ENERGY & FUELS
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2018
·
IF 3.024
Zhongqi Ren,Lu Wei,Zhiyong Zhou,Fan Zhang,Wei Liu
Deep desulfurization of fuels has attracted worldwide attention as a result of environmental concerns. In this study, a new series of protic ionic liquids (PILs) with different acidic anions were synthesized and the extraction desulfurization of dibenzothiophene (DBT), benzothiophene (BT), and 4,6-dimethyldibenzothiophene (DMDBT) in model oil was carried out. The result showed that the extraction efficiency of DBT decreased in the order of [1,8-diazabicyclo[5.4.0]undec-7-ene] ([DBU]) > [N-formylmorpholine] ([NFM]) > [N-methylimidazole] ([HMIM]) > [N-methylmorpholine] ([NMM]) while the PIL anion was formate and DBU-based PILs with different anions could remove more than 80% DBT and BT in 1 cycle. The extraction efficiencies of [DBU]Pr were 98.33% for DBT (from 500 to 8.35 ppm) and 98.67% for BT (from 500 to 6.65 ppm) after 3 extraction cycles. The value for DMDBT was 99.38% (from 500 to 3.10 ppm) after 5 cycles. The interaction energies of these PILs with three aromatic sulfur compounds were also studied through quantum chemistry calculation. Finally, the regeneration of the used PIL was performed by the back-extraction method and checked by 1H nuclear magnetic resonance.
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FOOD CHEMISTRY
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2018
·
IF 4.946
Hongliang Zeng,Yixin Zheng,Yan Lin,Cancan Huang,Shan Lin,Baodong Zheng,Yi Zhang
The aim of this study was to investigate the proliferation effect of fractionated lotus seed resistant starch (LRS3-20%, LRS3-30%) and the structural changes following fermentation. Fractionated lotus seed resistant starch, especially LRS3-20%, promoted the proliferation of these probiotics, and Bifidobacterium longum produced large quantities of acetic acid, while Lactobacillus delbrueckii subsp. bulgaricus produced lactic acid. Additionally, the probiotics with lotus seed resistant starch (LRS3) and LRS3-20% survived more successfully in simulated gastrointestinal solutions compared to glucose, LRS3-30% and high amylose maize starch, but LRS3 and LRS3-20% differed in their abilities to enhance the tolerance to acidic buffer, bile acid and simulated gastric juice. Furthermore, after fermentation, fractionated lotus seed resistant starch displayed a loose, rough surface. The crystalline and double helical structure increased as the amount of amorphous and sub-crystalline structure reduced following fermentation. Interestingly, structural changes were correlated with the original structures and utilisation by the probiotics.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
·
IF 3.909
Ang-Xin Song,Yu-Heng Mao,Ka-Chai Siu,Jian-Yong Wu
The bifidogenic effects of exopolysaccharide (EPS) of a medicinal fungus ( Cordyceps sinensis ) and a well-known food polysaccharide konjac glucomannan (KGM) with different molecular weight (MW) ranges were evaluated through in vitro experiments in liquid cultures of Bifidobacteria . Native EPS and KGM were partially degraded with power ultrasound (US) to improve the water solubility, and further hydrolysed with trifluoroacetic acid to much lower MW. The acid-hydrolysed fractions (EPS-AH and KGM-AH) supported the growth of all five tested bifidobacterial species, while the US-degraded high MW fractions, EPS-US and KGM-US, could only slightly support the growth of some species. All EPS fractions increased the acetic acid production of most bifidobacterial species. Most remarkably, the high MW EPS-US, EPS-AH and KGM-US fractions significantly enhanced the cell viability with much higher colony forming unit (CFU) counts, suggesting a protective effect of these high MW polysaccharides for the bacterial survival . The results have shown that MW was a significant factor on the bifidogenic properties of partially degraded EPS and KGM.
