NEUROREPORT
·
2024
·
IF 1.6
Guo Jianlian,Xu Yong,Liu Jie,Hou Xueqi
This project is conceived to reveal the role of lidocaine in the process of Alzheimer’s disease (AD) and its possible downstream targets. After the employment of AD cell model in mice hippocampal neuronal HT-22 cells in the presence of amyloid-β1-42 (Aβ1-42), Cell Counting Kit-8 method investigated cell viability. Oxidative damage was assayed based on a dichloro-dihydro-fluorescein diacetate fluorescent probe and commercially available kits. The 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolocarbocyanine iodide fluorescent probe estimated mitochondrial function. Terminal-deoxynucleotidyl transferase mediated nick end labeling, western blotting, and immunofluorescence appraised the apoptotic level. Western blot also ascertained the alternations of nerve growth factors (NGF)-protein kinase B (Akt) pathway-related proteins. Aβ1-42 concentration dependently triggered the viability loss, oxidative damage, and apoptosis in HT-22 cells. Lidocaine promoted the viability and reduced the mitochondrial impairment and mitochondria-dependent apoptosis in Aβ1-42-treated HT-22 cells in a concentration-dependent manner. Besides, lidocaine activated the NGF-Akt pathway and NGF absence blocked NGF-Akt pathway, aggravated mitochondrial dysfunction as well as mitochondria-dependent apoptosis in lidocaine-administrated HT-22 cells in response to Aβ1-42. Altogether, these observations concluded that lidocaine might stimulate NGF-Akt pathway to confer protection against mitochondrial impairment and apoptosis in Aβ1-42-mediated cellular model of AD.
研究领域:
神经科学
·
药理学
·
细胞生物学
·
分子生物学
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 22
·5960-5968
·
IF 7.779
Qiqiong Ren,Jian Zhang,Maxim S. Molokeev,Guojun Zhou,Xian-Ming Zhang
Low-dimensional metal halides have emerged as promising platforms for the development of new-generation phosphor-converted light emitting diodes (pc-LEDs), in which zero-dimensional (0D) hybrids with lone-pair ns2 states, in particular, show unprecedented competitiveness owing to their fascinating photoluminescence (PL) properties. Herein, we designed a novel 0D indium hybrid, (C20H20P)2InCl5, and proposed a co-doping strategy to incorporate Bi3+ (6s2) and Sb3+ (5s2) ions into this indium hybrid. Widely tunable emissions from blue to red are achieved, which are assigned to the triplet self-trapped excitons (STEs) (3P1 → 1S0) of Bi3+ (476 nm) and Sb3+ (658 nm), respectively. Importantly, an uncommon triplet–triplet energy transfer from Bi3+ to Sb3+ contributes to tunable dual emissions, and enables a single-phase cool white-light emission under ultraviolet (UV) excitation. Moreover, the energy transfer mechanism is discussed clearly by fluorescence photon dynamic analysis and DFT calculations. This work provides a deeper insight into triplet–triplet energy transfer, as well as presents a new model system for tuning the PL behaviours of ns2 configuration dopants.
研究领域:
材料科学
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光电技术
·
光子学
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DOI
高影响因子
INORGANIC CHEMISTRY
·
2026
·
IF 4.6
Qunhua Zhong,Yimeng Zhou,Tianle Ren,Jianjun Zhu,Di Li,Deli Jiang
Abstract Photocatalytic CO2 reduction to carbonaceous fuels is a promising strategy to mitigate massive carbon emissions, yet the highly selective CO2 conversion remains challenging due to the unsatisfactory charge separation and limited active sites of pristine semiconductor photocatalysts. Herein, we report the in situ fabrication of oxygen vacancy rich W/H co-doped rutile TiO2 (W/H-TiO2) via a two-step wet chemical approach for high-efficiency photocatalytic CO2 reduction to CO. The optimized W/H-TiO2 exhibited high activity and selectivity for the photocatalytic reduction of CO2 to CO (57.96 μmol g–1 h–1 and 96.3%), which were significantly higher than those of other TiO2 counterparts. Experimental characterizations and density functional theory (DFT) calculations reveal that the synergistic effect of H/W co-doping accelerates the migration and separation of photogenerated charge carriers and reduces the formation energy barrier for the key *COOH intermediate, thereby markedly boosting the CO2 photoreduction activity and product selectivity of W/H-TiO2. This work establishes a dual-doping-induced oxygen vacancy strategy for electronic structure engineering, providing a new paradigm for the rational design of high-performance TiO2 based photocatalysts toward efficient CO2 photoreduction.
