JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Yongkang Xi,Yuxiao Zou,Zhigang Luo,Liang Qi,Xuanxuan Lu
Lipid-based delivery systems (LBDSs) are widely applied in pharmaceuticals and health care because of the increased bioavailability of lipophilic components when they are coadministered with high-fat meals. However, how to accurately control their in vivo release and stability is still challenging. Here, after introducing the simple esterification and coprecipitation, we created the dual-functional composite ODS-β-CD-VE by the coassembly of β-cyclodextrin (β-CD), octadecenyl succinic anhydride (ODSA), and vitamin E (VE). The resulting dual-functional particle presented a uniform sheetlike shape and nanometer size. In addition, its chemical structure was clarified in detail via nuclear magnetic resonance (NMR), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). Benefiting from the antioxygenation of VE, lipid oxidation in the ODS-β-CD-VE-stabilized Pickering emulsion was effectively inhibited. Meanwhile, pH-induced protonation/deprotonation of carboxyl groups guaranteed that the emulsions kept steady at pH ≤4 but were unsteady under neutral conditions. In this way, the lipids contained in the emulsion were protected from gastric juice and then digested and accurately released as n-3 polyunsaturated fatty acids (PUFA) in the simulated intestine environment. This strategy sheds some light on the rational and efficient construction of LBDSs for nutrient supplements and even pharmaceuticals in a living digestive tract.
研究领域:
药剂学
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营养学
·
食品科学
✓ 已验证
DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2022
·
IF 11.322
Dan Liu,Jiajun Qiu,Ru Xu,Junyu Liu,Jiayin Feng,Liping Ouyang,Shi Qian,Yuqin Qiao,Xuanyong Liu
Bacterial infections in wounds often delay the healing process which threaten human health and life. The development of biocompatible hydrogels with antibacterial activity and self-healing to achieve excellent wound closure effectiveness is highly desirable in clinical applications. Herein, a new class of highly stretchable, biocompatible, and antibacterial hydrogel dressings called BPP hydrogel is designed and prepared by chemically cross-linking β-CD with PEI and then physically cross-linking with PVA. The BPP hydrogel exhibits superior properties including excellent antibacterial properties against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli , good biocompatibility for mouse fibroblasts , mouse embryonic fibroblasts and human umbilical vein endothelial cells, outstanding deformability and self-healing performance to protect the wound completely even in special scenes such as pulling and bending. Besides, after damage, the broken BPP hydrogel could heal together, and the healed BPP hydrogel could be stretched to 150% breaking deformation. Furthermore, in vivo experiments further verify that BPP hydrogel has excellent sterilization and healing effect on infectious wounds. This work proves that BPP hydrogel would be a promising material for wound healing and has good prospect for clinical translation.
研究领域:
材料科学
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医学
·
生物工程
✓ 已验证
DOI
高影响因子
PeerJ
·
2019
·
IF 2.353
Hongli Yin,Ji Ma,Jichun Han,Maoru Li,Jing Shang
Background Quercetin (Qr), isoquercitrin (IQ), and quercetin-3-O-β-D-glucuronide (QG) are powerful phytochemicals that have been shown to exhibit disease prevention and health promotion properties. However, there may exist transformations between Qr, IQ, and QG in vivo . And the pharmacokinetic profiles of Qr, IQ, and QG have not been systematically compared. The pharmacokinetics study would be helpful to better understand the pharmacological actions of them. Methods Herein, we developed a reliable HPLC-MS method to compare the pharmacokinetics of Qr, IQ, and QG after separate (50 mg/kg) oral administration of them in rats, using puerarin as internal standard. The detection was performed using negative selected ion monitoring. This method was validated in terms of selectivity, linearity, precision, accuracy, extraction recovery, matrix effect, and stability; and shows reliabilities in monitoring the pharmacokinetic behaviors of these three compounds. Results Our results showed that after separate oral administration of Qr, IQ, and QG, all of the compounds could be detected in plasma. In addition, QG could be detected in the Qr group; Qr and QG could be measured in the IQ group; and Qr could be found in rat plasma after 1.5 h of QG administration. Moreover, the AUC 0− t of Qr in the; Qr group (2,590.5 ± 987.9 mg/L*min), IQ group (2,212.7 ± 914.1 mg/L*min), and QG group (3,505.7 ± 1,565.0 mg/L*min) was larger than the AUC 0− t of QG in the; Qr group (1,550.0 ± 454.2 mg/L*min), IQ group (669.3 ± 188.3 mg/L*min), and QG group (962.7 ± 602.3 mg/L*min). The AUC 0− t of IQ was the lowest among all groups. Discussion Quercetin, IQ, and QG can all be absorbed into plasma. A mutual transformation exists between Qr and QG, and IQ can be metabolized into Qr and QG in SD rats. These results would provide a meaningful basis for understanding the pharmacological actions of these three compounds.
