ACS Nano
·
2017
·
IF 13.942
Xiao Sun,Ruohong Du,Li Zhang,Guilong Zhang,Xiaojia Zheng,Junchao Qian,Xiaohe Tian,Jiewen Zhou,Jiacai He,Yuanyin Wang,Yiqun Wu,Kai Zhong,Dongqing Cai,Duohong Zou,Zhengyan Wu
Incorporation of T1 and T2 contrast material in one nanosystem performing their respective MR contrast role and simultaneously serving as an efficient drug delivery system (DDS) has a significant potential application for clinical diagnosis and chemotherapy of cancer. However, inappropriate incorporation always encountered many issues, such as low contact area of T1 contrast material with water-proton, inappropriate distance between T2 contrast material and water molecule, and undesirable disturbance of T2 contrast material for T1 imaging. Those issues seriously limited the T1 or T2 contrast effect. In this work, we developed a yolk-like Fe3O4@Gd2O3 nanoplatform functionalized by polyethylene glycol and folic acid (FA), which could efficiently exert their tumor targeted T1–T2 dual-mode MR imaging and drug delivery role. First, this nanoplatform possessed a high longitudinal relaxation rate (r1) (7.91 mM–1 s–1) and a stronger transverse relaxation rate (r2) (386.5 mM–1 s–1) than that of original Fe3O4 (268.1 mM–1 s–1). Second, cisplatin could be efficiently loaded into this nanoplatform (112 mg/g) and showed pH-responsive release behavior. Third, this nanoplatform could be effectively internalized by HeLa cells with time and dosage dependence. Fourth, the FA receptor-mediated nanoplatform displayed excellent T1–T2 dual mode MR contrast enhancement and anticancer activity both in vitro and in vivo. Fifth, no apparent toxicity for vital organs was observed with systemic delivery of the nanoplatform in vivo. Thus, this nanoplatform could be a potential nanotheranostic for tumor targeted T1–T2 dual-mode MR imaging and chemotherapy.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
高影响因子
INORGANIC CHEMISTRY
·
2015
·
IF 4.762
Mingtai Sun,Huan Yu,Huihui Li,Hongda Xu,Dejian Huang,Suhua Wang
A weakly fluorescent complex derived from a binaphthol–benzimidazole ligand was designed and synthesized for hydrogen sulfide at different pH conditions. It was demonstrated that the probe showed the same reactivity to various hydrogen sulfide species in a broad range of pH values to generate highly fluorescent product through a displacement reaction mechanism, whereas the product’s fluorescence spectrum exhibited a hypsochromic shift of ∼73 nm (2393 cm–1) as pH increased from neutral to basic, which can be used for distinguishing the various species of hydrogen sulfide. This turn-on fluorescence probe was highly selective and sensitive to hydrogen sulfide with a detection limit of 0.11 μM. It was then applied for evaluating the total content of sulfide (including hydrogen sulfide, hydrosulfide, and sulfide) as well as for the visual detection of gaseous H2S in air using a simple test paper strip.
研究领域:
分析化学
·
生物化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 43
·6770-6777
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IF 5.047
Pan Yuan,Zheng Ruan,Tuanwei Li,Youliang Tian,Quan Cheng,Lifeng Yan
Mannose has been reported as a novel drug to kill cancer cells. The prodrug of mannose will promote its targeted delivery and enrichment at the tumor site and cancer cells. Here, a pH-sensitive polypeptide copolymer with a tertiary amine group has been prepared and a mannose molecule was conjugated to the polymer through the formation of a Schiff base. At the same time, an iodinated boron dipyrromethene (BDPI) photosensitizer with high singlet oxygen generation efficacy and near infrared (NIR) fluorescence was encapsulated by the nanoparticles, which makes it a potential pH-sensitive NIR imaging-guided chemotherapy/PDT agent. In vitro and in vivo studies reveal that in a tumor acidic environment, the protonation of the tertiary amine group destroyed the nanostructure of the nanoparticles, resulting in increased BDPI release. Meanwhile, the bond cleavage of the Schiff base led to the release of conjugated mannose and synergistic inhibition of tumor cell growth with the PDT effect was realized. The combination of these two kinds of tumor suppression effects and photodynamic therapy made this pH-sensitive polypeptide delivery system show great potential for further cancer therapy.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
