RSC Advances
·
2015
·Vol. 5
·期 56
·44828-44834
·
IF 3.84
Yaohui Xu,Ruixing Li
A combined bottom-up and top-down route was developed for the template-free synthesis of mesoporous CeO2 powders using Ce(NO3)3·6H2O, NH4HCO3, H2O2, and H2O as starting reagents. The flake-like Ce2(CO3)3·8H2O precursor was etched by H2O2, and CeO2 nucleated in situ with built-in equiaxed particles. Pores formed on the flakes owing to the loss of by-products of H2O and CO2. The formation of the mesostructured CeO2 could also be explained by the large change in volume induced as a result of the difference in density between Ce2(CO3)3·8H2O and CeO2. Accordingly, the original flake-like morphology of Ce2(CO3)3·8H2O was not preserved upon pore formation and during continuous stirring in the synthesis. A subsequent hydrothermal treatment destroyed the loose aggregates of CeO2 derived from the reaction between H2O2 and Ce2(CO3)3·8H2O. Rearrangement of the CeO2 particles via a dissolution–recrystallization process occurred under certain temperatures and pressures. Consequently, CeO2 particles with coarser sizes, smoother surfaces, and mesoporous structures were obtained. The specific surface area of the particles was 166.5 m2 g−1 after hydrothermal treatment at 200 °C for 24 h. The mesoporous CeO2 particles possessed better adsorption capacities of acid orange 7 dye than basic orange 2 dye in the absence of pH pre-adjustments. The saturated adsorption amount of acid orange 7 dye was 510.2 mg g−1 at 298 K based on Langmuir linear fitting of the experimental data.
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WATER SCIENCE AND TECHNOLOGY
·
2016
·Vol. 73
·期 8
·1802-1808
·
IF 1.064
Li Jing,Lin Heng,Yang Lin,Zhang Hui
The exhausted activated carbon generated from the adsorption of heavy metal wastewater needs further treatment/disposal. In this study, a new application of copper-spent activated carbon (Cu-AC) was proposed. Cu-AC was used to activate peroxydisulfate (PDS) for the decolorization of Acid Orange 7 (AO7) and electrical current was introduced to enhance the process. The decolorization followed a pseudo-first-order kinetic pattern well ( R 2 > 0.95). 92.4% of color removal at 60 min and 38.3% of total organic carbon removal at 180 min were achieved when initial pH value was 9.0, current density was 16 mA/cm 2 , PDS concentration was 5 mM and Cu-AC dosage was 0.25 g/L. The radical scavengers including methanol, tert -butanol and phenol, as well as electron paramagnetic resonance test, were employed to investigate the oxidizing species responsible for AO7 decolorization. The stability of Cu-AC was confirmed by three recycle experiments.
研究领域:
环境工程
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化学工程
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高级氧化技术
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废水处理
·
催化
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CHEMPHYSCHEM
·
2019
·Vol. 20
·期 6
·861-867
·
IF 3.077
Xiaojiao Kang,Wei Lü,Hongcheng Wang,Dongxiong Ling
A series of Ca 9 Ga(PO 4 ) 7 :Ce 3+ /Tb 3+ /Dy 3+ /Mn 2+ phosphors with tunable color, in which Ce 3+ acts as the sensitizer, was synthesized. Energy transfer (ET) from Ce 3+ to Tb 3+ /Dy 3+ /Mn 2+ was investigated in detail. Tb 3+ /Dy 3+ /Mn 2+ single-doped Ca 9 Ga(PO 4 ) 7 can exhibit green, yellow, and red emission, respectively. Incorporating Ce 3+ into a Tb 3+ /Dy 3+ /Mn 2+ single-doped Ca 9 Ga(PO 4 ) 7 phosphor can remarkably promote the luminous efficiency of the Tb 3+ /Dy 3+ /Mn 2+ ions. This enhancement originates from an efficient ET from Ce 3+ to Tb 3+ /Dy 3+ /Mn 2+ . The ET was validated by luminescence spectra, decay dynamics, and schematic energy levels. Moreover, the intensity ratio of red emission of Mn 2+ to violet emission of Ce 3+ was analyzed based on energy-transfer and lifetime measurements. In Ce 3+ -Tb 3+ , Ce 3+ -Dy 3+ , and Ce 3+ -Mn 2+ doped Ca 9 Ga(PO 4 ) 7 , the emitting color changed from violet to green, yellow, and red, respectively, which indicates the potential use of this new tunable phosphor in UV light-emitting diodes. Graphical Energy transfer from Ce 3+ to Tb 3+ /Dy 3+ /Mn 2+ in Ca 9 Ga(PO 4 ) 7 is investigated as a function of the Ce 3+ /Tb 3+ /Dy 3+ /Mn 2+ concentration and based on the photoluminescence emission/excitation spectra and decay curves. Through dual energy transfer, the emitting colors can change to green, yellow, and red from the initial blue color. The results suggest that the material is suitable for UV-white LEDs.
