JOURNAL OF POLYMER RESEARCH
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2023
·Vol. 30
·期 11
·1-18
·
IF 2.8
Li Xin,Zhan Shiping
Poly (L-lactic acid) (PLLA) is a bio-based biodegradable polymer with minimal immunogenicity, non-toxicity and excellent mechanical properties and has widely used in medical, pharmaceutical, food packaging and other fields. However, linear PLLA has the characteristics of high melting point, strong crystallinity, weak flowability and poor thermal stability, which cannot meet the requirements of various industrial processes and novel pharmaceutical formulations. With its low viscosity, controlled degradation cycle, and excellent melt flowability, star-shaped PLLA can be used in the fields of biocomposites, biomedical devices, drug delivery, and intelligent packaging. Presently, metal catalysts and organic solvents are frequently used in PLLA synthesis industries, and both residues continue to pose a safety risks. In existing studies, the performance of bioenzymes as optimal green catalysts in organic solvents is not satisfactory, and they are predominantly used to synthesise oligomers with low yields and lengthy reaction times. In this study, a four-armed star-shaped poly (L-lactic acid) (4s-PLLA) with a porous structure favourable for drug loading was synthesised using supercritical carbon dioxide (Sc-CO 2 ) as a solvent, lipase as a catalyst, and erythritol as a nucleus. Using Sc-CO 2 as a solvent the reaction activity and stability of the enzyme were increased so that the reaction yield could reach 83% and the reaction time was only 24 h, which provided a possibility for the practical application of the enzymes catalyze green process. Both the random copolymerization product four-armed star-shaped poly(L-lactic-glycolic acid) (4s-PLGA) and the block copolymerization product four-armed star-shaped poly (L-lactic-glycolic acid) (4s-PLLA-PGA) were subsequently synthesized by copolymerization modification, and their porous structures retained and hydrophilicity were enhanced. The response surface analyses were performed about the reaction time, reaction temperature and yield of synthetic reactions by using Design-Expert 12 software and the prediction equations were generated.
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Drug Delivery and Translational Research
·
2023
·
IF 5.4
Wang Yanzhi,Wang Linchao,Chang Hanyue,Shen Qing,Zhang Sai,Sun Shanshan,Liu Ying,Zheng Jiaxin,Liu Hongmin
In this study, we synthesized a novel compound, agmatine-cholesterol conjugate (AG-Chol), to enhance the anti-tumor activity of drug-loaded liposomes. We replaced cholesterol with AG-Chol in preparing doxorubicin hydrochloride (DOX) liposomes by using an active loading method for DOX. We assessed the physical and chemical properties of the resulting AG-Liposomes and evaluated their efficacy in vitro and in vivo. The results showed that AG-Liposomes were stable with high encapsulation efficiency. Compared with the control liposomes, AG-Liposomes exhibited a slower drug release rate in the release medium at pH 6.8. The in vitro cell experiments demonstrated that AG-Liposomes had higher tumor cell uptake rate, stronger migration inhibition rate, higher apoptosis rate, better anti-clonogenic ability, and higher lysosome escape ability than the control liposomes. In vivo distribution results demonstrate that liposomes prepared with AG-Chol instead of cholesterol can significantly enhance their tumor targeting abilities and reduce their distribution to non-targeted sites. In vivo tumor suppression experiments showed that AG-Liposomes had a higher tumor suppression rate than the control liposomes without causing apparent toxicity to normal tissues, as evidenced by histological staining. Therefore, substituting cholesterol with AG-Chol in the preparation of liposomes can result in enhanced lysosome escape, improved tumor targeting, and increased efficacy of anti-tumor drugs. Graphical Abstract
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 49
·108263-108273
·
IF 5.8
Shuaibu Nazifi Sani,Zhao Gaosheng,Chu Fengjian,Wang Xiaozhi
In this study, a soft microwave plasma torch (SMPT) combined with a mass spectrometer (MS) was used for the first time as an analytical method to detect and analyze various pharmaceutical and personal care products (PPCPs) in aquatic environments without the need for sample pretreatment. For this purpose, ambient SMPT was used to generate plasma for ionizing the analyte molecules. Accordingly, nine PPCPs were identified by the SMPT-MS, and their identification was verified by collision-induced dissociation (CID). The technique’s performance was verified with known PPCP samples, and the limits of detection (LOD) and quantification (LOQ) obtained over a linear range of 50–1 μg/L were 1.56 to 2.81 and 2.07 to 3.62 μg/L, respectively, with the standard addition recovery rate falling between 87.14 and 115.16%. These results show that the method has excellent sensitivity and selectivity, suggesting that SMPT can rapidly and directly detect PPCPs in environmental water, making it a promising method for rapid water quality inspection.
