FOOD CHEMISTRY
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2023
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IF 8.8
Xidian Yue,Qing Hua,Wenjuan Zhang,Feiyan Tang,Xiaobing Wang,Feng Luan,Xuming Zhuang,Chunyuan Tian
In this work, europium ion-doped gadolinium trioxide nanocrystals (Gd 2 O 3 :Eu 3+ NCs) were successfully synthesized and applied to construct an electrochemiluminescence (ECL) sensor. Compared with pure Gd 2 O 3 , the doping of Eu 3+ ions caused enhanced ECL intensity and more stable signals. Based on the excellent ECL performance of Gd 2 O 3 :Eu 3+ NCs, we constructed a new ECL sensing platform for the detection of organophosphorus pesticides (OPs). The ECL sensor showed a good linear relationship in the concentration range of 1 nM to 1 pM, with a limit of detection of 0.12 pM (S/N = 3) for dichlorvos (DDVP). In addition, the constructed ECL sensor was applied for the detection of DDVP in vegetable samples, and good recoveries were obtained. The results indicated that the ECL sensor exhibited fantastic performance properties and had good application prospects in OPs detection.
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Journal of Materials Chemistry B
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2023
·
IF 7
Yinsheng Liu,Mingyue Wang,Yinfei Hui,Lei Sun,Yanrui Hao,Henlong Ren,Hao Guo,Wu Yang
In this study, a rare-earth hybrid luminescent material (lanthanide@COF) was constructed for the detection of a biomarker for anthrax (dipicolinic acid, DPA). JCU-505-COOH was prepared by the hydrolysis of the cyano group in JCU-505 via a post-synthetic modification strategy, then the carboxyl groups in JCU-505-COOH coordinated with Tb3+ ions, similar to pincer vising nut. The prepared Tb3+@JCU-505-COOH exhibited a turn-on response toward DPA, which allowed the lanthanide@COF to serve as a fluorescence sensor with excellent selectivity and high sensitivity (binding constant Ka = 3.66 × 103). The fluorescent probe showed satisfactory performance for the determination of DPA in saliva and urine with a detection limit of 0.6 μM. Moreover, we established a facile point-of-care testing (POCT) using the Tb3+@JCU-505-COOH-based fluorescent test paper together with a smartphone for the initial diagnosis of anthrax. As expected, Tb3+@JCU-505-COOH showed great potential for the rapid screening of anthrax due to low cost, simple operation, and wide applicability.
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JOURNAL OF CONTROLLED RELEASE
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2023
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IF 10.8
Qian Hu,Hongbing Lan,Yinmei Tian,Xiaonan Li,Mengmeng Wang,Jiao Zhang,Yulin Yu,Wei Chen,Li Kong,Yuanyuan Guo,Zhiping Zhang
Coacervate droplets formed by liquid-liquid phase separation have attracted considerable attention due to their ability to enrich biomacromolecules while preserving their bioactivities. However, there are challenges to develop coacervate droplets as delivery vesicles for therapeutics resulting from the lack of physiological stability and inherent lack of membranes in coacervate droplets. Herein, polylysine-polynucleotide complex coacervate droplets with favorable physiological stability are formulated to efficiently and facilely concentrate small molecules, biomacromolecules and nanoparticles without organic solvents . To improve the biocompatibility , the PEGylated phospholipid membrane is further coated on the surface of the coacervate droplets to prepare coacervate-based artificial protocells (ArtPC) with membrane-like and cytoplasm-like structures. The ArtPC can confine the cyclic catalytic system of uricase and catalase inside to degrade uric acid and deplete the toxicity of H 2 O 2 . This biofunctional ArtPC effectively reduces blood uric acid levels and prevents renal injuries in mice with persistent hyperuricemia . The ArtPC-based therapy can bridge the disciplines of synthetic biology, pharmaceutics and therapeutics.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2023
·
IF 4.5
Shouhui Chen,Dan Zhou,Jingguo Yu,Qinghao Xiong,Zhenzhong Huang,Li Wang
It is important to simultaneously detect dopamine (DA) and uric acid (UA) for health monitoring and disease diagnostics. Studies shows that bimetallic catalysts with synergistic effect have a better catalytic performance in the simultaneous determination. Herein, a composite of N-doped CoFe on carbon matrix doped with (CoFe/ /NC) was prepared by pyrolyzing a metal-organic framework. Then the composite was modified on glassy carbon electrodes to simultaneously detect DA and UA. The study of double potential step chronoamperometry showed that the diffusion coefficients and the catalytic rate constants for UA were less than those of DA. Since the electrochemical signals related to DA and UA interfere with each other, the concentration calibration curve of one component would distort if the concentration of coexisting component varied. The simultaneous detection was executed via differential pulse voltammetry with the aid of chemometric methods. The models established by partial least squares regression analysis have little help for the simultaneous detection, especially for the concentration of UA in the samples. The models build by back propagation artificial neural network can realize the simultaneous determination with only 4 neurons in three-layer network. DA and UA in normal human serum were detected by the CoFe/ /NC electrode with the aids of chemometrics.
