International Journal of Nanomedicine
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2024
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IF 6.6
Yan Yang,Yiling Wang,Xinran Jiang,Jiahao Mi,Dizhang Ge,Yuna Tong,Yuxuan Zhu
Introduction Alzheimer’s disease (AD), a neurodegenerative condition, stands as the most prevalent form of dementia. Its complex pathological mechanisms and the formidable blood-brain barrier (BBB) pose significant challenges to current treatment approaches. Oxidative stress is recognized as a central factor in AD, underscoring the importance of antioxidative strategies in its treatment. In this study, we developed a novel brain-targeted nanoparticle, Ce/Zr-MOF@Cur-Lf, for AD therapy.Methods Layer-by-layer self-assembly technology was used to prepare Ce/Zr-MOF@Cur-Lf. In addition, the effect on the intracellular reactive oxygen species level, the uptake effect by PC12 and bEnd.3 cells and the in vitro BBB permeation effect were investigated. Finally, the mouse AD model was established by intrahippocampal injection of Aβ1-42, and the in vivo biodistribution, AD therapeutic effect and biosafety of the nanoparticles were researched at the animal level.Results As anticipated, Ce/Zr-MOF@Cur-Lf demonstrated efficient BBB penetration and uptake by PC12 cells, leading to attenuation of H2O2-induced oxidative damage. Moreover, intravenous administration of Ce/Zr-MOF@Cur-Lf resulted in rapid brain access and improvement of various pathological features of AD, including neuronal damage, amyloid-β deposition, dysregulated central cholinergic system, oxidative stress, and neuroinflammation.Conclusion Overall, Ce/Zr-MOF@Cur-Lf represents a promising approach for precise brain targeting and multi-target mechanisms in AD therapy, potentially serving as a viable option for future clinical treatment.
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PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Xiurong Zhu,Zhenxin Wang,Wenjing Xie,Wei Yan,Haijiang Lian,Pengkang Jin,Gen Wang
Transition metal oxides have been recently investigated as excellent catalyst for peroxydisulfate (PDS) activation, but suffers from slow redox cycle of metal species. In this work, a novel avenue for facilitating valence cycles of Cu 2+ /Cu + was proposed by overturned doping inert Ce into mesoporous CuO. Increased formation of active sites (Cu-Ce interface) and oxygen vacancy was achieved, resulting in accelerated interfacial electron transfer and facilitated valence cycles of Cu 2+ /Cu + . The Ce-doped mesoporous CuO (CeCuO x ) exhibited greatly enhanced activity toward PDS activation and efficient removal of different bisphenols in a wide pH working range. The degradation of bisphenols followed a nonradical oxidation pathway based on electron transfer process (ETP), and CeCuO x @PDS complex was proved to be the primary reactive species. The CeCuO x /PDS system exhibited good stability and superior catalytic performance in complicated water matrix, and would be a promising catalyst for wastewater purification. This work provides a new prospect for boosting the redox behavior of metal active sites for environmental remediation.
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CHEMICAL ENGINEERING JOURNAL
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2018
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IF 6.735
Chao Shan,You Xu,Ming Hua,Min Gu,Zhichao Yang,Peng Wang,Zhenda Lu,Weiming Zhang,Bingcai Pan
Most heterogeneous catalysts available for catalytic ozonation are present as powders and not ideal for column operation in advanced water treatment. In this study, a mesoporous Ce-Ti-Zr ternary oxide (CTZO) millisphere of large size (0.8–1.0 mm in diameter) and high surface area (180 m 2 g −1 ) was synthesized as a highly stable catalyst to meet the hydrodynamic demand in column ozonation. The fraction of Ce(III) is much higher on the surface of CTZO (49.2%) than CeO 2 (27.5%), resulting in its high catalytic activity in ozone decomposition and mineralization of oxalic acid (OA), an ozone-refractory probe compound. The most favorable catalytic ozonation of OA was observed at pH 3.0 and the adsorption of OA by CTZO via surface complexation is a requisite step for its ozonation. The EPR analysis and radical scavenging experiment confirmed that OH was the dominating reactive species in catalytic ozonation of OA by CTZO. XPS revealed that the oxidation of OA was mediated by the Ce(III)/Ce(IV) redox cycle, which continously accepts the electron supply from OA ligand and meanwhile donates electron to activate O 3 into OH. The catalytic ozonation of OA by CTZO was enhanced in the presence of sulfate due to the generation of sulfate radical. Cyclic runs demonstrated that the CTZO millispheres exhibited high stability for sustainable catalytic ozonation of OA without noticeable release of Ce or change of Ce valence state. This study will provide new insight for the development of efficient ozonation catalysts towards practical application in advanced water treatment.