Artificial Cells Nanomedicine and Biotechnology
·
2021
·
IF 5.678
Xiangcai Zou,Zhipeng Jiang,Liang Li,Zonghai Huang
Cancer-targeted drug delivery systems based on nanoparticles (NPs) have been considered promising therapies. In this study, we developed a pH-responsive smart NPs drug delivery system using silk fibroin (SF), selenium nanoparticles (Se NPs), fingolimod (FTY720), and heptapeptide (T7). The prepared FTY720@T7-SF-Se NPs were spheres with an average diameter of 120 nm, which would contribute to the enhanced permeability and retention effects in tumour regions. The encapsulation efficiency (EE) of the FTY720@T7-SF-Se NPs was 71.95 ± 3.81%. The release of FTY720 from the nanocarriers was pH-dependent, and the release of FTY720 was accelerated in an acidic environment. Both in vitro and in vivo studies showed that FTY720@T7-SF-Se NPs had an enhanced cellular uptake selectivity and antitumor activity for thyroid cancer. The bio-distribution study in vivo further demonstrated that FTY720@T7-SF-Se NPs could effectively accumulate in the tumour region, thereby enhancing the ability to kill cancer cells in vivo. In addition, studies of histology and immunohistochemistry showed that FTY720@T7-SF-Se NPs had low toxicity to the major organs of tumour-bearing mice, indicating the prepared NPs has good biocompatibility in vivo. These results suggest that the tumour-targeted NPs delivery system (FTY720@T7-SF-Se NPs) has great potential as a new tool for thyroid cancer therapy.
研究领域:
药剂学
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肿瘤学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
CELLULOSE
·
2020
·Vol. 27
·期 11
·6367-6381
·
IF 4.21
Cui Li,Hu Jin-jing,Wang Wei,Yan Chao,Guo Yi,Tu Chao
Abstract A kind of smart calcium alginate fiber having pH indicating properties was proposed to monitor wound healing. The smart calcium alginate fiber was prepared by dyeing the hydroxypropyl trimethyl ammonium chloride chitosan (HACC) modified calcium alginate fiber with alizarin dye and anthocyanin dye, respectively. It was worth noting that modification of calcium alginate fibers with HACC enhanced the dyeing and antibacterial properties, simultaneously. When the concentration of HACC was 10 g/L, the modified calcium alginate fiber had the best dyeing performance. At the same time, the dyeing process had no significant influence on the mechanical properties of the fibers with the strength loss only around 0.2 cN/dtex. The smart calcium alginate fibers exhibited a rapid and significant color change and reversible color response at pH 2–11. Moreover, the color change could be easily observed by naked eye. Therefore, the prepared calcium alginate fibers could be a good candidate for intelligent wound dressings for visual monitoring of wound healing. Graphic abstract
研究领域:
生物材料学
·
医学工程
·
化学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF FLUORESCENCE
·
2024
·
IF 2.6
Xue Weijian,Ling Xiangyu,Li Huiqian,Liu Yuhang,Zhao Bing,Yin Yanbing
In this work, a series of dibenzimidazole derivatives 1 – 4 , act as highly reversible colorimetric and fluorescent pH chemosensor, were designed and synthesized. Excellent reversible pH response of these sensors could be found by a specific pH change through obvious fluorescent color changes. The response is not affected by common cations (including Al 3+ , Cu 2+ , Ca 2+ , Cd 2+ , Co 2+ , Cr 3+ , Mg 2+ , Na + , K + , Ni 2+ , Pb 2+ and Zn 2+ ) and anions (including F − , Cl − , Br − , I − , ClO 4 − , H 2 PO 4 − , HSO 4 − , HCO 3 − and CH 3 COO − ). Notably, these sensors can be reused more than 10 times without losing functionality. Unlike previous reports, the distinct properties of 1 – 4 are attributed to the varied link groups. Based on comprehensive experimental data and mechanistic analyses, it is concluded that sensors 1 – 4 are promising candidates for use as highly reversible “on-off-on” fluorescence switches under precise pH control. Graphic Abstract
研究领域:
化学传感器
·
材料科学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS PROCESSING TECHNOLOGY
·
2025
·
IF 7.5
Fukun Li,Yang Bai,HaiXiang Hu,Guanbo Qiao,Lingzhong Li,Feng Zhang,Xuejun Zhang