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Advanced Materials Interfaces
·
2018
·Vol. 5
·期 22
·1801015
·
IF 4.834
Yang-Fan Xu,Xu-Dong Wang,Jin-Feng Liao,Bai-Xue Chen,Hong-Yan Chen,Dai-Bin Kuang
Artificially photocatalytic reduction of CO 2 into valuable chemicals, responding to the call of carbon neutral economy, has aroused considerable interests so far. Among those photocatalysts screened, an emerging and promising alternative of inorganic CsPbBr 3 perovskite has recently been reported. Here, to attain preferable photocatalytic performance, an amorphous-TiO 2 -encapsulated CsPbBr 3 nanocrystal (CsPbBr 3 NC/a-TiO 2 ) hybrid is demonstrated through a solution processing strategy. After optimizing the a-TiO 2 matrix amount by tuning the tetrabutyl titanate precursor volume, the CsPbBr 3 NC/a-TiO 2 composite exhibits a marvelous 6.5-fold improvement on the consumption of photoelectrons in photocatalytic CO 2 reduction reaction when compared with the individual CsPbBr 3 NC. Such significant enhancement is ascribed to the accelerated electron–hole separation and the multiplied CO 2 adsorption. Thus, as an available prototype, this work offers a rational encapsulation design for efficient halide perovskite photocatalyst.
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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
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2018
·Vol. 106
·期 11
·2955-2962
·
IF 3.231
Jinze Wang,Lin Liu,Liping Yin,Li Chen
To enhance anticancer efficacy and decrease side effects, the synergistic multi-agent therapy has now increasingly gotten great attention. Herein, the flexible polycaprolactone had been modified by histidine and formed assembles with PEGylated metallo-porphyrin via metal-coordinated supramolecular interaction. This supramolecular assembles showed excellent acid sensitivity. At neutral environment, the hydrophobic anticancer drug could be effectively co-encapsulated with photosensitizer Fe-TPP to improve the water solubility. While at the intracellular microenvironment, the changed acid environment would trigger the drug and Fe-TPP release due to the reduction of metal-coordinated interaction between histidine and metallo-porphyrin leading to the disintegration of assembles. The in vivo anticancer experiments toward HeLa and MCF-7 cells disclosed that this co-delivery system of anticancer drug and photosensitizer showed enhanced anticancer efficacy, implying that the synergistic chemo-photodynamic therapy could improve cellular proliferation inhibition. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 2955–2962, 2018.
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POLYMER DEGRADATION AND STABILITY
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2018
·
IF 3.193
Mengshuai Liu,Jiao Guo,Yongqiang Gu,Jun Gao,Fusheng Liu
The application of ionic liquids in chemical recycling of waste polycarbonate (PC) via the simple hydrolytic strategy has shown great potential. Herein, a series of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) based ILs were facilely synthesized and characterized, and could efficiently catalyze the hydrolysis of PC in the absence of transition metal and solvent. The catalyst structures and reaction conditions were optimized, and 100% PC conversion with 97% bisphenol A (BPA) yield could be obtained under the conditions of n (H 2 O)/ n (PC) = 3:1, n (Cat.)/ n (PC) = 0.1:1, 140 °C for 3.0 h. Based on the experimental results and in-situ FT-IR analysis of the PC residues and BPA product, a feasible molecular activation and catalytic pathway for [HDBU][LAc] catalyzed hydrolysis of PC was proposed.
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ACS Applied Bio Materials
·
2018
·
IF 0
Lantao Liu,Nan Li,Meijun Chen,Hailin Yang,Qian Tang,Chengbin Gong
The phototoxicity of UV light limits the application of conventional azobenzene-based photoresponsive molecularly imprinted polymers in the biomedical field. This paper reports a tetra-ortho-methoxy-substituted azobenzene, N-(4-((4-amino-2,6-dimethoxyphenyl)diazenyl)-3,5-dimethoxyphenyl)methacrylamide (ADDDM), whose photoswitching is induced by all visible-light irradiation (440 nm for trans form to cis form and 630 nm for cis form to trans form) in N,N-dimethylformamide and tetrahydrofuran (1:9, v/v). Using ADDDM as the monomer, a visible-light-responsive surface molecularly imprinted polymer (VSMIP) on silica microspheres was fabricated for acyclovir (ACV). VSMIP showed a higher drug loading capacity, better specificity, faster drug release rate, and faster photoisomerization rate constant to ACV than the corresponding visible-light-responsive surface molecularly nonimprinted polymer (VSNIP). The selectivity of VSMIP to ACV and competing materials (ganciclovir and triacetylganciclovir) was examined by ultraviolet–visible spectroscopy, and the VSMIP showed excellent specificity of recognition toward ACV. The VSMIP can realize a visible-light-triggered (440/630 nm) release and uptake of ACV through chicken skin tissue (1 mm in thickness).