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CERAMICS INTERNATIONAL
·
2025
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IF 5.6
Fengxin Ye,Xiaojian Guo,Yucheng Chen,Lichun Cheng,Qingrong Yao,Zhao Lu,Huaiying Zhou
In this paper, BaFe 12 O 19 (BFO) and Ce x Ba 1- x Fe 12 O 19 (CBFO- x , x = 0.1, 0.15, 0.2) were successfully synthesized using the sol-gel method. The study comprehensively explored the impact of incorporating elemental Ce on the structure and properties of barium ferrite. The results revealed that the introduction of Ce induced alterations in the microstructure of barium ferrite, enhancing its interfacial polarization and defect polarization. The interaction among ions increased the charge polarization and dipole polarization within the material. Additionally, the influence of Ce doping on the complex dielectric constant of BFO materials was investigated in this paper. The results demonstrate that Ce doping significantly enhances the dielectric performance of the material. The Cole-Cole Circle vividly illustrates the presence of multiple loss mechanisms that contribute to the dissipation of electromagnetic waves. Remarkably, the material exhibited a minimum reflection loss (RL) of −46.56 dB at x = 0.2 with a thickness of only 2.4 mm. Furthermore, at x = 0.15, the effective absorption bandwidth of the sample reached 4.16 GHz, highlighting its versatile applications. In comparison with other modifications of barium ferrite, this material offers a simple preparation process and excellent workability. The exceptional reflection loss and broad effective absorption bandwidth make it applicable across diverse fields.
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JOURNAL OF CATALYSIS
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2024
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IF 6.5
Cheng Liu,Huiling Chen,Qi Chen,Jinhong Bi,Jimmy C. Yu,Ling Wu
A series of Al 3+ -doped UiO-66(Ce) MOFs (U(Ce x Al 1−x )) was developed to reveal the roles of metal doping on active site formation and substrate activation in photocatalytic selective transformation of amines to imines. Al 3+ doping induced crystal structure distortion to form coordinately unsaturated metal (Al, Ce) sites as Lewis acid sites to chemisorb and activate benzylamine (BA). In situ FTIR revealed that the Al site with stronger acid strength facilitated BA activation. The activation degree of N–H bonds in BA was evaluated by changes of calculated force constant. The intermediate products were confirmed through time-dependent in situ FTIR. The Al 3+ -doped sample U(Ce 0.90 Al 0.10 ), the optimal catalyst, showed a significantly increased BA conversion (97.6 %) than that (47.5 %) of undoped sample, which was attributed to enough active sites and the optimal charge mobility. Finally, the present study proposes a synergistic photocatalytic mechanism associated with molecular activation to demonstrate selective oxidation pathways at the molecular level.
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MATERIALS RESEARCH BULLETIN
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2024
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IF 5.3
Yanli Deng,Lutong Li,Long Wang,Na Wu,Huihui Jin,Feng Gao,Zhihui Zeng
W-type ferrites possessing low cost and high chemical stability, show high potential in electromagnetic wave (EMW) absorption field. However, due to the low dielectric loss, developing high EMW absorption performance of W-type ferrites remains desired. Here, rare earth (RE) cerium (Ce)-doped W-type barium ferrites (Ba 1-y Ce y Ni 2 Fe 15.4 O 27 , y=0.1, 0.2, 0.3, 0.4, 0.5, 0.6) are prepared by a sol-gel approach. The influences of Ce doping are detailed analyzed. Ce ions with unpaired 4f electrons and strong spin-orbit coupling of angular momentum enhance the dielectric and magnetic properties of ferrites. Ba 0.7 Ce 0.3 Ni 2 Fe 15.4 O 27 achieves the minimum reflection loss (RL min ) value of -52 dB while Ba 0.6 Ce 0.4 Ni 2 Fe 15.4 O 27 showcases the widest effective absorption bandwidth (EAB) of 1.36 GHz associated with the RL min reaching -38 dB, significantly outperforming the undoped ferrites. This work thus demonstrates a high-efficiency utilization of Ce for enhancing the EMW absorption performance of widely employed W-type barium ferrites, efficiently advancing the application field of RE elements.
