ACS Applied Energy Materials
·
2021
·
IF 6.024
Qiang Chang,Liu Yao,Wenping Zha,Meifen Wu,Fangfang Xu,Zhaoyin Wen
Silicon is an attractive anode material for the high-energy-density lithium-ion battery due to its high theoretical capacity (4200 mA h g–1). However, larger volume expansion (∼300%) and pulverization during cycling hinder the commercialization of silicon anodes. The modification of silicon materials is a widely recognized approach to enhance the anode performance, but the volume expansion cannot be solved completely when only focusing on the active material but ignoring the overall structural optimization of the anode. In the study, additional hierarchical pores were constructed in the electrodes by in situ partial pyrolysis of the binder sodium carboxymethyl cellulose (CMC) at low temperature. Benefiting from the extra buffer space, the electrodes can accommodate more expansion and enhance the conduction of electrons and ions. In addition, the partially degraded CMC reduced the adsorption energy between the binder and the active material, reducing the stress during the swelling process, which is demonstrated by density functional theory. The as-obtained electrode delivered a high reversible capacity of 1035 mA h g–1 at 1000 mA g–1, while the capacity retention was 78.7%, and the Coulombic efficiency was stable at 99.3% after 200 cycles. The modification of the electrode structure provides guidance for the construction of high-efficiency anodes.
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高影响因子
ACS Catalysis
·
2019
·
IF 12.221
Xueping Qin,Lulu Zhang,Gui-Liang Xu,Shangqian Zhu,Qi Wang,Meng Gu,Xiaoyi Zhang,Chengjun Sun,Perla B. Balbuena,Khalil Amine,Minhua Shao
Improving the reaction kinetics of hydrogen evolution and oxidation reactions (HER/HOR) in alkaline media is critical to promote the development of alkaline fuel cells and electrolyzers. Here, we prepared Pd3Ru alloy nanocatalysts with Ru segregated on the surfaces, forming adatoms and clusters. This structure dramatically lowered the overpotential of Pd toward HER in 1 M KOH by 104 mV at 10 mA cm–2. The HER activity was even higher than that of Pt (6 mV improvement at 10 mA cm–2). Theoretical simulation results revealed that Ru adatoms/clusters on the surface could weaken the hydrogen-binding energy and promote the OH adsorption, consequently lowering the reaction barrier of the rate-determining step in HER. Our findings are of significance for clarifying the role of Ru in bimetallic catalysts and rational design of more active catalysts for HER/HOR.
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高影响因子
ACS Sensors
·
2024
·
IF 8.2
Kai Wang,Ke-Feng Gu,Jie Cao,Yu-Shun Yang,Hai-Liang Zhu,Jin-Hui Shang,Jie-Li Zhou
Copper ions, implicated in processes such as oxidative stress and inflammation, are believed to play a crucial role in cardiovascular disease, a prevalent and deadly disease. Despite this, current diagnostic methods fail to detect early stage cardiovascular disease or track copper ion accumulation, limiting our understanding of the disease’s progression. Therefore, the development of noninvasive techniques to image copper ions in cardiovascular disease is urgently needed to enhance diagnostic precision and therapeutic strategies. In this study, we report the successful synthesis and application of a copper ion-activated photoacoustic probe, CS-Cu, which exhibits high sensitivity and selectivity toward copper ions both in vitro and in vivo. CS-Cu was able to noninvasively monitor the changes in copper ion levels and differentiate between different mice based on copper ions in urine. Furthermore, the probe demonstrated good photoacoustic stability and exhibited no significant toxicity in the mice. These findings suggest that CS-Cu could be a promising tool for early detection and monitoring of Cu2+ levels in vivo and urine, providing a new perspective on the role of copper ions in cardiovascular disease.
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PubMed
高影响因子
TALANTA
·
2024
·
IF 5.6
Jiaying Geng,Zhongxi Huang,Qian Shen,Chenfeng Xu,Long Zhang,Cuilan Wei,Chan Fu,Weizhen An,Changmin Yu
With the emergence of numerous food safety problems, rapid and accurate detection of histamine in food spoilage remains a challenge. To this end, we developed a simple design and easy synthesis of fluorescein-based probe FCHO to achieve specific and rapid (<1 s) quantitative detection of histamine through “imine formation” reaction. Significant enhanced fluorescence signal in response to histamine enabled our probe with high sensitivity as low as 51 nM. Utilizing the visualized fluorescence color changes of the probe as histamine increasing, we combined it with paper-based test chip to construct a color-resolved and highly selective recognition system. In addition, our proposed probe has been successfully used to visually imaging histamine changes in fish samples. Finally, for the first time, we have proved it possesses reliable ability to directly in situ imaging the distribution of histamine in whole spoiled fish. Thus, our strategy will provide great potential for monitoring food spoilage.
