JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Wan Menghui,Gao Minjie,Luo Wen,Jin Lin,Zhao Yanbao,Sun Lei
Conventional pesticides generally suffer from low actual utilization efficiency due to their large particle sizes, weak leaf adhesion and rain erosion. Developing functional nanomaterials with high foliar affinity and rain-fastness remains a major challenge for enhancing pesticide utilization efficiency. Herein, we developed novel jellyfish-like nanocarriers for pesticide delivery. Firstly, jellyfish-like mesoporous polydopamine (J-mPDA) were prepared via an interface anisotropic self-assembly strategy. The unique jellyfish-like structure may enlarge the contact area and the topological interaction between the leaf surface and the nanocarrier. The synthesized J-mPDA carriers presented radial mesopores with a cross-sectional size of about 290 nm and an imidacloprid (IMI) loading efficiency of 22.4%. After loading IMI, tannic acid-copper ions (TA/Cu) networks were utilized to cap the loaded-pesticide pores (IMI@J-mPDA@TA/Cu). The obtained IMI@J-mPDA@TA/Cu exhibited pH/near-infrared dual responsiveness release properties. The IMI@J-mPDA@TA/Cu significantly improved the adhesion and retention efficiency of the foliar surface. Furthermore, the obtained nanoparticles displayed good biosafety and no significant inhibitory effect on bacteria and seed germination. In addition, IMI@J-mPDA@TA/Cu possessed an improved 6-fold anti-UV photostability compared with IMI, and high control efficacy against Plutella xylostella . As a result, this work provides a novel option to address adhesion inefficiencies and reduce pesticide runoff, making it a promising for efficient pesticide delivery. Graphical
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高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 7
·4713-4733
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IF 5.7
Chen Maoshuang,Ayaz Pirah,Xiao Yuanxiang,Li Yong,Wang Pei,Huang Wenjia,Zhao Shujun,Fu Feiya,Liu Xiangdong,Xiang Shuangfei
Versatile cotton fabrics can be used in a variety of special environments and offer unparalleled advantages in textile products. In this work, bio-based phytic acid (PA), octadecylamine (ODA) and TiO 2 (NPs) were used as raw materials to prepare multifunctional cotton fabrics with excellent flame retardant (LOI = 48.5%), hydrophobic (WCA = 152°), UV-blocking (UPF = 2000) and antibacterial (BR = 100%) properties through a facile and scalable dip coating and spraying process. Firstly, the phytic acid was grafted onto the surface of cotton fabric by esterification reaction between its phosphoric acid group and the hydroxyl group of cellulose molecules. Then ODA reacted with the residual phosphoric acid group of phytic acid to form an ODA layer, for further immobilizing TiO 2 (NPs) particles on the surface of cotton fabric. The resulting cotton fabric possessed excellent flame resistance (LOI > 36.2%), hydrophobicity (WCA > 138°), UV-blocking (UPF = 2000) and antibacterial abilities (BR > 96.0%) even after 20 washing cycles. Moreover, this modification process did not sacrifice the desired cotton properties, including water vapor permeability, flexibility and tensile strength. This work proposed a simple and scalable pad-dry curing method to construct stable and multifunctional cotton textiles, which have broadened application prospects in many fields. Graphical abstract
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Friction
·
2023
·
IF 6.8
Wang Hanwen,Wang Ying,Wen Ping,Ma Lin,Fan Mingjin,Dong Rui,Zhang Chunhua
Development of energy-efficient lubricants is a way to reduce energy consumption for transportation, with the tendency to design molecules that are beneficial in reducing the viscosity of synthetic oils. Oligoether esters (OEEs), as a low-viscosity ester base oil, have characteristics such as simple synthesis and excellent lubrication effect, however, the application of OEEs in tribology field has rarely been investigated. The objective of the present study is to investigate the effect of structure on the lubricating performance of OEEs and to develop a predictive model for OEEs based on quantitative structure-property relationship (QSPR) through a combination of experiment and statistical modeling. Results showed that glycol chains contribute positively to lubrication with the ether functional groups increasing the sites of adsorption. Compared to branched-chain OEEs, straight-chain OEEs exhibited reduced wear, which was mainly due to the thicker adsorption film formed by the straight-chain structure. Furthermore, carbon films were detected on lightly worn surfaces, indicating that OEEs underwent oxidation during the friction process. Based on the results of principal component analysis (PCA) and partial least squares (PLS), it could be found that the predictive models of viscosity–temperature performance, thermal stability performance, coefficient of friction (COF), and wear volume (WV) performed well and robustly. Among them, COF and WV can be best predicted with an R 2 of about 0.90.
