ACS Nano
·
2024
·
IF 15.8
Jianshuai Bao,Jiefei Wang,Sudi Chen,Shiqi Liu,Zhen Wang,Weiwei Zhang,Chenhui Zhao,Yuling Sha,Xiaoyan Yang,Yusen Li,Yong Zhong,Feng Bai
Reactive oxygen species (ROS) mediated tumor cell death is a powerful anticancer strategy. Cuproptosis is a copper-dependent and ROS-mediated prospective tumor therapy strategy. However, the complex tumor microenvironment (TME), low tumor specificity, poor therapy efficiency, and lack of imaging capability impair the therapy output of current cuproptosis drugs. Herein, we designed a dual-responsive two-dimensional metal–organic framework (2D MOF) nanotheranostic via a coordination self-assembly strategy using Au(III) tetra-(4-pyridyl) porphine (AuTPyP) as the ligand and copper ions (Cu2+) as nodes. The dual-stimulus combined with the protonation of the pyridyl group in AuTPyP and deep-penetration ultrasound (US) together triggered the controlled release in an acidic TME. The ultrathin structure (3.0 nm) of nanotheranostics promoted the release process. The released Cu2+ was reduced to Cu+ by depleting the overexpressed glutathione (GSH) in the tumor, which not only activated the Ferredoxin 1 (FDX1)-mediated cuproptosis but also catalyzed the overexpressed hydrogen peroxide (H2O2) in the tumor into reactive oxygen species via Fenton-like reaction. Simultaneously, the released AuTPyP could specifically bind with thioredoxin reductase and activate the redox imbalance of tumor cells. These together selectively induced significant mitochondrial vacuoles and prominent tumor cell death but did not damage the normal cells. The fluorescence and magnetic resonance imaging (MRI) results verified this nanotheranostic could target the HeLa tumor to greatly promote the self-enhanced effect of chemotherapy/cuproptosis and tumor inhibition efficiency. The work helped to elucidate the controlled assembly of multiresponsive nanotheranostics and the high-specificity ROS regulation for application in anticancer therapy.
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高影响因子
Journal of Environmental Chemical Engineering
·
2024
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IF 7.4
Xiaolin Shen,Zhiliang Zhu,Xiaochang Liu,Renlu Qiao,Hua Zhang,Yanling Qiu
Reutilization of spent adsorbent by converting the adsorbed organic pollutants into carbon matrix has attracted more attention in recent years, which delivers a greener way for the preparation of catalysis and environment remediation. In this work, CuBi 2 O 4 after adsorption of pollutant sulfamethazine was further transformed to a photocatalyst CBO-WC500 with high catalytic efficiency for degradation of typical pharmaceuticals. The XAFS analysis proved that Cu-C chemical bond was constructed during the preparation process. The obtained CBO-WC500 was applied to remove sulfamethoxazole (SMX) through photocatalytic Fenton-like reaction, and removal efficiency reached 88.9 % after 60 minutes with the initial 5 mg•L −1 SMX and 0.2 g•L −1 catalyst in peroxymonosulfate (PMS) system. The results showed that the introduction of carbon stem from waste improved separation of photo-generated carriers and electron transfer capability, thus more photo-induced electrons could participate in reaction with PMS. Moreover, Cu(I) and Cu(II) in CBO-WC500 with Cu-Bi-spinel structure played a vital role in PMS activation. Led by electron transportation, reactive species ( 1 O 2 , •OH, SO 4 •- ) originated from PMS contributed to degradation of SMX, and degradation pathway of target pollutant was proposed based on analysis of intermediates. Removal efficiency of CBO-WC500 for SMX kept stable after several cycles’ utilization, and it also showed decent eliminating performance of mixed pollutants in different water matrix. This study has provided a potential way for resource reuse of adsorbed pollutant and realizing reutilization of spent adsorbent as photocatalyst with higher efficiency.