研究领域:
材料科学
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发光材料
·
光学性质
·
固态化学
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光子学
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CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Yongli Zhang,Minghui Li,Zihui Kong,Chao Liang,Cheng Zhou,Mao Xia,Zhi Zhou
Outdoor lighting and other lighting systems can disrupt natural plant growth habits. Thus, LED lighting that is not detrimental to plant growth is required. In our study, Dy 3+ -doped Ca 8 ZnY(PO 4 ) 7 :Dy 3+ phosphor with enhanced luminescence properties caused by the co-dopants Mg 2+ and B 3+ were synthesised. The samples had multiple excitation peaks, indicating they are excited by either near-ultraviolet (n-UV) or blue chips. All samples exhibited bright narrow yellow and blue emission corresponding to the transitions of Dy 3+ ions with 4 F 9/2 → 6 H 13/2 and 4 F 9/2 → 6 H 13/2 , respectively. Moreover, doping with Mg 2+ and B 3+ enhanced the luminescence intensity, reaching 113.6 and 119.7%, respectively. In addition, the luminescence emission intensity at 150 °C was maintained at approximately 95% of the initial value at 25 °C, and its thermal stability increased by 123%. Devices assembled with an n-UV chip (388 nm) and the as-obtained CZMYP:Dy 3+ phosphor emitted a bright warm white light and simulated outdoor dark lighting for tobacco cultivation, indicating that the as-prepared phosphor is an excellent candidate material for plant habitat-conscious phosphors.
研究领域:
材料科学
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发光材料
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固态照明
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光学性质
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植物生理与照明
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FITOTERAPIA
·
2026
·
IF 2.9
Hengxing Ran,Yan Wen,Yiebi Qin,Kaiwen Kang,Zhengrong Wu,Yifan Li,Yu Wang,Rihui Wu,Dongli Li,Song Ang,Lishe Gan,Jingwei Jin
This study aims to identify the most primary hepatoprotective compound from Hypericum japonicum and elucidate its underlying mechanisms of liver protection. This study screened 15 compounds from Hypericum japonicum against D-GalN-induced AML12 cell injury, identifying TAX ( Compound 8 , taxifolin 7-rhamnoside) as the most hepatoprotective. This study indicates that TAX reduced AST, ALT, and MDA levels, while enhancing SOD and GSH levels in D-GalN-induced AML12 and LPS/D-GalN -induced liver. In addition, TAX attenuated LPS/D-GalN-induced hepatic injury by lowering inflammatory infiltration and pro-inflammatory cytokines (TNF-α, IL-6 and NO) levels. Network pharmacology analysis revealed common targets between TAX and drug-induced liver injury, forming a protein-protein interaction (PPI) network. Functional enrichment (GO/KEGG) and molecular docking indicated strong binding affinity between TAX and AKT1, confirmed by molecular dynamics simulations. Western blot analyses that TAX ameliorated inflammation and oxidative stress through down-regulating the AKT/NF-κB pathways and up-regulating Nrf2/HO-1 pathways in vivo, TAX inhibited apoptosis via up-regulating Bcl-2 and down-regulating Bax in vitro. Collectively, this study demonstrates that TAX ameliorates LPS/D-GalN-induced ALI by attenuating hepatocyte apoptosis, inflammatory responses, and oxidative stress.