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JOURNAL OF THERMAL SPRAY TECHNOLOGY
·
2023
·Vol. 32
·期 8
·2460-2477
·
IF 3.1
Wu Duoli,Wu Haotian,Yuan Ziyi,Wei Xinlong,Zhang Chao
To investigate the influence of Mo addition and water vapor content on the high-temperature corrosion resistance of Ni-Al-based coatings, 0Mo, 5Mo, and 10Mo coatings were deposited by APS thermal spray onto stainless steels. The chlorine-induced corrosion test was conducted in an experimental environment simulating a biomass boiler. The results show that adding the Mo element lowers the coating's ability to resist corrosion without water vapor. The coating is more prone to peeling because Mo prevents the coating from eventually forming a protective oxide layer. Water vapor significantly speeds up the production of oxides and modifies their morphology and structure. The combined effects of Mo and water vapor increase the coating's ability to resist corrosion. The development of thick and protective Ni and Al oxide layers on the coated surface is aided by the acceleration of oxide production by water vapor and the alteration of oxide structure by Mo components.
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 6
·1-14
·
IF 20.1
Liang Taixin,Song Ruidong,Chen Chong,Alomar Taghrid S.,Xiao Fei,AlMasoud Najla,El-Bahy Zeinhom M.,Yang Yuanyuan,Algadi Hassan,Sun Lufeng
In this work, graphene oxide–supported Cu/Co nano-catalysts with low scale and large surface area were prepared by solvothermal and heat treatment, and the composite of the catalyst and ammonium perchlorate was obtained by spray method. Scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), x-ray photoelectron spectroscopy (XPS), and Brunauer-Emmett-Teller (BET) were used to analyze the surface morphology, phase composition, and electronic structure of the catalyst and composites. The Kissinger equation and differential scanning calorimetry (DSC) test were used to determine the thermodynamic data. The results demonstrate that when the heating rate was 5 K/min and the catalyst GO/Cu-Co-MOF-650 was mixed mechanically, the high-temperature decomposition temperature of AP was decreased by 100 °C, and the activation energy was decreased by 38.99 kJ/mol. By using a composite spray instead of mechanical stirring, AP@GO/Cu-Co-MOF-650 completely eliminated the low-temperature decomposition temperature of ammonium perchlorate, increased the high-temperature decomposition temperature by 117.9 °C, decreased the activation energy by 54.24 kJ/mol, and increased the heat release of ammonium perchlorate by more than four times. These results suggest that the composite of the catalyst and the ammonium perchlorate increased the specific surface area of these two materials in contact with one another, further enhancing the catalytic efficiency.
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JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 38
·15035-15046
·
IF 4.5
Wang Xiongwei,Ma Rui-Juan,Guo Tingyu,Zhang Xuewei,Wang Hui,Zhao Xu
Abstract The hydrogen iodide decomposition reaction of the sulfur-iodine (SI) cycle is realized by electrolysis at room temperature to achieve efficient hydrogen production, while iodine is recycled throughout the SI reaction. In this work, we report a facile hydrothermal method for the synthesis of sulfur-doped titanium dioxide (S- \(\hbox {TiO}_2\) ) nanosheets with evenly distributed on the Ti foil (S- \(\hbox {TiO}_2\) /Ti). The noble metal-free S- \(\hbox {TiO}_2\) /Ti electrode demonstrates excellent electrochemical catalytic performance for iodine evolution reaction. It can deliver a high current density of 100 mA/ \(\hbox {cm}^2\) with a potential of 1.05 V, which is close to 90% of that of precious metal platinum and 5.6 times of bare Ti foil. Furthermore, the S- \(\hbox {TiO}_2\) /Ti electrode is stable in a mixed acid solution of HI and \(\hbox {H}_2\hbox {SO}_4\) . Compared to \(\hbox {TiO}_2\) /Ti, diffuse reflectance spectroscopy and ultraviolet photoelectron spectroscopy analysis evidence a reduction in the band gap and work function of S- \(\hbox {TiO}_2\) /Ti due to the doping of sulfur. Correspondingly, the current efficiency approaches to 100% under the electrolysis constant voltage 1.30 V. Eventually, the detailed mechanism to describe the improvement of the electrocatalytic performance was suggested. Graphical abstract
