WATER AIR AND SOIL POLLUTION
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2025
·Vol. 236
·期 8
·1-19
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IF 3
Ou Qianhui,Xiong Yan,Chen Li,He Deyong,Zhou Chuxiang,Wang Lan
The nanocomposite materials are highly promising candidates for adsorption applications in dyed wastewater due to their distinctive structural properties. In this work, the nanocomposite hybrids of UiO-66@GO were first synthesized by specifically anchoring Zr-based metal organic framework (MOF) of UiO-66 onto graphene oxide (GO) nanolayer through solvothermal method. Then the composite matrix microspheres (CMMs) of UiO-66@GO were subsequently prepared by embedding the obtained UiO-66@GO nanocomposite into sodium alginate (SA) microspheres through self-assembly cross-linking process. Finally, the prepared UiO-66@GO CMMs were applied for the adsorption of organic dye pollutant and showed efficient water purification performance. As a result, the UiO-66@GO CMMs exhibited selective cationic dye adsorption for Rhodamine B (RhB + ). The experimental results revealed that the adsorption kinetics followed by the pseudo-second-order (PSD) model with rate constant k 2 = 0.95 × 10 –3 g mg −1 min −1 , and the thermodynamics followed by the Langmuir model with adsorption capacity of 345.66 mg mg −1 . Notably, the UiO-66@GO CMMs demonstrated excellent adsorption removal of a significant removal efficiency of 98% towards 10 ppm Rh-B and a rapid adsorption response time of ~ 5 min. Meanwhile, the UiO-66@GO CMMs maintained long-term stability with adsorption efficiency > 95% over 30 days and effective reuse with resorption efficiency > 90% using DMF-H₂O as eluent. In this study, SA has served as a porous supporting matrix to immobilize UIO-66@GO nanoparticles, having mitigated issues of aggregation and leaching common to nanoscale adsorbents while improving reusability. The synergistic effect between UIO-66 and GO has further enhanced pollutant adsorption capacity, demonstrating significant potential for dye wastewater treatment applications.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-11
·
IF 3.9
Li Wenlan,Zhang Zijie,Jiang Zixiao,Barasarathi Jayanthi,Zhou Ying,Liu Sui,Lee Shiou Yih,Liu Yangyang
Psychotria rubra Herbal Tea (PRHT) is a traditional Chinese folk medicine used to treat in-flammation induced by respiratory infections. Its specific mechanisms of action, however, remain unclear. The study combined ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS), network pharmacology, and in vitro cell experiments to systematically analyze the chemical composition and validate the biological activity of PRHT. Protein-protein interaction (PPI) network analysis and molecular docking were used to identify key targets and mechanisms. PRHT was found to contain 128 active compounds, including alkaloids, amino acids and their derivatives, and flavonoids. Key targets such as STAT3, IL-6, and TP53 were identified through PPI network analysis. PRHT exhibited significant anti-inflammatory effects by modulating the STAT3/IL-6/TNF-α signaling pathway. Experimental results demonstrated that PRHT inhibited the release of inflammatory cytokines in a dose-dependent manner. Molecular docking confirmed strong interactions between PRHT components and core targets. The study reveals that PRHT exerts anti-inflammatory effects by regulating the STAT3/IL-6/TNF-α signaling pathway, contributing to inflammation balance and tis-sue repair. These findings provide scientific evidence for the development of PRHT as a functional anti-inflammatory agent and offer new insights into treatment strategies for respiratory infections.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 6
·1-11
·
IF 5.3
Cheng Yuliang,Zhao Yajie,Li Peizhen,Yu Hang,Xie Yunfei,Guo Yahui,Yao Weirong,Qian He
As one of the most extensively used antibiotics in aquaculture in China, enrofloxacin (ENR) tends to accumulate in human body and endanger people’s health. Rapid, sensitive, and facile assays for enrofloxacin are urgently needed. In this study, based on the solid-phase substrate preparation strategy combined with microsphere etching and magnetron sputtering, Ag@Au nanoparticle (Ag@Au NP) solid array (Ag@Au NSA) with high surface-enhanced Raman spectroscopy (SERS) enhancement factor (EF≈8.3 × 10 7 ) was developed. Finite-difference time-domain (FDTD) simulations revealed that the Ag@Au NSA achieved maximum electromagnetic enhancement (EM) under the following optimized conditions: 633 nm excitation wavelength, 7.9 nm Au shell thickness, and 30.5 nm Ag core size. Additionally, SERS mapping results confirmed both the excellent enhancement performance and signal reproducibility of Ag@Au NSA, due to the expected micro-region enhancement with long-term effects accompanied by a larger range of high-density “hot spots.” The proposed SERS sensing for ENR based on Ag@Au NSA had a limit of detection (LOD) of 0.076 ng/mL ( R 2 ≈ 0. 9991) and was further applied to real-sample detection of ENR in crayfish tail meat with good recoveries ranging from 91.36 to 112.60%, indicating its great potential in practice. Graphical
