CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2024
·
IF 3.7
Antai Kang,Jiangtao Li,Yubin Li,Min Cao,Li Qiu,Bo Qin,Yanze Du,Feng Yu,Sha Li,Ruifeng Li,Xiaoliang Yan
Bimetallic CuCo catalysts with different Cu to Co ratios on N-doped porous carbon materials (N-C) were achieved using impregnation method and applied in the hydrogenation of furfural (FAL) to furfuryl alcohol (FOL). The high hydrogenation activity of FAL over Cu 1 Co 1 /N-C was originated from the synergistic interactions of Cu and Co species, where Co 0 and Cu 0 simultaneously adsorb and activate H 2 , and Cu + served as Lewis acid sites to activate C═O. Meanwhile, electrons transfer from Cu to Co promoted the formation of Cu + . In situ Fourier transform infrared spectroscopy analysis indicated that Cu 1 Co 1 /N-C adsorbed FAL with a tilted η 1 -(O) configuration. The superior Cu 1 Co 1 /N-C showed excellent adsorbed ability towards H 2 and FAL, but weak adsorption for FOL. Therefore, Cu 1 Co 1 /N-C possessed 93.1% FAL conversion and 99.0% FOL selectivity after 5 h reaction, which also exhibited satisfactory reusability in FAL hydrogenation for five cycles.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Yu Wang,Haojie Yu,Li Wang,Lei Zhang,Jian Yang,Chenguang Ouyang,Jian Hu,Jingyi Feng,Zheng Deng,Chang Chen
Efficient glycemic control serves as the cornerstone of diabetes and its complication treatments, necessitating additional symptomatic medications or nutritional supplements tailored to various complications. However, different diseases and medications require specific treatment regimens and drug delivery methods. For instance, conventional subcutaneous insulin injections suffer from uncontrollable release rates and onset times. This study has developed a segmented microneedle array that integrates two controlled-release mechanisms within a single array. Different drugs are loaded into distinct regions, allowing for modular and simultaneous timed-release therapies. The posterior segment of the microneedle tip releases insulin via a glucose-sensitive mechanism, enabling real-time intelligent glycemic regulation and effective glycemic control for up to 43.7 h, which is nearly 8 times longer than subcutaneous injections. The anterior segment releases vitamin B9 via a sustained-release mechanism, which has potential preventive and reparative effects on diabetic neuropathy, providing a gentler and more sustained nutrient supply. The regionalized design of the microneedles significantly enhances drug delivery efficiency and the intelligent customization of drug release, especially in managing diabetic neuropathy.
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jiahao Liu,Qingnian Li,Hanyu Tu,Jie Feng,Xiaofei Fan,Ze Mi,Hongpei Han,Xiaoqian Ma,Qi Liang,Zheng Zhang,Hongshuai Hou,Pengfei Rong,Wenhu Zhou
Radiotherapy is a cornerstone in the treatment of malignant tumors, yet its efficacy is often hindered by intrinsic and acquired resistance mechanisms, notably limited radiation availability and tumor hypoxia within inner tumor region. This study introduces a multifunctional nanosensitizer, CD Bi,Mn-FA @CaP, with high tumor accumulation and deep penetration capabilities via dynamic conformational change. CD Bi,Mn-FA was bismuth manganese-doped carbon dots, offering radiosensitizing properties and catalase-like activity for oxygen generation. Folic acid modification further enhances tumor cell targeting. These carbon dots are encapsulated in calcium phosphate nanoparticles to form CD Bi,Mn-FA @CaP, which demonstrates improved in vivo circulation and tumor accumulation via the enhanced permeability and retention (EPR) effect. Upon encountering the acidic tumor microenvironment, the encapsulation degrades, releasing smaller CD Bi,Mn-FA particles that deeply penetrate tumor tissues. In vitro and in vivo experiments establish that CD Bi,Mn-FA @CaP effectively targets tumor tissue, enhances radiotherapy-induced apoptosis, and suppresses tumor growth. Notably, the nanoparticle achieves a 40 % tumor cure rate and ensures 100 % survival within 45 days post-treatment. Biocompatibility studies confirm minimal systemic impact, with efficient renal and fecal elimination, indicating promising clinical translational potential. This study introduces a novel radiation therapy sensitization strategy and underscores the potential of such size changeable nanoparticles as an advanced targeted drug delivery system for tumors.
