CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Shulin Qin,Lichun Ma,Runfeng Li,Pengfei Yuan,Yunfeng Shi,Xin Ji,Wei Xue,Yanli Li,Wen Liu
Although immune checkpoint blockade (ICB) therapy has been widely used for the treatment of a variety of cancers, its therapeutic efficacy is severely impaired by low tumor immunogenicity and the immunosuppressive microenvironment. Herein, we designed multifunctional immunomodulatory calcium nanoparticles to reshape the immunosuppressive tumor microenvironment. Our multifunctional calcium nanoparticles, CD@CaCO 3 P, are designed to release calcium ions and doxorubicin (DOX) into the acidic tumor microenvironment, which synergistically increase the tumor cell calcium ion concentration, while the release of combretastatin A4 phosphate (CA4P) further enhances T cell infiltration. Specifically, CD@CaCO 3 P effectively mediates the immunogenic cell death (ICD) of tumor cells and triggers the activation of nuclear factor kappa-B (NF-κB)/interferon regulatory factor 3 (IRF3), thereby regulating type I interferon (IFN-I) signaling pathways, and ultimately reprogramming the immunosuppressive tumor microenvironment by inducing M1-like macrophage polarization, promoting dendritic cell maturation, and increasing the infiltration of CD8 + T cells. Furthermore, CD@CaCO 3 P significantly increased tumor susceptibility to α-PD-1 checkpoint blocking immunotherapy and enhanced systemic immunotherapy performance against both primary and metastatic tumors. Our work provides new insights for the use functional calcium nanoparticles that modulate the tumor microenvironment to enhance the efficacy of cancer immunotherapy.
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Nanotechnology Reviews
·
2023
·Vol. 12
·期 1
·
IF 7.4
Wen-Juan Zhang,Ye-Zhi Ding,Ya-Xian Wang,You-Liang Wang,Yu-Long Fei,Meng-Yu Ran
The pollution of silver ion (Ag( i )) has become a serious environmental threat and hazard to ecosystem and human health. Thus, the nanoscale zero valent iron (nZVI)-doped polypyrrole-based carbon nanotube (nZVI/CNT) composites were synthesized by a facile method to remove Ag( i ) from wastewater due to the toxicity and scarcity nature of Ag( i ). In this process, Fe 3+ initiated the self-assembly of polypyrrole tubes in the presence of methyl orange, while it also served as an iron source generated nZVI/CNTs by carbothermal reduction method. The nZVI/CNT composites exhibited a homogeneous tubular structure, and the nZVI formed were uniformly dispersed in the nZVI/CNT composites. The nZVI/CNT composites were used as an adsorbent for the removal of Ag( i ) and showed a higher adsorption capacity compared to nZVI and CNTs, with a maximum adsorption capacity of 522.41 mg g −1 . Ag( i ) was adsorbed on nZVI/CNT composites by ion exchange and chelation, where Ag( i ) was reduced to non-toxic Ag due to the redox reaction among pyrrolic-N, nZVI, and Ag( i ). The adsorption process of Ag( i ) on nZVI/CNT composites was dominated by monolayer adsorption. According to our results, nZVI/CNT composites can be used as economical treatment for wastewater containing Ag( i ).
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Huihuang Xiong,Yong Fan,Xuejin Mao,Lan Guo,Aiping Yan,Xian Guo,Yiqun Wan,Hao Wan
Recently, the natural compound of aristolochic acid I (AAI) has attracted wide attentions due to its strong nephrotoxicity and carcinogenicity. However, the extraction of AAI based on conventional molecularly imprinted polymers (MIPs) are tedious with extensive eluent, causing secondary pollution and poor regeneration. Herein, thermosensitive and magnetic MIPs (TMMIPs) were synthesized by a surface imprinting method, which achieved thermosensitive capture/release of AAI, along with rapid magnetic separation, significantly shortening the elution time and reducing organic-solvent consumption. TMMIPs with dual-stimuli responses exhibited superior affinity, selectivity, kinetics, and regeneration ability towards AAI. TMMIPs were applied to analyze AAI in Houttuynia cordata via dispersive solid-phase extraction (d-SPE) coupled with high performance liquid chromatography (HPLC), yielding satisfactory recoveries (79.03–99.67%) and relative standard deviations (≤5.78%). The limit of detection of AAI was as low as 26.67 µg/L. TMMIPs demonstrate great applicability for fast, selective and eco-friendly extraction of AAI in complicated matrices.