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Phenomics
·
2025
·
IF 6.2
Hu Hongye,Wu Yanzhi,Hong Jingwei,Wang Huiying,Zhang Xiaohua,Huang Guanli,Zhu Xiaofang
Breast cancer (BC) remains the predominant form of cancer among women. Arsenic trioxide (ATO), an element in traditional Chinese medicine, has shown potential for treating BC, particularly when combined with resveratrol. However, the exact mechanisms of their combined action are not fully understood. This study aims to clarify their combined mechanisms through network pharmacology and experimental validation. In vitro experiments confirmed that compared with either agent alone, the combination of ATO and resveratrol more effectively inhibited the production of estrogen receptor 1 ( ESR1 ), tumor protein P53 ( TP53 ), and v-AKT murine thymoma viral oncogene homolog 1 ( AKT1 ) in MCF-7 cells. Our findings indicate that the combination of ATO and resveratrol significantly promotes cell apoptosis by suppressing ESR1 , TP53 , and AKT1 . Thus, ATO and resveratrol together may offer a promising strategy for BC treatment.
研究领域:
肿瘤学
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药理学
·
分子生物学
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中医中药
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癌症研究
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CHEMICO-BIOLOGICAL INTERACTIONS
·
2022
·
IF 5.168
Moath Refat,Guoqiang Zhang,Abdulaziz Ahmed A.Saad,Salem Baldi,Fang Zheng,Xin'an Wu
Cholestasis is primarily caused by bile acid homeostasis dysregulation, resulting in retention, aggregation, and accumulation of the toxic cholate in the hepatocytes. Existing therapies for cholestasis are limited, demanding the urgent development of novel drugs. As a result, targeting FXR specifically promises a unique treatment strategy for cholestasis. The current study aims to evaluate the influence of 7, 8-dihydroxy-4-methyl coumarin (DMC) against alpha-naphthyl isothiocyanate (ANIT)-induced liver injury in mice. The “Computer-Aided Drug Design” (CADD) and molecular docking study anticipated that DMC would proficiently bind and activate the FXR. Accordingly, the hepatoprotective activity of DMC against ANIT-induced hepatotoxicity and cholestasis was investigated in ANIT-treated HepaRG cells and the ANIT-induced cholestatic mouse model. Outcomes indicated the protective effects of DMC against ANIT toxicity in HepaRG cells after 24 h of intervention and animals after seven days of treatment. DMC partially blocks ANIT-induced increases in serum markers of hepatocellular injury , liver and gall bladder enlargement , and hepatic necrosis . Western blotting revealed that DMC alleviates ANIT-induced hepatotoxicity and cholestasis via activating the FXR receptor and regulating CYP7A1 , the enzyme responsible for bile acid synthesis. DMC exhibited protective activity against cholestasis through activating FXR, suggesting it might be a promising strategy for preventing and treating cholestatic liver disease.
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Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 11
·2478-2489
·
IF 7
Yanhao Zhang,Ji Wang,Chao Liu,Hanlei Xing,Yuhao Jiang,Xinsong Li
7-Ethyl-10-hydroxyl camptothecin (SN38), a semisynthetic derivative of camptothecin, exhibited extreme pharmacological activities in treating a range of cancers. However, its poor aqueous solubility and low stability hinder its clinical applications. Hence, a redox-responsive SN38 prodrug encapsulated human serum albumin (HSA) nanoparticle is developed to realize its potential in the clinic. First, a disulfide bond bridged 7-ethyl-10-hydroxyl camptothecin-undecanoic acid conjugate (SN38-SS-COOH) was synthesized and characterized structurally. After that, SN38-SS-COOH/HSA nanoparticles (SNH NPs) were prepared by the desolvation method. The SNH NPs with a feed molar ratio of 9 : 1 of SN38-SS-COOH : HSA showed a spherical structure with a diameter range of approximately 120–150 nm revealed by dynamic light scattering (DLS) and transmission electron microscopy (TEM). Fluorescence quenching confirmed the formation of SNH NP complexes by dual hydrophobic force and electrostatic interaction. The SNH NPs have a high drug loading of 10.44% and an encapsulation efficiency of 89.59% with good stability. Moreover, the redox responsiveness was validated by glutathione (GSH)-triggered accelerated release of parent drug SN38. In an in vivo pharmacokinetic study, the SNH NPs exhibited a significantly prolonged circulation time (t1/2, 3.77-fold) compared with free SN38. Finally, the in vivo antitumor efficacy and systemic toxicity of SNH NPs in a breast xenograft model were thoroughly evaluated. The inhibition rate of tumor growth induced by the SNH NPs reached 70.1%, while only 50.1% was achieved for irinotecan at an equivalent SN38 dosage of 10 mg kg−1. More importantly, the SNH NPs achieved a higher level of tumor growth inhibition (85.3%) by increasing the dosage to 60 mg kg−1 SN38 without obvious adverse effects. Taken together, the use of redox-responsive SN38 prodrug/HSA NPs could be a promising strategy to deliver highly active SN38 for breast cancer chemotherapy.