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CHEMICAL PHYSICS
·
2024
·
IF 2
Zhifeng Cai,Qi Liang,Yutong Wang,Xiao Wang,Lulu Jing,Yajie Cheng,Jinqi Liu,Zixuan Jia
Bright, blue fluorescent carbon quantum dots ( N -CDs) were carried out utilizing phenylenediamine and ascorbic acid as raw precursor through the hydrothermal method. The as-designed N -CDs suggested excitation-dependent characteristic changing from 340 nm to 380 nm. Moreover, Folic acid could availably quench the fluorescence intensity of the N -CDs. According to this experimental phenomenon, the sensitivity and selectivity of N -CDs for folic acid detection were developed. Under optimal experimental conditions, the as-prepared probe displayed excellent linearity with the folic acid concentration changing from 0.5 to 200 μM, and the limit of detection was 0.079 μM. Furthermore, the as-prepared probe indicated good sensitivity towards folic acid sensing in glucose and bovine serum samples. The recoveries of 95.9–104.8 % and 98.6–106.9 % were obtained in glucose and bovine serum samples, respectively. The corresponding relative standard deviation was lower than 2.74 % and 2.91 %, respectively. With preeminent sensitivity and selectivity, this as-developed nanosensor afforded a prospective platform for measuring folic acid in real samples. Furthermore, this N -CDs could be applied for the temperature detection.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2024
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IF 4.3
Zhifeng Cai,Yixuan Zhang,Manlin Zhao,Jinjia Bao,Ling Lv,Haoyang Li
Copper nanoclusters (FA@CuNCs) emitting blue fluorescence were successfully developed via a one-pot technique. In this method, the copper chloride, folic acid and hydrazine hydrate were applied as a precursor, protective agent and reducing agent, respectively. The absorption, fluorescence excitation and emission spectra of FA@CuNCs were carried out by using ultraviolet–visible and fluorescence spectrometry, respectively. The morphology, particle size, functional groups, oxidation states of elements of FA@CuNCs were discussed via using transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). The stability of FA@CuNCs was studied under various conditions, such as storage time at 25 ℃, ultraviolet radiation time, sodium chloride solutione and pH. The FA@CuNCs displayed blue fluorescence under the excitation wavelength of 361 nm, and the fluorescence quantum yield was 7.45 %. As a result of the inner filter effect, the alizarin red could significantly weaken the blue fluorescence of FA@CuNCs. Thus, the as-prepared FA@CuNCs could be utilized as fluorescence nanosensors for the trace determination of alizarin red. This platform suggested an excellent linear range for alizarin red varying from 0.5 to 200 μM with a fitting coefficient of 0.9955. The detection limit was calculated to be 0.064 μM in the light of the 3b/k (b and k refer to the standard deviation and slope of fitted curve, respectively). Furthermore, the as-developed FA@CuNCs could be used to detect the alizarin red in real samples and for the sensing of temperature.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 10.6
Huang Lanli,Yao Yi,Ruan Zhuren,Zhang Shengqing,Feng Xianjing,Lu Chun,Zhao Jinmin,Yin Feiying,Cao Cunwei,Zheng Li
Intra-articular drugs used to treat osteoarthritis (OA) often suffer from poor pharmacokinetics and stability. Nano-platforms as drug delivery systems for drug delivery are promising for OA therapy. In this study, we reported an M1 macrophage-targeted delivery system Bai@FA-UIO-66-NH2 based on folic acid (FA) -modified metal-organic framework (MOF) loaded with baicalin (Bai) as antioxidant agent for OA therapy. With outstanding biocompatibility and high drug loading efficiency, Bai@FA-UIO-66-NH2 could be specifically uptaken by LPS-induced macrophages to serve as a potent ROS scavenger, gradually releasing Bai at the subcellular level to reduce ROS production, modulate macrophage polarization to M2, leading to alleviation of synovial inflammation in OA joints. The synergistic effect of Bai@FA-UIO-66-NH2 on macrophage polarization and ROS scavenging significantly improved the therapeutic efficacy of OA, which may provide a new insight into the design of OA precision therapy.
