Nature Communications
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2023
·Vol. 14
·期 1
·1-14
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IF 16.6
Dai Shang,Xie Zhenming,Wang Binqiang,Ye Rui,Ou Xinwen,Wang Chen,Yu Ning,Huang Cheng,Zhao Jie,Cai Chunhui,Zhang Furong,Buratto Damiano,Khan Taimoor,Qiao Yan,Hua Yuejin,Zhou Ruhong,Tian Bing
Protocell fitness under extreme prebiotic conditions is critical in understanding the origin of life. However, little is known about protocell’s survival and fitness under prebiotic radiations. Here we present a radioresistant protocell model based on assembly of two types of coacervate droplets, which are formed through interactions of inorganic polyphosphate (polyP) with divalent metal cation and cationic tripeptide, respectively. Among the coacervate droplets, only the polyP-Mn droplet is radiotolerant and provides strong protection for recruited proteins. The radiosensitive polyP-tripeptide droplet sequestered with both proteins and DNA could be encapsulated inside the polyP-Mn droplet, and form into a compartmentalized protocell. The protocell protects the inner nucleoid-like condensate through efficient reactive oxygen species’ scavenging capacity of intracellular nonenzymic antioxidants including Mn-phosphate and Mn-peptide. Our results demonstrate a radioresistant protocell model with redox reaction system in response to ionizing radiation, which might enable the protocell fitness to prebiotic radiation on the primitive Earth preceding the emergence of enzyme-based fitness. This protocell might also provide applications in synthetic biology as bioreactor or drug delivery system.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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2023
·
IF 5.8
Wang Lanbin,Chen Yu,Xu Yangming,Ma Yanping,Du Yaguang
With the shortage of high-quality raw materials and increasingly strict environmental regulations, the recovery of metals from copper slag and pyrolusite has become a research hotspot. A novel method for simultaneously extracting Mn and Fe from pyrolusite and copper slag has been proposed. Under the optimal conditions (Copper slag / Pyrolusite = 2, H 2 SO 4 = 2 M, liquid—solid ratio = 10, T = 90 ℃, holding time = 60 min), the leaching efficiencies of Mn and Fe can reach 98.28% and 99.04%, respectively. In addition, the treated residue containing 60.04 wt% SiO 2 can be used as a raw building material. Through chemical kinetics and mineralogical transformation analyses, Fe 2 SiO 4 in copper slag decomposes to release Fe 2+ , which can reduce and leach Mn from pyrolusite. The unreacted shrinkage nuclear reaction model under the control of the surface chemical reaction is the most suitable model to describe the process, and when the apparent activation energy is 35.50 kJ/mol, the apparent rate equation is:
$$1-{\left(1-\times \right)}^{1/3}=979.65{\left[\mathrm{CS}/\mathrm{Pyrolusite}\right]}^{2.6072}{\left[{\mathrm{H}}_{4}{\mathrm{SO}}_{4}\right]}^{1.3143}{\left[\mathrm{L}/\mathrm{S}\right]}^{0.5649}e\mathrm{xp}\left(-35.50/\mathrm{RT}\right)$$ Graphical Abstract
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RARE METALS
·
2023
·Vol. 43
·期 2
·647-657
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IF 8.8
Ou Chuan,Tan Ming-Dong,Li Zhen-Bang,Li Zhao-Jie,Tian Fei,Qiao Zheng-Ping,Lei Dan-Ni,Wang Cheng-Xin
Owing to its high theoretical capacity and low cost, Sn has attracted significant attention in sodium-ion batteries. However, the slow kinetics of electrochemical reactions and the rapid decay of capacity resulting from drastic changes in the volume of Sn, as well as persistent side reactions between Sn and the organic electrolyte during the (de)sodium process, have limited its commercialization. To improve the electrochemical performance of Sn-based materials, the bottom-up method is normally used to prepare carbon-coated nanoparticles. However, its complex preparation processes and harsh conditions make it unsuitable for practical applications. Herein, a carbon-coated hybrid crystal composite (Sn/SnO x @C) was prepared using an up-bottom method with commercial Sn/SnO nanoparticles. Various effects accelerate the electrochemical kinetics and inhibit the coarsening of Sn crystals. The Sn/SnO x @C composite electrode exhibited capacity retention of 80.7% even after approximately 1000 cycles (360.4 mAh·g −1 ) at a current density of 1 A·g −1 . The high-load Na 3 V 2 (PO 4 ) 3 ||Sn/SnO x @C full cell presents a capacity retention rate of 91.7% after 150 cycles at the current density of 0.5 A·g −1 . This work may significantly accelerate the commercialization of the Sn/SnO x @C composite in sodium-ion batteries with high energy density. Graphical abstract
