INFLAMMATION
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2022
·Vol. 45
·期 3
·1362-1373
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IF 4.657
Ji Xiang-Fen,Fan Yu-Chen,Sun Fei,Wang Jing-Wei,Wang Kai
Acute liver failure (ALF) is a deadly clinical disorder with few effective treatments and unclear pathogenesis. In our previous study, we demonstrated that aberrant Wnt5a expression was involved in acute-on-chronic liver failure. However, the role of Wnt5a in ALF is unknown. We investigated the expression of Wnt5a and its downstream c-Jun N-terminal kinase (JNK) signaling in a mouse model of ALF established by coinjection of D-galactosamine (D-Gal) and lipopolysaccharide (LPS) in C57BL/6 mice. We also investigated the role of Box5, a Wnt5a antagonist, in vivo. Moreover, the effect of Wnt5a/JNK signaling on downstream inflammatory cytokine expression, phagocytosis, and migration in THP-1 macrophages was studied in vitro. Aberrant Wnt5a expression and JNK activation were detected in D-Gal/LPS-induced ALF mice. Box5 pretreatment reversed JNK activation and eventually decreased the mortality rate of D-Gal/LPS-treated mice, with reduced hepatic necrosis and apoptosis, serum ALT and AST levels, and liver inflammatory cytokine expression, although the latter was not significant. We further demonstrated that recombinant Wnt5a (rWnt5a)-induced tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) mRNA expression and increased THP-1 macrophage phagocytosis in a JNK-dependent manner, which could be restored by Box5. In addition, rWnt5a-induced migration of THP-1 macrophages was also reversed by Box5. Our findings suggested that Wnt5a/JNK signaling plays an important role in the development of ALF and that Box5 could have particular hepatoprotective effects in ALF.
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高影响因子
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
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2022
·Vol. 46
·期 11
·15722-15732
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IF 4.672
Yu Bai,Wenjuan Qiu,Shuangfeng Wang
Summary At present, there are few kinds of phase change materials that suitable for medium temperature heat storage. Among them, sugar alcohols have broad application prospects in the heat storage at medium temperature due to their suitable phase transition temperature. In this work, eutectic phase change material (PCM) was prepared with D-mannitol as PCM and KBr as melting point modifier. Expanded graphite (EG) was used as thermally conductive support network to prepare shape-stable composite phase change material (CPCM). The prepared CPCM—10% EG/PCM has an appropriate phase transition temperature (136.88°C), high phase melting enthalpy (215.7 J/g), and good photothermal conversion (81.9%). The thermal conductivity of 10% EG/PCM reached 6.01 W/(m K), which is approximately 10 times higher than D-mannitol (0.603 W/(m K)). Because of its excellent thermal properties, the applications of CPCM in energy storage and photothermal conversion can be further broadened.
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ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Xiaohui Niu,Simeng Yan,Jinliang Chen,Hongxia Li,Kunjie Wang
Chiral metal-organic frameworks (MOF) have received extensive attention from researchers due to their chiral properties and potential applications in chiral-related fields. However, the construction of chiral metal-organic framework remains challenging due to the unpredictability of the synthesis process and the difficulty in keeping chirality during the growth of chiral MOF. Herein, a chiral MOF (D-His-ZIF-8) is reported for the construction of electrochemical sensing interface, which was synthesized via in-situ substitution of 2-methylimidazole on ZIF-8 by D-histidine (D-His). The introduction of Ketjen Black (KB) to the D-His-ZIF-8 sensing interface can improve its conductivity. The electrochemical recognition results show that KB/D-His-ZIF-8 has enantiodiscrimination ability for amino acids in voltammetry experiments. The best recognition efficiency is observed with Trp enantiomers . The recognition mechanism shows that the chiral nanochannel of D-His-ZIF-8 is conducive to the binding of L-amino acid, which will lead to the recognition of chiral molecules of different configurations. This research points to the possibility of developing further chiral recognition protocols based on D-His-ZIF-8, particularly with the suggested improvement in the preparation procedure of chiral MOF.
