Nature Communications
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2021
·Vol. 12
·期 1
·1-11
·
IF 14.919
Wang Jinling,Dai Xingchao,Wang Hualin,Liu Honglai,Rabeah Jabor,Brückner Angelika,Shi Feng,Gong Ming,Yang Xuejing
Diminishing fossil fuel resources and calls for sustainability are driving the urgent need for efficient valorization of renewable resources with high atom efficiency. Inspired from the natural goethite mineral with Mn paragenesis, we develop cost-effective MnO 2 /goethite catalysts for the efficient valorization of dihydroxyacetone, an important biomass-based platform molecule, into value-added glycolic acid and formic acid with 83.2% and 93.4% yields. The DHA substrates first undergo C−C cleavage to selectively form glycolic acid and hydroxymethyl (·CH 2 OH) radicals, which are further oxidized into formic acid. The kinetic and isotopic labeling experiments reveal that the catalase-like activity of MnO 2 turns the oxidative radicals into oxygen, which then switches towards a hydroxymethyl peroxide (HMOO) pathway for formic acid generation and prevents formic acid over-oxidation. This nature-inspired catalyst design not only significantly improves the carbon efficiency to 86.6%, but also enhances the oxygen atom utilization efficiency from 11.2% to 46.6%, indicating a promising biomass valorization process.
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CELLULOSE
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2021
·Vol. 29
·期 2
·941-952
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IF 5.044
Hu Tao,Hu Xiaoli,Tang Cheng,Liu Dan
This paper describes the synthesis of a novel chelating material derived from cellulose, and its heavy metal ion adsorption properties from aqueous solution. The first section of this paper reports the chemical grafting of cellulose, that amino acetic acid groups were grafted onto the cellulose by in situ synthesis, a novel yet unreported modified cellulose derivative N,N-(dicarboxymethylaminoethyl, carboxymethyl)aminoethylamine carboxymethyl cellulose amide was synthesized. This obtained adsorbent was characterized by elemental analysis, infrared spectroscopy (IR) and Solid State Nuclear Magnetic Resonance (SSNMR) 13 C NMR spectroscopy. In the second section, the adsorption of Cu 2+ and Pb 2+ from single metal ion aqueous solutions onto this adsorbent were evaluated and analyzed by the Freundlich and Langmuir models. Further more, adsorption capacity for Ba 2+ , Mg 2+ , Mn 2+ , Co 2+ , Zn 2+ , Pb 2+ , Ni 2+ and Cu 2+ , and the competitive adsorption of this adsorbent between ions were also evaluated by ICP spectroscopy. The results indicated that this modified cellulose exhibited adsorption properties similar to those of EDTA, and showed good adsorption capacity for a wide range of metal ions.
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JOURNAL OF SOILS AND SEDIMENTS
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2021
·Vol. 22
·期 2
·470-481
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IF 3.308
Zhang Wantong,Kang Xiaoming,Kang Enze,Audet Joachim,Davidson Thomas A.,Zhang Xiaodong,Yan Liang,Li Yong,Yan Zhongqing,Zhang Kerou,Wang Jinzhi,Hu Zhengyi
Purpose Alpine wetland ecosystems can contribute large amounts of methane (CH 4 ) to the atmosphere; however, their emissions vary with environmental conditions. Microbial activity is known to drive CH 4 emissions, but how environmental conditions determine microbial activity is still uncertain. Here, we seek to quantify the variability of the CH 4 flux, to detect the effects of CH 4 -related microbes on CH 4 emissions, and to study the dependency of these effects on environmental conditions. Materials and methods We measured the CH 4 flux, environmental conditions, and CH 4 -related microbial communities ( mcrA and pmoA gene abundances for methanogens and methanotrophs, respectively) under three hydrological conditions (submerged, soil–water interface, and emerged) from seven sampling sites in the Zoige alpine wetland, China. Results and discussion The CH 4 flux varied greatly from 0 to 41 mg m −2 h −1 in the Zoige alpine wetland. The methanogenic and methanotrophic abundances both showed positive correlations with CH 4 flux, while CH 4 flux increased linearly with the increase of soil water content (SWC) when SWC was above 60%. CH 4 flux and methanogenic and methanotrophic abundances maintained the high levels when soil C:N ratio was in the range of 11–24 and decreased exponentially with the increase of soil DOC:TN ratio in Zoige alpine wetland, which might result from its influence on nutrient supply for microbial decomposition process. Conclusion The results provided new insight into the effects of CH 4 -related microbes on CH 4 emission and its response to different environmental conditions and helped us to comprehend the risks of high CH 4 emissions from alpine wetlands under climatic change and anthropogenic disturbance.
