FOOD CONTROL
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2024
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IF 5.6
Han Wang,Lele Shao,Yingying Sun,Yana Liu,Bo Zou,Yijie Zhao,Yuhan Wang,Xingmin Li,Ruitong Dai
This study investigated the alterations in cellular structure of ohmic heating (OH)-induced injured Staphylococcus aureus ( S. aureus ) during repair in nutrient broth, and the potential antibacterial approach of combining OH with food bacteriostatic agents and their application in milk. Specifically, the biological properties (surface hydrophobicity, zeta potential, particle size) and indicators related to cell membrane and cell wall integrity (peptidoglycan content, activities of β-galactosidase, alkaline phosphatase, and lactate dehydrogenase) of injured S. aureus during repair were measured. Additionally, scanning electron microscope and transmission electron microscope analyses were used to observe morphological changes, and protein changes were analyzed using fourier transform infrared spectroscopy and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The results suggested that OH destroyed the biological properties and membrane structure (membrane integrity and permeability increased, cell wall integrity increased, protein and functional group of membrane were damaged) of S. aureus , which could be partially restored after repair. However, the restoration process between cell membrane and cell wall were inconsistent, and morphological changes reinforce these findings. Notably, membrane proteins and functional groups on the bacterial cell surface were difficult to repair. Also, OH combined with low doses of bacteriostatic agents is a potential method to ensure food safety. Carvacrol and low temperatures could inhibit the repair of injured bacteria in pasteurized milk; and reduce precipitate formation and putrid gas production.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
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IF 5.3
Ying Yu,Shuang Ren,Lixia Shang,Baoyan Zuo,Guofei Li,Jingxin Gou,Wei Zhang
Tranexamic acid (TXA) is an anti-fibrinolysis agent widely used in postoperative blood loss management. As a highly water-soluble drug, TXA is suffering from rapid clearance from the action site, therefore, large amount of drug is required when administered either by intravenously or topically. In this study, a TXA preparation with prolonged action site residence was designed using the nano-micro strategy. TXA nanoparticles were dispersed in oil by emulsification followed by lyophilization to give a solid-in-oil suspension, which was used as the oil phase for the preparation of TXA-loaded solid-in-oil-in-water (TXA@S/O/W) system. The particle size of TXA in oil was 207.4 ± 13.50 nm, and the particle size of TXA@S/O/W was 40.5 μm. The emulsion-in-gel system (TXA@S/O/G) was prepared by dispersing TXA@S/O/W in water solution of PLGA-b-PEG-b-PLGA (PPP). And its gelling temperature was determined to be 26.6 ℃ by a rheometer. Sustained drug release was achieved by TXA@S/O/G with 72.85 ± 7.52 % of TXA released at 120 h. Formulation retention at the joint cavity was studied by live imaging, and the fluorescent signals dropped gradually during one week. Drug escape from the injection site via drainage and absorption was investigated by a self-made device and plasma TXA concentration determination, respectively. TXA@S/O/G showed the least drug drainage during test, while more than 70 % of drug was drained in TXA@S/O/W group and TXA solution group. Besides, low yet steady plasma TXA concentration (less than 400 ng/mL) was found after injecting TXA@S/O/G into rat knees at a dosage of 2.5 mg/kg, which was much lower than those of TXA dissolved in PPP gel or TXA solution. In conclusion, sustained drug release as well as prolonged action site retention were simultaneously achieved by the designed TXA@S/O/G system. More importantly, due to the steady plasma concentration, this strategy could be further applied to other highly water-soluble drugs with needs on sustained plasma exposure.