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Advanced Composites and Hybrid Materials
·
2023
·Vol. 6
·期 6
·1-15
·
IF 20.1
Xiang Lele,Darboe Abdou Karim,Luo Zhihong,Qi Xiaosi,Shao Jiao-jing,Ye Xiao-Juan,Liu Chun-Sheng,Sun Kai,Qu Yunpeng,Xu Jing,Zhong Wei
Interface engineering and/or impedance matching characteristic played a very important role in microwave absorption. To simultaneously make best of these aspects, herein, two-dimensional (2D)/2D reduced graphene oxide (RGO)/MoSe 2 van der Waals heterojunctions (VDWHs) were elaborately designed and successfully produced in large scale and high efficiency through a simple solvothermal method. By increasing the amount of graphene oxide (GO) from 15 to 45 mg, the designed 2D/2D RGO/MoSe 2 VDWHs with enhanced RGO contents and interfaces could be synthesized, which resulted in their progressively boosted comprehensive microwave absorption properties (MAPs). Furthermore, the proposed route could also be expanded to fabricate 2D/2D RGO/MoS 2 VDWHs. The obtained results demonstrated that the enhanced amount of GO effectively improved their impedance matching characteristics, conductivity loss, and polarization loss capabilities of 2D/2D RGO/MoX 2 (X = Se and S) VDWHs, which contributed to their enhanced comprehensive MAPs. In particular, the RGO/MoSe 2 VDWHs displayed a minimum reflection loss of − 65.34 dB at 6.40 GHz and an effective absorption bandwidth of 4.20 GHz. Therefore, the findings not only presented a combined composition modulation and interface engineering strategy to simultaneously take full advantage of impedance matching characteristics and interfaces for improving the comprehensive MAPs but also provided a simple and propagable route to design and synthesize 2D/2D RGO/MoX 2 (X = Se and S) VDWHs, which could be acted as the good candidates for lightweight high-efficiency microwave absorbers.
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Chinese Medicine
·
2023
·Vol. 18
·期 1
·1-14
·
IF 4.9
Wang Baolin,Wang Qinqin,Yuan Renyikun,Yang Shilin,Lu Meilin,Yuan Fuhong,Dong Zhidan,Mo Menghuan,Pan Qiming,Gao Hongwei
Background The successful launch of icaritin, a therapeutic drug for liver cancer derived from Epimedium brevicornu, has provided new impetus for the development of prenylated flavonoids in the field of oncology. Flemingia macrophylla is reported to contain characteristic prenylated flavonoids which can regulate the p53 protein. We aimed to isolate these constituents and conduct activity evaluation, structure–activity relationship, and mechanism studies to provide candidate compounds for antitumor drug development.Methods In this study, chromatographic techniques combined with spectroscopic methods were used to separate, purify, and identify the constituents of Flemingia macrophylla methanol extract. The cytotoxic activity of the constituents was evaluated using an MTT assay with A549 and H1975 cells as the model. The binding mechanism between the compounds and the p53 protein was investigated with molecular docking and validated with cellular thermal shift assay (CETSA). Western blotting (WB) was employed to detect the expression of p53 protein and apoptosis-related proteins in cells.Results Chiral HPLC separation of racemates 1 and 7 provided two pairs of undescribed enantiomers (1a/1b and 7a/7b), along with eight known compounds (2 − 9) isolated from Flemingia macrophylla roots. Their structures were elucidated by spectroscopic analysis, and the absolute configurations of the enantiomers were determined from experimental and calculated electronic circular dichroism data. Compounds 1 − 7, and the non-prenyl analogues 10 − 13, were evaluated for cytotoxic activity against the human lung cancer A549 and H1975 cell line. Compounds 5 − 7 displayed better cytotoxicity than the positive control icaritin in A549 and H1975, with IC50 values ranging from 4.50 to 19.83 μmol·L-1 and < 5 μmol·L-1, respectively. The structure–activity relationships of the chromone or flavonoid analogues against A549 cells were discussed. Molecular docking results demonstrated that compound 7a has strong interaction with p53 and WB indicated that 7a induced apoptosis by increasing the p53 protein, decreasing the anti-apoptotic protein Bcl-2, and activating the caspase family in A549 cells. These results suggest that prenylated flavonoids are potential p53 protein activators.Conclusion This study demonstrates that Flemingia macrophylla is rich in prenylated flavonoid constituents, among which compounds 5 and 7 exhibited significant cytotoxic activity against A549 cells and served as reference candidates for the design and development of prenylated compounds as antitumor therapeutic drugs.Graphical Abstract
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高影响因子
Journal of Biological Engineering
·
2023
·Vol. 17
·期 1
·1-11
·
IF 5.6
Karimi Hajishoreh Negar,Dadashpour Mehdi,Akbarzadeh Abolfazl