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ChemNanoMat
·
2017
·Vol. 4
·期 2
·213-219
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IF 2.937
Xuan Cai,Libo Shi,Hongli Zhao,Minbo Lan
Graphical It's super ! The p-n junction was introduced to electrochemical catalysts for superoxide detection. Based on the superoxide dismutase mimic activity of CeO 2 and the high electrochemical catalytic activity of CuO, a non-enzymatic superoxide sensor was established. Owing to the construction of a p-n heterojunction, the sensing performances of p-CuO/n-CeO 2 composites were further enhanced. This method could serve as an effective strategy to overcome the intrinsic defects of semiconductor catalysts and improve their applications in electrochemical sensors. The performance of electrochemical sensors is mainly limited by the intrinsic properties of electrocatalysts fabricated on the electrode. Introducing a p-n heterojunction into semiconducing electrocatalysts is an effective strategy to enhance the sensing performance. In this paper, p-n-heterojunction-based CuO/CeO 2 nanocomposites were synthesized by a simple hydrothermal process, and the effect of different Cu/Ce molar ratios was explored. p-CuO/n-CeO 2 was found to exhibit higher conductivity and electrocatalytic activity toward the target superoxide anion (O 2 .− ) when compared to both bare CuO and CeO 2 . Characterization shows that different Cu/Ce ratios in p-CuO/n-CeO 2 materials result in a considerable variation in the Ce 3+ /Ce 4+ level, and energy band gap of CeO 2 , greatly affecting the electrochemical performance of p-CuO/n-CeO 2 . Under optimized conditions, these sensors exhibit high sensitivity and low detection limit toward O 2 .− . These results demonstrate that the performance of semiconductor-based electrochemical sensors may be enhanced by the electron-transfer process of p-n junction interfaces.
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JOURNAL OF ELECTRONIC MATERIALS
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2025
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IF 2.5
Tan Shangrong,Yao Zhuo,Huang Hong,Liu Zechen,Guo Shiqi,Zhao Xinyun
Electrochemical supercapacitors, given their high power density and excellent cycling stability, have broad applications from electronic devices to electric vehicles. In this study, we have developed novel nanocomposites to serve as electrodes of high-performance supercapacitors. The nanocomposites, referred to as Cu/MnX x (X = O, S, C)-rGO (rGO: reduced graphene oxide), were fabricated through direct oxidation, sulfidation, and carbonization at elevated temperatures from their metal–organic framework origin, i.e., Cu/Mn-BTC-rGO (BTC: benzene–1,3,5-tricarboxylic acid). This process is cost-effective and scalable, and can be fine-tuned to achieve a variety of nanocomposites with the desired chemistry and structural characteristics. The carbonized product, Cu/MnC x -rGO, is made up of nanoparticles of MnO and copper in close contact supported on rGO nanosheets via strong coupling. This material demonstrates excellent charge storage, rate capability, and cycling stability, i.e., high specific capacitance of 718.6 F g −1 at a current density of 1 A g −1 , with 92.6% capacitance retention after 1000 cycles. The hierarchical 3D structured Cu/MnC x -rGO nanocomposite has unique chemistry, high surface area, and high electrical conductivity, and hence ensures rapid ion and electron transport beneficial to both pseudocapacitive and double-layer capacitive performance.
