MEDICINAL CHEMISTRY RESEARCH
·
2019
·Vol. 28
·期 9
·1388-1401
·
IF 1.72
Chen Xin,Liu Xiujie,Qiu kai,Xu Xiang,Li Caiwen,Wang Yan
According to the bio-isosterism theory, a series of N , N ’-disubstitutedphenyl-4-ethoxylbenzene-1, 3-disulfonamides ( 5a - p ) were designed and synthesized by two steps of reactions including chlorosulfonation and ammonolysis. The structures of all compounds have been confirmed by IR, 1 H-NMR, 13 C-NMR, and ESI-MS spectra. The in vitro anti-platelet aggregation activities were evaluated by Born’s test induced by adenosine diphosphate (ADP) and arachidonic acid (AA), respectively. The biological evaluation results revealed that compound 5h had the lowest IC 50 value (0.32 μM) and the highest inhibition rate (40.9 %) that of three positive control agents clopidogrel (0.41 μM, 23.5 %), aspirin (0.53 μM, 28.9 %), and picotamide (0.76 μM, 32.7 %). Afterwards, compounds with higher activities were selected to further study in vitro cytotoxicity via cell counting kit-8 (CCK-8) assay. The cytotoxicity results indicated that compound 5h had simultaneously the lowest cytotoxicity, while other compounds had no significant relationship between the anti-platelet activities and cytotoxicities. Based on above in vitro anti-platelet activity data, the SAR (Structure Activity Relationship) of the target compounds was preliminarily summarized. In general, N , N ’-disubstitutedphenyl-4-ethoxylbenzene-1, 3-disulfonamides have the potential of further study and very likely become safer and more effective anti-platelet agents.
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IEEE ELECTRON DEVICE LETTERS
·
2023
·Vol. 44
·期 7
·1152-1155
·
IF 4.9
Weishuai Duan,Zhe Liu,Xinfa Zhu,Biao He,Chao Fan,Yonghui Zhang,Mengjun Wang,Hongxing Zheng,Erping Li
Near-ultraviolet (NUV) detectors based on two-dimensional (2D) materials have garnered considerable attention owing to their atomic-scale thickness, varied bandgap, and strong interaction with incident light. In this work, homostructures composed of tin disulfide/chromium–doped tin disulfide (SnS
2
/Cr–SnS
2
) were proposed for 405 nm near-ultraviolet detectors. Afterward, superlative detectors were fabricated through the employment of micro-mechanical exfoliation and polydimethylsiloxane-assisted dry-transfer methods, anchored by the SnS
2
Cr–SnS
2
homostructures. The detectors demonstrated exceptional detection performance for 405 nm NUV radiation with a significant responsivity of
$2.04\times 10^{{3}}\,\,\text {A}\cdot \text {W}^{-{1}}$
and a short response time of 8 ms, exceeding that of detectors based on most 2D materials and even commercial light detectors (Thorlabs FD11A–Si). The work presents an effective homostructure for high-performance SnS
2
-based detectors, thereby opening an opportunity for the utilization of SnS
2
in NUV detectors.
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JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Taotao Zhan,Yuqi Su,Ying Zhang,Xiangyang Liu,Maogang He
The mutual diffusion coefficients of ethanol + n-heptane and diethyl carbonate (DEC) + n-heptane binary solutions were measured over the mass fraction from 0.05 to 0.95 at the pressure of 0.101 MPa, and at temperatures T = 288.15 K, 298.15 K, 308.15 K and 318.15 K. The expanded relative uncertainty ( k = 2) of the Mach-Zehnder digital holographic interferometry employed in the measurements was estimated to be less than 2.4% with the confidence level of 0.95. A semi-empirical correlation was used to fit the mutual diffusion coefficients as a function of concentration and temperature, which represents the experimental values with the absolute average relative deviations being 0.94% for ethanol + n-heptane and 0.90% for DEC + n-heptane. The temperature and concentration dependences of the mutual diffusion coefficients were investigated. The strongest non-ideal thermodynamic behaviors appear when the mass fraction of ethanol is within the limits of 0.45 to 0.65 or that of DEC is within the limits of 0.45 to 0.65. Besides, the mutual diffusion coefficients of ethanol + n-heptane and DEC + n-heptane binary solutions are found to be extremely sensitive to the solute concentration over the mass fraction of ethanol and DEC from 0.00 to 0.05, respectively.