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MACROMOLECULAR RESEARCH
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2021
·Vol. 29
·期 10
·727-734
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IF 2.227
Yang Haiyang,Li Duxin,Yang Jun,Wang Jin,Gan Shunchang,Cao Kaikai,Liu Yufeng
Polyamide-imide (PAI) materials with good heat resistance, excellent friction, wear properties, and low water absorption were prepared by acyl chloride process with diamine monomer containing trifluoromethyl in the side chain. The results showed that PAI prepared from 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine without flexible hinge group had the best heat resistance, with T g as high as 302.6 °C and T d5% as 490.1 °C. With the increase of the proportion of flexible hinge groups in diamine monomer, the thermal properties of PAI materials would decrease. The wear mechanism of PAI prepared from 2,2′-bis(trifluoromethyl)-[1,1′-biphenyl]-4,4′-diamine was mainly adhesive wear. With the increase of the proportion of flexible hinge groups in diamine monomer, the wear mechanism would change from abrasive wear, slight adhesive wear to severe adhesive wear. The friction coefficient and wear loss of PAI prepared by 1,4-bis(4-amino-2-trifluoromethylphenoxy)benzene were the smallest, which were 0.4706 and 3.5, respectively. PAI synthesized by diamine monomer containing trifluoromethyl had low water absorption and high water contact angle. With the increasing flexibility of monomer containing trifluoromethyl diamine, the elongation at break and tensile strength of the material increased gradually.
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Journal of Inorganic and Organometallic Polymers and Materials
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2021
·Vol. 32
·期 2
·478-485
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IF 3.543
Abdallah Rusul Mohammed,Al-Haddad Raad M. S.
Core–shell nanoparticles (CSNPs) have attracted attention in biomedical applications as they have highly useful materials with modified characteristics, such as high stability, dispersibility, higher permeability to certain target cells and reduction in consumption of precious materials. Synthesis of core–multishell nanoparticles with suitable sizes, structural characteristics and absorption using simple methods continues to be a challenge. In this study, \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs were synthesized in three stages to control their size and the potential for tuning their properties. Field emission scanning electron microscope images confirmed that \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs have a small particle size of about 22.5 nm, average crystalline size in X-ray diffractometer analysis was 22.8 nm, stability was about − 49.1 mV, and synthesis with magnetic and optical properties improved their biocompatibility. Treatment of CAL-51 and HBL-100 cell lines by \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs under NIR laser and alternating magnetic field generated enough heat to increase cell death.
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
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2023
·
IF 3.6
Chen Min,Huang Shanjiao,Weng Shuoyun,Weng Junting,Guo Rongjie,Shi Bingbing,Liu Danjuan
Septic cardiomyopathy (SCM) is manifested by impairment of cardiac contractile function with myocardial mitochondrial dysregulation. Natural product, songorine (SGR), a diterpenoid alkaloid derived from the lateral root of Aconitum carmichaeli , has been reported for the treatment of heart failure. Here, the protective role of SGR in heart injury of SCM was investigated and its underlying action of mechanism was explored. Firstly, the mouse and cardiomyocytes (H9C2 cell) SCM model induced by LPS were established to evaluate the therapeutic effect of SGR. The in vivo results exhibited that SGR rescued the survival rate of SCM mice, restored the loss of ejection fraction (EF) and fractional shortening (FS), and reduced left ventricular systolic diameter and left ventricular diastole diameter (LVIDs, LVIDd) by echocardiography. SGR improved the mitochondrial biosynthesis and myocardial fiber structure and arranged them neatly by transmission electron microscope (TEM). Further, SGR inhibited inflammatory targets myeloperoxidase (MPO) and tumor necrosis factor (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6), and plasminogen activator inhibitor-1 (PAI-1). And SGR activated the mitochondrial biosynthesis–related peroxisome proliferator–activated receptor-γ coactivator-1α (PGC-1α), β-catenin, and matrix metallopeptidase 2 (MMP2) proteins. Meanwhile, the in vitro results showed that SGR promoted the increased the myocardial H9C2 cell viability, and mitochondrial biosynthesis and structure. SGR also blocked the inflammatory factors and reversed PGC-1α, β-catenin, and MMP2 in vitro, while SGR alleviated the myocardial cell apoptosis via flow cytometry. The findings indicate that SGR mitigates sepsis-caused myocardial damage by Wnt/β-catenin signaling pathway–mediated mitochondrial biosynthesis. SGR may be a promising candidate for treatment of SCM. Graphical Abstract
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Drug Delivery and Translational Research
·
2023
·
IF 5.4
Liu Jie,Lin Chenshi,Wu Man,Wang Yingjie,Chen Shenyu,Yang Taiwang,Xie Chenlu,Kong Yue,Wu Wenliang,Wang Jiaping,Ma Xiaonan,Teng Chao