Achieving atomic-level surface integrity while maintaining a high material removal rate (MRR) remains a fundamental challenge in the polishing of fused silica due to its high hardness and brittleness. This study establishes a novel mechanistic framework for understanding how pH-driven interfacial bond dynamics govern chemo-mechanical polishing processes. By integrating multiscale experimental characterization (XPS, FTIR, Raman spectroscopy) with ReaxFF molecular dynamics simulations, we demonstrate for the first time that the dynamic equilibrium between the formation and rupture of Ce–O–Si interfacial bonds directly control removal efficiency and surface quality. Alkaline conditions enhance OH – activity, facilitating Si–O bond hydrolysis and stable Ce–O–Si linkage formation, resulting in the highest MRR (397.6 nm/min). Acidic environments promote citrate-mediated Ce 3 + complexation and nanocluster dispersion, enabling a rolling mechanism that achieves ultra-smooth surfaces (Sq = 0.086 nm). In contrast, neutral pH conditions suffer from PEG adsorption blocking active sites, leading to a 62 % reduction in MRR relative to alkaline systems. A 12.2-fold increase in MRR compared to SiO 2 abrasives (32.67 nm/min) confirms that chemical interfacial dynamics, rather than mechanical abrasion alone, are critical to material removal. This fundamental advancement provides a broadly generalizable theoretical basis for designing efficient, low-damage precision polishing processes across oxide-based optical materials and beyond.
研究领域:
材料科学
·
化学工程
·
光学材料加工
✓ 已验证
产品关联
DOI
高影响因子
Environmental Chemistry and Ecotoxicology
·
2025
·
IF 8.2
Zhigang Yang,Jiani Liu,Chunyu Chen,Khor Waiho,Chenchen Zhang,Aqin Chen,Youji Wang
Microplastics (MPs) pollution and freshwater acidification represent emerging threats to aquatic ecosystems. The combined toxic effects of these stressors on crustaceans and their underlying immune-metabolic mechanisms remain poorly understood. This study investigated the individual and combined toxic effects of low pH and polystyrene MPs on the Chinese mitten crab ( Eriocheir sinensis ). Through a 21-day exposure experiment combined with enzyme activity analysis, gut microbiota profiling, and hepatopancreas metabolomics, the findings revealed: (1) Combined exposure to low pH (pH 6.5) and MPs exacerbated oxidative damage and immune suppression, demonstrating synergistic toxicity; (2) MPs alone primarily affected pyrimidine metabolism, whereas combined exposure significantly disrupted the tricarboxylic acid (TCA) cycle and arginine biosynthesis while activating serotonin metabolism; (3) Although the α-diversity of gut microbiota remained stable, its COG functional profile underwent significant alterations. The results indicate that freshwater acidification amplifies the toxic effects of MPs on crustaceans through immune-metabolic interactions, highlighting the urgency of assessing multiple environmental stressors in the context of climate change. The study provides novel mechanistic insights for aquatic ecological risk assessment.
研究领域:
环境科学
·
生态毒理学
·
分子生物学
✓ 已验证
DOI
高影响因子
FOOD HYDROCOLLOIDS
·
2020
·
IF 7.053
Xingzhong Zhang,Xiaogang Luo,Yixiang Wang,Yan Li,Bin Li,Shilin Liu
In this work, concentrated Pickering emulsions had been prepared by using soybean protein isolate (SPI) and TEMPO-oxidized bacterial cellulose (TOBC) complex as solid stabilizers. The effects of solid particle content, pH and oil phase volume fraction on the morphology, stability and rheological behaviors of the emulsions had been investigated. It indicated that the emulsion droplets had uniform particle size distribution when the ratio of SPI/TOBC was controlled to 12.5:1 (wt/wt). The emulsification performance could be improved with the increase of solid complex particles content from 1.0% to 3.0%. Moreover, the pH played an important role in regulating the structure and properties of the emulsions. With microscopic observation, the emulsions at pH 7.0 had smaller droplet size (10–15 μm) than that (15–40 μm) of the emulsions at pH 3.0. While the emulsions at pH 3.0 maintained a low creaming index (CI) value than those at pH 7.0, and uniform cellular network structure could be seen by SEM observation. It suggested that the electrostatic complexation between soy proteins and anionic bacterial cellulose nanofibrils at pH 3.0 was more favorable for stabilizing emulsions than those at pH 7.0. This work would provide some guidance for regulating the properties of emulsions that stabilized by soy protein and cellulose nanofibrils.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