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DOI
高影响因子
MACROMOLECULES
·
2018
·
IF 5.914
Chao Lv,Zhijun Zhang,Jia Gao,Jinqiao Xue,Jianyuan Li,Jingjing Nie,Junting Xu,Binyang Du
A series of linear thermosensitive amphiphilic pentablock terpolymers PNIPAMx-b-PtBA90-b-PPO36-b-PtBA90-b-PNIPAMx (NxT90O36T90Nx) with various lengths x of PNIPAM block (x = 111, 107, 95, 58, 33, and 26) were synthesized via a two-step atom transfer radical polymerization (ATRP) using modified poly(propylene oxide) (PPO36) as the macroinitiator, tert-butyl acrylate (tBA) as the first monomer, and N-isopropylacrylamide (NIPAM) as the second monomer. The NxT90O36T90Nx pentablock terpolymers form micelles in dilute aqueous solution, whose structure and morphology are dependent on the length x of PNIPAM block and solution temperature. At 14 °C, below the lower critical solution temperature (LCST) of PNIPAM block, the morphology of NxT90O36T90Nx micelles changes from core–corona spherical micelles with homogeneous hydrophobic core to rodlike micelles, core–shell–corona spherical micelles with clear boundaries, core–shell–corona spherical micelles with blurry boundaries, and finally large compound spherical micelles with embedded hydrophilic chains in the hydrophobic region when x decreases from 111 to 26. This morphology change might be attributed to the different stretching factors of hydrophobic PPO and PtBA blocks in the micelles, which varied differently with length x of PNIPAM block and hence resulted in the change of compatibility of the two hydrophobic blocks. A scaling relationship between the length L0 of hydrophilic corona and the length x of PNIPAM block is found to be L0 ∼ x0.77±0.08, which falls in the range 0.5–0.86 theoretically predicted for the micelles of diblock copolymers. The size of hydrophobic regions increases with decreasing x. At 60 °C above the LCST of PNIPAM block, all NxT90O36T90Nx pentablock terpolymers form spherical micelles with uniform structure and size distribution in aqueous solution regardless of the length x of PNIPAM block.
研究领域:
高分子科学
·
材料化学
·
软物质物理
·
纳米技术
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DOI
高影响因子
Soft Matter
·
2018
·Vol. 14
·期 35
·7107-7112
·
IF 3.709
Ting Qu,Song Guan,Chen Zhang,Xiaoxiong Zheng,Yongbin Zhao,Aihua Chen
Block copolymer (BCP) films with perpendicularly aligned cylindrical domains of high aspect ratio have important applications in diverse fields. However, an aspect ratio of the cylinders as high as 200 has rarely been reported so far. Here we demonstrate an efficient route to the formation of normally aligned P4VP cylinders with high aspect ratio surrounded by a matrix of azobenzene-containing block (PMA(Az)) via hierarchical self-assembly. A crisscross structure, consisting of parallelly aligned liquid crystalline (LC) layers and normally aligned self-assembly domains, is expected to assist the formation of well-defined nanostructures. The LC layers in the cylindrical films self-assemble to form smectic phase after solvent annealing, as confirmed by WAXD and UV-vis spectra. We found that the aspect ratio of the vertical P4VP cylinders is up to 200 and the film thickness reaches 6 μm. P4VP is a functional polymer, making this P4VP-b-PMA(Az) film more suitable for advanced filters, multi-nanochannels, nanolithography, and high-density storage media, etc.