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TRANSITION METAL CHEMISTRY
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2025
·
IF 1.7
Wang Yuqin,He Lizi,Han Ning,Li Lishuang,Wang Meiyang
It is of great practical significance to explore and prepare cheap, high-performance, and stable catalysts for oxygen reduction reaction (ORR), but it is still in progress at present. Herein, a straightforward evaporation–pyrolysis strategy is designed for the preparation of 3D porous electrocatalysts (denoted as \(\textrm{Fe}-\textrm{Co}-\textrm{NC}\) , which represented carbonization products at °C) made of carbon nanoparticles combined with metallic Fe-Co-doped N-enriched bridged carbon nanotube by carbonization of a pristine ZIF8 as highly efficient and durable ORR electrocatalysts. The obtained Fe–Co–NC structure possesses 3D open porous texture, abundant active sites, desired nitrogen bonding type, and high specific surface area, providing them with excellent ORR activity. The optimal performing \(\textrm{Fe}-\textrm{Co}-\textrm{NC}\) catalyst presents an outstanding ORR performance in terms of a high onset potential ( \(\textrm{E}_{\text{ onset } }\) ) of 0.96 V (vs. RHE) and half-wave potential ( \(\textrm{E}_{1 / 2}\) ) of 0.86 V (vs. RHE), respectively, possible to rival those of the commercially available \(\textrm{Pt} / \textrm{C}\) in an alkaline electrolyte solution. Besides, the \(\textrm{Fe}-\textrm{Co}-\textrm{NC}\) catalyst manifests better stability than those of commercially available \(\textrm{Pt} / \textrm{C}\) , which is of importance for the optimization and characterization of novel electrocatalysts originated from non-precious metals.
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RESEARCH ON CHEMICAL INTERMEDIATES
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2025
·
IF 3.5
Hu Lan,Zhao Qiuyue,Zhang Xinling,Li Huipeng,Bian Cheng,Zeng Yiqing
Redox sites and acidic sites are the main active sites of bimetallic oxide catalysts used for selective catalytic oxidation of NH 3 (NH 3 -SCO). In this work, three MMoO x (M = Cr, Fe, and Mn) bimetallic oxides catalysts were prepared by simple grinding and calcination to investigate the effect of redox sites (M sites) on the NH 3 -SCO performance. The NH 3 -SCO test results showed that the activity of MMoO x is in the order of CrMoO x > MnMoO x > FeMoO x . The characterization results of H 2 -TPR, O 2 -TPD, NH 3 -TPD, and in situ DRIFTS proposed that the NH 3 -SCO reaction on MMoO x catalysts is proceed via i-SCR mechanism, and the formation of the intermediates of NH 3 -SCR reaction is the decisive reaction step. Owing to the excellent ability in promoting the formation of nitrate/nitrite species, CrMoO x and MnMoO x samples show much higher NH 3 -SCO activity than FeMoO x sample . CrMoO x can facilitate the formation of a large amount of –NH 2 species, which together with nitrate/nitrite species enhance the NH 3 -SCO reaction via i-SCR reaction route. Therefore, CrMoO x shows the highest NH 3 -SCO activity among the MMoO x catalysts. Through this work, the redox sites of bimetallic oxide catalysts are demonstrated as a vital role in inducing the formation of reaction-active intermediates, which highlight the importance of choosing the redox sites in designing NH 3 -SCO catalyst.
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Cancer Cell International
·
2025
·Vol. 25
·期 1
·1-10
·
IF 6
Zhang Hao,Liu Guoyan
GSDMB, a key protein in pyroptosis, is closely linked to various diseases. Nanomaterials can target and regulate specific pathways. Herein, we report a simple and efficient one-step method to develop multi-enzyme nanoparticles capable of suppressing GSDMB expression. 0.5ZnO@Cu5.4O can inhibit GSDMB, a capability that neither ZnO nor Cu5.4O possesses. ZnO@Cu5.4O with different ratios also exhibits varying inhibitory effects. The 0.5ZnO@Cu5.4O can be cleared quickly in vivo, ensuring biocompatibility. Additionally, 0.5ZnO@Cu5.4O significantly inhibits tumor progression, offering promising avenues for clinical cancer therapy, and the development of gene-regulating nanoparticles.