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JOURNAL OF MATERIALS CHEMISTRY
·
2012
·Vol. 22
·期 31
·15804-15811
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IF 5.968
Kedong Lu,Mingzhuo Cao,Weiwei Mao,Xuanrong Sun,Jianbin Tang,Youqing Shen,Meihua Sui
Amides with β-carboxylic acid groups are stable and negatively charged at physiological pH, but hydrolyze back to the corresponding amines and anhydrides once in an acidic environment. We thereby developed charge-reversal nanocarriers for drug delivery. In these systems, the anhydrides served only as groups to amidize the amines in cationic polymers and had no therapeutic use after being cleaved from the carrier in the cells. Herein, we utilized the characteristic anhydride structure of norcantharidin (NCTD) and the pH-dependent hydrolysis of its β-carboxylic amides and developed novel acid-labile conjugates for the targeted delivery of NCTD. In this study, NCTD was used as both an anticancer drug and an acid-labile anhydride to react with cationic polymers including PEI and PLL to form β-carboxylic amides. The obtained conjugates (PEI–NCTD and PLL–NCTD) had not only significantly improved NCTD solubility and high drug loading contents (as high as 72.3% and 56.8%, respectively, for PEI–NCTD and PLL–NCTD), but also favorable acid-labile capabilities. These conjugates were stable and negatively charged at neutral pH, but once in acidic environments (e.g. endo/lysosomes), they hydrolyzed and regenerated not only NCTD as an antitumor drug, but also the PEI or PLL, which could assist the endo/lysosomal escape and release of the drugs. Further, functionalizing the acid-labile conjugates with targeting moiety folic acid (FA) increased the cellular uptake of the conjugates into folate receptor-overexpressing tumor cells and thereby the in vitro cytotoxicity. These targeted acid-labile conjugates may help to reduce the side effects of NCTD and improve its clinical applications.
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ELECTROCHEMISTRY COMMUNICATIONS
·
2012
·
IF 4.859
Yuehong Pang,Zhaoqiang Ge,Yong Liu,Xiaofang Shen
Covalently conjugating folate on Au surface was achieved via click chemistry, copper (I)-catalyzed azide-alkyne cycloaddition reaction. Human leukemia K562 cells were used as a model system to investigate capturing cancer cells by folate-targeted electrode. Scanning optical microscopy and electrochemical method were used to monitor the capture of K562 cells on folate-clicked electrode.
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EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
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2012
·
IF 3.212
Jianian Chen,Shaoshun Li,Qi Shen
Dual- and multi-functional drug delivery systems , especially ligand-modified nanoparticles (NPs) loaded with chemotherapeutic agents are paid much attention to due to their excellent behavior in vitro and in vivo . Bifunctional NPs (BF-NPs), which were based on PLGA–PEG and modified with folic acid and cell penetrating peptide R 7 simultaneously, were developed. BF-NPs loaded with vincristine sulfate (VCR) were prepared via the water–oil–water emulsion solvent evaporation method. BF-NPs showed favorable particle size and zeta potentials , promising drug loading and entrapment efficiency. The release of VCR from BF-NPs exhibited a biphase release manner. Cellular uptake of BF-NPs was found to be higher than that of the NPs merely modified by folic acid or R 7 . In vitro cytotoxicity, cell apoptosis and cell cycle arrest studies also revealed that BF-NPs were more potent than those of the NPs merely modified by folic acid or R 7 . Therefore, the results demonstrated that BF-NPs developed in this study could be a potential vehicle for delivering chemotherapeutic agents such as VCR and breast cancer therapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Ziying Zhang,Weishen Zeng,Ning Guo,Mengnan Ran,Huixuan Gan,Quanxin Wu,Jiehua Xu,Hao Wang,Shisong Han,Yun Liu
As an emerging therapeutic method, the application of sonodynamic therapy (SDT) is hindered by its intrinsic unsatisfactory efficiency, the tumor hypoxia and low tumor specificity. Here, we reported the design of a tumor-targeting multifunctional nanodrug for O 2 -generation/O 2 -economization dually enhanced SDT/chemodynamic therapy (CDT) combination therapy. After the co-encapsulation of sonosensitizer indocyanine green (ICG) and oxidative phosphorylation inhibitor metformin (Met) into hollow MnO 2 (H-MnO 2 ) nanoparticles, ICG/Met@H-MnO 2 @MPN-FA (IMMMF) was conveniently prepared through the formation of metal–phenolic networks (MPNs) between Fe 3+ and folic acid (FA) immobilized tannic acid (TA, TA-FA) onto its surface. In vitro experiments indicated its selective uptake by 4T1 cells via the specific folate receptors-FA interactions. Responding to glutathione (GSH) and the acidic environment, the decomposition of IMMMF led to the release of Mn 2+ and Fe 2+ for enhanced CDT, and ICG for SDT. Furthermore, Met was continuously released to reduce O 2 consumption for enhanced SDT. More importantly, IMMMF catalyzed the endogenous H 2 O 2 into O 2 for further enhanced SDT. Expectedly, both in vitro and in vivo antitumor assays confirmed its satisfactory therapeutic efficiency via CDT/SDT synergistic therapy. Hence, this intelligent sonocatalytic nanoagent emerges as a promising candidate for CDT-enhanced SDT, which also provides a novel strategy for dually alleviating tumor hypoxia with better therapy.
