COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2020
·
IF 6.444
Neng-Jian Huang,Qiao-Qi Xia,Zhao-Hui Zhang,Li Zhao,Guo-Dong Zhang,Jie-Feng Gao,Long-Cheng Tang
A flame-retardant graphene oxide (GO) based nanocomposite paper was prepared for efficient fire alarm response via a one-step and green 3-mercaptopropyltrimethoxysilane (MPTS) functionalization process. Such MPTS modification not only improves thermal stability and flame resistance of GO network, but produces ultra-fast flame detection and efficient fire early warning response. Typically, the MPTS-GO-10 wt% paper shows a flame detection response signal of about 1.0 s and improved fire early warning response time at a relatively temperature of 200 °C. The structural observation and analysis suggest that the thermal reduction behavior of GO network can be promoted by the sulfydryl groups of MPTS molecules at high temperature, thus producing the rapid and sensitive transition of electrical resistance form insulating GO into conductive reduced GO network. The MPTS functionalization developed here show promising to tailor fire early warning response of flame-retardant GO based fire alarm sensor for potential fire safety and prevention applications.
研究领域:
材料科学
·
消防安全
·
化学工程
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DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2012
·
IF 3.456
Yu Zhang,Ruo Yuan,Yaqin Chai,Xia Zhong,Huaan Zhong
A novel material, sol–gel derived La(OH) 3 nanorods (La(OH) 3 NRs) with excellent film forming ability was prepared, and it was first designed to incorporate with carbon nanotubes (CNTs) to modify glassy carbon electrode (GCE) to simultaneously voltammetric determine ascorbic acid (AA), dopamine (DA), uric acid (UA), and nitrite (NO 2 − ). Cyclic voltammetry (CV), transmission electron microscopy (TEM), and X-ray diffraction (XRD) were employed to characterize the sensor. Under optimal conditions, the linear response range for AA, DA, UA, and NO 2 − were 0.5 μmol L −1 to 1.46 mmol L −1 , 50 nmol L −1 to 35.36 μmol L −1 , 50 nmol L −1 to 0.79 mmol L −1 , and 0.55 μmol L −1 to 0.72 mmol L −1 , respectively and the detection limits were 1.67 μmol L −1 , 1.67 nmol L −1 , 1.67 nmol L −1 , and 0.18 μmol L −1 . The sensor demonstrated well stability, high selectivity and sensitivity. More importance, this material can be extended to construct other electrochemical sensors by the immobilization of enzymes and antibodies.
研究领域:
分析化学
·
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2025
·
IF 6.2
Hao Li,Fei Liu,Lijin Cheng,Jiarui Huang,Shaojun Liu
Complex perovskite-structured Ba(Zn 1/3 Nb 2/3 )O 3 (BZN) ceramics with high B-site 1:2 ordering degree and excellent dielectric properties were successfully fabricated using digital light processing (DLP). BZN ceramic slurry with 82 wt. % solid loading, low viscosity, and high curing properties was used to prepare green bodies. The samples were exposed to debinding process in vacuum and then sintered at 1350–1450 ℃ for 4 h. The as-sintered BZN ceramics with disordered B-site structure exhibited significantly low dielectric properties. However, the BZN ceramics annealed at 1300 ℃ for 24 h with high B-site 1:2 ordering degree exhibited excellent dielectric properties ( ε r = 38.9, Q × f = 89,600 GHz, and τ f = 22 ppm/℃) that were identical to those of dry-pressed ceramics. Furthermore, a DLP-fabricated cylindrical BZN dielectric resonator antenna exhibited a >90% radiation efficiency and resonant frequency of 7.10 GHz ( S 11 = -29.94 dB), which is consistent with the simulation results.