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JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2023
·
IF 2.5
Lin Yueming,Dai Huimin,Su Siyu,Zhu Xiaohong
The hydrophilicity of carbon cloth was improved through pretreatment using an oxidation process resulting in activated carbon cloth with microscopically pronounced grooved cracks. This activated carbon cloth served as a highly hydrophilic substrate suitable for electrode material loading while also possessing attractive electrochemical properties. Polypyrrole/reduced graphene oxide (PPy/rGO) composites were subsequently polymerized and chemically reduced in situ on the pretreated carbon cloth (HCC), introducing nitrogen atoms of different valences into the composite. Contact angle and electrochemical tests demonstrate that the prepared electrode material displayed enhanced hydrophilicity and low impedance. Based on HCC/PPy/rGO, the symmetrical flexible quasi-solid supercapacitor exhibited a high energy density of 0.60 mWh cm −3 at a power density of 6.25 mW cm −3 , as well as a great power density of 62.5 mW cm −3 at 0.34 mWh cm −3 and good flexibility. Moreover, three fabricated supercapacitor devices connected in series illuminated a white LED for about 4 min, demonstrating the potential use of pretreated-carbon cloth/polypyrrole/rGO materials for flexible wearable devices.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·Vol. 30
·期 51
·111039-111050
·
IF 5.8
Dong Shiwen,Liu Xuan,Kong Xianxian,Dong Feilong,Yu Yan,Wang Lizhang,Wang Da,He Zhiqiao,Song Shuang
Metal-organic frameworks (MOFs) and covalent organic frameworks (COFs) have been proved as efficient catalysts for photocatalytic hydrogen (H 2 ) evolution, thanks to their tunable functionalities, permanent porosity, excellent visible light response, and physicochemical stability. Herein, a series of photocatalysts (termed NUBC) was fabricated by loading different amounts of Zr-UiO-66-NH 2 (NU) onto a benzoic acid–modified covalent triazine–based framework (BC) based on post-synthetic covalent modification. The resulting NUBC catalysts exhibited a type-II Z-scheme heterojunction structure formed via the amide covalent bonds between the amine groups on NU and carboxyl groups on BC. The optimal loading of NU on BC is 30 wt.% (30NUBC) and the corresponding photocatalytic H 2 evolution rate was 378 μmol h −1 g −1 , almost 445 and 2 times than that of NU and BC, respectively. The synergistic effect between the type-II Z-scheme heterojunctions and amide bonds was conducive to boosting visible light harvesting and facilitating charge transportation and separation. Furthermore, the prepared NUBC catalysts show great reusability and stability. Overall, this work sheds light on the design of novel MOF/COF hybrid materials and provides a systematic exploration of their photocatalytic H 2 evolution properties.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2023
·Vol. 21
·期 1
·1-17
·
IF 10.2
Ren Xunshan,Zhuang Huangming,Zhang Yuelong,Zhou Panghu
Background Tendon injuries have a high incidence and limited treatment options. Stem cell transplantation is essential for several medical conditions like tendon injuries. However, high local concentrations of reactive oxygen species (ROS) inhibit the activity of transplanted stem cells and hinder tendon repair. Cerium oxide nanoparticles (CeONPs) have emerged as antioxidant agents with reproducible reducibility. Results In this study, we synthesized polyethylene glycol-packed CeONPs (PEG-CeONPs), which were loaded into the human umbilical cord mesenchymal stem cells (hUCMSCs) to counteract oxidative damage. H 2 O 2 treatment was performed to evaluate the ROS scavenging ability of PEG-CeONPs in hUCMSCs. A rat model of patellar tendon defect was established to assess the effect of PEG-CeONPs-carrying hUCMSCs in vivo. The results showed that PEG-CeONPs exhibited excellent antioxidant activity both inside and outside the hUCMSCs. PEG-CeONPs protect hUCMSCs from senescence and apoptosis under excessive oxidative stress. Transplantation of hUCMSCs loaded with PEG-CeONPs reduced ROS levels in the tendon injury area and facilitated tendon healing. Mechanistically, NFκB activator tumor necrosis factor α and MAPK activator dehydrocrenatine, reversed the therapeutic effect of PEG-CeONPs in hUCMSCs, indicating that PEG-CeONPs act by inhibiting the NFκB and MAPK signaling pathways. Conclusions The carriage of the metal antioxidant oxidase PEG-CeONPs maintained the ability of hUCMSCs in the injured area, reduced the ROS levels in the microenvironment, and facilitated tendon regeneration. The data presented herein provide a novel therapeutic strategy for tendon healing and new insights into the use of stem cells for disease treatment. Graphical Abstract
