BIOCHEMICAL PHARMACOLOGY
·
2024
·
IF 5.3
Hongzhuan Yin,Di Wu,Qiao Qu,Zhilong Li,Lianrong Zhao
The tumor recurrence and metastasis of colorectal cancer (CRC) are responsible for most of CRC-linked mortalities. It is an urgent need to deeply investigate the pathogenesis of CRC metastasis and look for novel targets for its treatment. The current study aimed to investigate the effects of ubiquitin-specific peptidase 15 (USP-15) on the CRC progression. In vivo, a mouse model of liver metastasis of CRC tumor was established to investigate the role of USP-15. In vitro, the migrated and invasive abilities of CRC cells were assessed by transwell assay. Cell stemness was evaluated by using sphere formation assay. The underlying mechanism was further explored by employing the co-immunoprecipitation, dual luciferase reporter assay, oligonucleotide pull-down assay, and chromatin immunoprecipitation assay. The results showed that USP-15 was upregulated in CRC patients with liver metastasis and high metastatic potential cell lines of CRC. Loss of USP-15 repressed the epithelial-to-mesenchymal transition (EMT), migration, invasion, and stemness properties of CRC cells in vitro. Downregulation of USP-15 reduced the liver metastasis of mice in vivo. USP-15 upregulation obtained the contrary effects. Subsequently, USP-15 deubiquitinated transcription factor AP-4 (TFAP4) and enhanced its protein stability. TFAP4 could transcriptionally activated polycomb group ring finger 1 (PCGF1). The pro-cancer effects of USP-15 were rescue by the knockdown of TFAP4 or PCGF1. In conclusions: USP-15 facilitated the liver metastasis by the enhancement of cell stemness and EMT in CRC, which was at least partly mediated by the deubiquitination of TFAP4 upon the upregulation of PCGF1.
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高影响因子
Journal of Materials Chemistry A
·
2018
·Vol. 6
·期 17
·7409-7419
·
IF 9.931
Zhiyong Liu,Bo Sun,Xingyue Liu,Jinghui Han,Haibo Ye,Yuxue Tu,Chen Chen,Tielin Shi,Zirong Tang,Guanglan Liao
Perovskite solar cells (PSCs) are one of the most promising lab-scale technologies to deliver inexpensive solar electricity. Low-temperature printable carbon counter electrode based planar-heterojunction PSCs are particularly suitable for future large-scale manufacturing, but suffer from an inferior efficiency. Here, we demonstrate a TiO2/SnO2 bilayer as the electron transport layer (ETL) for carbon counter electrode based planar-heterojunction PSCs together with micromolecule Cu-phthalocyanine (CuPc) as the hole transport layer (HTL), yielding a high power conversion efficiency of 15.39% and an excellent stability over 1200 h. The improved performances are attributed to a better energy level transition, a suppressed electron–hole recombination, and a wider depletion region of the TiO2/SnO2 bilayer. Our work represents a great advancement in the fabrication and popularization of carbon counter electrode based PSCs. More importantly, the whole devices are processed at a temperature below 200 °C, providing potential application of PSCs in monolithic tandem devices and paving the way for the development of carbon based flexible PSCs.
研究领域:
材料科学
·
能源技术
·
光伏器件
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2021
·Vol. 32
·期 12
·1-13
·
IF 3.896
Xu Wanghan,Tan Wei,Li Chan,Wu Keke,Zeng Xinyi,Xiao Liwei
Periodontitis is a progressive infectious inflammatory disease, which leads to alveolar bone resorption and loss of periodontal attachment. It is imperative for us to develop a therapeutic scaffold to repair the alveolar bone defect of periodontitis. In this study, we designed a new composite scaffold loading metformin (MET) by using the freeze-drying method, which was composed of β-tricalcium phosphate (β-TCP), chitosan (CTS) and the mesoporous silica (SBA-15). The scaffolds were expected to combine the excellent biocompatibility of CTS, the good bioactivity of β-TCP, and the anti-inflammatory properties of MET. The MET-loaded β-TCP/CTS/SBA-15 scaffolds showed improved cell adhesion, appropriate porosity and good biocompatibility in vitro. This MET composite scaffold was implanted in the alveolar bone defects area of rats with periodontitis. After 12 weeks, Micro-CT and histological analysis were performed to evaluate different degrees of healing and mineralization. Results showed that the MET-loaded β-TCP/CTS/SBA-15 scaffolds promoted alveolar bone regeneration in a rat model of periodontitis. To our knowledge, this is the first report that MET-loaded β-TCP/CTS/SBA-15 scaffolds have a positive effect on alveolar bone regeneration in periodontitis. Our findings might provide a new and promising strategy for repairing alveolar bone defects under the condition of periodontitis.