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ACS Applied Nano Materials
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2025
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IF 5.5
Haopeng Jing,Kun Li,Shuling Xiang,Ran Jiang,Jumei Zhou,Hongliang Zhang
WO3 with nanocrystal-in-glass (nanocrystal-embedded amorphous matrix) characteristics is recognized as a highly promising electrochromic material. The demand for flexible and large-area electrochromic technologies is pushing the advancement of low-temperature and large-scale processes for WO3 thin films. This study presents a functional ink designed for the low-temperature preparation of WO3 thin films using blade-coating technology, enabling scalable and cost-effective production. The optimized WO3:Ti-PEDOT hybrid electrochromic thin film demonstrates a high light modulation rate of 86.05% (@ 633 nm), a coloration efficiency of 54.1 cm2 C–1, an outstanding cycle stability exceeding 1000 cycles, and an ionic diffusion coefficient of 3.69 × 10–8 cm2 s–1. One reason for the remarkably improved electrochromic performance is the synergistic effect of the nanostructured WO3 glass-nanocrystal composites induced by Ti doping and the enhanced electrochemical reaction kinetics facilitated by the use of poly(3,4-ethylenedioxythiophene) (PEDOT), a conductive polymer, as a binder. This work demonstrates a feasible and cost-effective method for producing WO3-based films for electrochromic smart windows, serving as an alternative to the existing vacuum-based WO3 thin film production methods.
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JOURNAL OF THE AMERICAN CERAMIC SOCIETY
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2025
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IF 3.8
Jimei Xue,Xiaoling Liu,Yuqiu Wang,Hepeng Zhao,Xiaomeng Fan
Oxide ceramic matrix composites (OCMC) have good high-temperature resistance, oxidation resistance, and mechanical properties. However, the microwave absorbing properties of OCMC areinsufficient due to the low dielectric and low loss characteristics of oxide ceramics, so it is urgent to develop a kind of the oxide ceramic matrix with adjustable microstructure and electromagnetic properties. PDC-SiOC ceramics are the optimal oxide ceramics whose component and microstructure can be adjusted by rare earth nitrate modified polysiloxane precursor. For Sc(NO 3 ) 3 modified PDC-SiOC ceramics, rare earth metals not only can react with siloxy groups to form silicates at high temperatures but also can catalyze the formation of SiCnws. Herein, rare earth nitrate modified polysiloxane precursor was pyrolyzed at 900°C, and then annealing at high temperature to form silicate and SiCnws. After annealing at 1400°C, a large amount SiCnws was in situ formed conductive network structure in SiOC ceramic, so the SiOC ceramic with SiCnws had great electromagnetic wave (EMW) absorbing properties, the maximum effective absorption bandwidth (EAB max ) and the minimum reflection coefficient (RC min ) at the thickness of 2.75 mm reach 4.0 GHz and −42.3 dB in X -band, respectively. By the double-layer impedance matching design, the EAB can be effectively improved, which provide a good way for the design and fabrication of OCMC with advanced (EMW) absorbing properties.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Lijia Huang,Jiao Shen,Yi Yuan,Yaoqi Huang,Ying Liang,Shaojun Yuan
The development of efficient photocatalysts for hydrogen sulfide (H 2 S) degradation under visible light remains a critical challenge due to constraints in light absorption efficiency and rapid electron-hole recombination. In this study, a novel dual S-scheme ternary heterojunction photocatalyst, In-TiO 2 @BiOBr@In-TCPP (IBP), was synthesized via a hydrothermal method for high-performance H 2 S desulfurization. Comprehensive characterization confirmed the successful formation of the heterostructure, where In-TiO 2 facilitated spontaneous H 2 S dissociation, BiOBr served as an efficient electron transport medium, and In-TCPP extended the light absorption spectrum to 1200 nm. The optimized IBP-3 demonstrated exceptional performance, achieving complete H 2 S degradation (100 %) within 120 min under visible light irradiation and retaining over 70 % efficiency even after 8 h of continuous operation. Mechanistic investigations revealed that the synergistic integration of In-TiO 2 , BiOBr, and In-TCPP enhanced visible light utilization, suppressed charge carrier recombination, and promoted reactive oxygen species (ROS) generation via internal electric fields (IEF) and S-scheme charge transfer pathways. This study not only presents the rational engineering of multi-component systems for designing advanced heterojunction photocatalysts to address industrial desulfurization challenges, but also emphasizes the potential of tailored heterostructures in advancing sustainable environmental remediation technologies.