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Chinese Journal of Integrative Medicine
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2023
·
IF 2.9
Xu Han,Xu Si-cong,Li Li-yan,Wu Yu-huang,Tan Yin-feng,Chen Long,Liu Pei,Liang Chang-fu,He Xiao-ning,Li Yong-hui
Objective To investigate the effects of Danmu Extract Syrup (DMS) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and explore the mechanism. Methods Seventy-two male Balb/C mice were randomly divided into 6 groups according to a random number table ( n =12), including control (normal saline), LPS (5 mg/kg), LPS+DMS 2.5 mL/kg, LPS+DMS 5 mL/kg, LPS+DMS 10 mL/kg, and LPS+Dexamethasone (DXM, 5 mg/kg) groups. After pretreatment with DMS and DXM, the ALI mice model was induced by LPS, and the bronchoalveolar lavage fluid (BALF) were collected to determine protein concentration, cell counts and inflammatory cytokines. The lung tissues of mice were stained with hematoxylin-eosin, and the wet/dry weight ratio (W/D) of lung tissue was calculated. The levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1 β in BALF of mice were detected by enzyme linked immunosorbent assay. The expression levels of Claudin-5, vascular endothelial (VE)-cadherin, vascular endothelial growth factor (VEGF), phospho-protein kinase B (p-Akt) and Akt were detected by Western blot analysis. Results DMS pre-treatment significantly ameliorated lung histopathological changes. Compared with the LPS group, the W/D ratio and protein contents in BALF were obviously reduced after DMS pretreatment ( P <0.05 or P <0.01). The number of cells in BALF and myeloperoxidase (MPO) activity decreased significantly after DMS pretreatment ( P <0.05 or P <0.01). DMS pre-treatment decreased the levels of TNF-α, IL-6 and IL-1 β ( P <0.01). Meanwhile, DMS activated the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) pathway and reversed the expressions of Claudin-5, VE-cadherin and VEGF ( P <0.01). Conclusions DMS attenuated LPS-induced ALI in mice through repairing endothelial barrier. It might be a potential therapeutic drug for LPS-induced lung injury.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-15
·
IF 16.6
Wei Shengjie,Sun Yibing,Qiu Yun-Ze,Li Ang,Chiang Ching-Yu,Xiao Hai,Qian Jieshu,Li Yadong
Carbon-defect engineering in metal single-atom catalysts by simple and robust strategy, boosting their catalytic activity, and revealing the carbon defect-catalytic activity relationship are meaningful but challenging. Herein, we report a facile self-carbon-thermal-reduction strategy for carbon-defect engineering of single Fe-N 4 sites in ZnO-Carbon nano-reactor, as efficient catalyst in Fenton-like reaction for degradation of phenol. The carbon vacancies are easily constructed adjacent to single Fe-N 4 sites during synthesis, facilitating the formation of C-O bonding and lowering the energy barrier of rate-determining-step during degradation of phenol. Consequently, the catalyst Fe-NCv-900 with carbon vacancies exhibits a much improved activity than the Fe-NC-900 without abundant carbon vacancies, with 13.5 times improvement in the first-order rate constant of phenol degradation. The Fe-NCv-900 shows high activity (97% removal ratio of phenol in only 5 min), good recyclability and the wide-ranging pH universality (pH range 3-9). This work not only provides a rational strategy for improving the Fenton-like activity of metal single-atom catalysts, but also deepens the fundamental understanding on how periphery carbon environment affects the property and performance of metal-N 4 sites.