研究领域:
材料科学
·
电子工程
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产品关联
DOI
高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 4
·2257-2272
·
IF 6.123
Shi Ning,Zhu Yuju,Qin Bangzhi,Liu Ying,Zhang Hongyan,Huang Hongsheng,Liu Yunhua
A simple and efficient biphasic system comprising H 2 O, tetrahydrofuran (THF), cyclohexane (CHX) and Al 2 (SO 4 ) 3 was employed to convert cellulose into 5-hydroxymethylfurfural (HMF). The volume ratio of the organic phase to the aqueous phase (V org /V aque ), concentration of Al 2 (SO 4 ) 3 in the aqueous phase (C[Al 2 (SO 4 ) 3 ] aque ) and concentration of Al 2 (SO 4 ) 3 in the organic phase (C[Al 2 (SO 4 ) 3 ] org ) of the biphasic system played critical roles in the conversion of cellulose into HMF. In the biphasic systems with H 2 O/THF/Al 2 (SO 4 ) 3 of 4/18/0.4 and H 2 O/THF/CHX/Al 2 (SO 4 ) 3 of 3/16/3/0.4, > 80% of the added H 2 O was dissolved in the organic phase, whereas most of the added Al 2 (SO 4 ) 3 remained in the aqueous phase under the reaction temperature, jointly leading to high V org /V aque , high C[Al 2 (SO 4 ) 3 ] aque and low C[Al 2 (SO 4 ) 3 ] org in the biphasic system. All of these results yield the excellent performance of these biphasic systems in the conversion of cellulose into HMF. The addition of CHX into the biphasic system can decrease the solubility of Al 2 (SO 4 ) 3 in the organic phase, thus improving the stability of HMF in the reaction system. The influences of catalyst usage, reaction temperature and time, and cellulose/solvent ratio were all explored, and a high HMF yield of 71.2% was obtained in the H 2 O–THF–CHX biphasic system with an H 2 O/THF/CHX volume ratio of 3/16/3 under optimized conditions. Graphical abstract
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产品关联
DOI
高影响因子
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
·
2014
·Vol. 172
·期 8
·3913-3925
·
IF 1.687
Zhang Jian-Fen,Yang Bo,Chen Weiqing,Chen Jing
A soluble glucoside 3-dehydrogenase (G3DH) was purified from a newly isolated Sphingobacterium faecium ZJF-D6 CCTCC M 2013251. The enzyme was purified to 35.71-fold with a yield of 41.91 % and was estimated by sodium dodecyl sulphate–polyacrylamide gel electrophoresis with a molecular mass of 62 kDa. The sequences of two peptides of the enzyme were all contained in a GMC family oxidoreductase (EFK55866) by mass spectrometry analysis. The optimal pH of the enzyme was around 6.2. The enzyme was stable within a pH range of 5.0–6.6 and was sensitive to heat. G3DH from S. faecium exhibited extremely broad substrate specificity and well regioselectivity to validoxylamine A. The enzyme was completely inhibited by Hg 2 Cl 2 and partly inhibited by Cu 2+ , Fe 2+ , Ca 2+ , and Cd 2+ . The apparent K
m
values for D-glucose, sucrose, and validoxylamine were calculated to be 1.1, 1.7, and 2.1 mM, respectively. With this purified enzyme, 3-keto sucrose was prepared at pH 5.0, 30 °C for 10 h with a yield of 28.7 %.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yonghang Mu,Zi Wang,Linhua Song,Kun Ma,Yao Chen,Peixun Li,Zifeng Yan
Sphingosine, an amphiphilic molecule, plays a pivotal role as the core structure of sphingolipids, essential constituents of cell membranes. Its unique capability to enhance the permeability of lipid membranes profoundly influences crucial life processes. The molecular structure of sphingosine dictates its mode of entry into lipid bilayers and governs its interactions with lipids, thereby determining membrane permeability. However, the incomplete elucidation of the relationship between the molecular structure of sphingosine and the permeability of lipid membranes persists due to challenges associated with synthesizing sphingosine molecules. A series of sphingosine-derived molecules, featuring diverse hydrophobic chain lengths and distinct headgroup structure, were meticulously designed and successfully synthesized. These molecules were employed to investigate the permeability of large unilamellar vesicles, functioning as model lipid bilayers. With a decrease in the hydrophobic chain length of sphingosine from C15 to C11, the transient leakage ratio of vesicle contents escalated from ∼ 13 % to ∼ 28 %. Although the presence of double bond did not exert a pronounced influence on transient leakage, it significantly affected the continuous leakage ratio. Conversely, modifying the chirality of the C-3 hydroxyl group gives the opposite result. Notably, methylation at the C-3 hydroxyl significantly elevates transient leakage while suppressing the continuous leakage ratio. Additionally, sphingosines that significantly affect vesicle permeability tend to have a more pronounced impact on cell viability. Throughout this leakage process, the charge state of sphingosine-derived molecule aggregates in the solution emerged as a pivotal factor influencing vesicle permeability. Fluorescence lifetime experiments further revealed discernible variations in the effect of sphingosine molecular structure on the mobility of hydrophobic regions within lipid bilayers. These observed distinctions emphasize the impact of molecular structure on intermolecular interactions, extending to the microscopic architecture of membranes, and underscore the significance of subtle alterations in molecular structure and their associated aggregation behaviors in governing membrane permeability.