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POLYMER SCIENCE SERIES A
·
2018
·Vol. 60
·期 5
·612-617
·
IF 0.729
Wang Jinjing,Wang Huifeng,Li Yan,Tian Li,Chen Shanmin,Liu Qiang,Guo Zhen
A novel copolymer surfactant has been prepared via a free radical copolymerization of CO 2 -switchable monomer N , N -diethylaminoethyl methacrylate and the hydrophilic monomer sodium vinyl-sulfonate and characterized. The results of conductivity, dynamic light scattering and cryogenic transmission electron microscopy study showed the change of the microstructure of copolymer in water by adding or removing of CO 2 . The copolymer aqueous solution was found to exhibit reversible switchability by the bubbling of CO 2 /N 2 .
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JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Jin Yan,Suijie Zhong,Xu Chen,Yihuan Luo,Hua Cao,Xiang Liu,Limin Zhao
Here, we report controlled and site-selective C–H alkenylation and dialkenylation of indolizines and pyrrolo[1,2-a]quinolines with β-alkoxyvinyl trifluoromethylketones under simple and practical conditions. Moreover, this direct C–H alkenylation strategy can also be extended to imidazo[1,2-a]pyridines. Notably, without a transition metal and external oxidant, efficient dehydrogenative β-alkenylation of tertiary amines with β-alkoxyvinyl trifluoromethylketones is presented.
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CHEMICAL ENGINEERING RESEARCH & DESIGN
·
2018
·
IF 2.795
Mengjie Sun,Meng Li,Pin Wang,Xu Zhang,Cuiming Wu,Yonghui Wu
Anion exchange membranes are prepared by phase inversion of P84 co -polyimide to obtain porous structure, and then chemically modified by branched polyethylenimine. The porous membranes are compared with a dense P84 membrane. The dense membrane is hydrophobic with large area resistance (>85 Ω cm 2 ), while the porous membranes are hydrophilic with low area resistance (2.4–3.5 Ω cm 2 ), lower than that of commercial membrane CJMA-3 (6.0 Ω cm 2 ). The ion exchange capacities are in the range of 0.83–0.86 mmol/g and the water uptake values are 90–130%, both of which are higher than those of dense P84 membrane and CJMA-3 membrane (0.5–0.6 mmol/g; 15–20%). The P84 co -polyimide membranes are utilized in bipolar membrane electrodialysis (BMED) process to produce N -2-hydroxyethylpiperazine- N ′-2-ethanesulfonic acid (HEPES). The porous membranes can decrease the transport resistance of HEPES − ions and yield high recovery ratio and current efficiency, while the dense membrane is unsuitable for BMED . The output of HEPES is increased significantly if the membranes have finger- or tear-like pores, as well as higher ion exchange capacity. The HEPES − recovery ratios are 52.3–61.6% after running 6 h under 40 V, which are higher than that of membrane CJMA-3 (46.5%). The current efficiency can reach up to 86.1% and the energy consumption is only 3.92 kWh/kg by using the optimal porous membrane M-1, which are better than membrane CJMA-3 (65.5%, 5.15 kWh/kg). Hence, the porous membranes have high potential for producing organic acid with high molecular weight.