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JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
Zhenxing Fang,Kuang Wu,Le Wang,Da Xu,Weiwei Wang,Yuhang Lin,Xiaohui Liu,Chun Sun
Mn doped two-dimensional (2D) layered perovskites , are becoming excellent candidates as red phosphor because of their high quantum yields (QY) and enhanced stability. However, these Mn doped 2D layered perovskites can only be excited by the near UV light , which largely limits the development of perovskites. Herein, blue-excitable Mn-doped PEA 2 (Pb/Mn)(Br/I) 4 PQDs are synthesized from anion exchange surface engineering strategy. After anion exchange, orange Mn 2+ emission from exciton-to-Mn energy transfer is acquired under the excitation of 450 nm. The PEA 2 (Pb/Mn)(Br/I) 4 compounds exhibit strong luminescence with photoluminescence (PL) QY of 52%, which is comparable to most of the reported red emitting phosphors. A prototype white light-emitting diode (WLED) with good optical performance was fabricated using commercial (Sr,Ba) 2 SiO 4 :Eu phosphor and as-prepared PEA 2 (Pb/Mn)(Br/I) 4 as green and orange color converters, showing great potential in the applications of solid state lighting.
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Materials
·
2020
·Vol. 13
·期 18
·4026
·
IF 3.057
Shasha Zhang,Wenxin Ji,Ning Feng,Liping Lan,Yuanyuan Li,Yulong Ma
In this study, a Rh(I)/Ru(III) catalyst with a bimetallic space structure was designed and synthesized. The interaction between the metals of the bimetallic catalyst and the structure of the bridged dimer can effectively reduce the steric hindrance effect and help speed up the reaction rate while ensuring the stability of the catalyst. X-ray photoelectron spectroscopy (XPS) results show that rhodium accepts electrons from chlorine, thereby increasing the electron-rich nature of rhodium and improving the catalytic activity. This promotes the nucleophilic reaction of the catalyst with methyl iodide and reduces the reaction energy barrier. The methanol carbonylation performance of the Rh/Ru catalyst was evaluated, and the results show that the conversion rate of methyl acetate and the yield of acetic acid are 96.0% under certain conditions. Furthermore, during the catalysis, no precipitate is formed and the amount of water is greatly reduced. It can be seen that the catalyst has good stability and activity.Keywords:carbonylation;acetic acid;bimetallic catalyst
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Green Energy & Environment
·
2020
·
IF 6.395
Li Cui,Lijuan Wang,Ming Feng,Li Fang,Yanxia Guo,Fangqin Cheng
Lithium (Li) is an important energy metal in the 21st century. However, the selective recovery of Li is still a big challenge, especially from acidic solutions with multiple metal ions existence. Herein we report a new ion pair induced mechanism for selectively extracting Li + from acidic chloride solutions by tributyl phosphate (TBP). It is shown that the acidity and the chloride ions in the aqueous phase have great effects on the extraction of Li + . The FT-IR, UV-Vis and ESI-MS experiments provide solid evidence for the formation of ion-pair complex [Li(TBP) n (H 2 O) m ] + [FeCl 4 ] − (n = 1, 2, 3; m = 0, 1) in the organic phase, which brings about the effective and efficient extraction of Li + . This mechanism can overcome the Hofmeister bias and allow for the selective extraction of Li + from the extremely hydrophilic chlorides. It has also been proved that the loaded Li in TBP can be effectively stripped by concentrated HCl solution with a Li/Fe separation factor > 500. The understanding of the ion-pair transport mechanism is helpful for optimizing the recovery process or further advancing more efficient recovery techniques for Li from acidic liquor.