研究领域:
生物化学
·
细胞生物学
·
膜科学
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DOI
PubMed
高影响因子
ORGANIC PROCESS RESEARCH & DEVELOPMENT
·
2024
·
IF 3.1
Chuanjun Wu,Heng Guo,Jiawei Tang,Lintao Xia,Jianfen Shao,Yongfu He,Fei Chen,Peng Peng,Yuewen Han,Chuanmeng Zhao,Fuli Zhang,Shaoxin Chen
In the present study, a practical chemoenzymatic method was developed for the synthesis of chiral phenylalanine derivative 1, which is the key intermediate of Lifitegrast. In this established process, a simple and effective Zn/HCl reduction system was employed to obtain N-acetyl-3-bromo-phenylalanine 6, which served as the substrate for the subsequent enzymatic resolution process. Then, the key chiral intermediate, 3-bromo-l-phenylalanine 7, could be obtained using acylase (ACY) AmACY. Upon process optimization, the chemical reaction was executed at a 300 g scale, with a notable substrate concentration reaching up to 100 g/L. The process achieved a yield of 40%, compared to a maximum theoretical yield of 50%, and exhibited an enantiomeric excess (ee) value reaching up to 99.9%. A simple and effective Zn/HCl reduction system was employed to obtain N-acetyl-3-bromo-phenylalanine 6, which served as the substrate for the subsequent enzymatic resolution process. This synthetic pathway was effectively executed, yielding 1·HCl with a purity of 99.7% and an ee value of 99.9%, culminating in an overall yield of 23.4%. Additionally, the undesired (D)-6 enantiomer was recycled to form (rac)-6, employing an acetanhydride/acetic acid (Ac2O/AcOH) system. This recycling process achieved a yield of 47.5%, relative to a maximum theoretical yield of 50%, and a purity level of 99.8%.
研究领域:
药物化学
·
生物催化
·
有机合成
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DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2020
·
IF 2.888
Xingchuan Yang,Huanxin Li,Chunmei Cao,Li Xu,Guoji Liu
Liquid-liquid equilibria (LLE) data for ternary systems of water + 1,6-hexanediol + 1-pentanol/ 3-methyl-1-butanol/ 2-methyl-2-butanol were measured at (293.15, 303.15, 313.15 and 323.15) K under 101.3 kPa. Cloud-point method was applied to determine the solubility curves data. Distribution coefficient and separation factors for 1,6-hexanediol were calculated from the measured tie-line data to evaluate the extraction effect of alcohols on 1,6-hexanediol. The reliability of experimental LLE data were tested by Othmer–Tobias equation and Hand equation, NRTL and UNIQUAC models were applied to correlate the measured data and the calculated results show that both models can fit the experimental data very well.
研究领域:
化学工程
·
热力学
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DOI
高影响因子
RSC Advances
·
2020
·Vol. 10
·期 65
·39814-39821
·
IF 3.119
Xin Min,Changchao Zhan,Ping Yan,Zhigang Ye
A novel hydroxyl-terminated π-allyl nickel initiator [η3-Ni(CH2CHCHCH2OCOCH3)][BPhF4] is synthesized for the first time. 1H-NMR analysis confirms that the Ni initiator possesses a typical π-allyl structure with a protected hydroxyl group. The Ni initiator is applied to synthesize hydroxyl-terminated poly(3-hexylthiophene). It successfully initiates the homopolymerization of thiophene, and yields narrow molecular weight distribution, hydroxyl-terminated poly(3-hexylthiophene). Moreover, it is found that [η3-Ni(CH2CHCHCH2OCOCH3)][BPhF4] has high initiating activity in the polymerization of styrene and butadiene. A hydroxyl-terminated polybutadiene-b-poly(3-hexylthiophene) block copolymer is synthesized by using [η3-Ni(CH2CHCHCH2OCOCH3)][BPhF4] to improve the workability and brittleness of poly(3-hexylthiophene).