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JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
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2023
·Vol. 38
·期 6
·1434-1439
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IF 1.6
Li Bibo,Dong Xiufang,Li Yu,Song Jian,Xie Wuxi,Zhang Wei,Liu Yunfei
The hollow strontium carbonate pompons was synthesized for the first time by a controlled reaction precipitation method with sodium dodecyl benzene sulfonate (SDBS) and polyvinyl pyrrolidone (PVP) work together as template. The sampled particles were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), nitrogen adsorption-desorption measurement, X-ray diffraction (XRD), Energy dispersive X-Ray spectroscopy (EDX), Fourier transform infrared spectroscopy (FTIR), Thermogravimetric analysis and differential scanning calorimetry (TGA-DSC), etc . It is shown that the assynthesized hollow strontium carbonate pompons with the size of about 2 µm consist of flake-like particles under the optimal reaction conditions. The formation mechanism of hollow strontium carbonate pompons was preliminarily explored.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Guo Luyao,Zhuge Kaixuan,Yan Siyang,Wang Shiyi,Zhao Jia,Wang Saisai,Qiao Panzhe,Liu Jiaxu,Mou Xiaoling,Zhu Hejun,Zhao Ziang,Yan Li,Lin Ronghe,Ding Yunjie
Supported metal clusters comprising of well-tailored low-nuclearity heteroatoms have great potentials in catalysis owing to the maximized exposure of active sites and metal synergy. However, atomically precise design of these architectures is still challenging for the lack of practical approaches. Here, we report a defect-driven nanostructuring strategy through combining defect engineering of nitrogen-doped carbons and sequential metal depositions to prepare a series of Pt and Mo ensembles ranging from single atoms to sub-nanoclusters. When applied in continuous gas-phase decomposition of formic acid, the low-nuclearity ensembles with unique Pt 3 Mo 1 N 3 configuration deliver high-purity hydrogen at full conversion with unexpected high activity of 0.62 mol HCOOH mol Pt −1 s −1 and remarkable stability, significantly outperforming the previously reported catalysts. The remarkable performance is rationalized by a joint operando dual-beam Fourier transformed infrared spectroscopy and density functional theory modeling study, pointing to the Pt-Mo synergy in creating a new reaction path for consecutive HCOOH dissociations.
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AAPS PHARMSCITECH
·
2023
·Vol. 24
·期 8
·1-16
·
IF 3.3
Ma Lin,Mao HeYing,Xu Jing,Piao Jingshu,Piao Mingguan
Nimodipine (NMD) is a 1,4-dihydropyridine calcium antagonist that is effective in the prevention and treatment of cerebral arterial vasospasm and cerebral ischemic injury caused by subarachnoid hemorrhage. Since the drug itself is highly insoluble in water and has low oral bioavailability, while injectable formulations may cause pain and inflammation, the blood–brain barrier (BBB) prevents the effective delivery of therapeutic agents to the brain tissue. Therefore, in the present study, NMD liposomes were prepared by ethanol injection and innovatively lyophilised and loaded into temperature-sensitive in situ gels for intranasal administration as sprays to deliver drugs to brain tissues bypassing the blood–brain barrier. The optimal gel formulation was obtained by screening in which liposomes were divided into lecithin, cholesterol, and NMD in the ratio of 40:10: 1; Pluronic P407, Pluronic P188, Tween 80, polyvinyl ketone and ethyl nipagin in the ratio of (180:20:3:1:1); Pluronic P407, Pluronic P188, Tween 80, polyvinyl ketone, and ethyl nipagin in the ratio of (180:20:3:1:1). The prepared flow gel can form a solidified gel after a temperature of 31.07–32.07°C and a time of 58.51–59.89 s. Meanwhile, the NMD liposome gel formulation achieved sustained release over 56 h. The pharmacokinetic results of the developed NMD liposomal temperature-sensitive in situ gel and NMD temperature-sensitive in situ gel showed that liposomal nasal mucosal in situ gel is a more effective brain-targeted drug delivery system for NMD. Graphical Abstract
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Nano Research
·
2023
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IF 9.9
Yang Mengmeng,Chen Zhaofeng,Ding Yang,Qiong Wu,Liu Tianlong,Li Manna,Yang Lixia,Cui Sheng
Ceramic fibrous aerogels are highly desirable for thermal management materials due to their high porosity, excellent elasticity, thermal conductivity, and good thermal resistance. However, the fabrication of nanofibrous aerogel with super-elasticity and good shape retention at the same time has remained challenging. To meet the requirements, a novel anisotropy nanofibrous-granular aerogel with a quasi-layered multi-arch-like and hierarchical-cellular structure is designed and prepared by vacuum-filtration-assisted freeze-drying and sintering. The quasi-layered multi-arch and flexible nanofibers endowed the aerogels with excellent mechanical robustness (ultimate stress up to 60 kPa with strain 60%) and super-elasticity with recoverable compression strain up to 60%. The introduced SiO 2 aerogel nanoparticles and nanofibers are assembled into an arch-like structure and become the connection point of adjacent nanofibers, which endows low thermal conductivity (0.024 mW/(mK)) of composite aerogel. This novel strategy provides a fresh perspective for the preparation of nanofibrous aerogel with robust mechanical in thermal insulation and other fields.
