ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Zhihao Sun,Yuxuan Du,Jinfeng Wang,Ran Yin,Gong Zhang,Jixian Wu,Tianyang Lu,Yusen Chen,Zhan Qu,Hongqiang Ren
The rapid fabrication of artificial intelligence-based hardware worldwide is intensifying the electronic waste (e-waste) crisis, threatening ecosystems and demanding urgent, sustainable solutions for metal recovery. Herein, a glucose-mediated hydrothermal strategy is reported for the efficient reclamation of high-value metals from complex e-waste. Glucose functions as a multifunctional ligand, establishing a specific pathway for metal–organic coordination, enabling selective metal recovery. By precisely regulating reaction kinetics and thermodynamic parameters, the proposed metal–ligand hydrothermal strategy exhibited exceptional recovery of 99.16% for iron (Fe) and 98.67% for silver (Ag), while concurrently converting toxic metals such as lead (Pb) and nickel (Ni) into value-added byproducts without any energy-intensive purification steps. Notably, the process was operated within a closed-loop system. All residual solutions were recycled, eliminating secondary wastewater discharge and enabling the use of the entire components present in the resource. Density functional theory calculations and radial distribution function analysis further revealed the molecular basis of selectivity: Fe(III) preferentially formed bidentate chelates with the aldehyde and hydroxyl groups of glucose, a process complemented by electrostatic interactions that promote rapid nucleation and precipitation. In contrast, other metal ions, Ag(I) and Pb(II), are coordinated primarily via single oxygen sites. Technoeconomic analysis confirmed the economic viability of the process, demonstrating a net profit of $2460 per ton of processed e-waste. This study provides a sustainable and economically compelling waste-to-resource platform guided by molecular-level insights into selective coordination chemistry for advanced e-waste recycling.
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高影响因子
Collagen and Leather
·
2026
·Vol. 8
·期 1
·8
·
IF 10.1
Pu Haoliang,Xiao Hanzhong,Wang Yujia,Huang Xin,Shi Bi
The next-generation on-skin devices are expected to provide identical textural characteristics to skin for accomplishing comfortable long-term wearability. Cattle hide is mainly consisted of type I collagen, which is therefore an ideal collagenous-matrix platform for developing skin-like on-skin devices. However, the raw cattle hide has a high water content that leads to poor wearability. Herein, we developed the skin-like wearable (SW) platform via a brand-new inter-fiber spacer-aided (IFS-aided) drying of cattle hide, where an amphiphilic nonionic surfactant that was capable of thoroughly infiltrating into the 3D hierarchical network of collagen fibers (CFs) was employed to work as the inter-fiber spacer to avoid the sticking of CFs during drying. Moreover, the inter-fiber spacer was easily eluted after drying for obtaining the collagenous matrix with highly dispersed fiber structure. The as-developed SW-platform exhibited ideal wearability by exhibiting full-protein nature, outstanding softness (6.808 mm), exceptional water-vapor permeability (5950 g·m -2 ·d -1 ) and high thermal stability. The hierarchical fiber structure with sufficient inter-fiber space endowed the SW-platform with reversible cross-scale deformations of CFs at both the nanoscale and microscale, which demonstrated its promising application in developing the skin-like and eco-friendly e-skins with outstanding sensing capability and flexible display function. Graphical
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Yazhou Qin,Xuqing Wang,Mengze Fu,Jikai Mao,Yingsheng He,Jiye Wang