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CATALYSIS TODAY
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2024
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IF 5.2
Yanan Jiang,Huayu Sun,Yuzhen Fang,Cuijuan Zhang,Yuan Liu
The sintering issue of Ni nanoparticles seriously limits the practical application of the Ni-based catalysts for CO 2 methanation. This work demonstrates that the La- and Ce- dual-promoted Ni/ZrO 2 shows better durability at 600 ºC and 60000 mL g cat −1 h −1 over 200 h compared with the La- or Ce- single-promoted. The composition and microstructure characterization indicates that the dispersion and sintering resistance of Ni nanoparticles is enhanced with the dual-promoted catalysts. Both depth profile of X-ray photoelectron spectroscopy and density functional theory calculation show that in the La- and Ce- dual-promoted Ni/ZrO 2 , the reduced dissolution of Ce into ZrO 2 lattice and the spread of La on ZrO 2 surface by forming a La 2 O 3 -CeO 2 solid solution improves the dispersion and stability of Ni nanoparticles. This work provides a facile strategy to mitigate the sintering of Ni nanoparticles and thus improve the stability of Ni-based catalysts for CO 2 methanation.
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Journal of Materials Chemistry A
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2024
·Vol. 12
·期 46
·32030-32044
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IF 10.7
Xue Bi,Kunpeng Song,Qianlong Li,Tao Lin,Ye-Tang Pan,Wei Wang,Jiyu He,Rongjie Yang
In recent years, there have been few reports on the application of zeolites in the field of flame retardants, although their excellent thermal stability indicates great potential as flame retardants. However, a key challenge that needs to be solved urgently is the compatibility between molecular sieves as inorganic fillers and polymer matrices, which directly affects their performance and stability in practical applications. In this work, ZSM-5 zeolite was used as the carrier, Ce ions were introduced through ion exchange, and the growth of Ce-MOF was restricted on its surface, and a Ce-MOF@ZSM-5 hybrid material was designed to improve the flame retardant and ultraviolet resistance properties of thermoplastic polyurethane elastomer (TPU). The absorbance value of TPU composites in the whole region is significantly higher than that of pure TPU, and its absorbance reaches 1.33. Compared with pure TPU, the peak heat release rate and peak smoke production rate of TPU/Ce-MOF@ZSM-5 composites were reduced by 26.0% and 34.8%, respectively. In addition, the chemical resistance of TPU composites has been significantly improved. This work provides the possibility of preparing three-proofing TPU materials with UV resistance, chemical resistance and fire resistance, and is expected to expand the application of TPU materials in other fields.
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RSC Advances
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2024
·Vol. 14
·期 48
·35993-36004
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IF 3.9
Jinlong Zhong,Xue feng Mao,Guanyu Wang,Heng Li,Junfang Li,Sijian Qu,Jianwei Zhao
Non-homogeneous ozone-catalyzed oxidation technology is one of the effective ways of treating wastewater, the core of which lies in the development of efficient ozone oxidation catalysts. This work proposes the design and synthesis of an efficient Cu/Mn/Ce multi-metal composite oxide catalyst by metal salt precursor mixing-direct granulation. The effect of metal doping on the catalyst properties was compared using Density function theory (DFT) calculations, and the Cu/Mn/Ce co-doping showed significant charge accumulation effect with a low ozonolysis energy barrier, which is more favorable for the generation of reactive oxygen species. The successful loading of the main active metal components, such as Mn, Cu, and Ce, was clarified by systematic characterization by X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and Brunauer–Emmett–Teller's test (BET), and the chemical oxygen demand (COD) removal could reach more than 60% for the simulated wastewater. The electron paramagnetic resonance (EPR) characterization clarified that the degradation of organic pollutants was mainly dominated by the combination of single-linear oxygen and superoxide radicals in the catalytic process, and the possible catalytic oxidation mechanism was proposed. This work advances the development of non-homogeneous ozone oxidation technology.
