JOURNAL OF RARE EARTHS
·
2022
·
IF 4.632
Yaqun Ma,Zhan Wang,Yanxing Wang,Zhenghao Liu,Yukun Wang,Ruichan Lv
Lanthanide-doped biocompatible nanoparticles have promising applications in near-infrared second region imaging due to their high chemical stability, enhanced photostability and sharp emission bandwidth. However, the weak light absorption capacity limits the application of rare-earth nanoparticles (RENPs) for bioimaging. We prepared a coumarin-derived dye sensitized NaYGdF 4 :Yb,Er nanoparticle probe, in which the organic dye enhances photon absorption through the sensitization process, improving the luminescence efficiency of the rare earth particles near 1000 and 1500 nm. In addition, good water solubility and stability of the probe are imparted by coating the particles with amphiphilic polymers distearoyl phosphatidylethanolamine-polyethylene glycol (DSPE-PEG) and polyacrylic acid. This composite probe with good biocompatibility and NIR II luminescence properties can be used for vascular imaging, providing a tool for the detection of hematologic-related diseases.
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JOURNAL OF LUMINESCENCE
·
2022
·
IF 4.171
Junshan Hu,Fengyi Wang,Wei Jin,Changchun Ding
Upconversion nanoparticles (UCNPs) have great potential applications in biological imaging, medical treatment and optical sensing. However, the development of an inorganic-organic hybrid fluorescent probe to accurately detect noxious ions and scientifically assess irritation in vivo remains a challenge. Herein, we demonstrate a fluorescent nanoprobe for detecting nitrites (NO 2 − ) and assessing the irritation in jellyfish cell. The nanoprobe was assembled by linking neutral red to the surface of polyethylene glycol (PEG) modified NaGdF 4 :Yb,Er@NaYF 4 core/shell nanoparticles. The nanoprobe could efficiently capture the NO 2 − in jellyfish and simultaneously visualize the process. It's known that the intensity ratio of green to red emission (IRGRE) of neutral red modified upconversion nanoparticles increases linearly with the amount of NO 2 − increasing. Moreover, the irritation of NO 2 − was assessed in jellyfish cells using neutral red modified fluorescent nanoprobe based on cell imaging and spectrum signals, that NO 2 − has irrecoverable injury to the cells. This work based on dye-modified upconversion luminescence nanoprobe is expected to shed further light on the biological analysis and detection of ions.
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DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 34
·13106-13118
·
IF 4.569
Hang Liu,Haiyan Wang,Xingke Zheng,Pengcheng Wang,Yuhong Zhang
In this work, Yb3+/RE3+ (RE = Er/Ho) co-doped Zn3Mo2O9 phosphors were synthesized by high-temperature solid-state reactions. Under 980 nm excitation, the upconversion (UC) luminescence thermal enhancement was obtained for Zn3Mo2O9:Yb3+/RE3+ phosphors. The green emission intensity of the Zn3Mo2O9:Yb3+/Er3+ sample was increased 5 times from 373 to 573 K. The red emission intensity of the Zn3Mo2O9:Yb3+/Ho3+ sample was enhanced 7.92 times. The anomalous thermal enhancement of UC emission was induced by the negative thermal expansion (NTE) of the Zn3Mo2O9 host. The energy transfer rate from the sensitizer (Yb3+) to the activator (RE3+) was enhanced because of the lattice contraction and distortion for NTE materials. Compared with the UC emission of Er3+single doped Zn3Mo2O9 sample, the luminescence thermal enhancement was absent, which contributed to proving the physical mechanism. The temperature sensing properties of the Zn3Mo2O9:Yb3+/Er3+ and Zn3Mo2O9:Yb3+/Ho3+ samples were also investigated based on the fluorescence intensity ratio (FIR) technology. The absolute sensitivity (SA) and relative sensitivity (SR) of Zn3Mo2O9:Yb3+/Er3+ phosphor reached 0.0060 K−1 and 0.72% K−1, which is based on the thermal coupling levels (2H11/2, 4S3/2) FIR of Er3+ ions. In addition, the SA and SR of Zn3Mo2O9:Yb3+/Ho3+ phosphor reached 0.0119 K−1 and 0.86% K−1, that is based on the non-thermal coupling levels (5S2/5F4, 5F5) FIR of Ho3+ ions. The research results indicate that the Zn3Mo2O9 host shows NET. The Yb3+/RE3+ co-doped Zn3Mo2O9 phosphors are good materials for highly sensitive optical temperature measurement, which can be used to develop thermally enhanced ratiometric optical thermometers.