研究领域:
药理学
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分析化学
✓ 已验证
DOI
PubMed
高影响因子
CHIRALITY
·
2019
·Vol. 32
·期 2
·168-184
·
IF 1.927
Yazhou Shuang,Yuqin Liao,Hui Wang,Yuanxing Wang,Laisheng Li
A triazole-bridged bis (β-cyclodextrin) was synthesized via a high-yield Click Chemistry reaction between 6-azido-β-cyclodextrin and 6-propynylamino-β-cyclodextrin, and then it was bonded onto ordered silica gel SBA-15 to obtain a novel triazole-bridged bis (β-cyclodextrin)–bonded chiral stationary phase (TBCDP). The structures of the bridged cyclodextrin and TBCDP were characterized by the infrared spectroscopy, mass spectrometry, elemental analysis, and thermogravimetric analysis. The chiral performance of TBCDP was evaluated by using chiral pesticides and drugs as probes including triazoles, flavanones, dansyl amino acids and β-blockers. Some effects of the composition in mobile phase and pH value on the enantioseparations were investigated in different modes. The nine triazoles, eight flavanones, and eight dansyl amino acids were successfully resolved on TBCDP under the reversed phase with the resolutions of hexaconazole, 2′-hydroxyflavanone, and dansyl- DL -tyrosine, which were 2.49, 5.40, and 3.25 within 30 minutes, respectively. The ten β-blockers were also separated under the polar organic mode with the resolution of arotinolol reached 1.71. Some related separation mechanisms were discussed preliminary. Compared with the native cyclodextrin stationary phase (CDSP), TBCDP has higher enantioselectivity to separate more analytes, which benefited from the synergistic inclusion ability of the two adjacent cavities and bridging linker of TBCDP, thereby enabling it a promising prospect in chiral drugs and food analysis.
研究领域:
分析化学
·
药物化学
✓ 已验证
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 46
·期 5
·2360-2367
·
IF 3.591
Xiaoyan Wang,Xiaona Hu,Shiqing Li,Wenhui Shi,Shujing Li,Yuxi Zhang
Sustained-release antimicrobial nanofibers (PVA-Lut-IC-NF) were prepared by incorporating a luteolin-hydroxypropyl-β-cyclodextrin inclusion complex (Lut-IC) into polyvinyl alcohol (PVA) via the electrospinning technique. PVA-Lut-IC-NF exhibits excellent water solubility and thermal stability. The results also showed significant antibacterial effects of PVA-Lut-IC-NF against Staphylococcus aureus, Candida albicans and Escherichia coli. Moreover, because of the sensitivities of different cytoderms to Lut, PVA-Lut-IC-NF was more effective against Staphylococcus aureus than Candida albicans and Escherichia coli. Additionally, PVA-Lut-IC-NF showed an appropriate slow release and maintained effective concentration in vitro release. PVA-Lut-IC-NF could have potential applications in food, pharmaceuticals, and healthcare due to its efficient antibacterial activity along with enhanced water solubility and thermal stability.