研究领域:
材料科学
·
纳米技术
·
聚合物科学
·
自组装
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DOI
高影响因子
MACROMOLECULAR RAPID COMMUNICATIONS
·
2023
·Vol. 44
·期 23
·2300381
·
IF 4.6
Zhengwei Hu,Juxuan Xie,Jiangkai Yu,Yi Zhang,Houji Cai,Yuanqing Bai,Kai Zhang,Chunchen Liu,Fei Huang,Yong Cao
The optoelectronic properties and photovoltaic performance of nonfullerene electron acceptors (NFEAs) in organic solar cells (OSCs) are greatly influenced by the rational structure regulation of the central core unit. This study introduces a novel type of six-membered fused electron-donating core containing B─N covalent bonds to construct acceptor–donor–acceptor (A–D–A)-type NFEAs. By modulating the branching alkyl chains on the nitrogen atom, two NFEAs, BN910 and BN1014, are synthesized and characterized. Both molecules exhibit strong near-infrared absorption, narrow bandgaps (≈1.45 eV), appropriate energy levels, and tunable molecular packing behaviors, positioning them as promising candidates for efficient NFEAs in OSCs. The investigation reveals that BN1014, with longer and C2-branched alkyl chains, demonstrates superior intermolecular packing and morphology within active layers, leading to enhanced exciton dissociation, improved charge transfer, and reduced charge recombination in OSCs. As a result, a power conversion efficiency (PCE) of 10.02% is achieved for D18:BN1014-based binary OSCs. Notably, BN1014 can be utilized as the third component in the D18:DT-Y6 binary system to fabricate the ternary OSCs, and a PCE of 17.65% is achieved, outperforming 17.05% of D18:DT-Y6-based binary OSCs. These findings highlight the potential of heteroarenes featuring B─N covalent bonds for constructing high-efficiency NFEAs in OSCs.
研究领域:
材料科学
·
有机电子学
·
太阳能
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Yanjia Guo,Juan Lu,Wenzhuo Wang,Hanyue Jiang,Guangping Ma,Pengfei Han,Li Tian,Tengying Ma
In this study, we developed novel copper-doped biomass carbon quantum dots (Cu-CQDs) utilizing cantaloupe peel and copper nitrate as precursors. Compared to undoped biomass carbon quantum dots (CQDs), the Cu-CQDs demonstrated a stronger electrochemiluminescent (ECL) signal when reacting with K 2 S 2 O 8 . By employing the synthesized Cu-CQDs as a luminescent reagent, we collaborated with the polymer donor PM6 to construct an innovative solid-state ECL sensor for the trace detection of Rhodamine B (RhB). The solid-state ECL sensor was developed using a layer-by-layer modification approach, sequentially modifying the electrode surface with the polymer donor PM6, Cu-CQDs, and chitosan (CS). The layered structure of the polymer donor PM6 serves as a carrier for Cu-CQDs, enhancing their effective concentration on the electrode surface. Additionally, its electron-donating properties facilitate electron transfer within the sensor system. Chitosan (CS), characterized by its viscosity, was modified as the outermost layer, further enhancing the stability and ECL intensity of the sensor. RhB exhibited a significant quenching effect on the ECL signal of the constructed sensor, with the quenching value being proportional to the logarithm of RhB concentration in the range of 5.0 × 10 −8 to 5.0 × 10 −13 M. This sensor was successfully applied to the detection of RhB in chili samples, providing an effective platform for food safety monitoring.
