CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2021
·Vol. 37
·期 5
·1085-1091
·
IF 1.307
Sun Di,Gao Wenqing,Wu Peng,Liu Jie,Li Shengmei,Li Shilin,Yu Meili,Ning Meng,Bai Ru,Li Tong,Liu Ying,Chen Chunying
E xtracorporeal membrane oxygenation(ECMO) has emerged as a viable treatment in severe cases of acute respiratory distress syndrome, acute respiratory failure, and adult respiratory distress syndrome. However, thromboembolic events stemming from the use of ECMO devices results in significant morbidity and mortality rates; the inner surface of the ECMO tubing comes into contact with the blood and can readily initiate coagulation. In addition, the tubing needs to be continually replaced due to thromboses on the inner tube wall, which not only increases the risk of infection but also the economic burden. Despite considerable effort, a surface modification strategy that effectively addresses these challenges has not yet been realized. In this study, we developed an integrated hollow core-shell-shell hydrogel tube of gelatin/alginate/acrylamide-bacterial nanocellulose(GAA) that meets the anticoagulant requirements for the inner tubing layer as well as the highly elastic soft material needed for the outer layer. Using static blood from healthy volunteers, we confirmed that the platelets or coagulation is not stimulated by the GAA tubing. Importantly, experiments with dynamic blood also demonstrated that the inner layer of the tubing does not elicit blood clotting. The one-pot-synthesized process may provide guidance for the design of anticoagulation tubes used clinically.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
npj Science of Food
·
2026
·
IF 9.7
Ma Fei,He Yajie,Yu Li,Li Peiwu
Aflatoxin contamination seriously endangers food safety and human health, and efficient detoxification technologies are still lacking. In this study, a customized device that combines micro-nano bubbles with ozone (MNBW-O 3 ) was developed to degrade four major aflatoxins (AFB 1 , AFB 2 , AFG 1 , AFG 2 ) in peanut byproduct. MNBW-O 3 exhibited superior degradation performance compared with the other five treatments. The operational parameters were systematically optimized, and the optimal conditions were determined to be an outlet pressure of 0.34 MPa, an O 3 flow rate of 2.5 L/min, a treatment time of 120 min, and a solid-to-liquid ratio of 12.5 g/L. Under these conditions, the removal rates of AFB 1 , AFB 2 , AFG 1 , and AFG 2 reached 87.76%, 77.93%, 79.91%, and 88.56%, respectively. Moreover, the developed MNBW-O 3 system demonstrated excellent stability, retaining high degradation efficiency over 12 consecutive reuse cycles. Reactive oxygen species scavenging experiments indicated that •OH, •O 2 ⁻ and O 3 participated in degradation, with •OH as the dominant species. Degradation of AFB 1 , AFB 2 , AFG 1 , and AFG 2 yielded 37, 14, 19, and 10 products via 18, 6, 7, and 4 pathways, respectively. The primary initial attack occurred at the terminal furan ring, followed by the lactone ring, cyclopentenone, and methoxy group. Theoretical calculations, nutrient analysis, toxicity prediction and cytotoxicity assays confirmed the reaction spontaneity, peanut meal and product safety. This study provides a green, stable and practical detoxification strategy for feed industrial application.