Due to their outstanding structures and properties, three-dimensional (3D) hydrogels and nanoparticles have been widely studied and indicated a very high potential for medical, therapeutic, and diagnostic applications. However, hydrogels and nanoparticles systems have particular drawbacks that limit their widespread applications. In recent years, the incorporation of nanostructured systems into hydrogel has been developed as a novel way for the formation of new biomaterials with various functions to solve biomedical challenges. In this study, alginate-loaded Zinc- laponite—curcumin (Zn/La/Cur) nanocomposites were fabricated via ionic cross-linking. The prepared nanocomposite hydrogels were characterized via FTIR and FE-SEM. Moreover, energy dispersive x-ray spectroscopy (EDX) was used to study the elements of the Zn/La/Cur nanocomposite. The NIH3T3 fibroblast cell line was utilized for the MTT assay to determine the cell viability of the fabricated alginate-loaded Zn/La/Cur nanocomposites. MTT results demonstrated that there was no evidence of toxicity in the samples. These outcomes suggest that applying Al/Zn/La/Cur nanocomposite as a biological agent could be a novel tissue engineering strategy for treating soft tissue disorders.Graphical Abstract
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Communications Physics
·
2023
·Vol. 6
·期 1
·1-10
·
IF 5.5
Zhang Zhengyang,Bai Pei,Xiao Yuhan,Guo Yunlong,Wang Yanming
Nanoscale polymeric thin films are widely used in diverse modern applications, where a satisfactory mechanical performance is a requirement to their full functionality. The mechanical response of polymer films is strongly affected by the size effects under nanoconfinement; however, the mechanism of such response in terms of molecular configurations and chain conformations has yet to be determined. In this work, we reveal the conformational origin of the stiffening behavior of crosslinked polymeric nanofilms via coarse-grained molecular dynamics and tailored experiments. We find that the biaxial modulus changes follow the alteration of polymer conformations, decoupled from size and thickness. We propose a theory to quantitatively link the elastic properties of the polymers to the distribution of their chain end-to-end distances, predicting a stiffening effect on uncoiled chains. Finally, we use such insight to obtain several PDMS nano-films of the same thickness but with a variability of two orders of magnitudes in their moduli.
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Nano Research
·
2021
·Vol. 15
·期 1
·716-727
·
IF 8.897
Zhao Meijiao,Zeng Qin,Li Xipeng,Xing Da,Zhang Tao
Tumor oxygen spatial heterogeneity is a critical challenge for the photodynamic inhibition of solid tumors. Development of an intelligent nanoagent to initiate optimal therapeutics according to the localized oxygen levels is an effective settlement. Herein, we report an activatable nanoagent (BDP-Oxide nanoparticles (NPs)) to enable the oxygen auto-adaptive photodynamic/photothermal complementary treatment. Upon the nanoagent accumulated in the tumor region, the low extracellular pH could trigger the disassociation of the nanoagent to release the phototheranostic agent, BDP-Oxide, which will subsequently afford the fluorescence imaging-guided photodynamic oxidation after it gets into the outer oxygen-rich tumors. Along with the penetration deepening in the solid tumor, furthermore, BDP-Oxide could be reduced into BDP by the cytochrome P450 (CYP450) enzymes activated in the low oxygen tension regions of inner hypoxic tumors, which will switch on the photothermal and photoacoustic effects. Overall, the BDP-Oxide NPs-enabled photodynamic/photothermal complementary therapy significantly suppressed the solid tumor growth (inhibition rate of 94.8%). This work proposes an intelligent platform to address the oxygen partial pressure for the optimization of cancer phototherapeutics.
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Journal of Food Measurement and Characterization
·
2023
·
IF 3.4
Yang Mao-Hui,Zhou Xin,Yang Yan,Chen Hua-Guo
Polygonatum sibiricum is a traditional Chinese medicine with homology of medicine and food. Exploring different methods for extracting polysaccharides from Polygonatum sibiricum will provide broader insights into the study of its structural characteristics and biological activities. In this study, polysaccharides (PSPs) were extracted from by different methods with water (cold and hot), alcohol solutions (different concentrations) under ultrasound. The structure characterization of PSPs was mainly composed of Glc, Man and Gal with different molar ratio. HPLC data showed that the glycosidic bond of PSPs existed in α, β-D-configurations. Congo red experiment indicated that PSPs had similar triple helix structure. The PSPs extracted by different methods had different biological activities. PSP-5 had the best ability to inhibit AChE activity, and its mechanism was further explored. Results showed AChE inhibitory activity of PSP-5 was reversible, and the inhibitory mechanism was mixed type I competitive inhibition. Compared with the AChE inhibitors, PSP-5 had the potential to become an excellent AChE inhibitor.