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ACS Omega
·
2017
·
IF 0
Fang Wang,Houzhen Chen,Qixing Wu,Riguo Mei,Yang Huang,Xu Li,Zhongkuan Luo
Aprotic lithium–air batteries have recently drawn considerable attention due to their ultrahigh specific energy. However, the chemical and electrochemical instability of the electrolyte is one of the most critical issues that need to be overcome. To increase the stability and maintain a relatively high conductivity of the lithium ion, a mixed electrolyte of sulfolane (TMS) and N,N-dimethylacetamide (DMA) was evaluated and tested in an aprotic lithium–air battery. The physical and chemical characterizations showed that the mixed electrolyte exhibited a relatively low viscosity, high ionic conductivity and oxygen solubility, and good stability. In addition, it was found that lithium–air batteries with an optimized electrolyte composition (DMA/TMS = 20:80, % v/v) showed a better cycle life and lower charge overpotential as compared to those with electrolytes with a single solvent, either DMA or TMS.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Fangshuo Jia,Yujuan Zhang,Xiaolong Ma,Zihao Zheng,Fuqiang An,Tuoping Hu
Water electrolysis coupling methanol oxidation is an energy-efficient hydrogen generation technology, while obtaining high-value formic acid, however, superior catalysts are often required to achieve efficient hydrogen production. Herein, the n - n heterojunction (NiCo 2 S 4 -MoS 2 ) composed of NiCo 2 S 4 nanoparticles uniformly dispersed on ultrathin MoS 2 nanosheet arrays has been prepared through hydrothermal-pyrolysis process. At a current density (j) of 10 mA cm −2 , the potentials of NiCo 2 S 4 -MoS 2 for methanol oxidation reaction (MOR) and hydrogen evolution reaction (HER) are respectively 1.282 V and −36 mV with very high selectivity for formic acid. Importantly, under the same conditions, by using the n - n heterojunction as electrodes, the voltage (1.355 V) of the methanol electrolysis is 216 mV lower than that of the water electrolysis. Meanwhile, at higher j of 100 mA cm −2 , the voltage of the methanol electrolysis is only 6.8 % higher than the original after 150 h chronopotentiometry (CP) test. The outstanding performance of NiCo 2 S 4 -MoS 2 exceeds that previously reported in most literature, which is primarily attributed to the fact that the built-in electric field (BEF) derived from the Fermi level (E F ) difference between NiCo 2 S 4 and MoS 2 , accelerates the charge transfer, optimizes the electronic structure of the heterojunctions, and thus improving the electrical conductivity. Furthermore, MoS 2 nanosheet arrays with large specific surface area provide a fast charge/mass transfer channel, uniformly dispersed NiCo 2 S 4 and defect sites produce abundant active sites. And the superior hydrophilicity and aerophobicity of the heterojunction surface accelerate the reaction kinetics. Finally, density functional theory (DFT) calculations show that the formation of the heterojunction optimizes the electron density and d-band center of composites, thus enhancing H* adsorption and CH 3 OH dehydrogenation kinetics.
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产品关联
DOI
PubMed
高影响因子
WATER RESEARCH
·
2025
·
IF 12.4
Jung-Hyun Son,Wen-Long Wang,Peng-Hui Liu,Hang Su,Ju-Won Lee,Min-Yong Lee,Qian-Yuan Wu
This study investigates the enhancement of ozonation efficiency through the introduction of manganese ions (O 3 /Mn(II)) that significantly improve the degradation of ozone-persistent organic pollutants. Manganese ions accelerate hydroxyl radical generation by catalyzing ozone decomposition, thereby facilitating more effective oxidative reactions. The application of O 3 /Mn(II) to degrade N, N-Diethyl-3-toluamide (DEET) achieved a decomposition efficiency of 3.6 to 4.1 times higher than ozonation alone. The promotive effect was highly pH-dependent, with the observed rate constant ( k obs ) for O 3 /Mn(II) reaching 97.05 M −1 s −1 at pH 4, approximately 3.3 times greater than ozonation alone, and 686.93 M −1 s −1 at pH 7, around 1.7 times higher. O 3 oxidation contributed approximately 1% to the overall process, while hydroxyl radicals accounted for approximately 80%, and manganese species accounted for approximately 20%. Furthermore, the oxidation state of manganese significantly influenced the cooperative oxidation efficiency, with Mn(VII) achieving the highest k obs (680.87 M −1 s −1 ), while Mn(IV) exhibited the lowest (304.6 M −1 s −1 ). Additionally, intermediate products formed during DEET oxidation were identified using Orbitrap technology, elucidating various degradation pathways (such as decarboxylation, tri-hydration, and aromatic ring opening). These findings provide valuable insights into enhancing ozonation processes for environmental remediation.
