ACS Applied Polymer Materials
·
2026
·
IF 5.2
Jakkree Intranuwong,Arin Kim,Nutcha Nongyai,Seong Kyu Shin,Yong Ku Kwon
Porous polymeric biodegradable monoliths (PHIPEn, where n denotes the number of arms of the PLA macroinitiator) based on poly(δ-valerolactone-co-l-lactide) were prepared via bulk ring-opening polymerization of a δ-valerolactone/l-lactide (VL/LA) eutectic mixture (80/20) using various PLA macroinitiators. Linear (one- and two-arm) or star-shaped (four- and six-arm) PLA macroinitiators were employed to investigate the effect of initiator functionality on the morphology and properties of PHIPEns. The variation in initiator functionality strongly affected the pore morphology, cross-link density, and overall physical properties of the materials. Increasing the number of arms resulted in smaller pore size, higher cross-link density, greater crystallinity, and improved compressive strength and modulus. Thermal analysis revealed that PHIPEns prepared from star-shaped macroinitiators exhibited improved thermal stability and higher PVL crystallinity compared with those derived from linear macroinitiators. Hydrolytic degradation in phosphate-buffered saline at 37 °C showed that PHIPEns synthesized from star-shaped macroinitiators degraded more slowly, absorbed less water, and maintained a more stable pH than those derived from linear ones. These results demonstrate that combining star-shaped macroinitiators with a VL/LA eutectic mixture provides an effective strategy for designing biodegradable porous materials with tunable properties.
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JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
·
2018
·Vol. 56
·期 22
·2574-2583
·
IF 2.588
Zhangxin Chen,Chang Su,Xiaogang Zhu,Ruoteng Xu,Lihuan Xu,Cheng Zhang
A novel organic conjugated polymer based on star-shaped triazine-functional triphenylamine framework poly[1,3,5-tris(4-diphenylamino-phenyl)triazine] (PTDAPTz) is designed and synthesized successfully by FeCl 3 -catalysted chemical oxidative polymerization. The polymer PTDAPTz powder exhibits a compactly packed pleated skirt shape-like morphology with a high surface area (~930 m 2 g −1 ) and a bimodal pore size distribution ranging from micropores (~0.55 nm) to small diameter mesopores (~2–6 nm). As explored as the cathode material, the obtained PTDAPTz presents the double charge–discharge process characteristics of both the free radical redox of triphenylamine unit and the bipolar redox of triazine unit in the polymer and a well-defined multistage charge/discharge voltage plateau (~3.8 V for p-doped and ~2.0 V for n-doped) during the charge–discharge process. Also, the PTDAPTz demonstrates an improved capacity (stabilized at 123 mA h g −1 until 50th cycle) and the enhanced rate performance compared to polytriphenylamine (PTPAn). Specially, the discharge curve for the part of triphenylamine unit presents an obviously improved discharge plateau (~3.8 V for PTDAPTz compared to ~3.6 V for PTPAn) due to the electron-withdrawing effect of the triazine unit to triphenylamine. The elaborate structural design and created micro-/mesoporous morphology with the double charge–discharge process make PTDAPTz a potential candidate as the performance-improved cathode of Li-organic battery. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018 , 56, 2574–2583
研究领域:
材料科学
·
电化学
·
有机合成
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2024
·
IF 4.3
Hongji Jiang,Zhong Wang,Bing Mao,Yan Bing,Ning Sun,Jie Yuan