✓ 已验证
产品关联
DOI
高影响因子
BMC MICROBIOLOGY
·
2026
·
IF 5.4
Xu Weijun,Xia Xuesen,Wang Xiaoyin,Zhang Qimin,Zhang Wenke,Liang Yusheng,Sun Cuicui,Chen Jianping,Wu Zhenqiang,Zhong Bin
Mechanisms supporting microbial survival under lethal selenite [Se(IV)] concentrations during bioremediation remain elusive. This study employed integrated multi-omics to analyze Lactiplantibacillus plantarum BSe (LPB) under extreme Se(IV) stress. LPB achieved 76.32% removal at 100 mM Se(IV), but this high efficiency came at a significant cost to cell viability and intracellular biomass. Multi-omics integration suggested a sophisticated survival strategy coupling metabolic reprogramming with a sacrificial cell lysis. Specifically, carbon flux was redirected from glycolysis to the pentose phosphate pathway to fuel NADPH generation. Furthermore, a > 35-fold surge in intracellular dehydroascorbic acid strongly suggests the putative activation of de novo ascorbic acid synthesis as a potential alternative reductant pathway. Finally, multi-omics data lead us to propose a mechanism whereby LPB adopts a putative sacrificial cell lysis to extrude SeNPs, evidenced by the downregulation of peptidoglycan-binding proteins and concurrent upregulation of autolysins like lysozyme and RecX. Collectively, these findings suggest LPB survives lethal Se(IV) stress through a trade-off mechanism: rewiring metabolism to power an ascorbic acid-associated Se(IV) reduction pathway while sacrificing structural integrity to export SeNPs.
✓ 已验证
产品关联
DOI
高影响因子
Chemical and Biological Technologies in Agriculture
·
2026
·
IF 5.8
Tian Shu,Cheng Feng,Wu Pan,Jia Xuewei,Qu Lili,Xu Chunping
Background Microbial exopolysaccharides (EPS) are renewable biopolymers of increasing importance in the agri-food sector, and producing them from low-cost substrates offers a route to valorize agro-industrial resources. Aureobasidium pullulans is an industrially important fungus that secretes the α-glucan pullulan; however, the structure of the EPS it produces under lactose fermentation—a means of upgrading a low-value, dairy-derived carbon source—has not been clearly defined, which limits its rational use as an agri-food bioproduct. This study aimed to produce, structurally characterize, and preliminarily evaluate the physiological activity of this EPS. Results A homogeneous EPS was obtained by ethanol precipitation, Sevag deproteinization, and gel-filtration chromatography. Fourier-transform infrared spectroscopy indicated an α-configured, neutral polysaccharide, and gas chromatography identified glucose as the sole monosaccharide. Size-exclusion chromatography coupled with multi-angle laser light scattering showed a high-molecular-weight polymer. One- and two-dimensional NMR analyses established that the EPS is a linear pullulan-type α-D-glucan with the repeating unit [→6)-α-D-Glcp-(1→4)-α-D-Glcp-(1→4)-α-D-Glcp-(1→] n, in which two α-(1→4)-linked glucose residues alternate with an α-(1→6) linkage. In a high-fat-diet-induced obese rat model, dietary supplementation with the glucan attenuated body-weight gain, improved serum lipid profiles (TG, TC, HDL-C/TC), and lowered serum endotoxin and tumour necrosis factor-α, together with enhanced colonic short-chain fatty acid production, consistent with fermentation of the glucan by the gut microbiota. Conclusions Lactose fermentation by A. pullulans yields a structurally defined, linear pullulan-type α-D-glucan, demonstrating a route to convert a low-value dairy-derived substrate into a value-added biopolymer. Its prebiotic-associated metabolic effects indicate potential as a functional ingredient for the agri-food chain and warrant further mechanistic and safety studies. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2021
·Vol. 413
·期 11
·3131-3140
·
IF 4.157
Zhao Haiyan,Qiao Xiujuan,Zhang Xuelian,Niu Chen,Yue Tianli,Sheng Qinglin