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ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Bao Pan,Ge Jin,Wen Chen,Jiani Qin,Fei Li,Chuanyi Wang
Transition metal doping and nanostructure engineering are effective strategies to overcome the limitations of photocatalysts in peroxomonosulfate (PMS) activation. In this study, Cu-doped MoS 2 with a hierarchical microspheric architecture was synthesized via a one-step hydrothermal method and employed for tetracycline (TC) degradation through PMS activation. Under visible light irradiation, the Cu 0.06 -MoS 2 catalyst achieved an 86.2% TC removal efficiency within 40 min, which was 2.3 times higher than that of pristine MoS 2 . The effects of various operation parameters, including initial PMS concentration, reaction temperature, solution pH, and coexisting inorganic anions on the TC degradation efficiency were thoroughly investigated. Characterization results and theoretical calculations demonstrated that the redox cycles of Cu 2+ /Cu + and Mo 6+ /Mo 4+ , as well as the 3D microspheric structure of Cu 0.06 -MoS 2 , support its ultra-high charge transfer capability and abundant exposure of active sites, thereby promoting efficient photocatalytic activation of PMS for TC degradation. Reactive species quenching experiments and EPR analysis revealed that ·O 2 − , •OH, and SO 4 •− are the primary reactive oxygen species involved in TC degradation. This study provides a promising direction for the development of highly efficient micropollutant degradation utilizing transition metals-modified sulfide photocatalysts with a 3D architecture.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
·
IF 5.8
Dandan Wu,Yufu Yan,Zijun Liu,Chengyong Wang
Silicon nitride (Si 3 N 4 ) ceramic matrix conductive composite materials have shown great promise as conductive layer materials for electrical transmission components. However, existing conductive phases struggle to form a three-dimensional (3D) interconnected network in Si 3 N 4 matrix, resulting in poor electrical conductivity . This study proposed a spark plasma sintering (SPS) process utilizing Si 3 N 4 as the substrate and Cu particles as the reinforcement phase to fabricate a novel electrical conductivity Si 3 N 4 /Cu composite material. The results indicated that the diffusion of Si atoms in Si 3 N 4 facilitated the formation of copper silicide (Cu i Si) interface between the two constituents during sintering, creating a strong chemical bonding for high conductivity. Simultaneously, composite materials with optimized Cu content formed a 3D interconnect network structure, providing a continuous path for electrical conduction. At Cu content of 30 vol%, the Si 3 N 4 /Cu composite exhibited a satisfying electrical conductivity of 295.37 S/m, which was 14 orders of magnitude higher than that of Si 3 N 4 . The composites also demonstrated a percolation phenomenon, with a theoretical percolation threshold of Cu particles at just 0.1 vol%, an order of magnitude lower than that of carbon reinforcement particles . Furthermore, an integrated design featuring external insulation and internal conductivity was achieved by wrapping a Si 3 N 4 insulation layer around the conductive Si 3 N 4 /Cu composites. The fabricated insulation layer exhibited higher resistivity (1.12×10 14 Ω) and a lower wear rate (1.3×10 −6 mm 3 /N·m) compared to some contemporary insulation ceramics, while the conductive layer had a lower calorific value , making them excellent candidates for electrical transmission component materials.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Ming Zhang,Ting An,Xiuduo Song,Fengqi Zhao,Ergang Yao,Yongqiang Xue,Ying Wang,Xueli Chen,Zhifeng Yuan,Libai Xiao
