JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 39
·45333
·
IF 1.86
Xi Yue,Wenjun Wu,Guodong Chen,Canrui Yang,Shijun Liao,Xiuhua Li
Quaternary ammonium functionalized poly(arylene ether) (QPAE-Br) membranes based on 2,2′,6,6′-tetramethyl biphenol for diffusion dialysis (DD) were designed and successfully fabricated via nucleophilic substitution polycondensation, bromination, film casting, and quaternization. The structures, thicknesses, ion-exchange capacities (IECs), water uptakes, swelling ratios, ion conductivities, and mechanical properties of QPAE-Br were used to characterize the membranes. The influence of the membrane structures on the DD performances was investigated by DD tests of simulated industrial pickling wastewater (1 mol/L HCl, 0.1 mol/L FeCl 2 ). The DD results show QPAE-a (IEC = 1.51 mmol/g) as the best DD candidate. Predialysis treatments further improved the DD performances of QPAE-Br. QPAE-a exhibited an excellent proton diffusion coefficient ( ) of 0.033 m/h and a high separation factor ( S ) of 95.45 after the predialysis treatment at room temperature; these values were much higher than those of the commercial DF-120B membrane (0.004 m/h for and 24.3 for S at 25 °C) and other reported DD membranes. QPAE-a has great potential for acid recovery via DD. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45333.
研究领域:
高分子科学
·
膜技术
·
化学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Xiaoyue Li,Penghui Li,Yingjie Li,Haitang Liu,Zongzheng Yang,Yanyan Chen,Xiaoyuan Liao
In situ generation of H 2 O 2 by photocatalyst with sterilization is an environmentally friendly method. In this work, we prepared three kinds of Zn-based ZIFs materials, i.e., MAF-6, ZIF-11 and ZIF-71, and systematically investigated their application in the area of photocatalytic H 2 O 2 production, and antibacterial efficiency. It is found that MAF-6 had the best ability of generate H 2 O 2 (1005 μmol h -1 g -1 ), 1.6 times more than ZIF-11, while ZIF-71 produced almost no H 2 O 2 . The sterilization rate of MAF-6 against Staphylococcus aureus and Escherichia coli can reach 97% and 91% in 3 h, respectively. It is worth noting that the more photo-generated reactive oxygen species (∙OH and ∙O 2 - ) are produced, the better sterilization effect . This work provides new material and insights into photocatalytic sterilization by in situ H 2 O 2 generation.
研究领域:
环境科学
·
材料科学
·
微生物学
✓ 已验证
DOI
高影响因子
Chemical Biology & Drug Design
·
2015
·Vol. 86
·期 4
·753-763
·
IF 2.485
Jianpeng Feng,Bing Xiao,Wenbo Chen,Ting Ding,Lingfeng Chen,Pengtian Yu,Fengli Xu,Huajie Zhang,Zhiguo Liu,Guang Liang
We previously reported a symmetric monocarbonyl analog of curcumin (MACs), C66, which demonstrated potential anti-inflammatory activity and low toxicity. In continuation of our ongoing research, we designed and synthesized 34 asymmetric MACs based on C66 as a lead molecule. A majority of the C66 analogs effectively inhibited LPS induction of TNF- α and IL-6 expression. Additionally, a preliminary SAR was conducted. Furthermore, active compounds 4a11 and 4a16 were found to effectively reduce the W/D ratio in the lungs and the protein concentration in the bronchoalveolar lavage fluid (BALF). Meanwhile, a histopathological examination indicated that these two analogs significantly attenuate tissue injury in the lungs with LPS-induced ALI rats. 4a11 and 4a16 also inhibited mRNA expression of several inflammatory cytokines, including TNF- α , IL-6, IL-1 β , COX-2, ICAM-1 and VCAM-1, in the Beas-2B cells after LPS challenge. Altogether, the data exhibit a series of new C66 analogs as promising anti-inflammatory agents for the treatment of LPS-induced ALI.
