly 10 dB and structural similarity index measure of images by approximately tenfold. Dark sectioning was validated using wide-field, confocal, two/three-dimensional structured illumination and one/two-photon microscopy with high-fidelity reconstruction. We further demonstrate its potential to improve the segmentation accuracy in deep tissues, resulting in better recognition of neurons in the mouse brain and accurate assessment of nuclei in prostate lesions or mouse brain sections. Dark sectioning is compatible with many other microscopy modalities, including light-sheet and light-field microscopy, as well as processing algorithms, including deconvolution and super-resolution optical fluctuation imaging.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
·
2024
·Vol. 17
·期 1
·1-15
·
IF 31.6
Yin Hao,Li Yanting,Tian Zhiying,Li Qichao,Jiang Chenhui,Liang Enfu,Guo Yiping
Monitoring minuscule mechanical signals, both in magnitude and direction, is imperative in many application scenarios, e.g., structural health monitoring and robotic sensing systems. However, the piezoelectric sensor struggles to satisfy the requirements for directional recognition due to the limited piezoelectric coefficient matrix, and achieving sensitivity for detecting micrometer-scale deformations is also challenging. Herein, we develop a vector sensor composed of lead zirconate titanate-electronic grade glass fiber composite filaments with oriented arrangement, capable of detecting minute anisotropic deformations. The as-prepared vector sensor can identify the deformation directions even when subjected to an unprecedented nominal strain of 0.06%, thereby enabling its utility in accurately discerning the 5 μm-height wrinkles in thin films and in monitoring human pulse waves. The ultra-high sensitivity is attributed to the formation of porous ferroelectret and the efficient load transfer efficiency of continuous lead zirconate titanate phase. Additionally, when integrated with machine learning techniques, the sensor’s capability to recognize multi-signals enables it to differentiate between 10 types of fine textures with 100% accuracy. The structural design in piezoelectric devices enables a more comprehensive perception of mechanical stimuli, offering a novel perspective for enhancing recognition accuracy.
✓ 已验证
DOI
高影响因子
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
·
2024
·Vol. 23
·期 4
·651-664
·
IF 2.7
Wu Zhiwen,Xie Zongbo,Zhu Ye’an,Wang Bo,Nie Yidan,Qiu Jialin,Le Zhanggao
Manufacturing high-performance and reusable materials from radioactive uranium-containing wastewater remains a significant challenge. Herein, a supramolecular self-assembly strategy was proposed, using melamine and cyanuric acid as precursors and using intermolecular hydrogen bond force to form carbon nitride (CN–D) in different solvents through a single thermal polymerization strategy. Supramolecular self-assembly method is a promising strategy to synthesize a novel carbon nitride with molecular regulatory properties. In addition, 98% of U(VI) in wastewater can be removed by using CN–D for 60 min under visible light. After five cycles of recycling, more than 95% of U(VI) can still be reduced, indicating that it has good recyclability and reusability. This study not only provides an efficient photocatalytic method of uranium reduction, but also provides a new method for self-assembly synthesis.
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2024
·Vol. 39
·期 9
·1449-1461
·
IF 2.7
Zhang Yeheng,Lin Wensong,Gao Ran,Lin Huanxia,He Yong
One-step co-precipitation method was used to prepare the flower-like BiOCl/BiOBr composite materials (BOBCs) with heterojunction structures, in which various amounts of BiOBr were used to adjust the band gap of BiOCl and thereby improve its photocatalytic activity. Based on photocatalytic performance experiments, BOBC2, in which the molar ratio of BiOCl to BiOBr is 1:0.75, exhibited the highest photodegradation efficiency (90.5%) to remove ofloxacin after 100 min illumination. The cyclic utilization performance of BOBC2 under the same conditions was tested by a cycle experiment. It was found that its photocatalytic activity remained at a high level after three cycles. The composition and microstructure of the material were analyzed by characterization techniques including XRD, FTIR, XPS, and SEM. The optical properties and the degradation process of the material were studied by DRS, PL, photocurrent, and active species trapping methods. The reasonable mechanism for photocatalytic degradation of ofloxacin was proposed. Graphical abstract
✓ 已验证
DOI
高影响因子
FIBERS AND POLYMERS
·
2023
·Vol. 24
·期 10
·3527-3536