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JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Tao Sun,Guangping Zhang,Zhongyuan Guo,Qinjun Chen,Yujie Zhang,Yongchao Chu,Qin Guo,Chao Li,Wenxi Zhou,Yiwen Zhang,Peixin Liu,Hongyi Chen,Haijun Yu,Liping Jiang,Chen Jiang
Chelating Cu from tumors has been verified as an effective and promising strategy for cancer therapy through antiangiogenesis. However, systematic removal Cu by injecting with Cu chelators will result unavoidable side effects, since Cu is indispensable to the body. In this work, a micelle targeting to tumors' newborn vessels based on a polypeptide was developed to co-load DOX and Probe X, which can go through an “OFF-to-ON” procedure to report the Cu + -capture events in vivo in a real-time way by giving near infrared (NIR) fluorescence and photoacoustic signal. By co-delivering antiangiogenesis and chemotherapeutic reagents, the tumor can be significantly suppressed, meanwhile with a low systematic toxicity. Hopefully, this work can offer new insights in designing sophisticated antitumor strategy.
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JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2020
·
IF 1.701
Long Wang,Zhiming Wang,Cuo Zhou,Weijun Song,Chunyan Sun
A cesium potentiometric microsensor based on magnetic ion-imprinted polymer (MIIP) has been developed for Cs(I) sensing. The core-shell structure Cs(I)-MIIP was synthesized by surface-imprinting technique, using functionalized magnetic Fe3O4@SiO2 microspheres, Cs(I) ion and carboxymethyl chitosan as supporter, template and functional monomers respectively. The resultant Cs(I)-MIIP was used as ionophore in the construction of the PVC membrane electrode to obtain a selective potentiometric microsensor toward Cs(I) ions. The fabricated sensor exhibited a highly sensitive Nernstian response (60.2 mV/decade) over the concentration range of 1 × 10−6 to 1 × 10−1 M of Cs(I). The response time of the microsensor was considerably short (less than 3 s) and its detection limit was determined as 3.0 × 10−7 M. The microsensor was effectively performed in the pH range of 4–6, and revealed desirable selectivity over a wide variety of other cations including alkali, alkaline earth and heavy metals. The proposed microsensor was also used for the determination of Cs(I) contents in the environmental water samples. The potentiometric results were in good harmony with the results obtained by the ICP-MS method.
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TOXICON
·
2021
·
IF 3.033
Xiong Zhang,Chen Feng,Yimao Li,Chenlin Su,Shuxin Zhao,Shengdi Su,Feng Yu,Ji LI
Aristolactam I (AL-I) is the main active ingredient in the Aristolochia plant species, which have been associated with severe nephrotoxicity. In order to investigate the mechanism of AL-I induced renal epithelial-mesenchymal transition (EMT), we established an AL-I induced EMT model in human proximal tubular epithelial cells (HK-2 cells). Biochemical analysis experiment including Morphological examination, 3-(4,5-dimethylthiazol-2-Yl)-2,5-diphenyltetrazolium bromide assay, and Western blot analysis were performed. The results showed that AL-I accumulates in the cytosol causing cytotoxicity and inhibition of proliferation in a concentration- and time-dependent manner. Morphological examination showed that with the increasing concentration of AL-I, the tendency of HK-2 cells transform form epithelial cell to fibroblast cells was stronger. In the Western blot analysis, the expression of α-Smooth muscle actin (α-SMA) and Transforming Growth Factor β1 (TGF-β1) were significantly up-regulated, the expression of E-cadherin was significantly down-regulated after administrating. The ratio of the expression of P-Smad2/3 and Smad2/3 was significantly up-regulated, suggested that TGF-β/Smad-dependent signaling pathway was activated in this process. With presence of TGF-β receptor inhibitor (LY364947), we found that the expressions of three EMT related proteins (E-cadherin, α-SMA and TGF-β1) were obviously reversed. In conclusion, we acknowledge that AL-I can induce renal EMT process in HK-2 cell, which is triggered by the activation of TGF-β/Smad-dependent signaling pathway.