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JOURNAL OF MATERIALS SCIENCE
·
2025
·
IF 3.9
Li Huaxin,Luo Ziqiang,Xiang Zhi,Li Yafei,Shi Chen,Lu Chuanyang,Yang Jianguo,He Yanming
The preparation of N-doped conductive SiC ceramics through conventional solid-state sintering typically requires extremely high temperatures and additional nitrogen solid solution treatments. To overcome this limitation, pre-synthesized N-doped SiC nanopowder containing 1 wt.% B 4 C were used to fabricate solid-sintered conductive SiC ceramics via spark plasma sintering (SPS) at sintering temperatures of 1850–1900 °C and holding times of 1–10 min. Localized overheating during SPS induced the formation of B-Si–O-C-N liquid phase within the ceramic matrix, a phenomenon not observed in conventional solid-state sintering processes, which significantly promoted densification. Notably, short holding times (1–5 min) preserved the liquid phase, resulting in incomplete solid-state sintering. In contrast, a prolonged holding time (10 min) led to complete decomposition and evaporation of the liquid phase, thereby inducing pores formation. The fracture toughness of the resulting ceramics exceeded 4 MPa·m 1/2 , outperforming those produced via traditional routes. Additionally, the N concentration remained below 1000 ppm, while the electrical resistivity ranged from 2.68 × 10 –1 to 4.12 × 10 –2 Ω·cm, well below the 100 Ω·cm threshold required for electrical discharge machining. Furthermore, competitive doping between N and B atoms modulated the carrier concentration and mobility, enabling effective tuning of electrical resistivity. Based on these findings, the densification mechanism and doping interaction effects were thoroughly elucidated. This work provides a foundation for optimizing the solid-state sintering process and designing high-performance conductive ceramics for advanced engineering applications.
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Nature Communications
·
2019
·Vol. 10
·期 1
·1-7
·
IF 11.878
Chen Chao,Gao Liang,Gao Wanru,Ge Cong,Du Xinyuan,Li Zha,Yang Ying,Niu Guangda,Tang Jiang
Circularly polarized light (CPL) detection is required in various fields such as drug screening, security surveillance and quantum optics. Conventionally, CPL photodetector needs the installation of optical elements, imposing difficulties for integrated and flexible devices. The established CPL detectors without optical elements rely on chiral organic semiconductor and metal metamaterials, but they suffer from extremely low responsivity. Organic-inorganic hybrid materials combine CPL-sensitive absorption induced by chiral organics and efficient charge transport of inorganic frameworks, providing an option for direct CPL detection. Here we report the CPL detector using chiral organic-inorganic hybrid perovskites, and obtain a device with responsivity of 797 mA W -1 , detectivity of 7.1 × 10 11 Jones, 3-dB frequency of 150 Hz and one-month stability, a competitive combined feature for circularly polarized light detection. Thanks to the solution processing, we further demonstrate flexible devices on polyethylene terephthalate substrate with comparable performance.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
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IF 15.7
Jiang Minwen,Zheng Jie,Tang Yi,Liu Hai,Yao Yawen,Zhou Jianfei,Lin Wei,Ma Yuan,Liu Jin,Zhou Jiajing
Antibiotic contamination has emerged as a global challenge, increasing antibiotic resistance and threatening human health and ecosystems. Bioremediation using microorganism offers sustainable methods to degrade such pharmaceutical contaminants. However, these microorganisms exhibit reduced activity under high-stress conditions, and are difficult to recycle and potentially leak into environment as microbial pollutions. Here we report bioprinted retrievable microalgae hydrogel networks (MHNs) by confining living microalgae in double-network hydrogels, which achieves enhanced antibiotic degradation (>99.3%) and recyclable ability. Particularly, coating MHN with tannic acid (MHN@TA) generates a semipermeable membrane to prevent the leakage of microalgae (<0.7% for 7 days), ensuring the containment of potential microbial biohazards. The biohybrid system protects the biological activity of microalgae, enabling antibiotic degradation up to 400 mg L −1 . Free-standing MHN@TA fencing systems are also manufactured to demonstrate their practical applications. This study provides insights of microalgae-material interactions in bioremediation and offers design rationales for biohybrid systems.