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Journal of Bionic Engineering
·
2023
·Vol. 20
·期 6
·2826-2839
·
IF 4
Tian Hongli,Du Wenbo,Zhan Yuchao,Tian Limei,Zhao Jie,Sun Jiyu
In this study, an integrative bioinspired coating system for antifouling and corrosion resistance was investigated, in which self-healing nanocapsules (tung oil calcium alginate, TO@CA), doped polyaniline and nano-titanium dioxide nanocomposites (SPAn–TiO 2 ) and a biostructure metal surface were combined. The antifouling property of the bioinspired coating resulted from the synergistic antifouling effect of nano-TiO 2 and acid-doped polyaniline in SPAn–TiO 2 . The protonated nitrogen with a positive charge in SPAn–TiO 2 and the intrinsic bactericidal property of nano-TiO 2 could damage negatively charged single-celled chlorella, endowing the composite coating with good antifouling performance (less algae attached on the surfaces after a 90-day antifouling test and a conductivity test). The composite bioinspired coating had excellent corrosion resistance, which was due to the good synergistic anticorrosion barrier effect of SPAn–TiO 2 with TO@CA nanocapsules and the repairing ability of microcracks of TO@CA nanocapsules during the corrosion process. The bioinspired coating with 2 wt% SPAn–TiO 2 and 2 wt% TO@CA nanocapsules exhibited a better adhesion, corrosion resistance and antifouling performance than the other coatings did.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 32
·1-16
·
IF 2.8
Guan Jiayan,Liu Xiangchun,Bai Ningna,Wang Fei,Yang Zhe,Zhang Jie,Gao Feng,Zhang Ping,Wei Ziyao
High-performance fluorescent carbon quantum dots (CQDs) prepared by hydrothermal method using citric acid and polyethyleneimine as raw materials. TiO 2 /ZnO/CQDs ternary composites were obtained by compositing different contents of CQDs with TiO 2 /ZnO. The phase structure, morphology, photocatalytic performance, and photocatalytic mechanism of ternary TiO 2 /ZnO/CQDs were investigated. The result shows that the CQDs synthesized by the hydrothermal method have good whole dispersibility, spherical shape, and particle size of 3–5 nm. When the hydrothermal time is 4 h and the hydrothermal temperature is 220 °C, the fluorescence luminescence performance of the prepared CQDs is the best. The prepared CQDs were loaded on the surface of TiO 2 /ZnO to form ternary TiO 2 /ZnO/CQDs photocatalysts. The results find that no other new phase is produced by the complex, and the TCZ-1 sample (When the amount of CQDs is 1 mL, the prepared ternary composite photocatalyst.) has a uniform grain size, with an average grain size of about 20 nm. CQDs can reduce the band gap bandwidth of TiO 2 /ZnO, and the polar hydrophilic functional groups of CQDs are displayed in the composite, which improves the photocatalytic performance and stability of TiO 2 /ZnO. TCZ-1 sample has the best photocatalytic performance, and the photocatalytic degradation rate of methylene blue (MB) solution is 96.7% within 90 min, and after 5 cycles of degradation, it drops to 80.2%, which is improved compared with zinc oxide catalyst.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2023
·Vol. 415
·期 29
·7223-7233
·
IF 4.3
Gong Yichen,Han Hongliang,Ma Zhanfang
Self-powered immunosensors (SPIs) based on enzymatic biofuel cell (EBFC) have low sensitivity and poor stability due to the high impedance of the immune sandwich and the vulnerability of enzymes to environmental factors. Here, we applied the Faraday cage-type sensing mode on a hybrid biofuel cell (HBFC)-based SPI for the first time, which exhibited high sensitivity and stability. Cytokeratin 19 fragment (CYFRA 21-1) was used as a model analyte. Au nanoparticle-reduced graphene oxide (Au-rGO) composite was used as the supporting matrix for immunoprobe immobilized with detection antibody and glucose dehydrogenase (GDH), also the builder for Faraday cage structure on the bioanode in the presence of antigen. After the combination of immunoprobe, antigen, and the antibody on the bioanode, the Faraday cage was constructed in case the AuNP-rGO was applied as a conductive cage for electron transfer from GDH to the bioanode without passing through the poorly conductive protein. With the assistance of the Faraday cage structure, the impedance of the bioanode decreased significantly from 4000 to 300 Ω, representing a decline of over 90%. The sensitivity of the SPI, defined as the changes of open circuit voltage (OCV) per unit concentration of the CYFRA 21-1, was 68 mV [log (ng mL −1 )] −1 . In addition, Fe-N-C was used as an inorganic cathode material to replace enzyme for oxygen reduction reaction (ORR), which endowed the sensor with 4-week long-term stability. This work demonstrates a novel sensing platform with high sensitivity and stability, bringing the concept of hybrid biofuel cell-based self-powered sensor. Graphical Abstract
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高影响因子
危险品化学品经营许可证（带存储）