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ANALYST
·
2019
·Vol. 144
·期 22
·6554-6560
·
IF 4.019
Liping Zhu,Jing Ye,Mengxia Yan,Qiuju Zhu,Xiurong Yang
In this study, a wavelength-resolved electrochemiluminescence resonance energy transfer (ECL-RET) ratiometric immunosensor from Au nanoparticle functionalized graphite-like carbon nitride nanosheets (Au-g-C3N4) to Au nanoclusters (Au NCs) has been constructed for the first time. At a working voltage of 0 to −1.2 V, Au-g-C3N4 showed a strong cathodic ECL emission with a peak at 460 nm, which overlapped well with the absorption spectra of Au NCs thus stimulating the fluorescence emission of Au NCs at 610 nm. Moreover, within this voltage range, the Au NCs showed no ECL signal; therefore, they would not interfere with the detection of the system. We used cardiac troponin I (cTnI) as an analytical model to construct a sandwich immunosensor based on the ECL-RET ratiometric strategy. By measuring the responses of the ECL460 nm/FL610 nm ratio at different cTnI concentrations, the sensitive detection of cTnI with a wide range of 50 fg mL−1 to 50 ng mL−1 and a low detection limit of 9.73 fg mL−1 can be achieved. This work enriches the wavelength-resolved ECL-RET system and provides an innovative reference for the development of more efficient and sensitive ECL-RET ratiometry.
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ANALYST
·
2019
·Vol. 144
·期 6
·2011-2016
·
IF 4.019
Yi Fen Xie,Yun Ying Cheng,Meng Li Liu,Hong Yan Zou,Cheng Zhi Huang
Highly sensitive colorimetric detection of silver(I) ions (Ag+) at the single-particle level was developed based on the color of a gold nanoparticle (AuNP) assembly captured by dark-field microscopy (DFM) imaging. Formation of C–Ag+–C bonding between cytosines was utilized to induce interparticle coupling of AuNPs modified with single-strand DNA, resulting in a color change as the signal transduction to quantify Ag+ under DFM imaging. This method allowed visual quantitation of Ag+ in the range of 0.05 nM–250.00 nM and a detection limit of 28.8 pM was achieved. Furthermore, we demonstrated its applicability for the colorimetric detection of Ag+ in a small quantity of real samples, showing the good potential of this developed method for environmental monitoring and drug quality control.
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CHEMICAL ENGINEERING JOURNAL
·
2019
·
IF 8.355
Yanjun Huang,Wenchao Zhao,Xiong Zhang,Hong Peng,Yuefa Gong
In this study, a novel adsorbent (TCP) for the selective adsorption of Ag (I) was synthesized by thiol-ene polymerization of dimercaptosuccinic acid and 1,3,5-triallyl-1,3,5-triazine-2,4,6-trione. Element analysis, FT-IR and NMR spectroscopy confirmed that TCP was a functional-group-dense polymer with abundant thioether/carboxyl groups. The results of batch adsorption experiments revealed that the maximum adsorption capacity for Ag (I) by TCP at pH 4 was 5.2 mmol g −1 , which was much higher than that at pH 2. Moreover, the adsorption isotherm of Ag (I) on TCP at pH 4 followed the Langmuir model better. However, the isothermal adsorption behavior at pH 2 fitted the Freundlich model well. The kinetic study demonstrated that both chemical adsorption and internal diffusion might be involved in the Ag (I) adsorption process. Furthermore, TCP showed much higher selectivity for Ag (I) in the presence of multiple interfering ions at pH 2 than that at pH 4. However, if the initial concentration of Ag (I) ions was high enough, TCP still exhibited good selectivity for Ag (I) in the presence of Cu (II) over a wide pH range: the selectivity coefficient (K Ag/Cu ) fluctuated between 40 and 60 in the pH range of 0.5–5. FT-IR spectroscopy and XPS analysis evidenced that the carboxyl and thioether groups in TCP could have synergistic effects on the adsorption of Ag (I), which might form five-membered or six-membered chelated rings, thereby inhibiting the combination of the carboxylic groups with other interfering ions. In addition, TCP showed high adsorption capacity and selectivity for Ag (I) in the treatment of simulated industrial effluent at pH 2.
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