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TOXICOLOGICAL SCIENCES
·
2018
·Vol. 166
·期 2
·382-393
·
IF 4.181
Jin Cuiyuan,Zeng Zhaoyang,Wang Caiyun,Luo Ting,Wang Siyu,Zhou Jicong,Ni Yingchun,Fu Zhengwei,Jin Yuanxiang
Carbendazim (CBZ), a systemic, broad-spectrum benzimidazole fungicide, is widely used to control fungal diseases and has been regarded as an endocrine disruptor that causes mammalian toxicity in different target organs. Here, we discovered that chronic administrations of CBZ at 0.2, 1, and 5 mg/kg body weight for 14 weeks not only changed the composition of gut microbiota but also induced significant increases in body, liver, and epididymal fat weight in mice. At the biochemical level, the serum triglyceride (TG) and glucose levels also increased after CBZ exposure. Moreover, the level of serum lipoprotein lipase (LPL), which plays an important role in fatty acid release from TG, was decreased significantly. For gut microbiota, 16S rRNA gene sequencing and real-time qPCR revealed that CBZ exposure significantly perturbed the mice gut microbiome, and gas chromatography found that the production of short-chain fatty acids were altered. Moreover, CBZ exposure increased the absorption of exogenous TG in the mice intestine and inhibited the TG consumption, eventually leading the serum triglyceride to maintain higher levels. The increase of lipid absorption in the intestine direct caused hyperlipidemia and the multi-tissue inflammatory response. In response to the rise of lipid in blood, the body maintains the balance of lipid metabolism in mice by reducing lipid synthesis in the liver and increasing lipid storage in the fat. Chronic CBZ exposure induced the gut microbiota dysbiosis and disturbed lipid metabolism, which promoted the intestinal absorption of excess triglyceride and caused multiple tissue inflammatory responses in mice.
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ACS Catalysis
·
2019
·
IF 12.221
Mengrui Zhang,Vikram Singh,Xuefu Hu,Xinyi Ma,Jingkun Lu,Chao Zhang,Jingping Wang,Jingyang Niu
Design and synthesis of high-performance heterogeneous catalysts are of immense interest in chemical industries. Herein, ultrafine H2O coordinated WOx nanoparticles (H2O–WOx, average diameter 2.24 nm) embedded into porous carbon matrix have been obtained via space-confinement pyrolysis with postmodification oxidation approach. The synthesized H2O–WOx nanoparticles exhibit high activities toward olefin epoxidation reaction using H2O2 as oxidant. In epoxidation of cis-cyclooctene, the turnover frequency of the catalyst can achieve as high as 949 h–1, an activity comparable to the highest of all reported early transition-metal based catalysts. UV–vis spectra and controlled catalytic experiments have been performed to ascertain the possible active site in the catalyst: compared with traditional WO3 and peroxide coordinated W-(η2-O2) species, the water coordinated H2O–WOx can transform to hydroperoxide HOO–WOx in the presence of H2O2, and the HOO–WOx species can be further activated by proton acid to enhance its catalytic activities.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
·
IF 4.784
Mingjia Wang,Guijie Chen,Dan Chen,Hong Ye,Yi Sun,Xiaoxiong Zeng,Zhonghua Liu
One purified fraction from crude Fuzhuan brick tea polysaccharides (FBTPS), FBTPS-3, was obtained through column chromatography of DEAE Sepharose Fast Flow. The chemical properties and probiotic effects of FBTPS-3 were evaluated by fermentation in vitro . Moreover, the effects of FBTPS-3 on the function and metabolic pathway of gut microbiota were investigated by metagenomic sequencing. The results showed that FBTPS-3 was an heteropolysaccharide with molecular weight of 741 kDa, which was mainly composed of Man, Rha, GalA, Gal and Ara in molar ratio of 8.7:15.5:42.2:19.7:13.9. The contents of carbohydrates and uronic acid in FBTPS-3 were 44.78 ± 2.85% and 40.4 ± 2.11%, respectively. After fermentation, the molecular weight of FBTPS-3 and content of carbohydrates were significantly decreased, indicating that FBTPS-3 could be utilized by gut microbiota. Furthermore, the relative abundances of Bacteroides , Megasphaera and Prevotella were significantly increased by FBTPS-3. FBTPS-3 also significantly promoted the production of acetic, propionic and n-butyric acids. Based on the metagenomic sequencing, it was found that FBTPS-3 significantly enriched the metabolic pathway of starch and sucrose. All the results suggest that FBTPS-3 is expected to be developed as functional ingredients or foods to improve the host health through regulating the gut microbiota and physiological metabolic functions.