Uric acid is the final metabolite in humans. High level of uric acid chronically induces urate deposition, aggravates kidney damage, and concomitantly causes an increase in inflammatory factors. Alleviating acute inflammation and decreasing uric acid levels are the key points in the treatment of inflammatory diseases associated with high uric acid. However, a drug delivery system that combines anti-inflammatory and uric acid reduction functions at the same time remains a challenge to be settled. Here, we designed a nanocrystal-based co-delivery platform, IND Nplex, characterized by loading of indomethacin (IND) and uricase. Compared with free IND or uricase, IND Nplex possessed a better anti-inflammatory effect by restraining the release of inflammation-related factors in vitro. In addition, pharmacokinetic and biodistribution studies revealed that IND Nplex significantly prolonged the retention time in vivo and was more concentrated in the kidney. In acute gouty arthritis model rats, IND Nplex markedly relieved ankle joint swelling and mitigated synovial inflammation. In acute kidney injury model rats, IND Nplex indicated better biocompatibility and significant amelioration of renal fibrosis. Moreover, IND Nplex showed the effect of anti-inflammatory and improved renal function via determination of inflammatory factors and biochemical markers in the serum and kidney. In conclusion, these results indicate that IND Nplex exerts anti-inflammatory activity and uric acid–lowering effect and could become a promising candidate for the treatment of uric acid–related diseases. Graphical Abstract
In this study, a stable neutral co-delivery platform (IND Nplex) was fabricated by using a co-delivery strategy, allowing for a combination of the anti-inflammation drug IND and the metabolic enzyme uricase. IND Nplex showed a good therapeutic effect on rats with acute gouty arthritis or acute kidney injury due to the dual effects of anti-inflammatory and uric acid lowering. This platform provided a novel strategy for high uric acid–related illnesses.
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Scientific Reports
·
2023
·Vol. 13
·期 1
·1-12
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IF 4.6
Huang Huiming,Zou Hui,Lin Hongting,Dai Yimin,Lin Jiangbo
Plants with partial or complete loss of chlorophylls and other pigments are frequently occurring in nature but not commonly found. In the present study, we characterize a leaf color mutant ‘ arly01 ’ with an albino stripe in the middle of the leaf, which is an uncommon ornamental trait in Anoectochilus roxburghii . The albino “mutant” middle portion and green “normal” leaf parts were observed by transmission electron microscopy (TEM), and their pigment contents were determined. The mutant portion exhibited underdevelopment of plastids and had reduced chlorophyll and other pigment (carotenoid, anthocyanin, and flavonoid) content compared to the normal portion. Meanwhile, comparative transcript analysis and metabolic pathways mapping showed that a total of 599 differentially expressed genes were mapped to 78 KEGG pathways, most of which were down-regulated in the mutant portion. The five most affected metabolic pathways were determined to be oxidative phosphorylation, photosynthesis system, carbon fixation & starch and sucrose metabolism, porphyrin and chlorophyll metabolism, and flavonoid biosynthesis. Our findings suggested that the mutant ‘ arly01 ’ was a partial albinism of A. roxburghii , characterized by the underdevelopment of chloroplasts, low contents of photosynthetic and other color pigments, and a number of down-regulated genes and metabolites. With the emergence of ornamental A. roxburghii in southern China, ‘ arly01 ’ could become a popular cultivar due to its unique aesthetics.
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IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
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2023
·
IF 2.1
Ke Shenghui,Feng Yiwei,Luo Liying,Qin Wanzhao,Liu Huayu,Nie Jingchong,Liang Beijiang,Ma Hongjie,Xie Mao,Li Jingyu,Niu Zhijie,Li Guojian,Tang Anzhou,Xia Wei,He Guangyao
A method for the in vitro isolation, purification, identification, and induced differentiation of satellite cells from adult tree shrew skeletal muscle was established. The mixed enzyme digestion method and differential adhesion method were used to obtain skeletal muscle satellite cells, which were identified and induced to differentiate to verify their pluripotency. The use of a mixture of collagenase II, hyaluronidase IV, and DNase I is an efficient method for isolating adult tree shrew skeletal muscle satellite cells. The P3 generation of cells had good morphology, rapid proliferation, high viability, and an “S”-shaped growth curve. Reverse transcription-polymerase chain reaction (RT-PCR) and immunofluorescence staining indicated that marker genes or proteins were expressed in skeletal muscle satellite cells. After myogenic differentiation was induced, multiple-nucleated myotubes were observed, and the MyHC protein was expressed. The expression of myogenic marker genes changed with the differentiation process. After the induction of adipogenic differentiation, orange-red lipid droplets were observed, and the expression of adipogenic marker genes increased gradually with the differentiation process. In summary, satellite cells from adult tree shrew skeletal muscle were successfully isolated using a mixed enzyme digestion method, and their potential for differentiation into myogenic and adipogenic cells was confirmed, laying a foundation for further in vitro study of tree shrew muscle damage.