To investigate the effects of steric hindrance fluorene and heavy-atom bromine on the general optoelectronic properties of star-shaped organic emitters based on 9-(2-cyanophenyl) carbazole ( OCzPhCN ) frameworks, heavy element of bromine and steric hindrance fluorene were introduced into OCzPhCN to produce four derivatives of 2-(3-bromo-9H-carbazol-9-yl)benzonitrile ( BrCzPhCN) , 2-(3-bromo-6-(9-(4-ethoxyphenyl)-9H-fluoren-9-yl)-9H-carbazol-9-yl)benzonitrile (BrFCzPhCN) , 2-(3-(9-(4-ethoxyphenyl)-9H-fluoren-9-yl)-9H-carbazol-9-yl)benzonitrile (FCzPhCN) and 2-(3,6-bis(9-(4-ethoxyphenyl)-9H-fluoren-9-yl)-9H-carbazol-9-yl)benzonitrile (2FCzPhCN) . The fluorene units obviously improve the thermal stability of the obtained compounds, and 2FCzPhCN has the highest thermal stability with 5 % mass heat loss temperature reaching 447 °C. In different polar solvents, the absorption peaks wavelength of OCzPhCN , FCzPhCN and 2FCzPhCN are basically unchanged, and the redshifted emission peaks are positively correlated with solvent polarity. The photoluminescence quantum yields (PLQYs) of OCzPhCN , BrCzPhCN , FCzPhCN , BrFCzPhCN and 2FCzPhCN powders were 20.17 %, 5.43 %, 30.75 %, 3.27 % and 23.56 %. The fluorescence and phosphorescent quantum efficiencies of OCzPhCN , BrCzPhCN, FCzPhCN , BrFCzPhCN and 2FCzPhCN powders are 9.76 % and 10.41 %, 1.2 % and 3.23 %, 28.45 % and 2.3 %, 3.27 % and 0 %, 23.56 % and 0 %. OCzPhCN , BrCzPhCN and FCzPhCN powders show obvious room temperature phosphorescent emission, and the phosphorescent emission lifetime of OCzPhCN , BrCzPhCN and FCzPhCN powders at 561 nm, 576 nm and 568 nm are 193.17 ms, 18.65 ms and 7.25 ms. Compared with OCzPhCN, the introduction of bromine decreases the PLQY and the phosphorescent lifetime of BrCzPhCN powder, while the fluorescence quantum efficiency of the compound FCzPhCN powder has been improved. The corresponding single-triplet energy splitting (ΔE ST ) of OCzPhCN , FCzPhCN and 2FCzPhCN in solutions are 0.49 eV, 0.63 eV and 0.63 eV, and the corresponding ΔE ST values of OCzPhCN, BrCzPhCN FCzPhCN powders are 1.19 eV, 0.74 eV and 0.55 eV. The steric hindrance fluorene units result in smaller and stabilized ΔE ST in the solid powder states, and the same situation is opposite in the unimolecular solutions. The maximum external quantum efficiency of organic light-emitting diode based on 10,10′-(4,4′-sulfonylbis (4,1-phenylene)) bis (9,9-dimethyl-9,10-dihydroacridine) hosted by OCzPhCN reaches 12.7 %, and the external quantum efficiency at 100 cd/m 2 rolls down to 11 %. OCzPhCN is the best emitters in terms of room temperature phosphorescent emission and host applications.
研究领域:
材料科学
·
光学
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PubMed
高影响因子
THERIOGENOLOGY
·
2026
·
IF 2.9
Jiahao Zhao,Xiangyu Zhou,Baoyi You,Bowen Cheng,Jiashuo Hu,Yuxuan Lu,Dianrui Xu,Xiwei Zhang,Chunlong Yan,Qingshan Gao,Haixing Liu,Qingguo Jin
Florfenicol (FLO) is widely used to treat bacterial respiratory diseases and hoof rot in cattle at various physiological stages. However, residues of FLO that accumulate in cattle may have adverse effects on animal health. Although FLO has been reported to exhibit embryotoxic and cytotoxic properties, the mechanism underlying its effects on bovine granulosa cells (GCs) remains poorly understood. In this study, we treated GCs with FLO at concentrations of 0, 10, and 100 μg/mL for 48 h to evaluate the effects of FLO on cell viability, mitochondrial function, and steroid hormone synthesis. The results showed that FLO treatment was associated with increased apoptosis, reduced GC proliferation, and impaired mitochondrial function. In addition, FLO treatment was accompanied by decreased ATP levels and increased intracellular reactive oxygen species (ROS). Furthermore, FLO exposure was associated with changes in PROG and E2 production, decreased protein expression of StAR and CYP11A1, and reduced levels of adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP), and protein kinase A (PKA). The antioxidant N-acetyl-L-cysteine (NAC) partially attenuated these changes. In conclusion, our findings suggest that FLO exposure is associated with GC dysfunction and impaired steroidogenesis. These effects may be related to oxidative stress, mitochondrial dysfunction, and alterations in the cAMP/PKA/StAR signaling pathway, although direct causal relationships remain to be further elucidated.