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Nano Energy
·
2023
·
IF 17.6
Guang Liu,Zijian An,Yanli Lu,Yue Wu,Zhenghan Shi,Xin Li,Jingjiang Lv,Hao Wen,Zheng Peng,Ray P.S. Han,Yan He,Qing Ye,Qingmei Chen,Fenni Zhang,Jun Liu,Qingjun Liu
Spontaneous conversion of environmental moisture energy to high-output electricity can help meet the massive electricity demand of wearable electronics. However, low power density and inefficient energy harvesting are the main challenges to power electronics currently. Herein, we developed a flexible moisture-enabled electricity generation (MEG) membrane with high output power. The asymmetrical structure of the moisture-enabled flexible units is composed of a bilayer of polyanion and polycation. The single device produced a sustained voltage of 0.8 V and can be customized by an aligned stacking strategy for scale integration on demand. Enhanced by increasing the diffusion speed of carriers with the metal-air reaction, the output power reached 286.5 μW/cm 2 , which is enough for long-term wearable health monitoring. Meanwhile, to solve the power supply challenge of the wearables, a fully self-powered system with an energy harvester, a power management module, and a wireless and wearable sensing module was developed. Biochemical indicators and body motion were detected and monitored by the sensor array, demonstrating the promising application in wearable health management, including harvesting energy from giant moisture and powering wearable electronics.
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ENVIRONMENTAL RESEARCH
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2023
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IF 8.3
Yan Cao,Qun Zhao,Fanshu Jiang,Yingxue Geng,Haoran Song,Linfeng Zhang,Chen Li,Jie Li,Yingjie Li,Xuewei Hu,Jianhong Huang,Senlin Tian
The relationship between microplastics (MPs) and human respiratory health has garnered significant attention since inhalation constitutes the primary pathway for atmospheric MP exposure. While recent studies have revealed respiratory risks associated with MPs, virgin MPs used as plastic surrogates in these experiments did not represent the MPs that occur naturally and that undergo aging effects. Thus, the effects of aged MPs on respiratory health remain unknown. We herein analyzed the interaction between inhalable aged MPs with lung surfactant (LS) extracted from porcine lungs vis-à-vis interfacial chemistry employing in-vitro experiments, and explored oxidative damage induced by aged MPs in simulated lung fluid (SLF) and the underlying mechanisms of action. Our results showed that aged MPs significantly increased the surface tension of the LS, accompanied by a diminution in its foaming ability. The stronger adsorptive capacity of the aged MPs toward the phospholipids of LS appeared to produce increased surface tension, while the change in foaming ability might have resulted from a variation in the protein secondary structure and the adsorption of proteins onto MPs. The adsorption of phospholipid and protein components then led to the aggregation of MPs in SLF, where the aged MPs exhibited smaller hydrodynamic diameters in comparison with the unaged MPs, likely interacting with biomolecules in bodily fluids to exacerbate health hazards. Persistent free radicals were also formed on aged MPs, inducing the formation of reactive oxygen species such as superoxide radicals (O 2 •– ), hydrogen peroxide (HOOH), and hydroxyl radicals (•OH); this would lead to LS lipid peroxidation and protein damage and increase the risk of respiratory disease. Our investigation was the first-ever to reveal a potential toxic effect of aged MPs and their actions on the human respiratory system, of great significance in understanding the risk of inhaled MPs on lung health.