·
IF 2.5
Feng Duchao,Qiao Luyang,Sun Guangdong,Hong Kangjing,Wu Mingyue,Wang Chenglong,Zheng Jinhuan
A magnetic field-driven photocurable superhydrophobic fabric coating technology was developed in this study. The coating, consisting of photoreactive carbonyl iron powder (CIP) assembled hydrophobic micro-nano structures, was constructed on the surface of polyester fabric by combining the magnetic field-driven assembly technology and blue light photocuring technology. Camphorquinone (CQ), ethyl 4-dimethylaminobenzoate (EDB) and diphenyliodonium hexafluorophosphate (DPI) were served as the photoinitiator formulation, while polyurethane diacrylate and hydroxyethyl acrylate (HEA) were used as the polymerization-cross-linking matrix for photocurable coating. Photo-differential scanning calorimetry (Photo-DSC) and rheometry were used to characterize the performance of coating formulations. Optical contact angle meter and scanning electron microscope (SEM) were used in combination with tensile performance test to explore the construction of superhydrophobic structure on coating surface induced by magnetic field. The optimal formulation of photoinitiators for coatings with excellent photopolymerization performance has been definitively established. Photocured coating film displayed a distinct hydrophobicity (the water contact angle is approx. 152.7°, and the sliding angle is approx. 7.2°) when the mass ratio of CIP to polymeric components was 1:1. The coated fabric eventually exhibited a satisfactory hydrophobicity (the water contact angle is approx. 153.3°) and mechanical properties. Graphical
✓ 已验证
DOI
高影响因子
CATALYSIS LETTERS
·
2024
·Vol. 154
·期 7
·3858-3866
·
IF 2.3
Lin Baining,Du Xuhong,Huang Zhijing,Liu Gonggang,Zhou Yonghua,Xiao Zhihong,Tu Yusong
Reducing the ignition temperature of aromatic volatile organic compounds (VOCs) is a long-term pursuit for environmental pollution treatment and industrial application. In this paper, the toluene catalytic combustion was ignited at ultra-low temperature of 73 °C over a poplar wood monolithic catalyst with highly dispersed Pd particles coated by nano-thick graphited carbon layer via in-situ carbonization. Combing the characterizations and DFT calculations, the satisfying catalytic performance could be attributed to two aspects: (i) the unrestricted mass transfer of reactant and the high dispersity of Pd were simultaneously ensured in the straight micrometer-channel with abundant surface anchoring groups of poplar wood; (ii) the nano-thick graphited carbon layer on Pd significantly enhanced the oxygen activation. Given the low cost of economic wood and facile preparation technique, this work opened up new alternative for the preparation of highly dispersed noble metal catalyst and the low temperature catalytic combustion of aromatic VOCs in industry. Graphical
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 21
·1-15
·
IF 2.8
Lu Jiaqi,Li Runkang,Cui Yi,Wang Ronglin,Lv Dongfeng,Wei Yingna,Chen Yuejun,Wei Hengyong,Bu Jinglong
Zirconium nitride nanofibers were synthesized by electrospinning method combined with carbon thermal reduction nitridation process, with zirconium chloride octahydrate and polyvinylpyrrolidone as raw materials. The phase composition, morphology and pore structure of the as-prepared nanofibers were analyzed by XRD, XPS, SEM, TEM and BET. In addition, the microwave absorption properties were measured using transmission line theory utilizing a vector network analyzer of zirconium nitride nanofibers/paraffin composites with different filler loadings. The results show that the as-prepared nanofibers are ZrN phase. The zirconium nitride nanofibers contain residual oxygen and carbon to form Zr(N,C,O) solid solution. The average diameter of the nanofibers is approximately 300 nm. There are particles distributed in it and the particle size ranges from 100 to 200 nm. The specific surface area of zirconium nitride nanofibers is 176.7 m 2 /g, and their pore volume is 0.26 cc/g. The pore sizes are mainly distributed at 3 nm. The granular structure and abundant pores of zirconium nitride nanofibers provide suitable conditions for impedance matching, interfacial polarization, multiple reflections, and scattering. These nanofibers exhibit excellent microwave absorption performance, achieving an optimum reflection loss of − 55.11 dB at a thickness of 1.55 mm with an effective absorption bandwidth of 3.51 GHz when the filler loading is 35 wt%. This study suggests that zirconium nitride nanofibers with good microwave absorption performance have the potential as novel transition metal nitride microwave absorption candidate materials.