In order to deal with the long-standing contradiction between safety and performance for propellent combustion catalyst, the TKX-50-M (M=Pb, Bi and Cu) were designed, synthesized and characterized. The density, thermal decomposition, mechanical sensitivity and energy performance of the prepared TKX-50-M were studied systemically. By taking NTO-Pb as the benchmark, the TKX-50-M exhibited much better energetic and safety properties. Besides, the combination of TKX-50-Pb, TKX-50-Cu and carbon black is conductive to the combustion of HMX-CMDB propellant. The burning rate of HMX-CMDB propellant increases from 16.80 to 21.28 mm s −1 at 20 MPa, and the pressure index reduces from 0.87 to 0.39 in the pressure range of 10–20 MPa. The catalytic mechanism of TKX-50-M were explored according to the results of combustion wave structure, flame image and characteristics of burning out surface. The catalytic effect of TKX-50-Pb is mainly reflected in the gas phase region, and the introduction of TKX-50-Cu and carbon black shows a significant synergistic catalytic effect. The results of this study not only help to explore insensitive high-energy combustion catalyst, but also helps to improve the combustion, energy and safety performance of CMDB propellants.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
·
IF 8.1
Peilin Jia,Dongzhi Zhang,Xingyan Shao,Jieshuo Zhai,Jishun Guo,Zijian Wang,Xinyi Ji
Hydrogen (H 2 ), as a clean energy source, exhibits significant promise in the realm of new energy vehicles. Utilizing hydrogen sensors with rapid response and high selectivity is crucial for monitoring vehicles and preventing hydrogen leakage incidents. In this study, In 2 O 3 nanomaterials were synthesized via a hydrothermal approach and effectively modified with Ag/Cu bimetallic nanoparticles to fabricate high-performance hydrogen sensors. The optimal work temperature for the Ag/Cu–In 2 O 3 sensor is determined to be 300 °C. At this temperature, the sensor exhibited a response of 9.66–100 ppm H 2 , which is four times higher than the pristine In 2 O 3 sensor. Excellent H 2 selectivity and outstanding long-term stability were exhibited by the sensor in typical interference gas environments encountered in new energy vehicles. The significant enhancement in sensor performance is attributed to the electronic and chemical sensitization effects of Ag/Cu bimetals and the synergistic effects of bimetallic modification. Additionally, computational studies based on density functional theory (DFT) further elucidated the reasons for the improved H 2 gas sensing performance of Ag/Cu–In 2 O 3 nanocomposites. The Ag/Cu–In 2 O 3 nanocomposites show great potential for hydrogen detection applications in the sensor field.
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Inorganic Chemistry Frontiers
·
2024
·
IF 6.1
Ao Xu,Yan Liu,Jiahui Wang,Yijing Wang,Fuyi Jiang,Yanli Zhou
Limited by the poor electronic conductivity and strong interaction between Mg2+ and MoS2, the 2H phase of MoS2 as the cathode materials exhibits a low capacity along with poor rate capability. How to adopt the structure engineering to largely boost the Mg2+ diffusion kinetics and enhance the reaction activity are the current tasks that need to be addressed. Herein, the cation doping strategy is adopted to elaborately design the defective Cu-doped metallic MoS2 nanosheets (Cu-MoS2) via a hydrothermal process. The Cu2+ doping widens the layer distance, induces the formation of metallic 1T phase of MoS2, and ameliorates the structural stability. Thus, the Mg2+ ions diffusion kinetics and the electronic conductivity of Cu-MoS2 are largely boosted. Meanwhile, the MgCl+ in the electrolyte can decrease the reaction energy barrier, and therefore fasten the electrochemical reaction. Therefore, the optimized Cu-MoS2 as the cathode materials toward magnesium ion batteries exerts remarkable magnesium storage properties, evidently superior to the pure MoS2. When cycled at 0.1 A g-1 over 100 cycles, the discharge capacity can reach as high as 369.5 mAh g-1. Even cycled at a high rate of 1 A g-1, the Cu-MoS2 maintains a specific capacity of 267.3 mAh g-1 over 200 long cycles. The related kinetics tests confirm its rapid reaction kinetics and pseudocapacitance dominated charge storage process. The ex-situ XPS and HRTEM data largely verify the conversion reaction mechanism of Cu-MoS2 during cycling. This work provides guidelines for the long-term development of MoS2 in the field of magnesium ion batteries.