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高影响因子
RSC Advances
·
2021
·Vol. 11
·期 58
·36689-36697
·
IF 3.361
Hang Liu,Xiukai Jian,Mingtai Liu,Kailin Wang,Guangyao Bai,Yuhong Zhang
SrWO4 phosphors doped with Ho3+(Er3+)/Yb3+ are successfully prepared by a high temperature solid-state reaction method. The upconversion (UC) luminescence properties of all the samples have been investigated under 980 nm excitation. Strong green emissions are obtained in the SrWO4:Yb3+/Ho3+ and SrWO4:Yb3+/Er3+ samples with the naked eyes. In a temperature range going from 303 K to 573 K, the UC emission spectra of the phosphors have been measured. Then the temperature sensing properties also have been discussed via fluorescence intensity ratio (FIR) technology. For the SrWO4:Yb3+/Ho3+ phosphor, the FIR technologies based on thermal coupling levels (TCLs)(5F4,5F5) and non-thermal coupling levels (non-TCLs)(5S2, 5F4/5F5) are used for investigating the sensitivity. The results show that the maximum absolute sensitivity reaches 0.0158 K−1 with non-TCLs. As for Yb3+/Er3+ codoped SrWO4 phosphor, the maximum absolute sensitivity reaches 0.013 K−1 with TCLs (2H11/2,4S5/2) at a temperature of 513 K. These significant results demonstrate that the SrWO4:Ho3+(Er3+)/Yb3+ phosphors are robust for optical temperature sensors.
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Nanoscale Research Letters
·
2021
·Vol. 16
·期 1
·1-10
·
IF 4.703
Xie Jun,Zhou Zonglang,Ma Sihan,Luo Xian,Liu Jiajing,Wang Shengyu,Chen Yuqiang,Yan Jianghua,Luo Fanghong
X-ray computed tomography (CT) has been widely used in clinical practice, and contrast agents such as Iohexol are often used to enhance the contrast of CT imaging between normal and diseased tissue. However, such contrast agents can have some toxicity. Thus, new CT contrast agents are urgently needed. Owing to the high atomic number ( Z = 83), low cost, good biological safety, and great X-ray attenuation property (5.74 cm 2 kg −1 at 100 keV), bismuth has gained great interest from researchers in the field of nano-sized CT contrast agents. Here, we synthesized BiF 3 : Ln@PVP nanoparticles (NPs) with an average particle size of about 380 nm. After coating them with polyvinylpyrrolidone (PVP), the BiF 3 : Ln@PVP NPs possessed good stability and great biocompatibility. Meanwhile, compared with the clinical contrast agent Iohexol, BiF 3 : Ln@PVP NPs showed superior in vitro CT imaging contrast. Subsequently, after in situ injection with BiF 3 : Ln@PVP NPs, the CT value of the tumor site after the injection was significantly higher than that before the injection (the CT value of the pre-injection and post-injection was 48.9 HU and 194.58 HU, respectively). The morphology of the gastrointestinal (GI) tract can be clearly observed over time after oral administration of BiF 3 : Ln@PVP NPs. Finally, the BiF 3 : Ln@PVP NPs were completely discharged from the GI tract of mice within 48 h of oral administration with no obvious damage to the GI tract. In summary, our easily synthesized BiF 3 : Ln@PVP NPs can be used as a potential clinical contrast agent and may have broad application prospects in CT imaging.