The incorporation of illegal drugs into e-cigarettes poses significant threats to both human health and societal safety. Therefore, the development of accurate and rapid detection methods for illicit drug additives in e-cigarettes is of significant importance. This study integrates deep learning with surface-enhanced Raman spectroscopy (SERS) to develop a highly sensitive detection method for nicotine and four etomidate isomers. First, Raman and SERS detection were performed on five drug standards. Furthermore, density functional theory calculations were employed to analyze the characteristic peak vibration modes of the various substances. Additionally, a liquid-liquid extraction pretreatment method for commercially available e-cigarettes was developed, facilitating the simultaneous detection of nicotine and etomidate isomers. Trace detection was successfully achieved for all five substances. Subsequently, an interpretable deep network model was constructed for the classification and identification of these substances, attaining an accuracy of 97.8%. To further enhance the model's transparency and interpretability, gradient-weighted class activation mapping (Grad-CAM) was utilized to reveal the critical SERS peaks necessary for molecular discrimination. This research provides robust technical support for the rapid on-site screening of illicit drugs in e-cigarettes.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Chenchen Shen,Weiwei Chen,Lin Guo,Yanrui Zou,Shuan Han,Ning Yu,Lin Gan,Jin Huang
Long-range piezoelectric transduction in flexible hydrogels is limited by the “trade-off” of conductive pathways between accelerating charge dissipation and suppressing dipole formation. Here, we introduce a surface-heterojunction strategy converting cellulose nanocrystals (CNCs) into conductive dipolar nanorods by deprotonation of poly(aminophenylboronic acid) (PABA) coating. Boronated ester bonding and hydrogen-bonds at CNCs/PABA interface collectively strengthen dipole moments while inducing n-type doping in PABA and thus enabling charge transport for 18.9-fold conductivity. Integrating molecular-level interfacial alignment of conjugated moieties, CNCs with higher aspect-ratio further promote percolation and reduce threshold by ~14%. The charge transport range in hydrogel is then elongated, which improves its conductivity by 7.0 times and yields robust piezo-electric/resistive dual-mode responsiveness. The hydrogen-bond network also improves adhesion, and imparts intrinsic sensitivity to temperature, salinity, and pH, for distinguishing complex motions and physiological events. This heterojunction-driven co-engineering of dipoles and conductivity offers a generalizable materials concept for advancing high-fidelity soft bioelectronic sensing.
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高影响因子
Biomolecules
·
2025
·Vol. 15
·期 6
·822
·
IF 4.8
Xiabin Chen,Yishuang Li,Jianzhuang Yao,Xiaoxuan Li,Hualing Li,Zelin Wu,Qi Hu,Nuo Xu,Tingjun Hou,Jiye Wang,Shurong Hou
6-monoacetylmorphine (6-MAM), a primary active metabolite of heroin that reaches the human brain, plays a crucial role in producing heroin-associated physiological and lethal effects. Therefore, 6-MAM has emerged as a key target for alleviating the adverse consequences of heroin abuse. In this study, the proposed 6-MAM hydrolaseE. coliaminopeptidase N (eAPN) was recombinantly produced, and its biochemical and functional profiles were investigated. eAPN’s biochemical properties, with respect to pH, metal ions, and temperature, and catalytic functions toward peptidase substrates and 6-MAM were thoroughly examined. Extensive experiments reveal that incorporation of an N-terminal His-tag notably affects eAPN’s aminopeptidase activity. This cost-effective recombinant eAPN exhibits favorable thermostability and optimal activity at pH 7.5. Kinetic analysis toward peptidase substrates reveals that eAPN preferentially cleaves peptides following amino acid residues in the order of Ala > Arg >> Met, Gly > Leu > Pro, indicating a preference for small or basic amino acid residues as substrates. Computational and experimental studies have, for the first time, discovered that eAPN is capable of catalyzing the hydrolysis of heroin and 6-MAM, which has shed light on its functional versatility and potential applications. This work elucidates the biochemical properties of eAPN and expands its catalytic functions, thereby laying the groundwork for a deep understanding and further reengineering of eAPN to enhance its activity toward 6-MAM for heroin detoxification.
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DOI
PubMed
高影响因子
APPLIED BIOCHEMISTRY AND MICROBIOLOGY
·
2025
·
IF 1.1
Wu S. J.,Chen F.,Ma X. J.,Sun S. Y.,Yan H. D.,Li T. T.,Qiu L. Q.
