Metabolites
·
2022
·Vol. 12
·期 7
·610
·
IF 5.581
Lin-Lin Cao,Yi Han,Lin Pei,Zhi-Hong Yue,Bo-Yu Liu,Jing-Wen Cui,Mei Jia,Hui Wang
Type 2 diabetes mellitus (T2DM) has been identified as an independent risk factor for hepatocellular cancer (HCC). However, there are no ideal biomarkers for the surveillance and early detection of HCC in the T2DM population at present. In this study, we aimed to explore novel metabolite biomarkers for T2DM-positive [T2DM(+)] HCC by metabolomic analysis. At first, many serum metabolites were found dysregulated in T2DM(+) HCC patients in untargeted metabolomic analyses. Targeted metabolite analyses confirmed that serum benzoic acid and citrulline were increased, and creatine was decreased in T2DM(+) HCC compared to the T2DM group. A metabolite classifier including benzoic acid, creatine, and citrulline was identified as a novel biomarker for the diagnosis of T2DM(+) HCC, with an area under the ROC curve (AUC) of 0.93 for discriminating T2DM(+) HCC patients from T2DM patients. In addition, the metabolite classifier detected small-size (AUC = 0.94), early-stage (AUC = 0.94), and AFP-negative (AUC = 0.96) tumors with high sensitivity and specificity. The combination of this metabolite classifier and AFP might be useful in the surveillance and early detection of HCC in the T2DM population. In conclusion, this study establishes a novel diagnostic tool for T2DM(+) HCC.Keywords:hepatocellular cancer;type 2 diabetes mellitus;metabolomics;metabolite classifier;benzoic acid;creatine;citrulline
研究领域:
肿瘤学
·
糖尿病学
·
代谢组学
·
生物标志物研究
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DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2016
·
IF 3.014
Yan Yuan,Junxiang Wang,Zongqian Hu,Haiping Lei,Donghua Tian,Shuqiang Jiao
A Prussian blue analogue, Na 2 Co 3 [Fe(CN) 6 ] 2 , has been fabricated by a facile co-precipitation method at room temperature as a potential cathode material for both lithium-ion and sodium-ion batteries. It found that the Na 2 Co 3 [Fe(CN) 6 ] 2 nanoparticles with a primary particle size of 30–40 nm have been synthesized, and exhibited an excellent electrochemical performance , including a long cycling behavior in lithium-ion batteries and a good rate performance in sodium-ion batteries. In lithium-ion batteries, the Na 2 Co 3 [Fe(CN) 6 ] 2 nanoparticles cathode can deliver an excellent cyclic performance with 73.0% retention of initial capacity after 50 cycles at 50 mA g −1 . Moreover, when Na 2 Co 3 [Fe(CN) 6 ] 2 is used as cathode material of sodium-ion batteries, it exhibits an outstanding rate performance exceeding 75.2% retention of initial capacity after 50 cycles at 200 mA g −1 . Therefore, the Na 2 Co 3 [Fe(CN) 6 ] 2 nanoparticles can be a potential cathode candidate for the application of lithium-ion and sodium-ion batteries due to its excellent electrochemical performance, easy preparation, low cost and environment benefits.
研究领域:
材料科学
·
电化学
·
能源存储
·
无机化学
·
纳米材料
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Sheng Chen,Wenji Wang,Mingming Yan,Qin Tu,Shu-Wei Chen,Tianbao Li,Mao-Sen Yuan,Jinyi Wang
The sensitive detection and quantification of heavy and transition metal ions are particularly important. Among them, mercury(II) (Hg 2+ ) and silver(I) (Ag + ) ions, as the most ubiquitous heavy metal ion pollutants, are difficult to discriminate in the same system because of their similar reactions and coordination abilities. Herein, we designed and synthesized a “turn-on” chemosensor, RBTP , which is an intergrant of rhodol and 2-hydroxy benzothiazole by introducing a benzothiazole unit to the ortho -position of the phenolic hydroxy of rhodol. RBTP showed a sensitive dual-channel fluorescence-enhanced response to Hg 2+ and Ag + at 595 and 520 nm with low detection limits of 0.27 and 0.45 μM, respectively. Studies of their sensing mechanism indicated that the Hg 2+ -induced orange fluorescence at 595 nm originates from an irreversible Hg 2+ -promoted oxadiazole forming reaction and the Ag + -induced green fluorescence at 520 nm originates from special molecular packing of the RBTP -Ag + complex. Furthermore, the potential of probe RBTP as practical biological imaging agents was further confirmed in HepG2 cells. Simultaneously, RBTP exhibited remarkable solid-state luminescence with an aggregation-induced emission (AIE) feature. The AIE mechanism was thoroughly explored using X-ray single-crystal structures and photophysical determinations.