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ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Jie Liu,Kai Sun,Rui Zhu,Xun Wang,Michael Gatheru Waigi,Shunyao Li
Bisphenol A (BPA) is a ubiquitous endocrine disruptor that poses adverse human health risks. Herein, biotransformation kinetics, products, and mechanisms of BPA undergoing a laccase-producing Trametes hirsuta La-7 metabolism were for the first time reported. Strain La-7 could completely biotransform ≤0.5 mmol·L −1 BPA within 6 d in vivo . Notably, its extracellular crude laccase solution (ECLS) and intracellular homogenized mycelium (HM) only required 6 h to convert 85.71% and 84.24% of 0.5 mmol·L −1 BPA in vitro , respectively. The removal of BPA was noticeably hampered by adding a cytochrome P-450 inhibitor (piperonyl butoxide) in HM, disclosing that cytochrome P-450 monooxygenase participated in BPA oxidation and metabolism. BPA intermediates were elaborately identified by high-resolution mass spectrometry (HRMS) combined with 13 C stable isotope ratios (BPA: 13 C 12 -BPA = 0.25: 0.25, molar concentration). Based on the accurate molecular mass, isotope labeling difference, and relative intensity ratio of product peaks, 6 versatile metabolic mechanisms of BPA, including polymerization, hydroxylation, dehydration, bond cleavage, dehydrogenation , and carboxylation in vivo and in vitro , were confirmed. Germination index values revealed that inoculating strain La-7 in a BPA-contaminated medium presented no phytotoxicity to the germinated radish ( Raphanus sativus L.) seeds. In vivo , Mg 2+ , Fe 2+ , Fe 3+ , and Mn 2+ were conducive to BPA removal, but Cd 2+ and Hg 2+ significantly obstructed BPA elimination. Additionally, strain La-7 also exhibited high-efficiency metabolic ability toward estrone (E1), 17 β -estradiol (E2), and 17 α -ethinylestradiol (EE2), with more than 96.13%, 96.65%, and 100% of E1, E2, and EE2 having been converted, respectively. Our findings provide an environmentally powerful laccase-producing fungus to decontaminate endocrine disruptor-contaminated water matrices by radical polymerization and oxidative decomposition.
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ACS Omega
·
2023
·
IF 4.1
Yue Zhao,Chaoyuan Tang,Jingyi Huang,Hongyan Zhang,Jingbin Shi,Shujun Xu,Lisha Ma,Chun Peng,Qi Liu,Yang Xiong
In this study, we established a simple and rapid in vitro method for screening multidrug resistance (MDR) reversal agents in traditional Chinese medicines (TCMs), which could better correspond to the MDR reversing effect in vivo. Here, D-luciferin, a substrate for the enzyme firefly luciferase and also a substrate for ATP-binding cassette transporters (ABC transporters), was used as the probe to detect its efflux kinetics caused by ABC transporters. First, we established a stable doxorubicin (DOX)-resistant cell line (MCF-7/DOXFluc) that overexpressed luciferase. Then, some kinds of TCMs were chosen for the MDR reversal agents to measure its effect on inhibiting the D-luciferin outflow from MCF-7/DOXFluc, and the ideal reversal agent with the least D-luciferin efflux from MCF-7/DOXFluc was selected to further investigate its effect combined with DOX on MCF-7/DOXFluc tumor-bearing mice. The results indicated that quercetin (Qu) could remarkably increase the retention of D-luciferin in MCF-7/DOXFlucin vitro and in vivo. Also, the combination of Qu and DOX could exceedingly inhibit the tumor growth, which proved the feasibility of this in vitro screening method. The study proposed a feasible method for mass screening of MDR agents from TCMs in vitro.