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·Vol. 140
·期 23
·e53905
·
IF 3
Xue Dong,Mengfei Long,Hongxia Liu,Ling Gao,Xinjie Xu,Xiaole Xia
Potential migration and toxicity limited applications of traditional plasticizers like bis(2-ethylhexyl) phthalate (DEHP) in food packing and medical machinery and so forth. Safe and feasible bio-based plasticizers have recently moved into the limelight of research hotspot. Here, we designed series polyester plasticizers of various branches with star-shaped poly(ε-caprolactone) (SPCLs) and net-shaped poly(ε-caprolactone) (NPCLs) structures by one-pot solvent-free synthesis with glycidol and polyglycerol as initiators. Structures of SPCLs and NPCLs were further verified by FTIR, 1 H NMR, and 13 C NMR. Moreover, the properties of the plasticizers and plasticized PVC were evaluated by differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA) and tensile test. PVC films plasticized with the SPCLs or NPCLs exhibited increased plasticizing effect, compatibility, flexibility and cold resistance. The lowest T g value of plasticized PVC samples (PVC/NPCL1-C4) was −45.3°C, which made the plasticization efficiency reach 122.5%. In particular, PVC/SPCLs-C4 (SPCL2-C4) had 107% higher elongation at break than PVC/DEHP. Meanwhile, the initial decomposition temperature T i value of the PVC blends maximum increased from 240 to 328°C when DEHP was completely replaced by SPCLs or NPCLs, indicating improved thermal stability of the plasticizer. Overall, “green” plasticizers with fining topological branch design would be promising to partially replace petroleum-based plasticizers.
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2018
·
IF 4.513
Yi Guo,Jingwen Shen,Meng Li,Yazhuo Shang,Honglai Liu
The interaction between star -shaped copolymer poly(2-(dimethylamino)ethyl methacrylate-b-2-(2-methoxyethoxy)ethyl methacrylate) (CDPDPM) and anionic surfactant sodium dodecyl sulfate (SDS) in aqueous solutions are investigated by using fluorescence and dynamic light scattering (DLS) techniques. The effects of nonionic surfactant dodecyl β-D-maltopyranoside (C 12 G 2 ) and salts including inorganic salt ammonium bromide (NH 4 Br) and organic salt tetra-n-butylammonium bromide (Bu 4 NBr) on the interaction between CDPDPM and SDS have been explored systematically. The results have suggested that SDS molecules can bind on CDPDPM by electrostatic interaction between the positively charged CDPDPM and negatively charged SDS and thus weaken the binding ability of CDPDPM to water molecules. CDPDPM exhibits temperature-responsive aggregation behavior in aqueous solution gradually with the increase of SDS concentration and the lower critical solution temperature (LCST) decreases correspondingly. The introduction of nonionic surfactant C 12 G 2 changes the interaction between CDPDPM and SDS significantly by participate the formation of complexes and the stability of the CDPDPM/SDS complexes declines leading to the chance of forming larger complexes is deprived at higher temperature. The addition of NH 4 Br to the CDPDPM/SDS system can retard the binding of SDS on the polymer chains because of electrostatic shielding. Correspondingly, LCST is higher and the formed aggregates are smaller. For CDPDPM/Bu 4 NBr/SDS system, the phenomenon is similar to that of the CDPDPM/C 12 G 2 /SDS system. This should be attributed to the nature of Bu 4 N + , possesses not only positive charges but also certain hydrophobicity , and thus Bu 4 N + has the ability to participate and facilitate the formation of SDS micelles . Obviously, the LCST of the mixed system can be tailored by adjusting the system composition on purpose.
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高影响因子
JOURNAL OF POWER SOURCES
·
2018
·
IF 6.945
Shi Wang,Ailian Wang,Chengkai Yang,Rui Gao,Xu Liu,Jie Chen,Zhinan Wang,Qinghui Zeng,Xiangfeng Liu,Henghui Zhou,Liaoyun Zhang
All-solid-state polymer electrolyte (SPE) matrices prepared by molecular design are still needed to be further perfected with excellent performance. In this paper, a controlled-structure discotic liquid crystal (DLC)-based six-arm star copolymer was designed and synthesized from a DLC initiator (2,3,6,7,10,11-hexakis(2-bromoisobutyryloxy)triphenylene) via the sequential atom transfer radical polymerization (ATRP) of styrene and poly(ethylene glycol) methyl ether methacrylate (PEGMA). Here, this class of discotic liquid crystal star polymer is applied as an SPE in LIBs for the first time. By solution casting , a suitable self-standing SPE film composed of the six-arm copolymer and lithium bis(trifluoromethanesulfonimide (LiTFSI)) can be easily formed, and the film shows long-range molecular orientation after annealing. It is confirmed that the electrolyte shows wide electrochemical window (5.1 V) and high lithium-ion transference number (0.37). Especially, the ionic conductivity (1.46 × 10 −4 , S cm −1 , 30 °C) of the obtained SPE is more than 8 times higher than that of the corresponding linear copolymer electrolytes. Furthermore, the results of battery performance demonstrate that the polymer electrolyte displays eminently reversible electrochemical reaction and outstanding cycling performance. The present work not only shows the advantages of DLC-based star SPE for LIBs but also paves the way for the design of SPE with excellent performances.