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PubMed
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MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
·
2020
·
IF 2.506
Xingchen Liu,Yihan Liu,Qi Cao,Ying Wu,Xueyun Huo,Xiaoyan Du,Zhenwen Chen
Age is an important factor in the evaluation of chemical toxicology. Chemical carcinogenic compounds can induce genomic mutations. However, few studies have been conducted on the association between genomic mutation frequency, such as microsatellite instability (MSI), and the age of mice treated with a nitrosourea mutagen. In the current work, we treated young (6 weeks) and old (10 months) mice with N -methyl- N -nitrosourea (MNU) for 4 months; the MSI frequency was then measured using polymerase chain reaction (PCR) and short tandem repeat (STR) scanning. The percentage of animals with MSI in the old group was significantly higher than that in the young group (100% and 75%). The frequency of MSI events was significantly different between the two groups as well (15.8% for old and 9.4% for young). The ratio of MSI loci displayed no obvious difference between the two groups. In addition, a few loci, including D15Mit5 and D8Mit14 exhibited the highest frequency of MSI events. Since specific loci showed increased MSI in the present study and a higher frequency in previous studies, these loci could be regarded as “hot spot”. These results suggested that old mice would be more susceptible to this mutagen, and prone to accrue MSI. The hot spot microsatellite loci are potentially useful markers for genomic instability analysis.
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PubMed
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 2
·B49
·
IF 3.12
Di Liu,Fangxin Hu,Han Zhang,Cong Zhang,Shihong Chen
A sandwich electrochemiluminescence (ECL) biosensing system for soybean agglutinin (SBA) detection was developed with AuPt@C60 nanoflowers (AuPt@C60 NFs) as a novel co-reactant accelerator to enhance the performance of N-(aminobutyl)-N-(ethylisoluminol) (ABEI). In this strategy, nanoflower-liked AuPt@C60 complex served as a matrix for loading a large sum of ABEI and galactosamine (Gal) by Au-N and Pt-N bonds to achieve the nanocomposite Gal-ABEI-AuPt@C60 NFs. Dissolved oxygen was used as a co-reaction reagent, while AuPt@C60 complex acted as a co-reactant accelerator for dissolved oxygen to enhanced the ECL emission of ABEI. Gal, as an identifying element, was highly loaded by electrodeposited gold nanoparticles (Dp Au) on the electrode to recognize SBA, and further combine with Gal-ABEI-AuPt@C60 NFs to form a sandwich model. As a result, the proposed SBA biosensor exhibited a wide linear range from 1.0 ng·mL−1 to 5.0 μg·mL−1 and a low detection limit of 0.33 ng·mL−1. In addition, the biosensor displayed an excellent selectivity and an acceptable stability and reproducibility. The combination of AuPt@C60 NFs and ABEI provided a new ECL sensing platform without exogenous co-reactant.
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CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jingwei Zhu,Yu Liu,Benlin He,Wenyu Zhang,Lifang Cui,Sudong Wang,Haiyan Chen,Yanyan Duan,Qunwei Tang
The back interface issues including numerous defects and imperfect contact, mismatched energy level are regarded as the key detrimental factors causing serious charge recombination and energy loss ( E loss ) and inferior charge extraction to achieve high efficiency Hole transport materials-free (HTMs-free) carbon-based Perovskite solar cells (PSCs). To address this drawback, an effective interface engineering via depositing N, N'-Dicyclohexylcarbodiimide (DCC) at PVSK/Carbon back interface is creatively implemented to passivate CsPbBr 3 surface defects through forming interaction between N atoms with lone pair electrons and uncoordinated ions (eg Pb 2+ and Cs + ions) to suppress the defect states induced non-radiative recombination and E loss . Concurrently, the smoothness and valence band of PVSK film with DCC modification are increased to improve the contact and band alignment at back interface, respectively, remarkably accelerating hole extraction and transportation and also reducing E loss as well as charge recombination. As a result, the comprehensive performance of DCC interface modified HTMs-free carbon-based CsPbBr 3 PSCs is significantly enhanced, especially the champion efficiency boosts to 10.16% from 6.60% of the control PSC. Furthermore, owing to the enhanced hydrophobicity and decreased imperfections of PVSK film with DCC modification, the optimized device without any encapsulation displays an excellent long-term stability under 85% RH air condition at 85 °C over 1200 h.
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