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2016
·
IF 2.76
Zhihai Cao,Qun Chen,Hangnan Chen,Zhijie Chen,Jia Yao,Shuning Zhao,Yushan Zhang,Dongming Qi
Polymeric/inorganic nanocomposite particles (NCPs) were tentatively prepared through miniemulsion polymerization using sodium dodecyl sulfate (SDS) as the sole surfactant. The representative inorganic nanoparticles (NPs), SiO 2 NPs, were pre-dispersed in monomer solutions. Particle morphology and size of the latex particles in the emulsions prepared from miniemulsions were investigated in terms of the SiO 2 and SDS content. The results indicate that the number fraction of polymer/SiO 2 NCPs ( f NCP ) in the latex particles was below 4%, and that plain polymer particles dominated in all of the emulsions regardless of the SiO 2 and SDS content when the sonication power was 95 W. The centrifugation experiments showed that there were three types of particles in the emulsions, namely, a dominant amount of plain polymer particles, a small amount of polymer/SiO 2 NCPs, and a very small amount of sub-micrometer polymer/SiO 2 aggregates. These particles evolved from small plain monomer droplets, medium monomer droplets containing SiO 2 NPs, and micrometer monomer droplets containing many SiO 2 NPs, respectively. Formation mechanisms of these three types of particles were proposed. On the basis of the mechanism, we used higher sonication power to improve the homogeneity of the number distribution of SiO 2 NPs among monomer droplets. The f NCP value markedly increased to ∼39% upon increase of the sonication power to 190 W. However, the formation efficiency of polymer/SiO 2 NCPs could not be improved with further increase of the sonication power.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2023
·Vol. 30
·期 6
·1-13
·
IF 2.8
Zhang Haoran,Xu Shuyan
With the advent of the 5G era, various thermal conductivity nanocomposites are being investigated to solve the heat accumulation on the surface of electronic devices. In this study, magnetic nanofiller ferroferric oxide-polydopamine-boron nitride nanosheets (Fe-PDA-BNNSs) are fabricated by mussel-inspired and coprecipitation methods with polydopamine (PDA) and ferroferric oxide (Fe 3 O 4 ). The aligned Fe-PDA-BNNSs/poly(vinyl alcohol) (PVA) composites with higher in-plane thermal conductivity and decent mechanical properties are prepared by applying a horizontal magnetic field. The in-plane thermal conductivity of the aligned composite at 30 wt% filler loading reaches 5.237 W/(m·K), which is 1.1 times and 20.5 times that of the unaligned composites and neat PVA. Moreover, the aligned composite maintains mechanical strength and obtains commendable thermal stability and heat dissipation capability, which can be applied to the thermal management of flexible electronic devices.
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高影响因子
FOOD CHEMISTRY
·
2019
·
IF 5.399
Shen-Zhi Wang,Hui-Qian Dai,Ke-Xian Chen,Juan Li,Zhong-Xiu Chen
Control of lipid digestibility by various food components has received great attention in recent decades. However, there is limited literature on investigating the synergistic effect of exogenous emulsifiers and endogenous sodium cholate (SC) on lipid digestion in a simulated physiological crowded medium. In this work, the synergistic interaction of Tween80 and SC according to the regular solution theory, and the hydrolysis of lipid emulsions containing tricaprylin, glyceryltrioleate or soybean oil in crowding medium was studied. The results show that emulsions stabilized by a combination of Tween80 and SC showed higher digestion rate and transformation than those with Tween80 or SC. The digestion rate could be increased by polyethylene glycols (PEGn) with varying crowding degree. The denaturation temperature of the lipase was increased in macromolecular crowded medium. This work allows for better understanding of the interaction between the amphiphiles and the macromolecular crowding effect on lipase digestion in the physiological environment.