( R )-citronellal is a key intermediate in the synthesis of L-menthol, one of the world’s three most important spices. It can be obtained by asymmetric reduction of ( E / Z )-citral using old yellow enzymes (OYEs), but catalysis by the wild-type enzyme suffers from poor enantioselectivity as well as low efficient conversion. A protein-directed evolution technique was used to enhance the activity and enantioselectivity of Ct OYE from Chroococcidiopsis thermalis . Upon the sequence alignment and molecular docking results, two amino acid residues at positions 103 and 351 were selected as saturation mutation sites. Finally, three single substitution variants of Ct OYE-W103E, Ct OYE-W103M, Ct OYE-W103P with improved enantioselectivity ( ee > 99%) and moderate conversion (>71%), and one double substitution variant Ct OYE-Y351Q/W103E with high enantioselectivity ( ee > 99%) and high conversion (83.2%) for reduction of ( E / Z )-citral were obtained.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xiaohai Zhang,Yijie Wang,Lei Zhang,Xinru Zhang,Yajie Guo,Bao Hao,Yongqiang Qin,Qiang Li,Lei Fan,Helei Dong,Qiulin Tan
Flexible pressure sensors with porous structures have a wide range of applications in many fields, including in flexible electronic skin, medical diagnosis, and human–computer interaction. As such, the fabrication of pressure-sensitive layers with porous structures capable of superior performance has become a significant research hotspot. Herein, we report a mechanically-sensitively enhanced structure of surface patchy protrusions and porous composites which can be used to accurately monitor limb movement, pulse, and breathing. Notably, the flexible pressure sensor exhibits high sensitivity (21.457 kPa −1 ), wide detection range (0.11–11.022 kPa), rapid response/recovery time (41.84 ms/20.82 ms), and excellent stability and cycle repeatability (up to 6000 cycles). Further, the pressure sensor array can act as an electronic skin to detect the pressure distribution. We further propose a newly developed miniaturized flexible wireless feedback system equipped with five pressure sensors. Using the detected pressure as input, the accurate recognition of nine gestures (98.22 %) was achieved with the help of a convolutional neural network (CNN) model.
研究领域:
材料科学
·
生物医学工程
·
电子工程
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Conglian Yang,Yuting Qin,Kun Tu,Chenfeng Xu,Zhen Li,Zhiping Zhang
Multidrug resistance (MDR) remains as an obstacle for effective cancer treatment. Herein, we developed a novel and efficient nanomedicine by virtue of the carrier characters and MDR inhibition effects of β-cyclodextrin (β-CD) and d-α-tocopheryl polyethylene glycol succinate (TPGS). A series of star-shaped polymers CD-g-TPGS with different TPGS substitution degree were synthesized for doxorubicin (DOX) delivery, where β-CD was identified as a core and TPGS as branches. These star polymers can self-assemble into nanoparticles with DOX . These nanoparticles showed no significant differences in size, zeta potential and morphology except for in vitro stability. They demonstrated good biocompatibility and enhanced cellular uptake in both drug sensitive and resistant cancer cells. Notably, the nanoparticles exhibited superiority of cytotoxicity in drug resistant cancer cells against free DOX . In vivo antitumor effect also demonstrated the improved cancer inhibition effect. This work suggests that star-shaped polymers CD-g-TPGS are promising drug carriers to overcome MDR in cancer treatment.
研究领域:
药学
·
纳米技术
·
癌症研究
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高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2022
·
IF 4.291
Fan Jin,Dawu Lv,Wenfeng Shen,Weijie Song,Ruiqin Tan
Intelligent flexible strain sensors based on fabric have caused tremendous attention in the application of wearable devices because of their lightweight and excellent air permeability . It is still a great challenge to achieve excellent stability, high sensitivity, and wide working range. In this work, a high-performance strain sensor with reduced graphene oxide (rGO) reinforced polyaniline (PANI) based on polydopamine (PDA) modified Lycra cotton (LC) electronic textile (e-textile) was fabricated. The strain sensor of PANI/rGO/PDA/LC exhibits high sensitivity with a gauge factor (GF) of 24, a wide strain range of 0.2–50%, and excellent mechanical durability and stability for 1500 stretching/releasing cycles test. Such e-textile is promising to be integrated with other wearable devices to track human motion signals in real-time for human-machine and medical monitoring.
研究领域:
材料科学
·
生物医学工程
·
可穿戴设备
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Lupeng Cui,Yumeng Qiu,Yu Liang,Chunjie Du,Weiliang Dong,Cheng Cheng,Bingfang He
The PET hydrolase from Ideonella sakaiensis ( Is PETase) is efficient for PET degradation, which provides a promising solution for environmental contamination by plastics. This study focuses on improving the excretion of Is PETase from E. coli by signal peptide (SP) engineering. A SP enhancer B1 (MERACVAV) was fused to the N-terminal of commonly-used SP (PelB, MalE, LamB, and OmpA) to mediate excretion of Is PETase. Strikingly, the modified SP B1OmpA, B1PelB, and B1MalE significantly increased the excretion of Is PETase, while Is PETase was basically expressed in periplasmic space without enhancer B1. The excretion efficiency of Is PETase mediated by B1PelB was improved by 62 folds compared to that of PelB. The hydrolysis of PET by crude Is PETase in culture solution was also enhanced. Furthermore, the amount of released MHET/TPA from PET by Is PETase was increased by 2.7 folds with pre-incubation of hydrophobin HFBII. Taken together, this work may provide a feasible strategy for the excretion and application of the Is PETase.