研究领域:
药理学
·
合成化学
·
免疫学
✓ 已验证
DOI
PubMed
高影响因子
Frontiers in Chemistry
·
2022
·
IF 5.545
Huang Meng,Huang Wenbin,Li Anqi,Yang Han,Jia Yijing,Yu Zhiqing,Xu Zhusong,Wang Xiaohan,Zhou Yasong,Wei Qiang
Experiments were carried out to research the different contents of Ga2O3 modification effects on the hydrodesulfurization (HDS) performance of 4,6-dimethyldibenzothiophene (4,6-DMDBT) catalyzed by the stepwise impregnation method. Characterization techniques such as XRD, BET, HRTEM, NH3-TPD, and Py-FTIR were performed to determine the effects of each modification of the catalyst by Ga on the properties of the prepared supports and catalysts. The catalytic effect of gallium is reflected in the fact that the empty d-orbitals of Ga elements participate in the formation of molecular orbitals in the active center and change their orbital properties, thus generating a direct desulfurization active phase suitable for complex sulfides for endpoint adsorption. The characterization results indicated that the introduction of Ga2O3 with appropriate content (2 wt.%) promoted Ni and Mo species to disperse uniformly and doping of more Ni atoms into the MoS2 crystals, which also increased the average stacking number and the length of MoS2. As a result, more NiMoS active phases were favored to form in the system. The specific surface area and the amounts of acid sites were increased, facilitating the adsorption of reactant molecules and the HDS reactions. The HDS results also suggested the effects of Ga modification play a very important role in the catalytic performance of the corresponding catalysts. The catalyst Ga–Ni–Mo/Al2O3 exhibited the highest conversion rate towards 4,6-DMDBT HDS when the amount of Ga2O3 loading was 2 wt.% with an LHSV of 2.5 h−1 at 290°C and Ga modification also can effectively improve the direct desulfurization (DDS) route selectivity in varying degrees.
研究领域:
催化化学
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
·
2015
·Vol. 54
·期 1
·784-788
·
IF 0.787
Fang-Ming Wang,Dan Bao,Bing-Xiang Hu,Ze-Yu Zhou,Deng-Deng Huang,Li-Zhuang Chen,Yuan-Yuan Dan
A series of novel 10-substituted 3,6-diphenyl-9-aryl-3,4,6,7,9,10-hexahydroacridine-1,8(2H,5H)-dione derivatives 2 were synthesized by condensation of compounds 1 with amines, which the compounds 1 were synthesized by 5-phenylcyclohexane-1,3-dione and aromatic aldehydes according to Knoevenagel, Michael, and cyclization reactions in the presence of a very small amount of l-proline as catalyzed at room temperature. The structures of all the synthesized compounds were characterized by IR, 1H NMR, and MS. In addition, the molecular structures of compound 1a have been determined by single-crystal X-ray diffraction analysis.
研究领域:
有机化学
·
药物化学
·
生物化学
✓ 已验证
DOI
高影响因子
Theranostics
·
2019
·
IF 8.063
Xiangjun Zhang,Qian Cheng,Lanlan Li,Liqing Shangguan,Chenwen Li,Shengke Li,Feihe Huang,Jianxiang Zhang,Ruibing Wang
Succinylcholine (Sch) is the only depolarizing neuromuscular blocking agent widely used for rapid sequence induction in emergency rooms. Unfortunately, a variety of (sometimes lethal) adverse effects, such as hyperkalemia and cardiac arrest, are associated with its use, and currently there are no specific antidotes to reverse Sch or to treat these side-effects. Methods: The binding behaviors of Sch and several synthetic receptors, including cucurbit[7]uril, sulfo-calix[4]arene and water-soluble carboxylatopillar[6]arene (WP[6]), were first investigated. With a mouse model, a leathal dose of Sch was selected for evaluation of the antidotal effects of these synthetic receptors on Sch induced mortality. The antidotal effects of a selected synthetic receptor, WP[6], on Sch induced cardiac arrhythmias, hyperkalemia, rhabdomyolysis and paralysis were subsequently evaluated with rat and mouse models. The reversal mechanism was also investigated at a cellular level. Results: All of these macrocyclic molecules exhibited relatively high binding affinities with Sch in vitro . In a Sch-overdosed mouse model, immediate injection of these synthetic receptors right after Sch administration increased the overall survival rate, with WP[6] standing out with the most effective antidotal effects. In addition, administration of WP[6] also reversed the paralysis induced by Sch in a mouse model. Moreover, infusion of WP[6] to Sch-overdosed rats reduced the incidence of cardiac arrhythmia, inhibited the otherwise abnormally high serum potassium levels, and relieved the muscular damage. At the cellular level, WP[6] reversed the Sch induced depolarization and reduced the efflux of intracellular potassium. Conclusion: Synthetic receptors, particularly WP[6], exhibited high binding affinities towards Sch, and presented a significant potential as supramolecular therapeutics to treat the various side effects of Sch by specifically sequestering Sch in vivo .