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Nature Communications
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2025
·Vol. 16
·期 1
·1-19
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IF 15.7
Li Wenchao,Chen SaiSai,Lu Jian,Mao Weipu,Zheng Shiya,Zhang Minhao,Wu Tiange,Chen Yurui,Lu Kai,Chu Chunyan,Shu Chuanjun,Hou Yue,Yang Xue,Shi Naipeng,Chen Zhijun,Zhang Lihua,Zhang Lei,Na Rong,Chen Ming,Ju Shenghong,Zhang Dingxiao,Ma Yi,Xu Bin
Immune checkpoint therapy for prostate cancer (PCa), a classic ‘immune-cold’ tumor characterized by an immunosuppressive tumor microenvironment, failed previously in clinical trials, but the underlying causes remain elusive. Here we find that YY1 + , immunosuppressive macrophages aggregate in the hypoxic areas of PCa. Mechanistically, hypoxia promotes the phase separation of YY1 in the nucleus, where YY1 binds to NUSAP1 and promotes the SUMOylation, phase separation and stabilization of HIF-1α. Either myeloid-specific conditional knockout of YY1 or a treatment with tenapanor for decreasing the YY1–NUSAP1–HIF-1α interaction impairs subcutaneous PCa tumor formation in mouse prostate tumor models. Lastly, a first-generation tetrahedral DNA nanostructure based on the proteolysis targeting chimera technique, termed YY1-DcTAC, allows targeting and degrading YY1 in tumor-associated macrophages for inducing antitumor effects and CD8 + T cell tumor infiltration in mouse tumor models. In summary, our findings underscore the pivotal role of YY1 in the hypoxia/HIF-1α pathway in tumor-associated macrophages and support the targeting of YY1 for treating PCa.
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ENERGY & FUELS
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2025
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IF 5.3
Lixin Zhu,Weian Huang,Jia He,Ting Yu,Xushuo Zhang,Jianghong Jia,Shuangjun Zhou
The development of effective lost circulation control materials for complex karst formations remains a critical challenge in deep and unconventional reservoir drilling. This study presents a water-responsive polymer synthesized through inverse emulsion copolymerization using hydrophilic monomers (acrylamide, acrylic acid, and 2-acrylamido-2-methylpropanesulfonic acid) and hydrophobic monomers (octadecyl acrylate). Advanced characterization techniques, including Fourier Transform Infrared Spectroscopy (FTIR), Gel Permeation Chromatography (GPC), Dynamic Light Scattering (DLS), Thermal Gravimetric Analysis (TGA), and Scanning Electron Microscopy (SEM), revealed a water-triggered structural transformation from irregular morphologies to three-dimensional cocontinuous networks. This transformation is driven by hydrogen bonding and van der Waals interactions, which facilitate the formation of supramolecular architecture through intermolecular hydrophobic associations. The polymer emulsion demonstrates exceptional thickening performance, maintaining high apparent viscosity in both distilled water (2150 mPa·s at 2 wt %) and saline conditions (1680 mPa·s at 2 wt %). It also exhibits favorable shear-thinning and static-thickening behavior, with dynamic viscosity reducing from 5140 mPa·s to 280 mPa·s at 200 s–1 (at 5 wt %). Prolonged water exposure enhances the sealing efficacy, achieving 10% linear expansion after 48 h. Additionally, thermal stability testing at 140 °C for 16 h demonstrates that the sealing integrity is maintained in sand beds. Integrated with optimized conventional materials, the composite plugging system effectively seals 3 mm-wide fractures under 8 MPa. Molecular dynamics simulations confirm the adsorption mechanisms and surface retention behavior that govern the fracture sealing. This salt-tolerant, thermally stable polymer emulsion system overcomes conventional retention limitations in karst formations, enabling efficient one-time plugging with industrial scalability. This work establishes a new paradigm for the development of stimuli-responsive materials to control complex downhole fluid losses.