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NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 44
·期 28
·12201-12207
·
IF 3.288
Yan Qiao,Xionglin Zhou,Hongchao Geng,Leilei Sun,Deshuai Zhen,Qingyun Cai
A β-NaYF4:Yb,Er,Gd nanorods@1T/2H-MoS2 nanocomposite was fabricated and used for photocatalytic sterilization under illumination from single near-infrared (NIR) light. Approximately 99.3% of Escherichia coli were killed effectively by 15 min irradiation of NIR light at a dose of 40 μg mL−1. The effective bactericidal activity is ascribed to the high upconversion luminescence efficiency of β-NaYF4:Yb,Er,Gd and the layered two-dimensional nanosheet structure of 1T/2H-MoS2. Under 980 nm light irradiation, β-NaYF4:Yb,Er,Gd emits visible light, which is absorbed by MoS2, producing strongly oxidative holes and reductive electrons. Photogenerated electron–hole pairs were able to react with H2O, O2 and OH− to produce reactive species in aqueous solution. These reactive species are strong nonselective oxidizing agents for sterilization.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Guomin Li,Bing Wang,Jian Zhang,Rui Wang,Huiling Liu
Through direct thermal condensation of a mixture of Er(NO 3 ) 3 ·5H 2 O and melamine at 550 °C for 2 h, a series of rare earth agent Er (III)-doped mesoporous g-C 3 N 4 (xECN, x = 1,2,3) with different Er content were successfully synthesized. XRD, solid-state 13 C CP/MAS, FT-IR, XPS, UV–Vis DRS, photocurrent, EIS, SEM, TEM, BET and Zeta potentials were used to characterize the phase, morphology, optical and surface properties of xECN photocatalysts. The photo-activities of xECN samples for degradation of Rhodamine B (RhB), tylosin (TYL) and tetracycline (TC) were enhanced compared with those of pure g-C 3 N 4 under the irradiation of simulated solar, and the 2ECN catalyst displayed the optimal degradation rate for all three organic pollutants. The UV–vis results demonstrated that Er doping narrowed the band gap while increasing the light harvesting ability, which improved the photocatalytic activity of g-C 3 N 4 catalyst. The leaching and toxicity tests were conducted with pakchoi seeds and Escherichia coli bacteria, demonstrating that the leaching toxicity of xECN could be ignored. Free radical capture tests were carried out to confirm the main active species for the degradation of RhB under the same experimental condition.
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MATERIALS RESEARCH BULLETIN
·
2018
·
IF 2.873
Zhilai Li,Omar Johnson,Jin Huang,Ting Feng,Chaoqing Yang,Zhongxin Liu,Wei Chen
Graphene oxide/NaYF 4 : Yb, Er nanocomposites have been synthesized via hydrothermal synthesis, in which spherical cubic phase NaYF 4 : Yb, Er nanocrystals with uniformity are implanted onto the surface of graphene oxide (GO). Using a near infrared laser set to 980 nm, the light-to-heat energy transfer efficiency of GO/NaYF 4 : Yb, Er is 13.9% higher than GO by itself, revealing that the photothermal conversion efficiency of GO could be enhanced by doping NaYF 4 : Yb, Er nanocrystals. This phenomenon can be attributed to the energy transfer between the NaYF 4 : Yb, Er nanocrystals to the energy receptor in the GO substrate.
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Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 21
·3586-3599
·
IF 4.776
Xiaoqin Chen,Jing Sun,Huan Zhao,Ke Yang,Yuda Zhu,Hongrong Luo,Kui Yu,Hongsong Fan,Xingdong Zhang
For synchronous theranostic systems, there are two areas of focus. These are: excellent in vivo imaging and a multi-drug resistance (MDR) reversing ability for chemotherapy. Upconversion nanoparticles (UCNPs) exhibiting bright red emission in the “optical window in biological tissue (600–1100 nm)” could be a very useful candidate, although there have only been a few reports on UCNP-based conjugates with a MDR reversal ability explored for chemotherapy. Herein, we report an innovative theranostic system (D-UNT) via binding of an antitumor drug (DOX) and a MDR reversal agent (TPGS) to NaY(Mn)F4:Yb/Er UCNPs (UN) with synthetic optimized red emission and properties. The in vitro study demonstrated that the D-UNT was uptaken into drug-resistant MCF-7/ADR cells via caveolin dependent endocytosis and overcame P-gp mediated efflux. The cytotoxicity was significantly promoted to be much higher than that of free DOX. Accordingly, our D-UNT illustrates an enhanced reversal ability for chemotherapy. Our in vivo study further indicated that the D-UNT had excellent therapeutic efficacy against MDR tumors with minimal organ toxicity detected. In vivo deep-tissue imaging showed that the D-UNT accurately diagnosed MDR tumors at a 1.5 cm depth with high-contrast luminescent signals. Thus, the D-UNT is an effective theranostic system for the diagnosis and therapeutic treatment of MDR tumors. The present work opens new pathways to engineering powerful theranostic agents to simultaneously target, image and kill deep-tissue MDR tumor cells.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2018
·
IF 3.118
Jingjing Wen,Hongfa Lin,Mengshu Zhao,Liang Tao,Yunxia Yang,Xi Xu,Aiqun Jia,Jianfa Zhang,Dan Weng
Piceatannol , a natural derivative of resveratrol , has been shown to exert similar anti-oxidant and anti-inflammatory effects as resveratrol. However, it remains unknown whether piceatannol has hepatoprotective effect against acute liver injury. In this study, we investigated the in vivo effect of piceatannol on D-GalN/LPS-induced fulminant hepatic failure (FHF), and its in vitro effect on ER stress-inducing drug thapsigargin (TG)-induced proinflammatory cytokines production and ROS release. Our results indicated that piceatannol markedly decreased the mortality rate, reduced the serum levels of alanine transaminase and aspartic aminotransferase, ameliorated the liver damage induced by D-GalN/LPS in mice. In addition, piceatannol reduced the expression of proinflammatory cytokines, including TNF-α, IL-1β and IL-6, the expression of ER stress markers CHOP and phosphorylated-IRE1α, and the generation of oxidative stress in D-GalN/LPS-treated mouse liver. In vitro results were consistent with in vivo observations, demonstrating that piceatannol suppressed the secretion of proinflammatory cytokines, inflammasome activation and the production of ROS induced by TG with or without LPS priming in J774A.1 macrophages. Our study proposes piceatannol as a promising medication for preventing acute liver failure and the mechanisms may be related to its inhibitory effects on ER stress, inflammation and oxidative stress.