研究领域:
药理学
·
药物化学
·
治疗学
✓ 已验证
DOI
PubMed
高影响因子
FEBS LETTERS
·
2016
·Vol. 590
·期 16
·2619-2628
·
IF 3.519
Yu-Ying Zhang,Rui-Xue Xu,Shuai Gao,Ai-Xia Cheng
Oroxylin A and hispidulin, compounds which are abundant in both Scutellaria and liverwort species, are important lead compounds for the treatment of ischemic cerebrovascular disease. Their enzymatic synthesis requires an O -methyltransferase able to interact with the related flavonoid's 6-OH group, but such an enzyme has yet to be identified in plants. Here, the gene encoding an O -methyltransferase (designated PaF6OMT) was isolated from the liverwort species Plagiochasma appendiculatum . A test of alternative substrates revealed that its strongest preferences were baicalein and scutellarein, which were converted into, respectively, oroxylin A and hispidulin. Allowed a sufficient reaction time, the conversion rate of these two substrates was, respectively, 90% and 100%. PaF6OMT offers an enzymatic route to the synthesis of oroxylin A and hispidulin.
研究领域:
植物学
·
生物化学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Lijing Yan,Xiaomin Zeng,Shu Zhao,Wei Jiang,Zeheng Li,Xuehui Gao,Tiefeng Liu,Zekai Ji,Tingli Ma,Min Ling,Chengdu Liang
Temporally intermittent and spatially dispersed renewable energy sources strongly call for large-scale energy storage devices. Aqueous aluminum-ion batteries show great potential for application due to their safety and low cost. Thus far, however, the ideal full-battery configuration is beyond the scope due to shortcomings with regards to suitable anode and cathode materials. Herein, we report a pioneering aqueous aluminum-ion battery system consisting of a Prussian white cathode, 1 M Al2(SO4)3 aqueous electrolyte, and an organic 9,10-anthraquinone anode. The oxidation capability of the Prussian white cathode during the first charging allows for the fabrication of the full battery without pre-inserting aluminum ions, thus making the rocking-chair-type battery feasible. Importantly, the open-framework structure of the Prussian white and distinct enolization charge storage mechanism of 9,10-anthraquinone ensure fast reaction kinetics. The full battery exhibits cycling stability with a capacity retention of 89.1% over 100 cycles at 500 mA g–1, finishing a cycle in about 10 min. This work provides a pathway for developing rechargeable aqueous aluminum-ion batteries.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 27
·21737-21745
·
IF 2.779
Lin Feng Li,Liu Bing,Song Kai Xin
NaLaMgWO 6 microwave dielectric ceramics have been synthesized via the standard solid-state reaction method. The Rietveld refinement of the X-ray diffraction patterns indicates that NaLaMgWO 6 crystallizes in a monoclinic crystal structure with a C 2/ m space group. Raman spectrum of the NaLaMgWO 6 ceramic is collected, and the correlations between the Raman active modes and chemical bond vibrations are systematically identified. The optimum microwave dielectric properties are obtained when sintered at 1550 °C, with ε r = 17.1, Q f = 26,150 GHz, and τ f = − 83.4 ppm/°C. A microstrip patch antenna operating at the sub-6 GHz band is fabricated using the NaLaMgWO 6 ceramic as the substrate. The fabricated antenna resonates at 3.82 GHz, which exhibits an excellent S 11 value of − 26 dB, a minimum VSWR value of 1.07, and a satisfactory simulated efficiency of 72.2%. The good antenna performance demonstrates the great application potential of NaLaMgWO 6 ceramic in the sub-6 GHz band antennas.