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ENERGY & FUELS
·
2018
·
IF 3.024
Yang Peng,Xiangjiang Liu,Xun Gong,Xiaomin Li,Yifu Liu,Erwei Leng,Yang Zhang
In this study, three kinds of monocarboxylic acids, formic, acetic, and propionic acids, are first applied to modified microalgae residuals (M1-RD, M2-RD, and M3-RD, respectively) after lipid extraction, aiming to enhance the adsorption capacity and selective binding ability for Hg(II) ions in simulated wastewater. The effect of pH, temperature, and initial Hg(II) concentration was investigated to identify the optimum adsorption conditions. Batch adsorption tests showed that the maximum adsorption efficiency obtained was 96.7% for M1-RD, 91.1% for M2-RD, and 84.4% for M3-RD at pH 4.05 compared to 48.5 and 57.6% for raw and residual microalgae at pH 5.01, respectively. The adsorption capacity of raw, residual, and modified microalgae increased with the increase of the temperature. Langmuir and Freundlich isotherm model tests showed that the maximum equilibrium adsorption capacity among three modified adsorbents reached 63 ± 3 mg/g for M1-RD, in contrast to 17 ± 1 and 25 ± 2 mg/g for raw and residual microalgae, respectively. The characterization of the modified sample by Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller, and scanning electron microscopy showed that the fibrous structure of the algae was decomposed by carboxyl groups in organic acids involved in microalgae, resulting in a larger surface area and more binding sites. In consideration of ion interference in the actual process, a kind of actual desulfurization wastewater from a 1000 MW coal-fired power plant (Guangdong, China) was introduced in the simulated adsorption system. Verification tests in desulfurization wastewater showed that up to 96% of Hg(II) ions were removed, probably as a result of co-precipitation of mercury and other co-existing ions.
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Analytical Methods
·
2024
·
IF 2.7
Hongxu Zhou,Qing Jiang,Xin He,Xian Fu,Jun-Yan Liu
Fatty acids (FAs) are essential molecules in all organisms and are involved in various physiological and pathophysiological processes. Pentafluorobenzyl bromide (PFBBr) is commonly used for FAs derivatization for gas chromatography-mass spectrometry (GC–MS) quantification by chemical ionization (CI). While CI is the conventional ionization mode for PFBBr derivatization, electron ionization (EI) source has also demonstrated efficacy in achieving satisfactory analytical performance for the analysis of PFB esters. In this study, we present a novel approach utilizing PFBBr-derivatization on a GC-EI-MS platform to quantitatively analyze a comprehensive range of 44 fatty acids (FAs) spanning from C2 to C24. The method's sensitivity, precision, accuracy, linearity, recovery, and matrix effect were rigorously validated against predetermined acceptance criteria. In comparison to the conventional CI ionization mode, the utilization of PFBBr-derivatization in GC-EI-MS exhibits a wider range of applications and achieves comparable sensitivity levels as the conventional CI platform. By using this method, we successfully quantified the 44 FAs in plasma and feces samples from the mice with deoxynivalenol (DON)-induced kidney injury. Among these, the levels of most FA species were increased in the DON-exposure group compared with the control group. The orthogonal partial least squares discriminant analysis (OPLS-DA) of all the tested FAs showed a visual separation of the two groups, indicating DON exposure resulted in a disturbance of FA profile in mice. These results indicate that the established method by integration of GC-MS with PFBBr derivatization is an efficient approach to quantify the comprehensive FA profile, which includes short-, medium- and long-chain FAs. In addition, our study provides new insights into the mechanism underlying DON exposure-induced kidney injury.
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