✓ 已验证
DOI
高影响因子
CATALYSIS LETTERS
·
2020
·Vol. 151
·期 2
·497-506
·
IF 2.482
Gao Xiaoxia,Wang Jiang,Xu Aiju,Jia Meilin
4Ni–Al layered double hydroxide (LDH) precursors were prepared by the following three methods: constant pH coprecipitation, variable pH coprecipitation and urea hydrolysis. The 4Ni–Al mixed metal oxide (MMO) catalysts were obtained by the calcination of LDH precursors at 600 °C, and their catalytic performances in ODHP from 350 to 550 °C were tested. The 4Ni–Al MMO from the urea hydrolysis method showed a higher and more stable propylene selectivity of ca. 40% with propylene yield of ca.11% at 500 °C, and that from the constant pH coprecipitation method was followed, while oxidative cracking of propane occurred on the 4Ni–Al MMO from the variable pH coprecipitation method. It is considered to be closely related to the dispersion and stability of the surface Ni(II) species through comprehensive analysis of XRD, N 2 -adsorption-desorption, TEM, XPS, H 2 -TPR and In-situ electrical conductivity. The urea hydrolysis method with a low salt concentration, leading to an excellent stability of the surface Ni(II) species at high reaction temperature, should be selected to prepare Ni–Al MMO catalysts for ODHP instead of the traditional variable pH coprecipitation method with a high salt concentration. Graphic
✓ 已验证
DOI
高影响因子
CHINESE SCIENCE BULLETIN
·
2012
·Vol. 57
·期 32
·4210-4214
·
IF 1.321
Zhang LeiLei,Wang ZhongLi,Xu Dan,Xu JiJing,Zhang XinBo,Wang LiMin
Lithium-air (Li-air) batteries have attracted worldwide attention due to their high energy density (11140 Wh kg −1 ) comparable to gasoline. In this work, we have synthesized the α-MnO 2 hollow clews via a simple method and characterized them by X-ray diffraction and scanning electron microscope. Interestingly, cycle performance of Li-air batteries is improved greatly when using the α-MnO 2 hollow clews as the catalyst. The first discharge capacity is 596 mAh g −1 , and the charge capacity is 590 mAh g-1 at the current density of 0.1 mA cm −2 between 2.0 and 4.2 V using the Vulcan XC-72 as the carbon material. Additionally, by re-assembling new batteries with the used lithium foil, separators and cathode separately, we find that the cathode is the key role to end the Li-air battery life.
✓ 已验证
DOI
高影响因子
Nano Research
·
2023
·Vol. 16
·期 8
·11312-11319
·
IF 9.9
Zeng Wanghong,Deng Weili,Yang Tao,Wang Shenglong,Sun Yue,Zhang Jieling,Ren Xiarong,Jin Long,Tang Lihua,Yang Weiqing
Real-time monitoring of ball–shoe interactions can provide essential information for high-quality instruction in personalized soccer training, yet existing monitoring systems struggle to reflect specific forces, loci, and durations of action. Here, we design a self-powered piezoelectric sensor constructed by the gradient carbon nanotube/polyvinylidene fluoride (CNT/PVDF) composite to monitor the interactions between the ball and the shoe. Two-dimensional Raman mapping demonstrates the gradient structure of CNT/PVDF prepared by programmable electrospinning combined with a hot pressing. Benefitting from the synergistic effect of local polarization caused by the enrichment of CNT and the reduced diffusion of silver patterns in gradient structure, the as-prepared composite exhibits enhanced force-electric coupling with an excellent sensitivity of 80 mV/N and durability over 15,000 cycles. On this basis, we conformally attach a 3 × 3 sensor array to a soccer shoe, enabling real-time acquisition of kick position and contact force, which could provide quantitative assessment and personalize guidance for the training of soccer players. This self-powered piezoelectric sensor network system offers a promising paradigm for wearable monitoring under strong impact forces.
✓ 已验证
DOI
高影响因子
Discover Nano
·
2023
·Vol. 18
·期 1
·1-11
·
IF 0
Zhu Xiaofeng,Cheng Kangning,Ding Yue,Liu Huanqing,Xie Shuqi,Cao Yuwei,Yue Weiwei
Herein, we have constructed a magnetic graphene field-effect transistor biosensor (MGFETs) for highly sensitive detection of cardiac troponin I (CTNI). Graphene films transferred to ITO conductive glass as conductive channels. CTNI aptamer was immobilized onto the graphene film via 1-pyrene-butanoic acid succinimidyl ester (PBASE) to capture CTNI. Magnetic nanobeads (MBs) modified with CTNI antibody were added to the reaction chamber to form an aptamer/CTNI/antibody/magnetic nanobeads sandwich-type complex. We found that the magnetic force exerted on the complex leads to an impedance change of the graphene film. The reason for this result is that the magnetic field exerts an influence on the MBs, causing CTNI aptamer strand to bend, resulting in a change in the distance between the double conductive layers of the graphene film surface and the test solution. With periodic sampling integration, different concentrations of CTNI can be detected with high sensitivity. Due to the stringent recognition capability and high affinity between the CTNI aptamer and CTNI, MGFETs have the potential to detect various types of proteins. Furthermore, MGFETs also have the potential to be utilized for the detection of DNA or specific cells in the future.
✓ 已验证
DOI
危险品化学品经营许可证（带存储）