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POWDER TECHNOLOGY
·
2012
·
IF 2.08
Wanyue Shao,Ruinian Hua,Wei Zhang,Yue Tian,Jun Zhao,Liyan Na,Jicheng Yu,Zhengang Sun
Carboxylic acid-functionalized Yb 3 + /Er 3 + co-doped α - and β -NaYF 4 nano-/micro-spheres were prepared through a simple poly(acrylic acid) (PAA)-assisted hydrothermal process. Bovine serum albumin (BSA) protein was conjugated with Yb 3 + /Er 3 + co-doped α -( β -)NaYF 4 upconversion phosphors via free carboxylic acid groups on the surface of phosphors. The final products were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), infrared (IR) spectrophotometer, ultraviolet (UV) spectrophotometer and photoluminescence spectroscopy (PL). XRD results showed that pure α -NaYF 4 :Yb 3 + , Er 3 + nanospheres could be obtained via PAA assisted hydrothermal process at the pH value of 4–5 and 160 °C for 1–4 h. The obtained product is a mixture of α and β phases NaYF 4 :Yb 3 + , Er 3 + when the reaction time increased from 5 to 24 h. When the solution was treated at 200 °C for 8–24 h at the pH value of 8–9, pure β -NaYF 4 :Yb 3 + , Er 3 + microspheres were obtained. The FE-SEM results showed that the morphology of pure α -NaYF 4 :Yb 3 + , Er 3 + was spherical nanoparticles with an average diameter of about 70 nm and the pure β -NaYF 4 :Yb 3 + , Er 3 + was microsphere with an average diameter of about 700 nm, which is composed of spherical nanoparticles (30 nm). The FT-IR and UV spectra showed that BSA had been conjugated with α -NaYF 4 :Yb 3 + , Er 3 + upconversion phosphors. The luminescence properties of α -( β -) NaYF 4 :Yb 3 + , Er 3 + phosphors were also studied. Under 980 nm excitation, the upconversion luminescence (UCL) intensity of β -NaYF 4 :Yb 3 + , Er 3 + microspheres was much stronger than that of α - NaYF 4 :Yb 3 + , Er 3 + nanoparticles. Moreover, both red and green upconversion were ascribed to the two-photon process.
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Nanoscale
·
2015
·Vol. 8
·期 2
·1040-1048
·
IF 7.394
Xiaojuan Huang,Bo Li,Chen Peng,Guosheng Song,Yuxuan Peng,Zhiyin Xiao,Xijian Liu,Jianmao Yang,Li Yu,Junqing Hu
Imaging guided photothermal agents have attracted great attention for accurate diagnosis and treatment of tumors. Herein, multifunctional NaYF4:Yb/Er@polypyrrole (PPy) core–shell nanoplates are developed by combining a thermal decomposition reaction and a chemical oxidative polymerization reaction. Within such a composite nanomaterial, the core of the NaYF4:Yb/Er nanoplate can serve as an efficient nanoprobe for upconversion luminescence (UCL)/X-ray computed tomography (CT) dual-modal imaging, the shell of the PPy shows strong near infrared (NIR) region absorption and makes it effective in photothermal ablation of cancer cells and infrared thermal imaging in vivo. Thus, this platform can be simultaneously used for cancer diagnosis and photothermal therapy, and compensates for the deficiencies of individual imaging modalities and satisfies the higher requirements on the efficiency and accuracy for diagnosis and therapy of cancer. The results further provide some insight into the exploration of multifunctional nanocomposites in the photothermal theragnosis therapy of cancers.
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