研究领域:
材料科学
·
电子工程
✓ 已验证
DOI
高影响因子
AQUACULTURE
·
2018
·
IF 2.71
Shengli Fu,Mingmei Ding,Yanjian Yang,Jingrong Kong,Yuan Li,Zheng Guo,Anli Wang,Jianmin Ye
Caspases are a family of proteases involved in many important biological processes, including inflammation, cell differentiation and apoptosis. Among them, caspase-6 plays an important role in the execution phase of the apoptotic death cascade. In this study, the full-length of puffer fish caspase - 6 ( Pfcasp - 6 ) was cloned and characterized, containing an open reading frame of 912 bp, a 5′-UTR of 168 bp and a 3′-UTR of 632 bp with a poly (A) tail. The Pfcasp - 6 encoded a polypeptide of 303 amino acids with an estimated molecular mass of 34.09 kDa and a predicted isoelectric point of 5.35. Phylogenetic analysis indicated that Pfcasp-6 was highly homology to that of other teleostean species. Spatial mRNA expression analysis revealed that the ubiquitous expression of Pfcasp - 6 in all examined tissues, with high expression in skin, followed by gill, intestine, kidney , blood, heart and spleen. After the challenges of high temperatures and Aeromonas hydrophila , the transcript expressions of Pfcasp - 6 were significantly up-regulated in blood and spleen. In addition, cellular localization analysis indicated that the distribution of Pfcasp-6 was in the cytoplasm and nucleus. Overexpression of Pfcasp-6 was able to trigger a significant level of cell death in HeLa cells, suggesting its putative role in cell apoptosis. Taken together, the results of this study suggested that Pfcasp - 6 might be an important component in the caspases cascade, and was likely to get involved in the response to different stress in puffer fish.
研究领域:
分子生物学
·
免疫学
·
鱼类生理学
·
基因表达
✓ 已验证
DOI
高影响因子
CHEMICO-BIOLOGICAL INTERACTIONS
·
2022
·
IF 5.168
Wei Li,Yin-Nan Chen,Yue-Yue Chen,Zhe Wang,Zhen Wang,Li-Li Jiang,Hong-Can Shi,Yong Liu
UGT1A1 is the main enzyme that catalyzes the metabolic elimination and detoxification of SN-38, the active form of the drug irinotecan . Milk thistle products have been used widely to protect the liver from injury associated with the use of chemotherapeutic agents. To evaluate whether SN-38 metabolism can be affected by milk thistle products, the inhibitory effects of silybins on UGT1A1*1 and UGT1A1*6 were evaluated in the present investigation. Both silybin A and silybin B potently inhibited SN-38 glucuronidation catalyzed by UGT1A1*1 or UGT1A1*6. It was noteworthy that silybin A and silybin B showed synergistic effect in UGT1A1*1 microsomes at concentration around IC 50 , while additive effect in UGT1A1*6. According to the predicted AUC i /AUC ratios (the ratio of the area under the plasma concentration–time curve of SN-38 in the presence and absence of silybins), the coadministration of irinotecan and several milk thistle products, including silybin-phosphatidylcholine complex, two Legalon capsules , four Silymarin tablets or four Liverman capsules, may lead to clinically significant herb-drug interactions (HDI) via UGT1A1 inhibition. Meanwhile, R gut values were much higher than 11 in all the groups, indicating potential HDI due to intestinal UGT1A1 inhibition.
研究领域:
药理学
·
肿瘤学
·
草药医学
✓ 已验证
DOI
PubMed
高影响因子
TISSUE & CELL
·
2020
·
IF 1.837
Haocong Zhang,Meihui Piao,Mingming Guo,Lingzhi Meng,Hailong Yu
The recovery of spinal cord injury (SCI) involves multiple factors, of which miRNAs take an important part. In this study, we evaluated the function of microRNA-211−5p (miR-211−5p) on SCI in a rat model. SCI model was established using modified Allen's weight-drop method and Basso-Bcattie-Bresnahan score was applied to assess the locomotor function. MiR-211−5p agomir was utilized to increase miR-211−5p expression and endoplasmic reticulum (ER) stress inhibitor, 4-PBA (4-phenylbutyric acid), was utilized to suppress ER stress. Neuron apoptosis and the expressions of miR-211−5p, activating transcription factor 6 (ATF6), apoptosis-related proteins, pro-inflammatory cytokines and endoplasmic reticulum stress-related proteins were detected. Dual luciferase reporter gene assay was performed to verify the binding between miR-211−5p and ATF6. The results showed that miR-211−5p directly targeted ATF6. MiR-211−5p was down-regulated and ATF6 was up-regulated in SCI rats. Both interferences with miR-211−5p agomir and 4-PBA effectively attenuated neuron apoptosis and reversed the expressions of apoptosis, inflammation and endoplasmic reticulum stress-related molecules post SCI in rats. These findings demonstrated that miR-211−5p could effectively alleviate SCI-induced neuron apoptosis and inflammation via directly targeting ATF-6 and regulating ER stress.
研究领域:
神经科学
·
分子生物学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）