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2018
·
IF 3.997
Yong-E. Gao,Shuang Bai,Xiaoxiao Shi,Meili Hou,Xiaoqian Ma,Tian Zhang,Bo Xiao,Peng Xue,Yuejun Kang,Zhigang Xu
Nanomedicine based polymeric prodrug have showed high impact in the inhibition of tumor growth due to its high therapeutic efficiency and improved biocompatibility. Herein, we synthesized a novel star-like amphiphilic copolymer [β-CD–P(Ir- co -OEGMA), denoted as CPIO] through atom transfer radical polymerization (ATRP) to deliver the hydrophilic anticancer drug irinotecan (Ir). The polymer could form monodisperse unimolecular micelles and had excellent stability in aqueous solution. Moreover, the reduction-responsive feature of the micelles facilitated controlled release of drug, thus achieving targeted therapy and reduced toxicity to healthy cells. The in vitro cytotoxicity assays indicated that CPIO had a notable anticancer effect against HeLa and MCF-7 tumor cells. The confocal laser scanning microscopy and flow cytometry experiments revealed that CPIO micelles could be internalized into tumor cells efficiently. Furthermore, the obtained prodrug micelles produced better efficacy compared to free Ir. Moreover, the CPIO micelles showed excellent biocompatibility in vivo after intravenous injection on a mouse model. This study demonstrated that CPIO carrier could provide a rational design of a stimuli-responsive polymeric prodrug for delivery of irinotecan.
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2017
·Vol. 21
·期 8
·2355-2364
·
IF 2.316
Wang Ailian,Xu Hao,Zhou Qian,Liu Xu,Li Zhengyao,Gao Rui,Liu Xiangfeng,Zhang Liaoyun
A new composite polymer electrolyte membrane composed of hyperbranched star polymers (HBPS-(PMMA- b -PPEGMA) 30 (the hyperbranched star polymer with hyperbranched polystyrene as core and polymethyl methacrylate block poly(ethylene glycol) methyl ether methacrylate) as arms)), ionic liquid (1-butyl-3-methylimidazolium tetrafluoroborate (BMImBF 4 ) or 1-butyl-3-methylimidazolium hexafluorophosphate (BMImPF 6 )), and lithium bis(trifluoromethanesulfonyl) imide (LiTFSI) has been fabricated by solution casting method. This type of solid polymer electrolyte membrane shows an excellent flexibility, transparency, and free-standing properties. Room temperature ionic conductivity of composite electrolytes with 40 wt% BMImBF 4 or 40 wt% BMImPF 6 can reach 2.5 × 10 −4 and 4.1 × 10 −5 S cm −1 , respectively. The HBPS-(PMMA- b -PPEGMA) 30 /BMImPF 6 /LiTFSI (the composite polymer electrolyte with 1-butyl-3-methylimidazolium hexafluorophosphate) composite polymer electrolyte displays better performances including a good thermal stability with decomposition temperature of 350 °C, a wide electrochemical window with oxidation potential of 4.3 V, and the excellent interfacial compatibility with lithium electrode. Moreover, the Li/LiFePO 4 batteries based on HBPS-(PMMA- b -PPEGMA) 30 /BMImPF 6 /LiTFSI electrolyte retain about 96% of their highest discharge capacity (120.5 mAh g −1 ) after 100 cycles under a current density of 0.1 C at 60 °C, exhibiting the excellent reversible cyclability.
The free-standing composite electrolyte films composed of ionic liquids, hyperbranched star polymers and lithium salts show the high ionic conductivities.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2016
·Vol. 40
·期 10
·8397-8407
·
IF 3.277
Beibei Lu,Lei Li,Jianning Wu,Lulu Wei,Jun Hou,Zhiyong Liu,Xuhong Guo
Well-defined dual pH and temperature responsive triblock star-shaped amphiphilic copolymers of β-cyclodextrin-g-poly(2-hydroxyethylmethacrylate)-b-poly(N-isopropylacrylamide)-b-poly(2-(dimethylamino)ethylmethacrylate) (β-CD-g-(PHEMA-b-PNIPAM-b-PDMAEMA)) were synthesized by the combination of reversible addition–fragmentation chain transfer (RAFT) polymerizations. The chemical structures and compositions of these copolymers were characterized by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR), and gel permeation chromatography (GPC) measurements. Subsequently, the obtained triblock copolymers could self-assemble into micelles in aqueous solution owing to their amphiphilic property resulting from the hydrophobic β-CD core and the hydrophilic PHEMA, PNIPAM, and PDMAEMA segments, which were investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The triblock copolymer nanoparticles exhibited two separate lower critical solution temperatures (LCSTs) and these triblock copolymers in aqueous solutions were investigated at the different pH values of 5.0 and 7.4 as doxorubicin (DOX) delivery systems for controlled release. Polymeric micelles exhibited a pH controlled release performance. Investigation of DOX release from the micelles indicated that the release rate of the drug could be effectively controlled by altering the pH, encapsulating DOX in neutral surroundings (blood circulation or extracellular matrix) and triggering DOX release in acidic surroundings (intracellular endosomes). CCK-8 assays and confocal laser scanning microscopy (CLSM) against HeLa cells indicated that the polymeric micelles themselves had no associated cytotoxicity and possessed good biodegradability and biocompatibility and that the micelles identified the location of the DOX in the HeLa cells. On the other hand, the DOX-loaded micelles possessed a high cytotoxicity to HeLa cells and exhibited inhibition of the proliferation of HeLa cells. Hence, this type of biodegradable, biocompatible, and stimuli-responsive copolymer could serve as a promising material for drug delivery.