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Analytical Methods
·
2024
·Vol. 16
·期 6
·939-949
·
IF 2.7
Qian Du,Xiaoyu Zhao,Xiping Mei,Yaqin Zhao,Chuan Dong,Junfen Li
To develop a feasible, sensitive, and essential sensor is important for the identification of Fe3+ ions and ascorbic acid (AA). Herein, highly fluorescent heteroatom co-doped carbon dots (N,S-CDs) with a quantum yield (QY) of 24.6% were synthesized, using hydrothermal treatment of L-cysteine (Cys) and 1-amino-2-naphthol-4-sulfonic acid (ANSA). The fluorescence emission of the as-prepared N,S-CDs was quenched strongly by Fe3+ ions, and this was further recovered by the reduction effect of AA on Fe3+. Based on this, continuous fluorescence sensing of Fe3+ and AA with an “on-off-on” style was developed. The detection of Fe3+ and AA were in relatively wider linear ranges of 5.00–105 μmol L−1 and 4.97–54.8 μmol L−1, with a detection limit of 0.10 μmol L−1 and 2.4 nmol L−1 (S/N = 3), respectively. Then, the N,S-CDs were successfully used to measure Fe3+ ions and AA in some daily food samples, and this method exhibited some advantages over most other reported techniques in the term of response speed, quantum yield, and detection limit.
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INTERNATIONAL JOURNAL OF FOOD PROPERTIES
·
2024
·
IF 3.1
Jun Zhu,Wenlin Sun,Wenqi Zhang,Nuo Hong,Yuying Liao,Yiling Yao,Lala Cai,Chunhua Xiong,Lanying Yao
The aim of the present study was to determine the binding mechanisms between zein and folic acid in an ethanol – water solution. Fluorescence spectroscopy demonstrated that folic acid quenched the fluorescence intensity of zein by both dynamic and static fluorescence quenching mechanisms, with static quenching playing a prominent role. The binding constants (Ka) of the zein-folic acid complex at 292, 302, and 312 K were evaluated to be 5.97 × 105, 3.00 × 105 and 1.54 × 105 L/mol, respectively. The process of folic acid binding zein was driven by ∆H0 = –51.24 kJ/mol, ∆S0 = –64.90 J/mol•K. Van der Waals forces and hydrogen bonding primarily governed the formation of the zein-folic acid complex. Confirmation of the complex formation was obtained via UV-visible absorption spectroscopy, Fourier transform infrared spectroscopy, and circular dichroism spectroscopy, which also revealed alterations in the secondary structure of zein upon binding to folic acid. Measurements of particle size and zeta potential demonstrated an enhancement in the stability of the complex system. Scanning electron microscopy and transmission electron microscopy showed the complex to possess a spherical morphology, with significant changes in the zein’s morphology following its binding to folic acid. Additionally, zein increased the photostability of folic acid against UV light radiation. Molecular docking and molecular dynamics simulations were used to investigate the binding mechanisms involved further, and the results effectively elucidated the observed experimental phenomena. This research establishes a significant theoretical foundation for the utilization of zein as a system for delivering and safeguarding folic acid.
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