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LIFE SCIENCES
·
2023
·
IF 6.1
Haijie Wu,Xiaohu Shi,Yingda Zang,Xiaodi Zhao,Xikun Liu,Weida Wang,Wenying Shi,Clarence T.T. Wong,Li Sheng,Xiaoguang Chen,Sen Zhang
Aims Cisplatin is a widely-used drug in the clinical treatment of tumors, but kidney nephrotoxicity is one of the reasons that limits its widespread use. We previously found that 7-hydroxycoumarin-β-D-glucuronide (7-HCG) was one of metabolites of skimmin and highly enriched in the kidneys and maintained a high blood concentration in skimmin-treated rats. Therefore, we investigated whether 7-HCG has a protective effect on cisplatin-induced acute kidney injury. Materials and methods Male C57BL/6 mice were continuously administered 7-HCG for five days, and on the third day, an intraperitoneal injection of cisplatin was given to induce acute kidney injury. After 72 h, the mice were sacrificed for analysis. Serum and renal tissue were collected for renal function evaluation. RNA sequencing was used to explore mechanism, and further validated by western blot and immunohistochemistry. In addition, pharmacokinetic study of oral 7-HCG administration was performed to examine how much 7-hydroxycoumarin (7-HC) was metabolized and 7-HC possible effect on renal protection. Key findings 7-HCG significantly reduced serum BUN and SCR levels, and alleviated pathological damage in renal tissue, and reduced the renal index. RNA sequencing revealed that 7-HCG could reverse p38 MAPK regulation and apoptosis. By western blotting, it was found that 7-HCG could reduce renal injury by reducing p-p38, p-ERK, p-JNK, cleaved-caspase3 and Bax. The immunohistochemical results of cleaved-caspase3 were consistent with western blotting. 7-HCG also significantly reduced the production of ROS in kidney tissue. Pharmacokinetic experiments have shown that 7-HCG in the blood increased rapidly and was eliminated slowly, with an average t 1/2β of 18.3 h. And the concentration of 7-HCG in the target organ kidney was about 4 times higher than that in blood. Significance Our findings indicate that 7-HCG could exert its protective effect against cisplatin-induced acute kidney injury by inhibiting apoptosis via p38 MAPK regulation and elucidates its pharmacokinetics.
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FOOD CHEMISTRY
·
2022
·
IF 9.231
Xin Zhang,Li Tian,Zhuo Sun,Qian Wu,Xiangyu Shan,Yingjie Zhao,Ruizhan Chen,Juan Lu
A molecular-imprinted electrochemiluminescence sensor for procymidone (PCM) detection was reported based on Ru(bpy) 3 2+ @ZIF-7. A novel self-accelerated Ru(bpy) 3 2+ @ZIF-7 was prepared by one-step synthesis method, which exhibited high electrochemiluminescence (ECL) emission as a coreactant in the presence of tri- n -propylamine (TPrA). Concretely, ZIF-7 was not only the carrier of Ru(bpy) 3 2+ , but also the co-reaction promoter of Ru(bpy) 3 2+ /TPrA ECL system. The introduction of molecular imprint polymer (MIP) with PCM gave new characteristics of specific recognition of analyte PCM. The change value of ECL intensity (ΔI) was proportional to the logarithm of PCM concentration, with a wide linear range and a low detection limit of 1.0 × 10 −10 to 1.0 × 10 −6 mol L −1 and 2.0 × 10 −11 mol L −1 , respectively. The presented MIP-ECL sensor had high sensitivity, selectivity and stability, and had great potential in the field of food safety detection.
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