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Small Methods
·
2023
·Vol. 8
·期 3
·2301184
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IF 12.4
Yangyi Huang,Rongliang Yang,Haosong Zhong,Connie Kong Wai Lee,Yexin Pan,Min Tan,Yi Chen,Na Jiang,Mitch Guijun Li
A portable sweat urea sensing system is a promising solution to satisfy the booming requirement of kidney function tele-monitoring. However, the complicated manufacturing route and the cumbersome electrochemical testing system still need to be improved to develop the urea point-of-care testing (POCT) and tele-monitoring devices. Here, a universal technical route based on a high-throughput automatic laser printing strategy for fabricating the portable integrated urea monitoring system is proposed. This integrated system includes a high-performance laser-printed urea sensing electrode, a planar three-electrode system, and a self-developed wireless mini-electrochemical workstation. A precursor donor layer is activated by laser scribing and in situ transferred into functional nanoparticles for the drop-on-demand printing of the urea sensing electrode. The obtained electrodes show high sensitivity, low detection limit, fast response time, high selectivity, good average recovery, and long-term stability for urea sensing. Additionally, a laser-induced graphene circuit-based miniature planar three-electrode system and a wireless mini-electrochemical workstation are designed for sensing data collection and transmitting, achieving real-time urea POCT and tele-monitoring. This scalable method provides a universal solution for high-throughput and ultra-fast fabrication of urea-sensing electrodes. The portable integrated urea monitoring system is a competitive option to achieve cost-effective POCT and tele-monitoring for kidney function.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2023
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IF 4.4
Yingying Guo,Tianlu Zhao,Qiaonan Guo,Mingji Ding,Xiangrong Chen,Jianqing Lin
Up-conversion nanoparticles (UCNPs), especially single-band bright red UCNPs, have better penetration of biological tissues, absorb less lost energy, and have higher sensitivity and accuracy in the determination of actual biological samples in the field of biosensing. Here, a novel colorimetric and fluorescent dual-channel method based upon an internal filtration effect (IFE) quenching mechanism was proposed for the quantitative analysis of xanthine (XA) by using red UCNPs as fluorescence indicator and 3,3′,5,5′ -tetramethylbenzidine (TMB) as chromogenic substrate. The sensitivity of the detection system was also enhanced by a cycle signal amplification strategy based on the Fenton reaction. Under the best conditions, the detection limits of XA by fluorescent and colorimetric methods were 0.58 μM and 1.19 μM, respectively. The developed method was applied to the detection of XA in actual serum samples, and the recoveries of the spiked samples by fluorescent and colorimetric methods were in the range of 96.3–104.3 % and 94.3–105.4 %, respectively. In addition, the commercial ELISA method was used to verify the application of the proposed method and the test results of XA were close to those obtained by fluorescent and colorimetric methods, indicating that the accuracy of the developed nanosensing system was acceptable.
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JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2023
·
IF 4.5
Haifeng Yao,Yahui Zhang,Yongping Dong,Mingfu Ye
Graphdiyne (GDY) is considered as another promising carbon material in biosensing field. However, the application of GDY in ECL sensing is in its infancy stage, and different roles of GDY are urgent to be discovered. In this work, strong anodic Ru(bpy) 3 2+ electrochemiluminescence (ECL) was obtained at a cucurbit[8]uril (Q[8]) modified electrode. Although GDY exhibited electrocatalytic effect on the oxidation of Ru(bpy) 3 2+ , an apparent inhibiting effect of GDY on the ECL signal was observed due to the energy transfer. An “on-off-on” mode ECL sensor was fabricated to detect pancuronium (PMD) based on the competitive host–guest interaction between ferrocene (Fc), PMD and Q[8]. Fc modified single-stranded DNA was immobilized onto the surface of GDY, which could be attached onto the electrode through the interaction between Fc and Q[8]. The quenching effect of GDY could apparently decrease ECL signal. PMD exhibited stronger combining ability with Q[8] than Fc, and could replace Fc from the cavity of Q[8], leading to the recovery of ECL signal. The variation of ECL intensity changed linearly with the PMD concentration in the range of 10 nM to 50 μM with a detection limit of 5 nM (3σ). The proposed sensor has high sensitivity, outstanding specificity and accuracy, indicating that GDY has promising potential application in ECL sensing field based on its inhibiting effect.