Simultaneous detection of patulin (PAT) and ochratoxin A (OTA) in food products is in great demand, which can prevent toxins from being exposed to human and animal bodies. However, simultaneous detection of multiple targets still faces a challenge. Herein, we developed a novel electrochemical aptasensor for the simultaneous detection of PAT and OTA in apple juice based on gold nanoparticles decorated black phosphorus (AuNPs-BP) nanomaterial. AuNPs-BP function?/work? as a sensing platform for loading much different electrochemical signal molecules functionalized aptamers. In this context, methylene blue functionalized PAT aptamers (Mb-PAT-aptamers) and ferrocene functionalized OTA aptamers (Fc-OTA-aptamers) have been introduced here to fabricate the aptasensor. Fc close to electrode surface showed a strong signal, whereas Mb was far away from electrode surface so exhibited a weak signal in the absence of OTA and PAT. Two kinds of electrochemical signal changes have been recorded dependent on target of OTA and PAT concentrations. So, simultaneous detection of OTA and PAT is achieved. Under the optimum conditions, using this developed biosensor, PAT and OTA can be quantified at a linearity range of 0.01 × 10 −7 μg·mL −1 ~ 0.10 μg·mL −1 . In addition, it also has good selectivity, stability and repeatability. For the practical application, it shows promising performance for the simultaneous detection of PAT and OTA in apple juice.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2026
·Vol. 156
·期 10
·282
·
IF 2.5
Ye Qihang,Zhong Zhaoping,Yang Yuxuan,Wang Wei,Jia You,Xiong Qi,Chen Huanqi,Zheng Xiang
Furfural, a key biomass-derived platform chemical, requires efficient hydrogenation for economic and research benefits. Herein, we propose a carbon-encapsulated catalyst with optimized active sites (using carbon-containing organics) for its highly selective hydrogenation. Experimental results demonstrated that carbon loading facilitated the conversion of strong acid sites to medium‑strong acid sites on the catalyst support, and also increased the Lewis/Brønsted (L/B) ratio. Through optimization of reaction conditions and carbon loading, complete conversion of furfural and a furfuryl alcohol selectivity as high as 99.17% were achieved at 160 °C for 4 h. The prepared catalyst maintained high furfuryl alcohol selectivity even after five cycles, owing to the protective carbon layer on the active support and the well-dispersed Cu species on its surface. DFT calculations further revealed that furfural preferentially adsorbs on the catalyst surface via the η¹(O)-aldehyde configuration, confirming the promotional role of the catalyst in furfural hydrogenation. Graphical
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2026
·Vol. 33
·期 9
·395
·
IF 3.5
Zhang Zhaoxin,Dong Xiang,Dai Guo-wei,Rong Caiyu,Ma Yan,Zhao Gaoxiang,Zhang Jiayi,Wei Jiahao,Lin Zixin,Nie Shibin,Tian Konghu
Currently, chitosan (CS)-based shape memory materials typically require the incorporation of reversible phases, which impair CS’s intrinsic properties. This study proposed a facile strategy to solve this problem: replacing the traditional organic reversible phases with novel functional inorganic nanomaterials. Hexagonal boron nitride (h-BN) nanosheets were modified with silver nanoparticles (AgNPs) and then used to fabricate the AgNPs@dopamine@BN/chitosan nanopaper (BDAC), a dual thermal- and electrical-triggered shape memory nanocomposite. The results show that BDAC-1 has a thermal conductivity of 1.38 W/(mK)—a 138% increase compared to neat CS—and a good electrical conductivity of 35.6 S/cm. A triple-folded BDAC-1 sample (1 × 4 cm²) fully recovered to a flat state in 43 s on a 120 °C heating platform, reaching 91.5 °C internally. Under 8.5 V, it achieved full shape recovery in 132 s, with an internal temperature of 96.7 °C. The peak heat release rate (pHRR) of BDAC-1 is only 21.4 W/g, which has decreased by 39.5% compared with the neat CS, revealing significantly improved flame retardancy. In addition, BDAC presents high-efficient thermal management performance, which alleviates the risks of heat accumulation and fire. Furthermore, we demonstrated the versatile applicability of BDAC by integrating it into thermal/electrical dual-triggered hierarchical alarm devices and micro-mechanical grippers, highlighting the exceptional application potential of this high-performance soft actuator.