研究领域:
材料科学
·
分析化学
·
食品安全
·
纳米技术
·
电化学
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产品关联
DOI
高影响因子
ONCOLOGY REPORTS
·
2024
·Vol. 52
·期 4
·1-8
·
IF 3.8
Tong Wang,Xu Ye,Hao Jiang,Yu Gao
B‑cell lymphoma is difficult to cure because of its biological and clinical heterogeneity, and due to native chemoresistance. Immunotherapies that overcome cancer‑induced immune evasion have been the center of recent developments in oncology. This is emphasized by the accomplishment of various agents that disrupt programmed cell death protein 1 (PD‑1)‑mediated immune suppression in diverse tumors. However, while PD‑1 blockade has been effective in numerous malignancies, a significant proportion of cancers, including B‑cell lymphoma, show certain rates of primary resistance to these therapeutic strategies. Histone deacetylase inhibitors (HDACis) have exhibited anticancer activity though suppressing cell proliferation, inducing differentiation and triggering apoptosis. The present study aimed to explore a therapeutic strategy combining a HDACi (romidepsin) and PD‑1 blockade (BMS‑1) in B‑cell lymphoma, utilizing a constructed mouse model of B‑cell lymphoma. The IC50 of the two inhibitors was confirmed by MTT assay, and their inhibitory effects were revealed to be dose‑ and time‑dependent. The data demonstrated that the combined treatment of romidepsin and BMS‑1 synergistically inhibited the growth of B‑cell lymphoma. Furthermore, it was revealed that romidepsin and BMS‑1 synergistically triggered apoptosis in mouse B‑cell lymphoma. The synergistic effect of these agents was capable of activating tumor‑infiltrating lymphocytes, particularly CD3+CD4+ and CD3+CD8+ T cells. The results of the present study underscore the potential of HDAC inhibition in conjunction with PD‑1 blockade as a novel therapeutic approach for B‑cell lymphoma, highlighting the synergistic effects of these two mechanisms in enhancing antitumor immunity.
研究领域:
肿瘤学
·
免疫学
·
分子生物学
·
癌症治疗
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DOI
PubMed
高影响因子
Toxins
·
2025
·Vol. 17
·期 9
·438
·
IF 4
Wenjing Xia,Nianqing Zhu,Jie Mei,Yueqin Peng,Fanglin Song,Shuai Ding,Fei Li,Xue Zhou
Mycotoxin contamination in agricultural products poses severe global health risks, with ochratoxins (particularly OTA and OTB) exhibiting marked nephrotoxicity and classified as Group 2B carcinogens by IARC. Conventional physical/chemical detoxification methods often impair food nutritional quality, highlighting the need for enzymatic alternatives. Herein, we systematically investigated the degradation mechanisms of ochratoxin A (OTA) and ochratoxin B (OTB) usingPleurotus ostreatusdye-decolorizing peroxidase (PoDyP4) coupled with redox mediators. Remarkably, hydroxybenzotriazole (HBT) enhanced degradation efficiency 26.7-fold for OTA and 10.6-fold for OTB compared to mediator-free systems, establishing it as the optimal catalytic enhancer. Through LC-MS/MS analysis, we identified five key degradation products, including 6-OH-OTA and OTB-quinone, elucidating a putative oxidative degradation pathway. In vitro cytotoxicological evaluation in HK-2 cells demonstrated thatPoDyP4-treated ochratoxins significantly attenuated cytotoxicity, reducing malondialdehyde (MDA) levels by 48.7% (OTA) and 42.3% (OTB) (p< 0.01) and suppressing ROS generation. Molecular docking revealed strong binding affinities betweenPoDyP4 and ochratoxins, with calculated binding energies of −7.6 kcal/mol (OTA) and −8.6 kcal/mol (OTB), stabilized by hydrogen bond networks (1.9–3.4 Å). These findings positionPoDyP4 as a promising biocatalyst for mycotoxin mitigation in food systems, offering a sustainable alternative to traditional detoxification methods.