研究领域:
分析化学
·
环境科学
·
生物成像
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DOI
高影响因子
JOURNAL OF PORPHYRINS AND PHTHALOCYANINES
·
2021
·
IF 1.811
Safi Ullah,Keisuke Ogumi,Xuelin Zhen,Huan Wang,Yutaka Matsuo
A Suzuki–Miyaura coupling reaction was performed to synthesize 5,15- meso -bis(2-chlorothiophen-3-yl)porphyrins in order to obtain a building block for further functional porphyrins. Photophysical and electrochemical properties were investigated to understand the effect of 2-chloro substituted thiophenes which are connected at their 3-position to the meso -position of the porphyrin. A computational calculation with counterpoise method was demonstrated to estimate the relative intermolecular interaction in order to compare solubility. Installed chloro atoms at the 2-position of thiophen-3-yl decreased in intermolecular interaction which caused an increase in solubility.
研究领域:
有机化学
·
材料科学
·
计算化学
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DOI
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Le Zhang,Xin Zhou,Shaohua Chai,Jian Guan,Guijun Fan,Wuxinchen Yang,Guojun Ma,Ning Han,Yunfa Chen
There is a high demand to synthesize ozone decomposition catalysts especially in high-space-velocity and high-relative-humidity (RH) environments. Herein, two polymorphs of cobalt hydroxide, α- and β-Co(OH)2, are synthesized and applied for ozone elimination. β-Co(OH)2 shows ∼90% ozone decomposition efficiency under high space velocity (weight hourly space velocity (WHSV) = 1,200,000 mL g–1 h–1, 25 °C, 40 ppm), which is far higher than that of α-Co(OH)2 (∼5%). β-Co(OH)2 has high spin Co(II) in distorted octahedral coordination caused by the Jahn-Teller effect, leading to a higher crystal field splitting energy level and thus contributing to the easier electron transfer between the ozone and catalyst. Moreover, β-Co(OH)2 still shows high performance (∼87%) even in humid conditions (RH ∼50%, 25 °C, 40 ppm, WHSV = 600,000 mL g–1 h–1), which is attributable to its abundant surface non-hydrogen-bonded hydroxyls weakening water molecule adsorption, providing an idea to develop highly efficient catalysts for ozone decomposition in humid environments.
研究领域:
材料科学
·
催化
·
环境科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2018
·Vol. 29
·期 8
·1-12
·
IF 2.448
Li Qing,Li Jing,Liao Guangfu,Xu Zushun
1,3,5-Tris(4-aminophenoxy) benzene (TAPOB) and 2,2-bis [4-(3,4-dicarboxyphenoxy) phenyl] propane dianhydride (BPADA) were used to synthesize an amino-terminated hyperbranched polyimide (AM-HBPI). Then, the 2-methacryloyloxyethyl phosphorylcholine-modified hyperbranched polyimide (HBPI-MPC) was obtained through the graft modification of MPC onto AM-HBPI by Michael addition. The infrared spectroscopy and X-ray photoelectron spectroscopy spectra showed MPC molecules were successfully grafted onto the HBPI molecules. The HBPI-MPC films exhibited slightly decreased thermal stabilities with 5% weight loss temperature in the range of of 418–483 °C in nitrogen, compared with the pure HBPI film. With the increase of MPC grafting amount, the static water contact angles decreased from average 84.0° of the pure HBPI film to average 45.0° of the HBPI-MPC film with 20% MPC. Meanwhile, the increased surface roughness of the HBPI-MPC films increased the contact areas with the platelets, enhancing their anticoagulant efficiency. The number of platelet adhesion declined and the shape of platelet changed from flat to round. The recalcification times grew from average 300 s of pure HBPI to average 551 s of the HBPI-MPC film with 20% MPC, indicating improved anticoagulant properties and biocompatibility. Bacterial adhesion test also demonstrated the number of bacterial adhesion was significantly reduced and antibacterial properties were improved. Thus, the HBPI-MPC films have great application prospects as biomedical anticoagulant materials.