✓ 已验证
产品关联
DOI
高影响因子
npj Clean Water
·
2023
·Vol. 6
·期 1
·1-12
·
IF 11.4
Jiang Runren,Lu Guanghua,Wang Min,Chen Yufang,Liu Jianchao,Yan Zhenhua,Xie Haijiao
Both piezoelectricity and self-Fenton catalysis are effective ways to degrade water pollution, but little research has combined them to construct a more efficient water pollution treatment method. Here, a Fe-doped SnS 2 (Sn 1-x Fe x S 2 ) piezoelectric self-Fenton system was constructed, which shows superior water treatment performance. The best piezoelectric properties of the Sn 0.97 Fe 0.03 S 2 system were verified by degrading rhodamine B (RhB). The toxicity analysis of degradation intermediates and solutions confirmed that the toxicity of RhB decreased after degradation. In addition, Kelvin probe force microscopy and photoelectrochemical analysis confirmed the better piezoelectric properties of Sn 0.97 Fe 0.03 S 2 . It has demonstrated the enhancement of systematic piezoelectricity by Fe lattice defects and the formation of self-Fenton by Fe as an active center in the degradation of RhB. In this work, an efficient piezoelectric and self-Fenton technology is constructed to remove organic pollutants from water, which is significant for developing water treatment technology.
✓ 已验证
产品关联
DOI
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2023
·
IF 8.2
Wu Jun,Zhao Miao,Jin Yu-chen,Li Min,Yu Ke-xin,Yu Hai-bo
Epilepsy is a prevalent and severe neurological disorder and approximately 30% of patients are resistant to existing medications. It is of utmost importance to develop alternative therapies to treat epilepsy. Schisandrin B (SchB) is a major bioactive constituent of Schisandra chinensis (Turcz.) Baill and has multiple neuroprotective effects, sedative and hypnotic activities. In this study, we investigated the antiseizure effect of SchB in various mouse models of seizure and explored the underlying mechanisms. Pentylenetetrazole (PTZ), strychnine (STR), and pilocarpine-induced mouse seizure models were established. We showed that injection of SchB (10, 30, 60 mg/kg, i.p.) dose-dependently delayed the onset of generalized tonic-clonic seizures (GTCS), reduced the incidence of GTCS and mortality in PTZ and STR models. Meanwhile, injection of SchB (30 mg/kg, i.p.) exhibited therapeutic potential in pilocarpine-induced status epilepticus model, which was considered as a drug-resistant model. In whole-cell recording from CHO/HEK-239 cells stably expressing recombinant human GABA A receptors (GABA A Rs) and glycine receptors (GlyRs) and cultured hippocampal neurons, co-application of SchB dose-dependently enhanced GABA or glycine-induced current with EC 50 values at around 5 μM, and application of SchB (10 μM) alone did not activate the channels in the absence of GABA or glycine. Furthermore, SchB (10 μM) eliminated both PTZ-induced inhibition on GABA-induced current ( I GABA ) and strychnine (STR)-induced inhibition on glycine-induced current ( I glycine ). Moreover, SchB (10 μM) efficiently rescued the impaired GABA A Rs associated with genetic epilepsies. In addition, the homologous mutants in both GlyRs-α1(S267Q) and GABA A Rs-α1(S297Q)β2(N289S)γ2L receptors by site-directed mutagenesis tests abolished SchB-induced potentiation of I GABA and I glycine . In conclusion, we have identified SchB as a natural positive allosteric modulator of GABA A Rs and GlyRs, supporting its potential as alternative therapies for epilepsy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-15
·
IF 16.6
Gong Ting-Ting,Guo Shuang,Liu Fang-Hua,Huo Yun-Long,Zhang Meng,Yan Shi,Zhou Han-Xiao,Pan Xu,Wang Xin-Yue,Xu He-Li,Kang Ye,Li Yi-Zi,Qin Xue,Xiao Qian,Huang Dong-Hui,Li Xiao-Ying,Zhao Yue-Yang,Zhao Xin-Xin,Wang Ya-Li,Ma Xiao-Xin,Gao Song,Zhao Yu-Hong,Ning Shang-Wei,Wu Qi-Jun
Clear cell carcinoma (CCC), endometrioid carcinoma (EC), and serous carcinoma (SC) are the major histological subtypes of epithelial ovarian cancer (EOC), whose differences in carcinogenesis are still unclear. Here, we undertake comprehensive proteomic profiling of 80 CCC, 79 EC, 80 SC, and 30 control samples. Our analysis reveals the prognostic or diagnostic value of dysregulated proteins and phosphorylation sites in important pathways. Moreover, protein co-expression network not only provides comprehensive view of biological features of each histological subtype, but also indicates potential prognostic biomarkers and progression landmarks. Notably, EOC have strong inter-tumor heterogeneity, with significantly different clinical characteristics, proteomic patterns and signaling pathway disorders in CCC, EC, and SC. Finally, we infer MPP7 protein as potential therapeutic target for SC, whose biological functions are confirmed in SC cells. Our proteomic cohort provides valuable resources for understanding molecular mechanisms and developing treatment strategies of distinct histological subtypes.