研究领域:
高分子化学
·
材料科学
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DOI
高影响因子
Energy Storage Materials
·
2019
·
IF 0
Jian Zhang,Xudong Zhao,Yuzhu Song,Qiang Li,Yongchang Liu,Jun Chen,Xianran Xing
Na 3 V 2 (PO 4 ) 3 is one of the most promising cathodes for sodium-ion batteries (SIBs) due to its three-dimensional framework. To meet practical feasibility, the substitution of vanadium with low-cost active elements is urgent. Here the Na + superionic conductor (NASICON)-type Na 3.5 Mn 0.5 V 1.5 (PO 4 ) 3 nanoparticles homogeneously embedded in porous carbon matrix are prepared and investigated as a novel cathode for SIBs. The as-prepared Na 3.5 Mn 0.5 V 1.5 (PO 4 ) 3 /C could deliver a desirable average discharge potential of 3.43 V vs. Na + /Na with fascinating rate capability of 92.7 mA h g −1 at 60C and impressive capacity retention of 87.2% after 4000 cycles at 20C. In situ X-ray diffraction reveals that the electrochemical process undergoes highly reversible biphasic transition and single phase change with a relatively small volume change (8.21%), ensuring the high structural stability and excellent cyclic capability. The reversible evolution of Mn 2+/3+ and V 3+/4+ redox couples upon Na + extraction/insertion has been revealed by the confirmation of valence state via both ex situ X-ray absorption near-edge structure spectra and X-ray photoelectron spectroscopy. The superior performance of Na 3.5 Mn 0.5 V 1.5 (PO 4 ) 3 could be attributed to the high electronic/ionic conductivity and low sodium-ion diffusion energy barrier, which is supported by the electrochemical impedance spectroscopy and cyclic voltammetry measurements, as well as density functional theory computations.
研究领域:
材料科学
·
能源存储
·
电化学
·
电池技术
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DOI
ARCHIV DER PHARMAZIE
·
2019
·Vol. 353
·期 2
·1900231
·
IF 2.145
Xiujie Liu,Xin Chen,Kai Qiu,Zhihao Zhang
A series of 4-methoxy-3-arylamido- N -(substitutedphenyl)benzamides 6a – u were designed according to the splicing principle of structural design in the medicinal chemistry theory and were synthesized in five steps: nitration, acylation, ammoniation, reduction, and secondary ammoniation. The structures of the target compounds were characterized and verified by infrared, 1 H nuclear magnetic resonance (NMR), 13 C NMR, and electron spray ionization spectroscopy. Their in vitro antiplatelet aggregation activities induced by adenosine diphosphate (ADP) or arachidonic acid (AA) were assessed by Born's method. The biological evaluation revealed that all compounds exhibited certain levels of activities in both of the antiplatelet aggregation assays; compounds 6c (IC 50 = 3.84 μM) and 6f (IC 50 = 3.12 μM) displayed the strongest antiplatelet aggregation activities in the ADP-induced and AA-induced assay, separately. Moreover, compounds that had stronger activities were chosen for cell toxicity testing via the cell counting kit-8 assay. The results indicated that none of the compounds had obvious cell toxicity against L929 cells at the doses of 10 and 20 μM. It is worth pointing out that compound 6c showed the highest antiplatelet activity and the lowest cell toxicity. In general, 4-methoxy-3-arylamido- N -(substitutedphenyl)benzamides have the potential to become a kind of safer and more effective antiplatelet agents.
研究领域:
药物化学
·
药理学
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DOI
PubMed
高影响因子
Nanoscale
·
2018
·Vol. 11
·期 3
·962-967
·
IF 7.233
Zhaohong Su,Xiaolin Xu,Yongbing Cheng,Yueming Tan,Langtao Xiao,Daili Tang,Hongmei Jiang,Xiaoli Qin,Huixian Wang
A porous graphene (PG) bionanocomposite of PG, gold nanoparticles (AuNPs) and anti-indole-3-acetic acid (anti-IAA) antibody for sensitive and label-free amperometric immunoassay of IAA was reported. A PG film was produced by a pre-reduction/electrochemical reduction process on a glassy carbon electrode (GCE) and then a homogeneous AuNPs layer electrodeposition on the PG film. The anti-IAA antibody was immobilized onto the AuNPs through electrostatic adsorption and covalent conjugation. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), Raman spectroscopy, energy dispersive spectroscopy (EDS), Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), elecro-chemical impedance spectroscopy (EIS), ultraviolet visible spectroscopy (UV-vis) and differential pulse voltammetry (DPV) were used to characterize the PG film and the stepwise modification of the immunosensor. The electrochemical immunosensor exhibited a wide linear range from 2 × 10−11 to 2 × 10−8 g mL−1 with a detection limit of 0.016 ng mL−1 (S/N = 3) and showed significant linearity R2 = 0.9970. In addition, the proposed immunosensor showed acceptable selectivity and has been applied to the determination of IAA in the extract samples of several plant seeds with acceptable relative derivation (%) ranging from −5.25% to 4.24% between the immunosensor and high performance liquid chromatography. The proposed chemical pre-reduction and electro-reduction guided protocol can be extended to the preparation of many other functionalized PG nanocomposite films for wide applications.
研究领域:
生物传感
·
纳米生物技术
·
分析化学
·
植物生理学
·
电化学
·
免疫分析
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DOI
高影响因子
危险品化学品经营许可证（带存储）