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高影响因子
Current Computer-Aided Drug Design
·
2023
·Vol. 21
·期 1
·50-66
·
IF 1.7
Hongyi Liang,Guoliang Yin,Guangxi Shi,Xiaofei Liu,Zhiyong Liu,Jingwei Li
AimsBreast cancer (BC) is by far seen as the most common malignancy globally, with 2.261 million patients newly diagnosed, accounting for 11.7% of all cancer patients, according to the Global Cancer Statistics Report (2020). The luminal A subtype accounts for at least half of all BC diagnoses. According to TCM theory, Bushen Huoxue Decoction (BSHXD) is a prescription used for cancer treatment that may influence luminal A subtype breast cancer (LASBC).ObjectivesTo analyze the clinical efficacy and underlying mechanisms of BSHXD in LASBC.Materials and MethodsNetwork pharmacology and in vitro experiments were utilized to foresee the underlying mechanism of BSHXD for LASBC.ResultsAccording to the bioinformatics analysis, BSHXD induced several proliferation and apoptosis processes against LASBC, and the presumed targets of active components in BSHXD were mainly enriched in the HIF-1 and PI3K/AKT pathways. Flow cytometry assay and western blotting results revealed that the rate of apoptosis enhanced in a dose-dependent manner with BSHXD concentration increasing, respectively. BSHXD notably downregulated the expressions of HIF-1α, P-PI3K, PI3K, P-AKT and AKT proteins. However, adding an HIF-1α agonist restored those protein levels.ConclusionThe study proved that the mechanism of BSHXD in LASBC may be connected to suppressing proliferation by inhibiting the activity of the HIF-1α/PI3K/AKT signaling pathway and promoting apoptosis via the Caspase cascade in LASBC cells.
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高影响因子
JOURNAL OF SOLID STATE ELECTROCHEMISTRY
·
2016
·Vol. 21
·期 3
·715-724
·
IF 2.327
Zhang Kaiyue,Chen Si,Feng Yaqing,Shan Zhongqiang,Meng Shuxian
A novel polymer gel electrolyte was used to improve the performance and long-term stability in dye-sensitized solar cells (DSSCs). The polymer gel electrolyte (PGE) was prepared by mixing 5 wt% poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) and 2 % TiO 2 nanoparticles. The conductivity of PGE with P25 reached 9.98 × 10 −3 S/cm, which increased by 34.9 % compared with 7.40 × 10 −3 S/cm of PGE without P25, and the diffusion coefficient was also increased by 19.0 %. Different photoelectrodes were obtained by using three kinds of surfactants (cetylamine, octadecylamine, and P123) as pore-forming materials, and their morphologies were contrasted through scanning electron microscopy (SEM). The results showed that gel electrolyte can increase the short-circuit current density ( J
sc ) from 11.01 to 12.99 mA/cm 2 in DSSCs. Moreover, unlike the liquid electrolyte, the gel electrolyte is more conducive to the TiO 2 photoelectrodes with larger pores. In conclusion, the efficiency of DSSC with gel electrolyte and P123 as pore-forming material was 6.73 %, which was 12 % higher than the liquid electrolyte in the same test condition. In addition, the sealed gel electrolyte DSSCs showed better stability than did liquid electrolyte DSSCs during nearly 600 h.