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Drug Delivery and Translational Research
·
2023
·
IF 5.4
Fang Ruiyue,Zhao Ying,Lin Shiyuan,Wei Yue,Chen Hui
This study aimed to enhance the oral absorption of Panax notoginseng saponins (PNS) via nanoparticles modified with thiolated trimethyl chitosan (TMC-Cys) and wheat germ agglutinin (WGA), termed PP-WT NPs. In vitro investigations revealed that PP-WT NPs exhibited delayed release of PNS and a strong tolerance to the gastric acids and digestive enzymes. Moreover, PP-WT NPs exhibited efficient cellular uptake and transport capabilities in the Caco-2/HT29-co-cultured cell model. In vivo animal experiments demonstrated that PP-WT NPs effectively overcame the mucus layer barrier, with the effective permeability coefficients of R1, Rg1, and Rb1 in the small intestine being 1.68, 1.64, and 1.63 times higher than those of free PNS, respectively. Taken together, thiolated trimethyl chitosan and wheat germ agglutinin–modified nanoparticles hold significant potential for improving the oral absorption of PNS, representing an attractive strategy for enhanced therapeutic efficacy.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-9
·
IF 16.6
Shi Yonghong,Han Jianlei,Li Chengxi,Zhao Tonghan,Jin Xue,Duan Pengfei
Existing circularly polarized luminescence materials can hardly satisfy the requirements of both large luminescence dissymmetry factor and high luminescent quantum yield, which hinders their practical applications. Here, we present a soft photonic crystal film embedded with chiral nanopores that possesses excellent circularly polarized luminescence performance with a high luminescence dissymmetry factor as well as a large luminescent quantum yield when loaded with various luminescent dyes. Benefitting from the retention of chiral nanopores imprinted from a chiral liquid crystal arrangement, the chiral soft photonic crystal film can not only endow dyes with chiral properties, but also effectively avoid severe aggregation of guest dye molecules. More importantly, the soft photonic crystal film can be recycled many times by loading and eluting guest dye molecules while retaining good stability as well as circularly polarized luminescence performance, enabling various applications, including smart windows, multi-color circularly polarized luminescence and anticounterfeiting.
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Nature Communications
·
2023
·Vol. 14
·期 1
·1-8
·
IF 16.6
Song Zihao,Du Xinyuan,He Xin,Wang Hanqi,Liu Zhiqiang,Wu Haodi,Luo Hongde,Jin Libo,Xu Ling,Zheng Zhiping,Niu Guangda,Tang Jiang
Solution-processed polycrystalline perovskite film is promising for the next generation X-ray imaging. However, the spatial resolution of current perovskite X-ray panel detectors is far lower than the theoretical limit. Herein we find that the pixel level non-uniformity, also known as fixed pattern noise, is the chief culprit affecting the signal-to-noise ratio and reducing the resolution of perovskite detectors. We report a synergistic strategy of rheological engineering the perovskite suspensions to achieve X-ray flat panel detectors with pixel-level high uniformity and near-to-limit spatial resolution. Our approach includes the addition of methylammonium iodide and polyacrylonitrile to the perovskite suspension, to synergistically enhance the flowability and particle stability of the oversaturated solution. The obtained suspension perfectly suits for the blade-coating process, avoiding the uneven distribution of solutes and particles within perovskite films. The assembled perovskite panel detector exhibits greatly improved fixed pattern noise value (1.39%), high sensitivity (2.24 × 10 4 μC Gy air −1 cm −2 ), low detection limit (28.57 nGy air ·s −1 ) as well as good working stability, close to the performance of single crystal detectors. Moreover, the detector achieves a near-to-limit resolution of 0.51 lp/pix.
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