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JOURNAL OF MOLECULAR LIQUIDS
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2021
·
IF 6.165
Ting Huang,Huang-xian Zhang,Xiao-hua Zhang,Da-yong Peng,Xu-liang Nie,Jing Chen,Wan-ming Xiong
A kind of functionalized diallylimidazole ionic liquids (CnDAIMF) was synthesized and applied in the dehydration of D-fructose to produce 5-HMF under the microwave radiation. The results showed that X-ray, 1 H NMR and FT-IR confirmed the production. The target ILs existed in a highly centrally symmetric, and crystalline state at room temperature, with a good thermal stability up to 300 °C (HTD ≥ 340 °C). In the experiments of conversion D-fructose to 5-HMF, 5-HMF could be obtained via the catalysis of diallylimidazole IL whether in water or DMSO. The catalytic performance of these ILs was not much different from that of solid acid (like camphor sulfonic acid or solid carbon sulfonic acid), and which was higher than that of the monoimidazole hexafluorophosphate or imidazole class bromine salt, but there were no obvious changes can be found with the variation of carbon chain length between imidazole rings in diallylimidazole IL. The effects of temperature and solvent on the reaction were more significant. The optimized yield of 5-HMF was 52.59% at 185 °C in a water-C 2 DAIMF solvent (t = 10 min), while 73.71% at 195 °C in DMSO-C 2 DAIMF solvent. Furthermore, six CnDAIMF have a considerable effect on the conversion in water and 5-HMF yield of about 50% could be obtained, which is satisfactory compared with other similar processes, especially in the microwave system of aqueous solution. Therefore, this process may be benefit for many researches and applications related to functionalized ionic liquid research and biomass conversion applications.
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ELECTROCHIMICA ACTA
·
2020
·
IF 6.215
You Zhou,Zhengyong Huang,Jian Li,Huijun Liao,Hanxiang Wang,Yu Wang,Guanglei Wu
A compound electrode of carbonaceous materials and NiCo 2 O 4 is extensively studied because of higher capacitance and better rate capability compared to those of pure NiCo 2 O 4 . However, the tedious preparation process, harsh synthesis condition, high consumption, and especially limited electrochemical property by using modifiers hinder its practical application. Herein, modifier-free electrodes (C/NiCo 2 O 4 ) with various morphologies based on D-ribose are successfully synthesized via a one-step hydrothermal-calcination method. D-ribose concurrently acts as carbon source and structure-directing agent. The structure of NiCo 2 O 4 changes from the nanosheets into nanowires after adding D-ribose. Each element is evenly distributed throughout C/NiCo 2 O 4 , significantly improving the electrical conductivity. Furthermore, there is a strong interaction between carbon and NiCo 2 O 4 , which keeps the structure stable. Benefiting from the structural characteristics, the C/NiCo 2 O 4 composites display the improved electrochemical performance. Remarkably, the maximum specific capacitance of C/NiCo 2 O 4 -2 is 1583.9 F g −1 at 2 A g −1 in 3 M KOH aqueous solution, and it exhibits remarkable rate capability of 1354.8 F g −1 even at 20 A g −1 . After 20,000 charge-discharge cycles at 20 A g −1 , a high capacity retention of 90.6% can be achieved. The C/NiCo 2 O 4 -2 is a promising electrode material for supercapacitor. In addition, a dynamic growth mechanism of C/NiCo 2 O 4 under the coordinate bond of metal ions with D-ribose is discussed in the paper.