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高影响因子
Food Analytical Methods
·
2022
·Vol. 15
·期 7
·2036-2047
·
IF 3.498
Gao Ming,Wang Hui,Wang Jun,Wang Xuedong,Wang Huili
Herein, we developed an effervescent reaction-enhanced dispersive liquid–liquid microextraction method for the preconcentration/extraction of bisphenols (BPs) in milk and milky tea samples. This microextraction method was based on the utilization of acidic ionic liquid (AIL) and in situ metathesis reaction (AI-EDLM). Compared to the traditional imidazolium-based ionic liquid, AIL can not only be used as an extractant, but also as an acidic source in the effervescent reaction. Under such a case, it can avoid the use of additional acidic source and also achieve a rapid dispersion effect due to vigorous CO 2 bubbles, which simplify the experimental procedures and decrease the preparation cost of effervescent tablets. By employing the one-factor-at-a-time approach, the main parameters were optimized as follows: 400 mg of [BMIM][HSO 4 ] as extractant, 100 mg of Na 2 CO 3 as alkaline source, 400 mg of Li[NTf] 2 as the ionic-exchange reagent, 4% of NaCl, 5 min of centrifugation and 1.5 mL of ether as the elution solvent. Under optimized conditions, the limits of detection ranged from 0.12 to 0.32 μg L −1 , and the extraction recoveries for BPA, BPB, and BPAF spanned the range of 85.7–106.2% in five kinds of milk samples. Therefore, the AIL ([BMIM][HSO 4 ]) played dual roles, i.e., extractant and pH regulator, in the AI-EDLM procedures. Overall, this proposed method is simple, quick, and environment-friendly with low detection limits and high recoveries for BPs, and thus has excellent application value in the sample pretreatment field in milk and milky tea samples.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2020
·Vol. 85
·期 4
·1285-1291
·
IF 2.479
Zi-Teng Wang,Ying Xue,Hong Sun,Zhe Zhang,Zhi-Jia Tang,Shuai-Bing Liu,Wei-Min Cai
Green tea is widely consumed as a beverage and/or dietary supplement worldwide, resulting in the difficulty to avoid the comedication with ticagrelor for acute coronary syndrome (ACS) patients receiving antiplatelet therapy. This study was designed to investigate the effect of the most abundant content in green tea, tea polyphenols on the oral and intravenous pharmacokinetics of ticagrelor in rats and its in vitro metabolism. Rats were orally treated with either saline or tea polyphenol extracts (TPEs) dissolved in saline once daily for 6 consecutive days. On day 6, after the last dose of saline or TPE, ticagrelor was given to the rats orally or intravenously. Plasma samples were collected for pharmacokinetic analysis. Human liver and intestinal microsomes were then used to investigate the inhibition by TPE, as well as its major constituents on the metabolism of ticagrelor to its two metabolites, AR-C124910XX and AR-C133913XX. Apparent kinetic constants and inhibition potency (IC 50 ) for each metabolic pathway of each compound were estimated. Oral study indicated that exposure of ticagrelor and AR-C124910XX was significantly decreased after TPE administration, while no significant differences were observed in pharmacokinetic parameters after intravenous administration of ticagrelor. TPE effectively inhibited the metabolism of ticagrelor in vitro , with epigallocatechin-3-gallate as the major constituent responsible for the observed inhibitory effects in human liver microsomes and intestinal microsomes (IC 50 = 4.23 ± 0.18 µM). Caution should be taken for ACS patients receiving ticagrelor therapy with daily drinking of green tea. Practical Application Potential interactions between tea polyphenols and ticagrelor were revealed for the first time. Results can provide suggestions for clinicians to optimize the dosing of ticagrelor while they are in the face of ACS patients receiving ticagrelor therapy, who also take green tea or its related products in their daily life.
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高影响因子
Environmental Systems Research
·
2024
·Vol. 13
·期 1
·1-10
·
IF 0
Du Hairong,Zhu Xiaoling,Yao Yunying,Yao Wei
Neonicotinoid insecticides (NNIs), as a new type of insecticide, are widely used in agriculture and daily life. Because of the low volatility of NNIs, few studies have evaluated them in atmospheric particulate matter. In this study, 101 outdoor PM 2.5 samples were collected from the Wuhan urban area from 2019 to 2021, leading to the detection of seven NNIs and three of their metabolites. The detection frequencies of all 10 substances were more than 60%, with DIN (dinotefuran) and IMI (imidacloprid) reaching 100%. DIN (52.4 pg/m 3 ) and IMI (43.0 pg/m 3 ) had higher median concentrations than other substances. Concentration distributions of the four substances ACE (acetamiprid), DIN, IMI, and 5-OH-IMI (5-Hydro-Imidacloprid) exhibited statistically significant differences ( P < 0.05) across the four seasons. Concentration levels of ACE, CLO (clothianidin), and IMI were statistically different between the three years ( P < 0.05). The median concentration of imidacloprid-equivalent total neonicotinoids (IMIeq: generated by the relative potency factor method) was 256.1 pg/m 3 . Finally, the estimated daily intake (EDI) of NNIs via respiration was greater in infants and young children than in the rest of the population, suggesting that infants and young children were more likely to be exposed to the health effects of airborne residual PM 2.5 .
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危险品化学品经营许可证（带存储）