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ACS Applied Materials & Interfaces
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2024
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IF 8.3
Liyuan Wang,Lingli Dong,Liyuan Xie,Zhitao Wang,Linpo Li,Enbo Shangguan,Jing Li
Regulating metal nodes to innovate the metal–organic framework (MOF) structure is of great interest to boost the performance of MOFs-incorporated composite solid electrolytes. Herein, Ce4+ with a low-lying 4f orbital is selected as metal center to coordinate with organic ligand to prepare MOF of Ce-UiO-66. The unsaturated open metal sites and defected oxygen vacancies furnish Ce-UiO-66 with strengthened Lewis acidity, which promotes Ce-UiO-66 interacting effectively with both poly(ethylene oxide) (PEO) and Li salt anions. Accordingly, Ce-UiO-66 as additive fillers can be uniformly dispersed in PEO matrix to form an advanced composite solid-state electrolyte (Ce-UiO@PEO) with accelerated Li+ transport. The optimized Ce-UiO@PEO displays a boosted ionic conductivity of 4.20 × 10–4 S cm–1 and an improved Li+ transference number of 0.39 at 60 °C, which are highly comparable to those of other MOFs@PEO electrolytes. Combined with the mechanical and thermal stabilities, such a Ce-UiO@PEO electrolyte enables Li/Li symmetric and Li/LiFePO4 full cells with superior cycling stability and rate performance. The Ce-UiO@PEO electrolytes are of great potential to be applied in high-performance lithium metal batteries.
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CERAMICS INTERNATIONAL
·
2021
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IF 4.527
Yong Zhang,Yutao Zhang,Caihong Wu,Yiting Yang,Qiang Li,Yongnan Chen
To improve the high-temperature oxidation resistance and electrical conductivity of ferritic stainless steels , protective Ce-doped NiMn 2 O 4 spinel coatings were fabricated on the surface of SUS430 steel by electrophoretic deposition (EPD). The phase structure and microstructure of Ce-doped NiMn 2 O 4 in both powder and coating forms were characterized using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The high-temperature oxidation of the NiMn 2 O 4 spinel coating before and after Ce doping in the air at 800 °C for 168 h was studied by weight gain experiments. The area-specific resistance (ASR) of coatings was measured by a standard four-probe method. It was found that the Ce-doped NiMn 2 O 4 spinel powder displayed a stable structure, high crystallinity, fine grain size, and decreased agglomeration when the Ce content was fixed at 0.05 mol∙L −1 . The oxidation kinetics of NiMn 2 O 4 -coated SUS430 steel before and after Ce doping obeyed a parabolic law with parabolic rate constants of 4.58 × 10 −15 g 2 cm −4 s −1 and 1.83 × 10 −15 g 2 cm −4 s −1 , respectively. When oxidized at 800 °C for 50 h, the ASR value of the coated samples before and after Ce doping stabilized at about 15.2 mΩ∙cm 2 and 14.5 mΩ∙cm 2 , respectively. This work demonstrated that the Ce-doped NiMn 2 O 4 spinel coating improved the high-temperature oxidation resistance and the electrical conductivity of metal interconnects.
研究领域:
材料科学
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表面工程
·
高温材料
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高影响因子
CATALYSIS LETTERS
·
2021
·Vol. 152
·期 8
·2270-2279
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IF 3.186
Bie Xuan,Jiao Kunling,Gong Chunqin,Qu Baozhong,Liu Daokuan,Ma Shuangchen
To develop highly efficient NH 3 -SCR catalysts with a wide temperature range, catalysts based on MnAlO x and Cerium elements loading with various mixing ratios were prepared for selective catalytic reduction of NO by NH 3 . The special role of cerium was demonstrated by the surface structure characteristics and unique catalytic performance, involving the surface-active sites and compositions analysis. Interestingly, the strengthening of Mn 1.2 Al 0.8 Ce a O x on both acid sites, especially medium acids and strong acids, were clearly manifested. Meanwhile, the strong interaction between MnAlOx and CeO 2 enabled favorable electron transfers from MnOx to CeO 2 while generating more oxygen vacancies and active oxygen species, consequently accelerating the redox cycle. The results illustrate that the NOx conversion and the selectivity of N 2 can be improved with more medium acids tuned by appropriate Ce adding. However, an opposite effect will appear by excessive addition. In addition, the reaction mechanisms at different acid sites are revealed. Our findings, therefore, provide a strategy for the rational design of moderate-temperature NH 3 -SCR catalysts through adding-induced component engineering of composite materials. Graphic Abstract Mn 1.2 Al 0.8 Ce a O x Catalysts with different surface features were fabricated by an environment-friendly method. The strong interaction between MnAlOx and CeO 2 was systematically illustrated. Meanwhile, the importance of medium acids was convincingly revealed. And the reaction mechanisms at different acid sites were demonstrated. These provide a strategy for the rational design of moderate-temperature NH 3 -SCR catalysts through adding-induced component engineering of composite materials.
研究领域:
催化化学
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环境科学
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材料科学
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