研究领域:
牙科材料
·
组织工程
·
生物材料
·
口腔生物学
·
再生医学
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2026
·
IF 6.3
Chen Feng,Haoxi Jiang,Hao Gong,Lingtao Wang,Guochao Yang
Background CO 2 methanation plays a critical role in reducing carbon emissions. The development of Ni-based catalysts with simple synthesis processes and low costs for low-temperature methanation demonstrates promising industrial application prospects, yet it also faces significant challenges. Ni-based catalysts generally require higher metal loadings, which in turn makes it difficult to achieve high metal dispersion, severely limiting their low-temperature catalytic activity. Methods In this study, a simple co-impregnation method was employed in combination with a dual-strategy approach: hydrogen peroxide pretreatment to increase the concentration of silanol groups on the SBA-15 silica support surface and the assistance of ethylene glycol (EG) during the impregnation process. Significant findings The significant finding of this work lies in the demonstrated synergy of a dual strategies to stabilize highly dispersed Ni catalysts for CO 2 methanation. While high dispersion and good low-temperature activity have been reported elsewhere, this study specifically shows that combining (1) ethylene glycol-assisted impregnation to improve initial dispersion with (2) the utilization of SBA-15 silanol groups as anchoring sites effectively mitigates sintering. This combined approach resulted in a catalyst achieving 77% CO 2 conversion and 100% CH 4 selectivity at 250 °C, with characterization confirming the enhanced stability afforded by the synergy.
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高影响因子
RSC Advances
·
2012
·Vol. 2
·期 24
·9192-9200
·
IF 0
Yan-Fei Shao,Bing Yan,Zhao-Yan Jiang
In this paper, methacrylic-group-modified ZnO nanoparticles (designated ZnO-MAA) are prepared through the sol–gel reaction between zinc methacrylate and LiOH, which is then functionalized with 2-hydroxyethyl methacrylate (HEMA) to form the ZnO-MAA-PHEMA hybrid system after addition polymerization reaction. Then ZnO-MAA-PHEMA unit is modified with 3-(triethoxysilyl)-propyl isocyanate (TEPIC) through the addition reaction and subsequently to achieve the functionalized SBA-15 mesoporous hybrids (ZnO-MAA-PHEMA-SBA-15) by co-condensation of tetraethoxysilane (TEOS) and modified polymer ligand (HEMASi) in the presence of Pluronic P123 surfactant as template. Finally, lanthanide (Eu3+, Tb3+, Nd3+) complex systems with β-diketonates (2-thenoyltrifluoroacetonate (TTA), 1,3-diphenyl-1,3-propanedionate (DBM), 4,4,4-trifluoro-1-phenyl-1,3-butanedionate (BTA) and nicotinate (NTA)) are introduced to obtain multicomponent organic–inorganic hybrid materials through the coordination bonds between the lanthanide ion and the carbonyl group of ZnO-MAA-PHEMA-SBA-15. The detailed physical characterization and especially the photoluminescence of these hybrid materials are studied in detail. The results provide a strategy to assemble luminescent lanthanide hybrids with multicomponent units such as semiconductors, polymers and mesoporous silica and lanthanide complexes.
研究领域:
材料化学
·
无机化学
·
光致发光
·
纳米材料
·
杂化材料科学
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DOI
CHINESE JOURNAL OF POLYMER SCIENCE
·
2014
·Vol. 32
·期 3
·371-376
·
IF 1.42
Cao Jing,Feng Jun-xiang,Wu Shi
Novel conjugated polymers with aza-15-crown-5 as pendant groups, P1 were synthesized by the Sonogashira coupling reaction. The polymer P1 was found to show fluorescence enhancement response towards Ba 2+ . The gradual recovery and turning-point of emission intensity of polymers appeared in the addition of Ba 2+ , which provided good evidence for the fluorescence amplification mechanism of conjugated polymers.