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WEAR
·
2024
·
IF 5.3
Min Zhong,Shengzhi Duan,Xiaowen Wu,Jiajie Kang,Hao Ding,Zhaohui Huang,Minghao Fang,Xin Min,Wen Yue
The tight interface between graphene and Cu is the key to give full play to the comprehensive properties of Cu/C composites. In this study, reduced graphene oxide(RGO) was used as a reinforcing phase of Cu marix, and the interfacial bonding strength between RGO and Cu was enhanced by introducing Ni metal nanoparticles . RGO supported Ni nanosheets (Ni-RGO) were successfully prepared by in-situ chemical reduction of graphene oxide (GO) and the introduction of Ni nanoparticles into GO. Ni nanoparticles were tightly attached to the graphene sheets . The mechanical properties and tribological properties of Ni-RGO/Cu composites were significantly improved. The bending strength of Ni-RGO/Cu composites reached 162.2 MPa, which was much higher than that of the pure Cu. At the same time, Ni-RGO composites have the lowest wear rate, and the friction coefficient is stable between 0.1 and 0.2. The comprehensive performance of Ni-RGO composites is significantly enhanced due to the unique structure of Ni-RGO, and the introduction of Ni nanoparticles realizes the effective bonding between GO-Ni-Cu. This study provides a new and effective strategy for enhancing the interfacial bonding of Cu/C composites.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Chao Yang,Xueying Zhao,Yunlong Zhao,Chenchen Ji,Ronglan Wu,Lu Wang,Xueqing Shao
CuO x -decorated TiO 2 (CuO x /TiO 2 ) nanoparticles have been prepared by the pyrolysis of Cu(II) complex on TiO 2 in an oxygen-limited atmosphere. A solution phase deposition method combined with freeze drying was employed for depositing the 2-methylimidazole-Cu(II) complex onto TiO 2 nanoparticles . The effect of decoration of CuO x on TiO 2 nanoparticles in terms of the crystal phase, morphology, chemical compositions , surface area , surface elemental states, optical absorption and emission properties, was investigated using a series of characterization tools. The oxygen-limited pyrolysis of 2-methylimidazole resulted in the reduction of partial Ti 4+ and Cu 2+ ions into Ti 3+ , Cu + and Cu 0 species, respectively. The surface decoration of CuO x was found to improve the separation and migration of photogenerated electron-hole pairs and increase the life time of excitons. Furthermore, the photocatalytic performance of CuO x /TiO 2 nanoparticles was evaluated for hydrogen evolution in aqueous methanol solution under UV–visible light irradiation . The CuO x /TiO 2 photocatalyst with the optimal cocatalyst loading achieved hydrogen evolution rate of 4.34 mmol h −1 g −1 , with 71- and 5.5-fold enhancement in activity over neat TiO 2 and CuO x /P25, respectively. It is expected that the combination of deposition and pyrolysis of 2-methylimidazole-Cu(II) complex could be an effective approach for the decoration of Cu and its oxides on other supports.
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International Journal of Electrochemical Science
·
2024
·
IF 1.3
Rusi Hao,Wenliang Sun
Lithium iron phosphate (LiFePO 4 , LFP) is a frequently utilized cathode material for lithium-ion batteries. However, its practical applications are constrained by its relatively low ionic and electronic conductivities. To address this issue, it is possible to utilize highly conductive metallic coatings to enhance the material's electronic conductivity. Herein, LiFePO 4 with Cu composites (LFP/Cu) as cathode was synthesized by a simple solid-state process via one-step grinding in the presence of CuNO 3 and ascorbic acid. The discharge capacity of the LFP/Cu cathode with 0.75 wt% Cu was found to be 160.9 mA h g −1 at 0.1 C, representing a close approximation of its theoretical capacity and a notable enhancement compared to pure LFP (145.9 mA h g −1 ). Furthermore, it demonstrates excellent stability with a capacity retention of 136.5 mA h g −1 after 100 cycles at 2 C, as well as good rate performance. The electrochemical impedance spectra demonstrate that the incorporation of copper results in a further reduction in the resistance of LFP/Cu compared to pure LFP. The incorporation of copper particles into lithium iron phosphate has been shown to enhance its electronic conductivity, thereby further enhancing its electrochemical performance. In this study, we present a facile and cost-effective room-temperature synthesis method for the preparation of LiFePO 4 /Cu composites with improved electrochemical properties. This work provides a promising avenue for the design of cathode materials in lithium-ion batteries.
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