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TALANTA
·
2023
·
IF 6.1
Shuyan Ruan,Ru Liu,Xi Chen,Qian Huang,Chongxin Xiao,Ruiyun You,Luqiang Huang,Yunzhen Liu,Jingbo Chen,Xiufeng Xiao,Qingqiang Lin,Yudong Lu
As a reactive oxygen species (ROS), excessive production of H 2 O 2 contributes to the development of several diseases such as, inflammation, cancer, and respiratory diseases. Supplementation with endogenous or exogenous antioxidants can scavenge ROS and reduce the oxidation of cellular molecules, thus alleviating the generation of diseases. Therefore, the determination of H 2 O 2 content and its antioxidant activity is of great importance in disease diagnosis and treatment. In this paper, a ratiometric SERS sensor with a flexible cellulose membrane was designed for quantitative detection of H 2 O 2 and assessment of antioxidant activity. First, gold seeds were reduced on bacterial cellulose membrane (BCM) and Au NPs were smoothly deposited on the bacterial cellulose membrane (BCM) using halides to reduce the reduction potential in the growth solution to form a flexible BCM@Au NPs SERS substrate. Afterwards, the oxidation of H 2 O 2 was used to convert 3-mercaptophenylboronic acid (3-MPBA) to the corresponding phenol form 3-hydroxyphenylethanol (3-HTP). The change of substance resulted in a good linear relationship between the intensity ratio corresponding to the two Raman shifts of 881 cm −1 and 995 cm −1 and the H 2 O 2 concentration with a detection limit of 0.0186 μM. This opens up a new method for the detection of H 2 O 2 with high sensitivity and accuracy. In addition, this SERS platform was successfully used for the determination of antioxidant activity. It is promising to be applied to disease diagnosis and efficacy evaluation.
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ANALYTICA CHIMICA ACTA
·
2023
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IF 6.2
Minjie Peng,Yufeng Sun,Wen Zang,Changyong Gao,Lijing Miao,Aiguo Wu,Yujie Zhang
Background As a common industrial raw material and chemical intermediate, p-Aminophenol (pAP) is recognized as a serious pollutant that poses harm to both the environment and human health. The traditional detection methods for pAP have the advantages of good selectivity and high sensitivity, but their complex operation and time-consuming defects limit their application in on-site detection. Therefore, it is necessary to develop a simple, low-cost, rapid and high-sensitivity method for the detection of pAP. Results Noble metal nanoparticles have been widely used in colorimetric sensing because of their simplicity and practicality. Herein, we presented a simple, excellent sensitive and selective colorimetric method for high-performance detection of pAP based on Cu–Au nanoparticles (Cu–Au NPs) and KIO 3 . In the presence of pAP, KIO 3 was reduced to I 2 , which subsequently chemically adsorbed onto Cu–Au NPs surface and induced the dispersion and reorganization of Cu–Au NPs, along with prominent color change of the dispersion from gray-blue to pink and the transformation of Cu–Au NPs from chain-like aggregates to individual dispersed, irregular, subspherical nanoparticles. The mechanism was verified by TEM , DLS , Zeta potential , UV–vis and XPS . Meanwhile, Cu–Au NPs probe can rapidly detect pAP within 25 min, the limit of detection of pAP probe is 5 μM by the naked eyes and 0.03 μM by UV–vis absorption spectrum . Significance and novelty This is the first colorimetric assay for pAP based on Cu–Au NPs probe. The satisfactory linearity (R 2 = 0.9984) indicates that the colorimetric probe based on Cu–Au NPs and KIO 3 can be utilized for quantitative detection of pAP. The detection results of pAP in real environmental water samples, urine samples and paracetamol tables demonstrate the practicability of pAP colorimetric probe.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2023
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IF 6.2
Quan Li,Xing Wang,Xiaolan Cui,Xin Liu,Wentai Wang
Hydrogen peroxide (H 2 O 2 ) is a major transmitter of redox signals during chemical processes. Cost-effective and easy-to-operate sensors for H 2 O 2 are in high demand in a variety of fields. A novel photoelectrochemical (PEC) sensor for H 2 O 2 detection was investigated, using BiOBr/TiO 2 NAs/FTO (BiOBr/TNAs) as a PEC electrode which is obtained by successive ionic layer adsorption and reaction (SILAR) method. This non-enzymatic PEC BiOBr/TNAs electrode shows excellent selectivity, stability, and reproducibility for H 2 O 2 detection in optimizing modes. The linear relationship is in a broad range from 4 to 1800 μM (R 2 = 0.994) and a detection limit of 0.65 μM (S/N = 3). In the detection of H 2 O 2 in apple juice and milk real samples, the BiOBr/TNAs show outstanding recovery ranging from 98.0 % to 102.0 %, indicating great potential in practical applications. Meanwhile, the p-n heterojunction formed between BiOBr and TiO 2 improves the utilization of visible light and effectively promotes the separation of photogenerated electrons and holes. This work provides a new strategy for the non-enzymatic detection of hydrogen peroxide in PEC mode.
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