研究领域:
材料科学
·
高分子化学
·
分析化学
·
传感器
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Jinna Liu,Yi Wang,Yang Li,Peiliang Sun,Zhichao Sun,Ying-Ya Liu,Chong Peng
Encapsulating the USY zeolite within a mesoporous SBA-15 shell is a promising strategy to construct hierarchical catalysts with regulated acidity. However, the acidic conditions required for SBA-15 synthesis pose a stability challenge to the acid-sensitive USY core. In this work, we first systematically investigated the physicochemical evolution of USY under simulated SBA-15 synthesis conditions by varying the acid concentration, temperature, and treatment time. Through XRD, N2 physisorption, NH3-TPD, and Py-FTIR analysis, the optimal conditions for USY to retain its framework integrity and Brønsted acidity were determined to be ≤1.0 M HCl and treatment time ≤24 h. This acid-tailored optimization is essential for the subsequent fabrication of the core–shell structure. Guided by these findings, the Ni–Mo/USY@SBA-15 core–shell catalyst is successfully prepared and evaluated in naphthalene hydrocracking, achieving 97.8% conversion and 51.6% BTX selectivity, outperforming conventional Ni–Mo/USY (92.6% conversion and 26.0% BTX selectivity). XPS analysis provides direct evidence of the spatially regulated metal-acid distribution and enhanced electron density on active sites. The performance enhancement is attributed to the hierarchical pore structure and the spatially regulated metal-acid distribution, which together enhance mass transfer, optimize acid site accessibility, and suppress overcracking. This study provides an acid-tolerance-guided synthesis strategy for designing high-performance core–shell zeolite catalysts.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2011
·Vol. 82
·期 1
·340-344
·
IF 1.77
Yong Xiang Wu,Jing Cao,Hai Yan Deng,Jun Xiang Feng
A novel fluoroionophore 1 based on 3,4-dimethylthieno[2,3-b]thiophene bearing two monoaza-15-crown-5 ethers at 3- and 4-positions was prepared. UV–vis and fluorescence responses of compound 1 upon the addition of alkali and alkaline earth metal cations were evaluated in acetonitrile solution. Receptor 1 showed unique response for Ba 2+ due to the formation of an intramolecular sandwich complex.
研究领域:
超分子化学
·
分析化学
·
有机合成
·
荧光光谱学
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高影响因子
Materials
·
2022
·Vol. 15
·期 24
·8879
·
IF 3.748
Hongxia Liu,Yijia Lao,Jiayi Wang,Junjie Jiang,Chuanbai Yu,Yuanli Liu
The development of composite materials with functional additives proved to be an effective way to improve or supplement the required properties of polymers. Herein, mesoporous silica (SBA-15) with different pore sizes were used as functional additives to prepare SBA-15/PF (phenolic resin) nanocomposites, which were prepared by in situ polymerization and then, compression molding. The physical properties and structural parameters of SBA-15 with different pore sizes were characterized by N2adsorption–desorption, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The thermal properties of the SBA-15/PF hybrid were investigated by differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). The mechanical, friction, and dynamic mechanical properties of SBA-15/PF nanocomposites were also studied. The results revealed that the pore sizes of SBA-15 have a significant effect on the resulting SBA-15/PF hybrid and SBA-15/PF nanocomposites. The thermal stability of the SBA-15/PF hybrid was dramatically improved in comparison with pure PF. The friction and dynamic mechanical properties of the SBA-15/PF nanocomposites were enhanced significantly. Specifically, the glass transition temperature (Tg) of the nanocomposite increased by 19.0 °C for the SBA-15/PF nanocomposites modified with SBA-15-3. In addition, the nanocomposite exhibited a more stable friction coefficient and a lower wear rate at a high temperature. The enhancement in thermal and frictional properties for the nanocomposites is ascribed to the confinement of the PF chains or chain segments in the mesopores channels.Keywords:SBA-15/PF;nanocomposites;pore expanding;thermal properties;frictional properties
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2021
·
IF 5.455
Yanan Qin,Junmei Luo,Qingda An,Zuoyi Xiao,Jingai Hao,Yao Tong,Shangru Zhai
A facile and environmentally friendly method to synthesize efficient catalysts for activating peroxymonosulfate (PMS) to degrade contaminants is highly important yet remains challenging. By combining the superiorities of ordered Co/N@ZS and alginate hydrogels, namely regular and stable channels, large specific surface area, outstanding hydrophilicity and unique three-dimensional structure, an excellent recovery and recyclability catalyst, Co 0·6 /N@ZS-SA, exhibited outstanding performance in activating 0.50 g/L PMS for ciprofloxacin degradation (20 mg/L) with a high degradation rate of 82.52%. The effect of diversified influencing parameters, stability and recyclability on the degradation efficiency was systematically investigated. More importantly, the composite hydrogel with excellent recovery and recyclability could still degrade more than 63.4% CIP after three consecutive reactions. In addition, combined EPR analysis and ROS quenching research indicated that HO • , SO 4 •− , O 2 •− and 1 O 2 were generated but CIP degradation dominated by the radical mechanism comprising the yield of SO 4 •− . Besides, the intermediate products were identified by LC-MS analyses to propose the possible degradation pathways.