研究领域:
食品安全
·
霉菌毒素学
·
酶催化
·
生物修复
·
分子毒理学
·
生物化学
·
真菌酶
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产品关联
DOI
PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Yuanxun Gong,Danlei Tong,Ping Qiu,Rilian Song,Zhidan Li,Yanlin He,Qisheng Luo,Qianli Tang,Kai Zhang,Xianjiu Liao
B-type natriuretic peptide (BNP) is a biomarker for heart failure, a serious and prevalent disease that requires rapid and accurate diagnosis. In this study, we developed a novel electrochemical biosensor for BNP detection based on CRISPR/Cas13a and chain substitution reaction. The biosensor consists of a DNA aptamer that specifically binds to BNP, a T7 RNA polymerase that amplifies the signal, a CRISPR/Cas13a system that cleaves the target RNA, and a two-dimensional DNA nanoprobe that generates an electrochemical signal. The biosensor exhibits high sensitivity, specificity, and stability, with a detection limit of 0.74 aM. The biosensor can also detect BNP in human serum samples with negligible interference, demonstrating its potential for clinical and point-of-care applications. This study presents a novel strategy for integrating CRISPR/Cas13a and chain substitution reaction into biosensor design, offering a versatile and effective platform for biomolecule detection.
研究领域:
生物技术
·
生物化学
·
分子生物学
·
电化学
·
医学诊断
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DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 8
·1292
·
IF 5.1
Chunxiao Li,Xiaolei Zhao,Xiaofei Yin,Shuting Zhang,Jinxing He
2-amino-1-methyl-6-phenyl-imidazo [4,5-b] pyridine (PhIP) is a harmful compound that is formed during the high-temperature processing of meat products, and the risk of cancer may be increased with the prolonged intake of foods containing high levels of PhIP. This study aimed to develop an innovative detection method specifically for PhIP in meat products. Utilizing hydrogel-molecular-imprinting electrochemical sensing technology, the preparation conditions of molecularly imprinted hydrogels (MIHs) were optimized. Consequently, a highly selective and rapid detection method for PhIP was successfully established, integrated with an electrochemical workstation. The results indicate that the prepared MIHs exhibit an excellent specific recognition performance for PhIP. The sensor exhibited a linear response within the concentration range of 1.0–200.0 ng/mL, with a detection limit of 0.07 ng/mL (S/N = 3) under optimized conditions. In addition, the accuracy and reliability of the method were verified by spiked recovery experiments, and the recoveries ranged from 75.9% to 108.8%, which demonstrated its high accuracy and potential for practical application.
研究领域:
食品安全
·
分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Qing Zhu,Nan Lan,Weikang Xu,Yifan Liu,Qiao Wang,Yiting Cao,Hong Deng,Xueming Liu,Yuan Liu
Addressing the formidable challenge of treating significant quantities of organic dyes and heavy metal chromium in tannery wastewater, this study synthesized a novel Z-scheme La-MOF/BiOBr composite heterojunction photocatalyst via the hydrothermal method and established an efficient visible-light photocatalytic system. To comprehensively evaluate the photocatalytic redox activity, rhodamine B (RhB) and heavy metal Cr(VI) were selected as target pollutants. Kinetic analysis revealed that the optimal LM-BB-50 catalyst achieved over 99 % degradation of RhB and Cr(VI) within 15 min illumination, indicating the remarkable enhancement of Z-scheme heterojunction in photocatalytic oxidation and reduction efficiency. Based on various photoelectric analysis techniques, it was elucidated that the superior activity of the Z-scheme heterojunction originated from the modulation of the band structure upon La-MOF and BiOBr integration, significantly improving visible light absorption, electron-hole pair separation efficiency, and endowing the energy band with robust redox capabilities. Free radical capture and quenching experiments confirmed that photogenerated holes and superoxide radicals played a crucial role in RhB oxidation , while photogenerated electrons were the primary active species for Cr(VI) reduction.
研究领域:
环境科学
·
材料科学
·
化学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）