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Yang Kun,Xu Haiting,Liu Ga,Bao Shengfei,Yang Qiang,Gao Qiang,Chen Li,Cao Yingui,Wang Yajun,Zu Menghang,Liu Jinyao,Xiao Bo
Oral vaccines hold great promise for colorectal cancer (CRC) immunotherapy but are limited by inefficient mucosal delivery and a lack of spatiotemporal control over immune activation. Here we report a spatiotemporally programmed oral nanovaccine that implements a dual-site vaccination strategy through a sequential and causally linked immune cascade, initiating immune priming in Peyer’s patches of the small intestine and subsequently amplifying immunity at colorectal tumor sites. The nanovaccine (DPML@OVA-CpG), composed of antigen- and CpG-loaded mesoporous polydopamine nanoparticles stabilized by β -glucan and plant-derived lipids, resists gastrointestinal degradation and targets gut-associated lymphoid tissues. Following oral administration, it induces robust systemic effector and memory T cell responses via small intestinal priming, while a fraction traffics to colorectal tumors. There, near-infrared irradiation triggers immunogenic cell death of tumor cells and, together with locally released CpG, converts tumors into autologous in situ vaccine factories. This spatiotemporally orchestrated strategy achieves potent therapeutic efficacy against liver metastatic CRC, extending survival compared to PD-L1 antibody therapy and traditional single-site oral vaccination.
✓ 已验证
产品关联
DOI
高影响因子
ONCOGENE
·
2026
·
IF 9.1
Yu Weidong,Wang Bo,Meng Fanhao,Ren Xiaojun,Zhou Danyi,Wei Huanxin,Yang Zhengquan,Sun Hongwei,Jiang Minghua,Xia Tao,Cui Wei,Fang Hezhi
Pancreatic ductal adenocarcinoma (PDAC) cells rely on fatty acid oxidation (FAO) for proliferation; however, the regulatory mechanisms governing this dependency and their clinical implications remain unclear. Here, we report that PDAC patients exhibit decreased plasma levels of propionyl-CoA intermediates, alongside accelerated propionyl-CoA catabolic activity within both human PDAC tumors and Pd x1-Cre/ Kras G12D/+ / Trp53 R 172H/+ (KPC) mouse tumors. Specifically, PDAC cells upregulate propionyl-CoA carboxylase (PCC) to accelerate propionyl-CoA catabolism, thereby establishing a metabolic signature distinct from that of healthy tissues. Mechanistically, PCC is essential for PDAC growth, not by fueling the TCA cycle, but by preventing toxic propionyl-CoA accumulation. We further demonstrate that elevated propionyl-CoA leads to the propionylation-induced inactivation of the mitochondrial fatty acid oxidation (FAO) enzyme ACAA2 at Lysine 137, thereby blocking the FAO flux required for tumor proliferation. Moreover, high PCCA expression in patient PDAC tumors is significantly associated with decreased lipid accumulation, and PDAC cells with high PCC levels are more sensitive to etomoxir-induced cell proliferation arrest. These findings establish the PCC-ACAA2 axis as a critical metabolic vulnerability and a promising target for diagnostic and therapeutic interventions in PDAC.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）