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COLLOID AND POLYMER SCIENCE
·
2025
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IF 2.3
Xiao Ting,Zou Wenjie,Tian Congzhong,Hu Wentao,He Jiancheng,Zhang Zhijun,Xu Chengyan,Zhou Fang
Flocculation technique is extensively adopted in the tackling of sulfide mineral processing wastewater, which contains abundant suspended solids and heavy metal ions. The functional groups of polymeric flocculants significantly influence the interactions between flocculants and pollutants. Herein, self-assembled monolayers (SAMs) terminated with − NH 2 , − OH, − COOH, and − CH 3 and in situ polymerization coating of acrylamide exclusively containing − CONH 2 were fabricated via the vapor-phase deposition, self-assembly molecular membrane, and atomic transfer radical polymerization methods. X-ray photoelectron spectroscopy, water contact angle measurements, and AFM imaging were utilized for the characterization of functionalized surfaces. The adsorption behavior of kaolin and Pb 2+ on these surfaces was explored using quartz crystal microbalance with dissipation (QCM-D). The amount of kaolin adsorbed on functionalized surfaces followed the sequence of − CONH 2 (∆ f of − 1360.55 Hz) > − NH 2 (∆ f of − 395.43 Hz) > − OH (∆ f of − 181.31 Hz) > − COOH (∆ f of − 1.75 Hz) > − CH 3 (∆ f of − 0.1 Hz). The polymer coating with acrylamide (CONH 2 -functionalized surface) with a specific molecular weight exhibited strong bridging effect, capturing quantities of kaolin. The amino group underwent protonation to form NH 3 + , combining with the negatively charged kaolin through electrostatic attraction. These indicated that both the bridging effect of flocculants and the electrical neutralization between flocculants and particles were critical factors influencing the settlement of kaolin. For Pb 2+ , its adsorption amount on functionalized surfaces followed the order of − COOH (∆ f of − 1.53 Hz) > − OH (∆ f of − 1.27 Hz) > − CH 3 (∆ f of − 0.34 Hz). The carboxyl group played a critical role in facilitating the adsorption of Pb 2+ through chelation and electrostatic interaction, confirming its function as an active site. Our findings provide profound insights into the structure–activity relationship of flocculants, underscoring the importance of designing efficient flocculants for wastewater treatment. Graphical
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Materials Today Bio
·
2025
·
IF 10.2
Huiwen Lu,Yucong Li,Jingle Chen,Da Song,Xiaoqi Luo,Xinhao Lu,Xuhui Huang,Wei Tan,Chao Xie,Changjun Wang
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, with high postoperative recurrence rates due to occult micrometastases or minimal residual disease, markedly worsening the prognosis for HCC patients. Current therapies lack effective strategies to prevent recurrence, while traditional Chinese medicine (TCM) shows potential in delaying HCC progression. Combining a hemostatic hydrogel with nanoparticle-based delivery of active TCM components provides a strategy to enhance tumor recurrence prevention. Herein, we develop a nanocomposite hydrogel (HPS@ZCJ) by encapsulating Jianpi-Huayu essential oils (JEO) into zein-based nanoparticles (zein@chondroitin sulfate@JEO, ZCJ) and embedding them in a hydroxymethyl cellulose/Pluronic F-127/sodium alginate (HPS) hydrogel matrix. HPS@ZCJ hydrogel enhances cytotoxic T-lymphocyte infiltration, inhibits the polarization of tumor-associated macrophages to M2 phenotype, induces tumor cell death, reverses immunosuppression, and inhibits angiogenesis within the tumor. The antitumor mechanism involves dual downregulation of GPNMB and DHCR7, key genes in HCC progression and immune evasion. In vitro and in vivo experiments demonstrate that HPS@ZCJ hydrogel-mediated targeted comprehensive therapy simultaneously achieves intraoperative hemostasis, impedes primary tumor growth and prevents HCC postoperative recurrence. This study provides a promising postoperative HCC treatment strategy, leveraging TCM's therapeutic potential with significant clinical translation prospects.