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Advanced Materials Technologies
·
2020
·Vol. 5
·期 7
·2000138
·
IF 5.969
Junjie Hao,Yiwen Li,Xiaoqian Xu,Fenghuan Zhao,Ruikun Pan,Junzi Li,Haochen Liu,Kai Wang,Jiagen Li,Xi Zhu,Marie-Hélène Delville,Ming Zhang,Tingchao He,Jiaji Cheng
Chiral transition metal oxides nanoparticles (NPs) with tunable optical properties are widely accepted as promising toolbox for chiral recognition, stereoselective synthesis, and chiroptical devices. Herein, chirality-based strategy is presented for discrimination of d -glucose from its enantiomer through a cooperative synergy between chiral cysteine capped MoO 2 NPs and the glucose oxidase nanosystem. The valence-state-dependent chirality induced by metal-ligand charge transfer effect is found to be ultrasensitive to its redox environment such as the presence of hydrogen peroxide, which is a key indicator of the stereoselective enzymatic reaction between glucose oxidase and d -glucose. With this know-how, glucose enantiomers can be precisely quantified with a limit of detection of 0.446 µ m . Such a chiral bio-nanosystem would be an ideal platform for a rational design of new types of biosensors, photocatalysts, and chirality-based nanodevices.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Dongwei Miao,Dongkui Liu,Yanbo Zeng,Guobao Zhou,Wei Xie,Yiwen Yang,Hailong Wang,Jian Zhang,Yunyun Zhai,Zulei Zhang,Lei Li
A novel fluorescent biosensor based on dabcyl [(E)-4-((4-(dimethylamino) phenyl) diazenyl)benzoic acid] -modified anti-Mb aptamer (D-AMA) and 6-FAM(6-carboxyfluorescein) -modified complementary short chain (F-CSC)for the specific and sensitive detection of Mb levels is presented in this study. In PBS buffer solution, D-AMA bound to F-CSC, and then dabcyl quenched the fluorescence of 6-FAM. After adding Mb into the system, D-AMA bound to Mb and separated from F-CSC. The fluorescence of 6-FAM was restored after it separated from dabcyl. The assay exhibited high specificity and sensitivity toward Mb, with a low limit of detection of 0.07 ng/mL (S/N = 3) and linear relationships of 0.1–5 ng/mL. It was further applied to detect Mb levels in spiked human blood sera samples.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Qi Wang,Lingfang Li,Tingxuan Wu,Xiangpeng Kong,Qingguo Ma,Chunlei Ma
Taking consideration of metal-induced fluorescence quenching and excellent coordination effect of D-penicillamine (D-PA), a graphene quantum dots (GQDs)-based fluorescent switch for D-PA detection was designed and established firstly with the help of lead ions . GQDs obtained from citric acids made them rich in carboxyl and hydroxyl groups , giving GQDs the ability to combine with lead ions. As anticipated, the fluorescence intensity was quenched by Pb 2+ through electron transfer process. Further, the addition of D-PA effectively recovered the fluorescence due to the departure of Pb 2+ from GQDs aroused by the strong coordination between D-PA and Pb 2+ . Thus, a fluorescent switch was activated for D-PA detection. The fluorescence recovery efficiencies were found to be proportional to the concentration of D-PA in the range of 0.6–50 μmol L − 1 and the detection limit was 0.47 μmol L − 1 . The real sample detection was performed in human urea sample and satisfactory recoveries of 96.84%–102.13% were obtained. The GQDs-Pb 2+ based fluorescent switch sensing method was firstly established with low detection limit and wide linear range, making it a supplement and improvement for D-PA detection.
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International Journal of Nanomedicine
·
2023
·
IF 8
Xinyu Fan,Jiachen Shi,Ye Liu,Mengqiu Zhang,Min Lu,Ding Qu
Background Berberine (BR) shows promise as a candidate for treating irritable bowel syndrome with diarrhea (IBS-D). However, the undesired physicochemical properties and poor oral absorption limit its clinical translation. A ketogenic diet (KD) can induce intestinal overexpression of cannabidiol (CB) receptors, which may offer a potential target for IBS-D-specific delivery of BR.Methods The microemulsions loaded with BR and decorated with cannabidiol (CBD/BR-MEs) were developed through a one-step emulsion method. The pharmaceutical behaviors of the CBD/BR-MEs were measured using dynamic light scattering and high-performance liquid chromatography. The efficacy of the anti-IBS-D therapy was evaluated by assessing fecal water content, Bristol score, and AWR score. The intestinal permeability were assessed through immunofluorescent staining of CB1 and ZO-1, respectively. The signaling of CREB/BDNF/c-Fos was also studied along with immunofluorescent and immunohistochemical examination of brain sections.Results The CBD/BR-MEs, which had a particle size of approximately 30 nm and a surface density of 2% (wt%) CBD, achieved greater than 80% (wt%) encapsulation efficiency of BR. The pharmacokinetics performance of CBD/BR-MEs was significantly improved in the KD-fed IBS-D rats than the standard diet-fed ones, which is highly related to intestinal expression of CB1 receptors. The treatment with CBD/BR-MEs and KD exhibited evident comprehensive advantages over the other groups in terms of anti-IBS-D efficacy. CBD/BR-MEs and KD synergistically decreased intestinal permeability. Moreover, the treatment with CBD/BR-MEs and KD not only blocked the CREB/BDNF/c-Fos signaling in the brain but also decreased the levels of neurotrophic factors, neurotransmitters, and inflammatory cytokines in the serum of IBS-D model rats.Conclusion Such a design represents the first attempt at IBS-D-targeted drug delivery for improved oral absorption and efficacy through KD-induced target exposure, which holds promising potential for the treatment of IBS-D.