研究领域:
材料科学
·
生物医学工程
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DOI
PubMed
高影响因子
Scientific Reports
·
2025
·Vol. 15
·期 1
·44020
·
IF 3.9
Li Zhipeng,Liu Zhaoheng,Wei Wan,Niu Jie,Wu Jianjun,Jiao Yang
This study explored the therapeutic potential of Number 2 Feibi Recipe (FBR2), a traditional Chinese medicine prescription, in the treatment of idiopathic pulmonary fibrosis (IPF). Specifically, it investigated whether FBR2 mediated its effects by modulating miR-199a-5p expression, activating the SIRT1/AMPK/mTOR pathway and then promoting autophagy. Eighty-four mice were divided into seven groups: Control, bleomycin (BLM), FBR2, self-complementary adeno-associated virus expressing miR-199a-5p (scAAV-miR-199a-5p), scAAV-negative control (scAAV-NC), FBR2 + BLM + scAAV-miR-199a-5p, and FBR2 + BLM + scAAV-NC. Fluorescence staining, miR-199a-5p expression levels, histopathological changes, protein expression and autophagy activity were assessed using various techniques, including RT-qPCR, histopathological staining, Western blotting, Elisa and transmission electron microscopy (TEM). FBR2 treatment significantly reduced miR-199a-5p expression elevated by BLM and improved histopathology, reduced levels of α-smooth muscle actin (α-SMA) and collagen-III, and increased E-cadherin expression. FBR2 also enhanced autophagy, as evidenced by elevated LC3-II and Beclin-1 levels and reduced p62 expression. Additionally, it activated the SIRT1/AMPK/mTOR pathway. Finally, network pharmacology identified 227 compounds in FBR2, among which Kaempferol and Quercetin (two major shared constituents) showed strong binding to miR-199a-5p in molecular docking, suggesting their potential as key active components. This study showed FBR2 attenuated BLM-induced pulmonary fibrosis in mice by reducing miR-199a-5p expression and promoting autophagy which may be achieved by modulating the SIRT1/AMPK/mTOR pathway. These findings provide novel insights into the mechanism of FBR2 and its potential as a therapeutic approach for IPF.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PROSTHETIC DENTISTRY
·
2022
·
IF 4.148
Hao Yang,Xianju Xie,Xiaowei Li,Yuxing Bai
Statement of problem Polymethyl methacrylate (PMMA) is commonly used in dentistry, including as a denture base material. However, the colonization of a PMMA surface by microbial microorganisms could increase the risk of oral diseases such as denture stomatitis and gingivitis. The development of PMMA with antibacterial properties should improve its clinical application, but whether adding ε-poly-L-lysine (ε-PL) and 2-methacryloyloxyethyl phosphorylcholine (MPC) provides antimicrobial effects is unclear. Purpose This in vitro study aimed to develop a novel antibacterial PMMA resin containing the natural nontoxic antibacterial agent ε-PL and the protein repellent agent MPC. The mechanical properties, protein repellency, and antimicrobial activities of the resin were then evaluated. Material and methods Different mass fractions of ε-PL and MPC were mixed into PMMA as the experimental groups, with unaltered PMMA as the control group. The flexural strength (n=10) and surface roughness (n=6) of the resulting mixtures were measured to determine their mechanical properties. The antiprotein properties were measured by using the micro bicinchoninic acid method (n=6). The antimicrobial effect of the resin was assessed using live/dead staining (n=6) and methyltransferase (MTT) assays (n=10). According to the variance homogeneity and normal distribution results, 1-way analysis of variance followed by the Tukey honestly significant difference test or the Welch test and the Games-Howell test were used (α=.05 for all tests). Results No significant differences were found in the flexural strength values and surface roughness of the specimens containing 1.5% MPC and 1.5% ε-PL compared with those of the control ( P >.05). The addition of ε-PL to the PMMA resin alone significantly increased its bactericidal properties ( P <.05). Adding both ε-PL and MPC further increased the antibacterial activity of the PMMA resin without increasing protein adhesion more than in the control group. Conclusions The incorporation of both ε-PL and MPC into PMMA improved its antibacterial capacity without affecting its mechanical properties and did not increase protein adhesion. Therefore, the novel PMMA fabricated in this study shows promise for dental applications.
研究领域:
口腔医学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF RARE EARTHS
·
2013
·
IF 1.363
Hongzhen XIE,Guanzhong LU
Five lanthanide complexes of Ln 2 (dpdc) 2 (tpy) 2 (NO 3 ) 2 (H 2 O) 2 [Ln=La ( 1 ), Ce ( 2 ), Pr ( 3 ), Sm ( 4 ), Gd ( 5 ), H 2 dpdc=2,2’-biphenyldicarboxylic acid and tpy=2,2′:6′,2″-terpyridine] were prepared at room temperature and characterized by X-ray diffraction, FT-IR and thermo-gravimetric analysis. The results showed that complexes 1–5 were isostructural and consisted of dinuclear units [Ln 2 (dpdc) 2 (tpy) 2 (NO 3 )(H 2 O) 2 ] bridged by two dpdc 2− ligands. The dinuclear units with strong intramolecular hydrogen bonds were assembled into 2D supramolecular layers by the weak π … π staking interactions between pyridine rings of tpy. The TG analysis showed that the complexes 1 – 5 behaved higher thermal stability with no mass loss at < 320 °C. The lanthanide contraction effect and the solid state luminescence properties of complexes 1 – 5 were also investigated. The luminescence emission spectra of complexes 1 – 5 exhibited ligands emission bands and complex 3 and 4 had no typical emission in the visible region.