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高影响因子
FASEB JOURNAL
·
2024
·Vol. 38
·期 13
·e23781
·
IF 4.4
Wenfang Lai,Siying Huang,Junjie Liu,Binbin Zhou,Zhengshuang Yu,John Brown,Guizhu Hong
Reactive astrocytes are important pathophysiologically and synthesize neurosteroids. We observed that LPS increased immunoreactive TLR4 and key steroidogenic enzymes in cortical astrocytes of rats and investigated whether corticosteroids are produced and mediate astrocytic TLR4-dependent innate immune responses. We found that LPS increased steroidogenic acute regulatory protein (StAR) and StAR-dependent aldosterone production in purified astrocytes. Both increases were blocked by the TLR4 antagonist TAK242. LPS also increased 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and corticosterone production, and both were prevented by TAK242 and by siRNAs against 11β-HSD1, StAR, or aldosterone synthase (CYP11B2). Knockdown of 11β-HSD1, StAR, or CYP11B2 or blocking either mineralocorticoid receptors (MR) or glucocorticoid receptors (GR) prevented dephosphorylation of p-Ser 9 GSK-3β, activation of NF-κB, and the GSK-3β-dependent increases of C3, IL-1β, and TNF-α caused by LPS. Exogenous aldosterone mimicked the MR- and GSK-3β-dependent pro-inflammatory effects of LPS in astrocytes, but corticosterone did not. Supernatants from astrocytes treated with LPS reduced MAP2 and viability of cultured neurons except when astrocytic StAR or MR was inhibited. In adrenalectomized rats, intracerebroventricular injection of LPS increased astrocytic TLR4, StAR, CYP11B2, and 11β-HSD1, NF-κB, C3 and IL-1β, decreased astrocytic p-Ser 9 GSK-3β in the cortex and was neurotoxic, except when spironolactone was co-injected, consistent with the in vitro results. LPS also activated NF-κB in some NeuN + and CD11b + cells in the cortex, and these effects were prevented by spironolactone. We conclude that intracrine aldosterone may be involved in the TLR4-dependent innate immune responses of astrocytes and can trigger paracrine effects by activating astrocytic MR/GSK-3β/NF-κB signaling.
研究领域:
神经科学
·
免疫学
·
药理学
·
分子生物学
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PubMed
高影响因子
JOURNAL OF SURFACTANTS AND DETERGENTS
·
2015
·Vol. 19
·期 1
·129-135
·
IF 1.685
Li Xu,Xing Fenglan,Xu Qun,Sun Xiaolong,Wang Yuping,Wang Liyan,Wang Pinglang
A novel homologous series of trimeric anionic surfactants, 3C
n
TE3CNa (where n is a fatty acid chain length of 7, 10, or 12), with three hydrocarbon chains and three carboxylate heads connected via tri-etheric bonds were synthesized from long-chain α-bromo fatty acids and a triol, 1,1,1-tris(hydroxymethyl)ethane. The obtained trimeric carboxylic acids were esterified and purified by silica gel column chromatography, then hydrolyzed with dilute sodium hydroxide solution to form a series of trimeric carboxylate surfactant products. All prepared compounds were analyzed by IR, 1 H NMR, and 13 C NMR spectroscopy to confirm their chemical structures. Their surface-active properties were investigated. The critical micelle concentrations (cmc) of 3C
n
TE3CNa were in the range of 0.12–0.71 mmol/L, and the surface tensions at the cmc ( γ
cmc ) were 29.3–34.8 mN/m.
研究领域:
化学
·
材料科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）