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Journal of Analysis and Testing
·
2023
·
IF 4.7
Chai Shuiqin,Chi Yuting,Sun Wanlin,Pei Xinyu,Pei Shuchen,Sun Chengyu,Luo Kang,Yao Bo
Silicon quantum dots (SiQDs) with high water-soluble and favorable photostability were prepared by a one-step hydrothermal method. The average diameter of SiQDs was 2.02 nm characterized by transmission electron microscope. It was to be noted that the as-prepared SiQDs showed effective antibacterial activity, which was attributed to electrostatic interaction and the generation of reactive oxygen species. The minimum inhibitory concentration of SiQDs against Escherichia coli and Staphylococcus aureus was 0.45 mg/mL and 0.38 mg/mL, respectively. Besides, based on the static quenching effect-induced fluorescence quenching mechanism, the SiQDs exhibited high sensitivity and selectivity for detecting tetracyclines (TC). A good linear relationship was obtained between the fluorescence intensity of SiQDs and the concentration of tetracycline (TC) in the range of 0–0.08 μmol/L ( R 2 = 0.9993) with a detection limit of 0.0176 μmol/L. Furthermore, the TC content in the honey samples was determined using the SiQDs. All the results suggest that the as-prepared SiQDs can be a potential fluorescent probe for application in antibacterial and analysis.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-13
·
IF 16.6
Dang Qi,Zhang Wei,Liu Jiqing,Wang Liting,Wu Deli,Wang Dejin,Lei Zhendong,Tang Liang
Photoelectrochemical (PEC) systems have emerged as a prominent renewable energy-based technology for wastewater treatment, offering sustainable advantages such as eliminating dependence on fossil fuels or grid electricity compared to traditional electrochemical treatment methods. However, previous PEC systems often overlook the potential of ions present in wastewater as an alternative to externally applied bias voltage for enhancing carrier separation efficiency. Here we report a bias-free driven ion assisted photoelectrochemical (IAPEC) system by integration of an electron-ion acceptor cathode, which leverages its fast ion-electron coupling capability to significantly enhance the separation of electrons and holes at the photoanode. We demonstrate that Prussian blue analogues (PBAs) can serve as robust and reversible electron-ion acceptors that provide reaction sites for photoelectron coupling cations, thus driving the hole oxidation to produce strong oxidant free radicals at photoanode. Our IAPEC system exhibits superior degradation performance in wastewater containing chloride medium. This indicates that, in addition to the cations (e.g., Na + ) accelerating the electron transfer rate, the presence of Cl – ions further enhance efficient and sustainable wastewater treatment. This work highlights the potential of utilizing abundant sodium chloride in seawater as a cost-effective additive for wastewater treatment, offering crucial insights into the use of local materials for effective, low-carbon, and sustainable treatment processes.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2023
·
IF 2.3
Zhang Cong,Feng Shuangjiu,Kan Xucai,Chi Shangpeng,Sun Wei,Li Mingling,Liu Xiansong
Soft magnetic composites mean ferromagnetic powder coated by an electrical insulation layer, which is often used for high-power electromagnetic applications. In this work, toroidal magnetic cores such as FeSiAl and FeNi were fabricated by injection molding, and the electromagnetic properties were studied. Magnetic hysteresis loops of composite samples were measured at 25 and 100 °C to study the change of saturation magnetization and coercivity at room temperature and operating temperature. Effective permeability values of magnetic cores were between 8.8 and 18.9, and they were relatively stable within the frequency range of 70 MHz. Each kind of magnetic core shows low power loss at the frequency range of 100 kHz to 1 MHz, and the power loss of FeSiAl core was as low as 168 mW/cm 3 at 1 MHz and 20 mT. DC bias permeability of all samples exceeded 70% at a bias field of 300 Oe. Compared with the high-pressure molded core, the injection magnetic cores have lower power loss and good DC bias characteristics, which are beneficial to the application of high frequency and high current.
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