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产品关联
DOI
高影响因子
CHEMICAL PAPERS
·
2019
·Vol. 73
·期 6
·1333-1345
·
IF 1.246
Jin Shuyu,Sun Xiuyun,Liu Dan,Xie Hua,Rao Yu
The discovery and development of a novel HER-2 tyrosine kinase inhibitor for the treatment of HER2-positive breast cancer are presented in this article. EGFR family has been recognized as a crucial meditator in the cancer progression; HER-2 tyrosine kinase was one of the members among them. In the effort to explore potent HER-2 inhibitors, a novel series of 4-anilino-3-cyanoquinoline derivatives have been designed, synthesized and evaluated. Most compounds possessed modest proliferation inhibition on SK-BR-3 cell line and HER-2 kinase. Compound 16 appeared to be the most potent compound (HER-2 kinase IC 50 : 19.4 nM, SK-BR-3 IC 50 : 94 nM). In the experiment of cellular cytotoxicity assay, compound 16 shows a much lower cytotoxicity than neratinib on Beas-2b cell line (Human bronchial epithelial cells). In conclusion, compound 16 would be a promising lead compound for further anti-breast cancer drug discovery.
研究领域:
药理学
·
肿瘤学
·
药物化学
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DOI
高影响因子
Nanoscale Advances
·
2022
·Vol. 4
·期 3
·871-883
·
IF 5.598
Ojodomo J. Achadu,Njemuwa Nwaji,Dongkyu Lee,Jaebeom Lee,Eser M. Akinoglu,Michael Giersig,Enoch Y. Park
The global pandemic of COVID-19 is an example of how quickly a disease-causing virus can take root and threaten our civilization. Nowadays, ultrasensitive and rapid detection of contagious pathogens is in high demand. Here, we present a novel hierarchically porous 3-dimensional magnetic molybdenum trioxide–polydopamine-gold functionalized nanosphere (3D mag-MoO3–PDA@Au NS) composed of plasmonic, semiconductor, and magnetic nanoparticles as a multifunctional nanosculptured hybrid. Based on the synthesized 3D mag-MoO3–PDA@Au NS, a universal “plug and play” biosensor for pathogens is proposed. Specifically, a magnetically-induced nanogap-enhanced Raman scattering (MINERS) detection platform was developed using the 3D nanostructure. Through a magnetic actuation process, the MINERS system overcomes Raman signal stability and reproducibility challenges for the ultrasensitive detection of SARS-CoV-2 spike protein over a wide dynamic range up to a detection limit of 10−15 g mL−1. The proposed MINERS platform will facilitate the broader use of Raman spectroscopy as a powerful analytical detection tool in diverse fields.
研究领域:
生物传感器技术
·
材料科学
·
病毒学
✓ 已验证
DOI
PubMed
高影响因子
IONICS
·
2024
·Vol. 30
·期 4
·2375-2385
·
IF 2.4
Cao Lin-an,Wei Min,Guo Xin,Wang Dailian,Chen Lu,Guo Jing
Ni 3 (HITP) 2 (HITP: 2,3,6,7,10,11-hexaiminotriphenylene) is a very typical 2D electrically conductive metal–organic framework (EC-MOF) material with great promising as active materials in electronic devices. Gas–liquid interface self-assembly is a common method of processing free-standing thin films for this EC-MOF. Owing to the different contact environment during growth process, Ni 3 (HITP) 2 film prepared by gas–liquid interface method has different morphology for up-side surface exposed to air and down-side surface infiltrated in solution. However, the asymmetrical morphology of Ni 3 (HITP) 2 film and its influence on sensing performance have never been implemented. In this work, gas–liquid interface self-assembly method is used to obtain an asymmetrical Ni 3 (HITP) 2 nanofilm in surface morphology with a flat up-side surface and an island-like down-side surface. The surface morphology of as-prepared film has a remarkable influence on the glucose sensing property. The island-like structure for down-side surface film exhibits more excellent glucose sensing performance because of its abundant crystal defect which play an important role in enhancing glucose catalytic oxidation capacity. Graphical abstract
研究领域:
材料科学
·
纳米技术
·
传感器
·
电化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）