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JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Ruijun Zhang,Wenqian Zhu,Jiayu Tian,Shanshan Gao,Bart Van der Bruggen
Reverse osmosis is an effective seawater desalination way extending the available sources of fresh water, but challenged by the gypsum scaling. Herein, D (+)-glucosamine (DGA) was rationally selected and utilized to prepare a novel polyesteramide (PEA) NF membrane that can reject SO 4 2− but release Ca 2+ . Then it was employed in the pretreatment of seawater reverse osmosis to spatially isolate SO 4 2− and Ca 2+ , thus removing the “foundation” for forming gypsum. Compared to the referenced NF270, the optimized sample denoted as DGA-PEA-NF has a looser structure with stronger negative charge, as well as a higher resistance to both organic fouling and chlorine attack. During the pretreatment of seawater, both the water permeability and SO4 2− /Ca 2+ selectivity of the DGA-PEA-NF membrane were much higher than those of NF270; the seawater permeance and SO 4 2− /Ca 2+ selectivity of DGA-PEA-NF were 10.25 L m −2 ·h −1 ·bar −1 and 7.62, respectively, while those of NF270 were only 5.11 L m −2 ·h −1 ·bar −1 and 2.08. Consequently, the DGA-PEA-NF membrane effectively reduced the gypsum scaling both in NF and RO stages rather than just transferring the fouling problem forwards to NF stage. The implementation of this research is expected to provide guidance for a targeted fabrication of NF membranes, as well as support for the sustainable development of seawater desalination.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Tengfei Xiang,Yanli Zhang,Linjing Cui,Jiaqi Wang,Depeng Chen,Shunli Zheng,Yujie Qiang
Herein, the synergistic inhibition of two typical corrosion inhibitors benzotriazole (BTA) and sodium D -gluconate (SD) on the corrosion of Q235 steel in simulated concrete pore solution (SCP) were systematically studied. The results demonstrated that the mixed BTA/SD showed an excellent anti-corrosion performance and the inhibition efficiency of (BTA/SD, 1ː1) was as large as 98.33 % which is higher than that of BTA (88.65 %) and SD (92.16 %). Furthermore, the synergistic inhibition effect of BTA/SD was also researched by surface analysis technologies, the X-ray photoelectron spectroscopy (XPS) result verified that the BTA/SD adsorbed on steel, while both scanning electron microscopy (SEM) and atomic force microscopy (AFM) images proved that the mixed BTA/SD can effectively protect the steel from corrosion in SCP solution which containing corrosive ions. In addition, the anti-corrosion mechanism of the mixed BTA and SD was revealed by adsorption model and molecular dynamics (MD) simulation, the mixed BTA/SD corrosion inhibitors showed the largest K ads , the lowest ∆ G ads and the largest binding energy values , demonstrating the strong adsorption on steel and the best anti-corrosion performance. The results of this work can provide experimental and theoretical references for the corrosion protection of reinforced concrete structures while using synergistic inhibitors.
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JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Xiaoyan Guo,Shougang Fan,Yandi Hu,Xiaolin Fu,Huaiqi Shao,Qixing Zhou
D-amino acid (DAA) an environmentally friendly biofilm inhibitor, has low efficiency for membrane biofouling control due to its instability. To address this challenge, a novel nanocomposite was prepared with DAA adhering to polydopamine (PDA)-coated halloysite nanotube (HNTs) through the interactions of H-bonding and π-π stacking between PDA and DAA. Membrane modified with such nanocomposite was fabricated via blending phase inversion, and the nanocomposite was uniformly distributed in the modified membrane matrix. In comparison with the pristine membrane, the addition of nanocomposites resulted in robust mechanical property for modified membrane with the ultimate stress and strain increased by 23.97% and 35.62%, respectively. Moreover, an excellent tradeoff between water flux (2.5 folds of pristine membrane) and selectivity was achieved, probably due to the improved membrane hydrophilicity. Meanwhile, bovine serum protein (BSA) static adsorption as well as dynamic filtration experiments exhibited excellent antifouling ability of the modified membrane. Most importantly, a superior anti-biofouling stability over a 10-day period was obtained for the membrane modified with nanocomposite, indicating that the activity of DAA to mitigate biofouling was effectively maintained. This study developed a novel and promising strategy for membrane biofouling mitigation.
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