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PROGRESS IN ORGANIC COATINGS
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2025
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IF 7.3
Feiyang Cheng,Xiangfeng Zhu,Fucheng Yun,Mengting Wei,Chen Shi,Jian Han
As one of the most widely utilized polymer coating systems, polyvinyl chloride (PVC) is extensively applied in industrial protection fields due to its excellent processability and cost efficiency. To meet rising performance demands in extreme environments, developing PVC coatings with efficient flame retardancy and smoke suppression has become a key research focus. This study developed an innovative BiOCl@Cu-MOF hybrid through an in situ growth strategy. Incorporating the additive at 15 phr increased the limiting oxygen index (LOI) from 23.4 % to 29.4 %. The PVC coating also passed the UL-94 rating test, reaching the highest V-0 level. Cone calorimetry analysis showed a 55.9 % reduction in peak heat release rate, indicating superior flame retardant behavior. In terms of smoke suppression, the coating achieved a 66.7 % decrease in peak smoke production rate. More importantly, the peak carbon monoxide production, a critical lethal factor in fires, was suppressed by 46.9 %. The PVC coating further exhibited 99.9 % antibacterial efficacy against both Staphylococcus aureus and Escherichia coli . This work establishes a pioneering design paradigm for multifunctional protective coatings, offering significant potential in fire-safe building materials, electronics encapsulation, and bio-secure applications.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
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2024
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IF 5.3
Yuying Chen,Qingwei He,Huangjie Lu,Jie Yang,Jiongming Han,Ying Zhu,Ping Hu
This study addresses the challenging task of quantitatively investigating drug release from PLGA microspheres after in vivo administration. The objective is to employ Förster resonance energy transfer (FRET) to visualize drug-encapsulated microspheres in both in vitro and in vivo settings. The primary goal is to establish a quantitative correlation between FRET fluorescence changes and microsphere drug release. The study selects drugs with diverse structures and lipid solubility to explore release mechanisms, using PLGA as the matrix material. Clozapine and risperidone serve as model drugs. FRET molecules, Cy5 and Cy5.5, along with Cy7 derivatives, create FRET donor–acceptor pairs. In vitro results show that FRET fluorescence changes align closely with microsphere drug release, particularly for the Cy5.5-Cy7 pair. In vivo experiments involve subcutaneous administration of microspheres to rats, tracking FRET fluorescence changes while collecting blood samples. Pharmacokinetic studies on clozapine and risperidone reveal in vivo absorption fractions using the Loo-Riegelman method. Correlating FRET and in vivo absorption data establishes an in vitro – in vivo relationship (IVIVR). The study demonstrates that FRET-based fluorescence changes quantitatively link to microsphere drug release, offering an innovative method for visualizing and monitoring release in both in vitro and in vivo settings, potentially advancing clinical applications of such formulations.
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JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Ligui Wu,Hao Luo,Jingcheng Xu,Ling Yu,Jiangtao Xiong,Yizhi Liu,Xiangfeng Huang,Xiaoming Zou
The extensive use of antidiabetic drugs (ADDs) and their detection in high concentrations in the environment have been extensively documented. However, the mechanism of ADDs dissipation in aquatic environments is still not well understood. This study thoroughly investigates the dissipation behavior of ADDs and the underlying mechanisms in the aerobic activated sludge system. The results indicate that the removal efficiencies of ADDs range from 3.98% to 100% within 48 h, largely due to the biodegradation process. Additionally, the gene expression of cytochrome P450 (CYP450) is shown to be significantly upregulated in most ADDs-polluted samples (P < 0.05), indicating the vital role of CYP450 enzymes in the biodegradation of ADDs. Enzyme inhibition experiments validated this hypothesis. Moreover, molecular docking and simulation results indicate that a strong correlation between the biodegradation of ADDs and the interactions between ADDs and CYP450 (E binding ). The differences in dissipation behavior among the tested ADDs are possibly due to their electrophilic characteristics. Overall, this study makes the initial contribution to a more profound comprehension of the crucial function of CYP450 enzymes in the dissipation behavior of ADDs in a typical aquatic environment. Environmental Implication This work underscores the role of CYP450 enzymes in the biodegradation of antidiabetic drugs (ADDs). While removal efficiencies vary widely, the biodegradation process can lead to the formation of degradation products potentially more toxic than the original compounds. This points to a critical need for advanced wastewater treatment technologies capable of addressing not only the removal of ADDs but also the mitigation of their toxic byproducts. The study's findings emphasize the importance of understanding the specific mechanisms of pharmaceutical pollution, which is essential for protecting aquatic ecosystems and, by extension, human health from the unintended consequences of widespread pharmaceutical use.
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