研究领域:
生物工程
·
环境科学
·
分子生物学
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Theranostics
·
2017
·
IF 8.766
Jing-Bo Hu,Xu-Qi Kang,Jing Liang,Xiao-Juan Wang,Xiao-Ling Xu,Ping Yang,Xiao-Ying Ying,Sai-Ping Jiang,Yong-Zhong Du
The effective treatment for acute kidney injury (AKI) is currently limited, and care is primarily supportive. Sialic acid (SA) is main component of Sialyl Lewis x antigen on the mammalian cell surface, which participates in E-selectin binding. Therefore, dexamethasone(DXM)-loaded E-selectin-targeting sialic acid-polyethylene glycol-dexamethasone (SA-PEG-DXM/DXM) conjugate micelles are designed for ameliorating AKI. The conjugates are synthesized via the esterification reaction between PEG and SA or DXM, and can spontaneously form micelles in an aqueous solution with a 65.6 µg/mL critical micelle concentration. Free DXM is incorporated into the micelles with 6.28 ± 0.21% drug loading content. In vitro DXM release from SA-PEG-DXM/DXM micelles can be prolonged to 48h. Much more SA-PEG-DXM micelles can be internalized by lipopolysaccharide (LPS)-activated human umbilical vein endothelial cells (HUVECs) in comparison to PEG-DXM micelles due to specific interaction between SA and E-selectin expressed on HUVECs, and consequently more SA-PEG-DXM micelles are accumulated in the kidney of AKI murine model. Furthermore, SA in SA-PEG-DXM conjugates can significantly ameliorate LPS-induced production of pro-inflammatory cytokines via suppressing LPS-activated Beclin-1/Atg5-Atg12-mediated autophagy to attenuate toxicity. Compared with free DXM and PEG-DXM/DXM micelles, SA-PEG-DXM/DXM micelles show better therapeutical effects, as reflected by the improved renal function, histopathological changes, pro-inflammatory cytokines, oxidative stress and expression of apoptotic related proteins.
研究领域:
药学
·
纳米技术
·
药理学
·
炎症
·
肾脏生理
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高影响因子
JOURNAL OF COMPOSITE MATERIALS
·
2026
·
IF 2.9
Abuzar Es’haghi Oskui,Elyas Haddadi
The influence of tailoring the carrier-fluid chemistry of shear-thickening fluids (STFs) on the dynamic response of three-dimensional (3D) E-glass fabric laminates is investigated. Silica-based STFs (50 wt%) were formulated in polyethylene glycol (PEG-400), and the PEG was further modified using diacid chemistry (oxalic and glutaric) to tune chain interactions and hydrogen-bonding density. Fabrics were impregnated via deep coating and the add-on was quantified. Rheology, surface morphology (SEM), yarn pull-out response, and low-velocity drop-weight compression were evaluated for 1-, 3-, 5-, and 7-ply stacks. Post-critical viscosity was increased by PEG modification, and larger apparent particle agglomerates were observed within yarn interstices relative to the unmodified STF, indicating strengthened fabric–fluid–particle interlocking. During yarn pull-out, inter-yarn friction and energy absorption were increased; relative to untreated E-glass, energy absorption gains of ≈25.95%, 31.08%, and 61.38% were obtained for pure-STF, oxalic-modified, and glutaric-modified STF composites, respectively. Under compressive impact, STF impregnation reduced the compressive peak force (CPF) and extended the force-duration window; CPF ratios of ∼0.85, 0.76, and 0.65 (relative to untreated fabric) were measured for pure-, oxalic-, and glutaric-modified STFs, with further improvements as ply count increased, while peak-force time and impulse duration were systematically shifted to later times. To interpret the cushioning dynamics, a compact regression model combining a Gaussian peak term (capturing peak force and timing) with linear components was established; material-specific parameterizations were shown to reproduce measured force–time histories and to enable prediction across ply counts. Overall, scalable improvements in energy dissipation, inter-yarn friction, and impact cushioning were achieved through modest PEG-chemistry modifications, enabling tunable protection for diverse engineering and armor applications.
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