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COLLOID AND POLYMER SCIENCE
·
2024
·
IF 2.2
Zhao Dan,Yang Weili,Shen Guanglite,Zhang Wenhui,Feng Huixia
Phenol–formaldehyde resin can be used to improve oil recovery; its key lies in its aggregation behavior and blocking strength. However, the traditional phenol–formaldehyde resin used in the petroleum field is all prepared by phenol and formaldehyde. In order to get rid of the dependence on fossil resources and make full use of renewable biomass resources, we used the abandoned walnut shells of the unique agricultural and forestry crops in Gansu province, which contains lignin partially replaced phenol to synthesize the new sulfonated lignin-based phenol–formaldehyde resin (SLPFR). The results showed that the optimum conditions for microwave polymers were polystyrene substitution rate of 20 wt%, decomposition temperature of 160 ℃, decommissioning time of 20 min, and sodium hydroxide concentration of 0.3 mol/L. Infrared spectroscopes and scanning telescopes have shown that after disintegration, there was an increased concentration of phosphorus, which had more active spots and was more suitable for replacing phenylphenol-synthetic formaldehyde resins. LC–MS indicated the molecular mass of SLPFR and the possible structure of molecules, indicating the successful synthesis of SLPFR. In this work, the aggregation behavior and dispersion stability of SLPFR were investigated from the composition of formation water. The effects of metal cations (Na + , Mg 2+ , Ca 2+ ) on the dispersion stability of SLPFR in formation water were determined by turbidimetry, and the effects of metal cations on the particle size and zeta potential of the SLPFR system were measured by dynamic light scattering method and electrophoretic light scattering method. The stability of the aggregate structure of the SLPFR system was calculated by combining the fractal dimension. In this paper, the surfactant + SLPFR system and partially hydrolyzed polyacrylamide (HPAM) + SLPFR system were designed for the specific conditions of oil reservoirs, and the effects of metal cations on the aggregation behavior and dispersion stability of these two systems were studied. Based on the above comprehensive analysis, aggregation models were constructed to describe the aggregation behavior and dispersion stability of the HPAM + surfactant + SLPFR system. This makes it possible to predict in real time the migration and plugging of SLPFR aggregates in formation water. Graphical abstract
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Cell Discovery
·
2025
·Vol. 11
·期 1
·1-14
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IF 12.5
Wang Jinrui,Niu Shenghui,Hu Xiao,Li Tianxing,Liu Shengduo,Tu Yingfeng,Shang Zehua,Zhao Lin,Xu Pinglong,Lin Jingwen,Chen Lu,Billadeau Daniel D.,Jia Da
The cGAS-STING pathway mediates the innate immune response to cytosolic DNA, contributing to surveillance against microbial invasion or cellular damage. Once activated, STING recruits TBK1 at the trans-Golgi network (TGN), which in turn phosphorylates IRF3 to induce type I interferon (IFN-I) expression. In contrast to STING, little is known about how TBK1 is transported to the TGN for activation. Here, we show that multiple TGN tethering factors, a group of proteins involved in vesicle capturing, are indispensable for STING-IFN-I signaling. Deletion of TBC1D23, a recently reported tethering factor, in mice impairs the STING-IFN-I signaling, but with insignificant effect on STING-NF-κB signaling. Mechanistically, TBC1D23 interacts with TBK1 via the WASH complex subunit FAM21 and promotes its endosome-to-TGN translocation. Furthermore, multiple TGN tethering factors were reduced in aged mice and senescent fibroblasts. In summary, our study uncovers that TGN tethering factors are key regulators of the STING-IFN-I signaling and suggests that their reduction in senescence may produce aberrant STING signaling.
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Italian Journal of Pediatrics
·
2025
·
IF 3.1
Feiyu Yan,Shengnan Wang,Yilin Wang,Yan Sun,Jing Yang,Lirong Sun,Yekaterina Y Zaytseva,Pan Deng,Lingzhen Wang
Background Acute lymphoblastic leukemia (ALL) is a prevalent hematologic malignancy that primarily affects children. The diagnosis and treatment of pediatric ALL remain challenging. This study aimed to identify differential lipids and metabolites that may hold potential for improving ALL treatment. Methods In this retrospective case-control study, serum samples obtained from children with ALL and healthy controls were analyzed. Serum lipidome and metabolome alterations of ALL were analyzed by comparing pediatric patients with ALL with healthy controls based on liquid chromatography high-resolution mass spectrometry analysis of serum lipidomic and metabolomic signatures. Results We identified 2,298 lipid features in the serum. Among them, 72 (3.13%) differed significantly in pediatric patients with ALL compared to healthy controls. Notably, sphingolipids (ceramide and sphingomyelin) and phospholipids exhibited the most pronounced changes. Targeted analysis of ceramides revealed significantly elevated levels of Cer 18:0 and Cer 20:0 in the serum of pediatric patients with ALL. Additionally, gut microbial-related lipids (such as sulfonolipids and fatty acid esters of hydroxy fatty acids) showed significant alterations. Metabolomic analysis identified 15 differential metabolites, indicating disrupted nucleotide and amino acid metabolism. Furthermore, the dysregulated lipids and metabolites correlated with various blood indicators, with ceramide and nucleosides positively associated with white blood cell count but negatively correlated with hemoglobin and platelet. Conclusion These findings shed light on abnormal molecular signatures contributing to pediatric ALL and may serve as potential biomarker panel for therapy of ALL.
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