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高影响因子
CATALYSIS LETTERS
·
2021
·Vol. 151
·期 9
·2513-2526
·
IF 3.186
Cui Kai,Qian Wei,Shao Zhengjiang,Zhao Xiuge,Gong Honghui,Wei Xinjia,Wang Jiajia,Chen Manyu,Cao Xiaoming,Hou Zhenshan
Furfural (FFR) is one of the most important biomass-derived chemicals. Its large-scale availability calls for the exploration of new transformation methods for further valorization. Herein, we demonstrate that Ru nanoparticles (Ru NPs)-supported on a sulfonated carbon layer coated SBA-15 can be employed as an efficient bi-functional catalyst for one step conversion of FFR into 1,4-pentanediol (1,4-PeDO). The optimum bi-functional catalyst can afford the full the conversion of FFR and 86% selectivity to 1,4-PeDO. The catalysts have been characterized thoroughly by using a complementary combination of powder X-ray diffraction, N 2 adsorption–desorption, scanning/transmission electron microscopy, Fourier transform infrared spectroscopy, elemental analysis, and X-ray photoelectron spectroscopy. The characterization revealed that acidic groups (–SO 3 H) have been introduced on the surface of the carbon layer coated SBA-15 support after sulfonation with 98% H 2 SO 4 and the surface acidity can be tuned facilely by the sulfonating time. Meantime, Ru(0) sites was highly dispersed via an impregnation and sequential reduction and directly adjacent to the surface –SO 3 H group. There existed an electronic interaction between Ru(0) sites and sulfonic groups, in which the electronic transfer from sulfonic sites to Ru(0) sites occurred. Brönsted acid sites (–SO 3 H) have a significant influence on the FFR conversion and the selectivity to 1,4-PeDO. The ordered mesoporous structure, the appropriate density of acid sites and the electron-rich Ru(0) sites accounted for the the excellent performance of the catalyst for an efficient production of 1,4-PeDO from FFR. Graphic Abstract
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2020
·
IF 2.369
Yang Li,Yang Zhang,Xue Zhong Wang
The solubility of dimethyl 2,2′-azobis(2-methylpropionate) (AIBME) was determined in 15 pure solvents, including cyclohexane, dichloromethane, diethyl ether, acetone, tetrahydrofuran, ethyl acetate, tetrachloromethane, acetonitrile, methylbenzene, methanol, ethanol, n-propyl alcohol, isopropanol, n-butyl alcohol, and iso-butyl alcohol, and in a binary solvent system (methanol + water) at the temperature range from 253.15 to 293.15 K at atmospheric pressure. Between 278.15 and 293.15 K, the solubility of AIBME is more sensitive to temperature in alcohol solvents than in other solvents. However, the solubility of AIBME in nonalcoholic solvents decreased more rapidly than in alcohol solvents below 278.15 K. The AIBME solubility in the binary solvent system (methanol + water) is positive to temperature and the initial mole fraction of methanol. The measured solubility data of AIBME in pure solvents were correlated by the modified Apelblat equation, the λh equation, the nonrandom two-liquid (NRTL) model, and the Wilson model. The measured solubility data of AIBME in binary solvent systems were correlated by the modified Apelblat equation, the nonrandom two-liquid (NRTL) model, and the Wilson model. Among the four models, the NRTL model is the best model to fit the solubility of AIBME, especially in alcohol solvents. In addition, the mixing properties of AIBME in 15 pure solvents, including standard mixing Gibbs energy, mixing enthalpy, and mixing entropy, were calculated and discussed. The results provide useful information for practical optimization of AIBME crystallization processes.
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