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JOURNAL OF MATERIALS SCIENCE
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2023
·Vol. 58
·期 46
·17610-17622
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IF 4.5
Zhao Sheng-Nan,Tang Run-Hua,Deng Shu-Jun,Chen Gui-E,Ye Jing,Xu Zhen-Liang
It is urgent to develop functional nanocarriers for targeted drug therapy of cancer. This work developed a smart drug controlled release system based on the dendritic mesoporous silica nanoparticle (DMSN) for dual gatekeepers drug delivery. The DMSN-Cys grafted with disulfide bonds appeared as spheres of uniform size with a porous structure, which enabled a drug loading efficiency of 68.32%. Since the protonated amino groups of chitosan were responsive to pH and the disulfide bonds were sensitive to glutathione, the modified 5-Fu@DMSN-Cys/CS can be used for pH/GSH responsive drug delivery. Release behaviors showed excellent drug controlled release effects. Good biocompatibility and pronounced cytotoxicity of 5-Fu@DMSN-Cys/CS were confirmed by cytotoxicity test. Noted specially, the microcosmic adsorption interaction between drug molecules and DMSN-Cys has been evaluated through molecular dynamic simulation. Electrostatic potential and adsorption simulation confirmed that the driving force of 5-Fu adsorption was originated from electrostatic force and hydrogen bonding interaction between the nanocarriers and 5-Fu molecules. These results indicated that 5-Fu@DMSN-Cys/CS could be potential carriers for anticancer drug delivery. Graphical Abstract
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Nano Research
·
2023
·
IF 9.9
Rong Qian,Yuwen Chao,Liu Yingkai,Liu Yuanrong,Wang Chunyang,Wang Yang,Zhang Ding,Wen Zhen
Developing highly robust and efficient electrode materials is of critical importance to promoting the energy density of current supercapacitors for commercialization. Herein, we report an efficient catalyst with monodispersed Mn single-atoms embedded in carbon nanotubes (Mn-CNTs) for enhancing the electrode performance of supercapacitors. A high specific capacitance (1523.6 F·g −1 at 1.0 A·g −1 ) can be achieved, which is about twice as high as the specific capacitance of the electrode material without the introduction of Mn single-atoms. Remarkably, the asymmetric electrochemical capacitor created with Mn-CNT and activated carbon exhibits a high energy density of 180.8 Wh·kg −1 at a power density of 1.4 kW·kg −1 , much higher than most reported results. The study shows that the integration of Mn atoms into the CNT can enhance the charge transport capacity and the number of polar active sites of Mn-CNT and then facilitate chemical interactions between Mn-CNT and OH − . This work provides a novel strategy to enable high-energy storage in supercapacitors by introducing single-atoms into carbon nanotubes to improve electrodes’ energy density and cycle life.
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Nature Metabolism
·
2023
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IF 20.8
Wang Pei,Wu Peng-Fei,Wang Hua-Jie,Liao Fang,Wang Fang,Chen Jian-Guo
Ammonia has been long recognized as a metabolic waste product with well-known neurotoxic effects. However, little is known about the beneficial function of endogenous ammonia. Here, we show that gut ammonia links microbe nitrogen metabolism to host stress vulnerability by maintaining brain glutamine availability in male mice. Chronic stress decreases blood ammonia levels by altering gut urease-positive microbiota. A representative urease-producing strain, Streptococcus thermophilus , can reverse depression-like behaviours induced by gut microbiota that was altered by stress, whereas pharmacological inhibition of gut ammonia production increases stress vulnerability. Notably, abnormally low blood ammonia levels limit the brain’s availability of glutamine, a key metabolite produced by astrocytes that is required for presynaptic γ-aminobutyric acid (GABA) replenishment and confers stress vulnerability through cortical GABAergic dysfunction. Of therapeutic interest, ammonium chloride (NH 4 Cl), a commonly used expectorant in the clinic, can rescue behavioural abnormalities and GABAergic deficits in mouse models of depression. In sum, ammonia produced by the gut microbiome can help buffer stress in the host, providing a gut–brain signalling basis for emotional behaviour.
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