·
2019
·
IF 3.829
Mengna Liu,Bingjie Wang,Chunjing Guo,Xiaoya Hou,Ziting Cheng,Daquan Chen
In this study, novel multifunctional folic acid, biotin, and CD44 receptors targeted and pH-sensitive “nano-actiniaes” were fabricated with icariin (ICA) and curcumin (Cur) as loaded model drugs for breast cancer therapy. The newly synthesized polymer oligomeric hyaluronic acid-hydrazone bond-folic acid-biotin (Bio-oHA-Hyd-FA) was characterized by 1H NMR spectrogram (proton nuclear magnetic resonance). The obtained drug carrier Bio-oHA-Hyd-FA self-assembled into nanomicelles, named as “nano-actiniaes”, in aqueous media with hydrodynamic diameter of 162.7 ± 5 nm. The size, surface zeta potential, and morphology of the “nano-actiniaes” were observed via TEM. The in vitro release experiment indicated that much more encapsulated icariin (ICA) and curcumin (Cur) were released from the Bio-oHA-Hyd-FA micelles (nano-actiniaes) in the acidic environment. Additionally, the cytotoxicity research demonstrated that the Bio-oHA-Hyd-FA carrier material was completely nontoxic, and the ICA&Cur “nano-actiniaes” had greater cytotoxicity compared with other control groups. In addition, the “nano-actiniaes” were found to significantly inhibit cancer cell invasion by Transwell assay. Moreover, in vivo evaluation of anti-tumor effect illustrated that the ICA and Cur “nano-actiniaes” possessed inhibitory effect on tumors. Consequently, the multi-targeted pH-sensitive “nano-actiniaes” can realize significant tumor targeting and effectively inhibit tumor growth.
研究领域:
药剂学
·
肿瘤学
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2016
·Vol. 409
·期 5
·1387-1394
·
IF 3.125
Li Songyang,Liu Zhiming,Su Chengkang,Chen Haolin,Fei Xixi,Guo Zhouyi
The biological pH plays an important role in various cellular processes. In this work, a novel strategy is reported for biological pH sensing by using Raman spectroscopy and polyaniline nanoparticles (PANI NPs) as the pH-sensitive Raman probe. It is found that the Raman spectrum of PANI NPs is strongly dependent on the pH value. The intensities of Raman spectral bands at 1225 and 1454 cm −1 increase obviously with pH value varying from 5.5 to 8.0, which covers the range of regular biological pH variation. The pH-dependent Raman performance of PANI NPs, as well as their robust Raman signals and sensitivities to pH, was well retained after the nanoparticles incorporated into living 4T1 breast adenocarcinoma cells. The data indicate that such PANI NPs can be used as an effective biological pH sensor. Most interestingly, the PANI spherical nanostructures can be acquired by a low-cost, metal-free, and one-pot oxidative polymerization, which gives them excellent biocompatibility for further biological applications.
研究领域:
生物化学
·
分析化学
·
材料科学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2020
·
IF 6.092
Zexuan Ding,Guhuan Liu,Jinming Hu
Visualization of intracellular transport pathways is crucial to investigate the internalization mechanism and understand the intracellular behavior of nanomaterials. Herein, we rationalized the design of micellar nanoparticles (NPs) for ratiometric fluorescent mapping of intracellular pH and glutathione (GSH), two essential parameters for maintaining normal cellular functions. Specifically, pH-sensitive naphthalimide-based probe (NPI) and pH-inert rhodamine B (RhB) were covalently labeled to double hydrophilic block copolymers (DHBCs) using the thiolactone chemistry, enabling the covalent attachment of NPI and RhB to one molecule with a redox-responsive disulfide linkage. The dually labeled DHBCs exhibited blue/orange dual emissions in acidic pH, which was further converted into green/orange dual emissions in neutral pH because of the deprotonation of NPI moieties and the sole green emission in the presence of GSH at neutral pH because of the decreased Förster resonance energy transfer efficiency between an NPI donor and an RhB acceptor as a result of GSH-mediated cleavage of disulfide bonds. These remarkable ratiometric fluorescence changes allowed for not only the simultaneous mapping of the intracellular pH and GSH but also the intracellular transport pathways of internalized NPs.
研究领域:
生物医学工程
·
分子生物学
·
纳米医学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）