研究领域:
材料科学
·
微生物学
·
药剂学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2024
·
IF 3.3
Enbo Yu,Jun Li,Yue Wang,Ya Chen,Fuhong Xiao,Guo-Jun Deng
A copper-catalyzed three-component coupling reaction of styrene oxide, aryl iodide, and carbon disulfide for the construction of β-hydroxysulfides has been developed. In this process, readily available CS2 was used as the sulfur source to construct C–S bonds for the synthesis of phenyl-β-hydroxysulfides and (benzo[d]thiazol)-β-hydroxysulfides. This process features mild reaction conditions, simple operation, and wide substrate scope (>50 examples).
研究领域:
有机化学
·
合成化学
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2016
·
IF 2.933
Rong Tu,Dingheng Zheng,Hong Cheng,Mingwei Hu,Song Zhang,Mingxu Han,Takashi Goto,Lianmeng Zhang
Halide chemical vapor deposition process was carried out for fast fabricating oriented stoichiometric β-SiC through controlling flow rate of precursors (SiCl 4 and CH 4 ). The effects of molar ratio of C and Si precursors ( R C/Si ) on composition, preferred orientation, microstructure and deposition rate ( R dep ) were investigated. The deposits transformed from silicon-rich to stoichiometric β-SiC to carbon-rich with increasing R C/Si . 〈110〉-oriented stoichiometric β-SiC with lower density of defects were obtained at R C/Si in the range of 0.86–1.00, where the maximum R dep was 883 μm/h at R C/Si = 1.00, leading to a thickness of 1.7 mm in 2 h deposition. Formation of ridge-like morphology has been discussed based on a twin plane propagation model .
研究领域:
材料科学
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无机非金属材料
·
薄膜制备技术
·
晶体生长
·
结构表征
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2016
·
IF 7.476
Cong Tang,Zhaosheng Qian,Yuanyuan Huang,Jiamin Xu,Hang Ao,Meizhi Zhao,Jin Zhou,Jianrong Chen,Hui Feng
A convenient, reliable and highly sensitive assay for alkaline phosphatase (ALP) activity in the real-time manner is developed based on β-cyclodextrin-modified carbon quantum dots (β-CD-CQDs) nanoprobe through specific host-guest recognition. Carbon quantum dots were first functionalized with 3-aminophenyl boronic acid to produce boronic acid-functionalized CQDs, and then further modified with hydropropyl β-cyclodextrins (β-CD) through B-O bonds to form β-CD-CQDs nanoprobe. p -Nitrophenol phosphate disodium salt is used as the substrate of ALP, and can hydrolyze to p -nitrophenol under the catalysis of ALP. The resulting p -nitrophenol can enter the cavity of β-CD moiety in the nanoprobe due to their specific host-guest recognition, where photoinduced electron transfer process between p -nitrophenol and CQDs takes place to efficiently quench the fluorescence of the probe. The correlation between quenched fluorescence and ALP level can be used to establish quantitative evaluation of ALP activity in a broad range from 3.4 to 100.0 U/L with the detection limit of 0.9 U/L. This assay shows a high sensitivity to ALP even in the presence of a very high concentration of glucose. This study demonstrates a good electron donor/acceptor pair, which can be used to design general detection strategy through PET process, and also broadens the application of host-guest recognition for enzymes detection in clinical practice.
研究领域:
生物化学
·
医学检验
·
纳米生物学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Siru Guo,Huiting Han,Xinru Gao,Yilin Zhai,Juan Wang,Zhaona Zhang,Xuetong Liu,Ruoyu Yuan,Lina Yang,Xinxing Wang
Bisphenol A (BPA), as an endocrine disruptive compound of public concern, is widely present in natural water and wastewater. The development of BPA detection technology is of great significance. However, the insoluble organic nature of BPA hinders its adsorption and electron transfer at hydrophilic sensing interfaces, limiting the improvement of electrochemical sensing performance. Based on the high affinity and selectivity of β -cyclodextrin ( β -CD) toward BPA, a composite material (CNT@CD-MOF) of β -cyclodextrin metal–organic framework (CD-MOF) embedded with carbon nanotubes (CNTs) was prepared in this article for electrochemical sensing of BPA. Compared with β -CD, the three-dimensional ordered structure of CD-MOF promoted the adsorption and enrichment of BPA. The doping of CNTs led to the growth of smaller sized CD-MOF, improved the material’s charge transfer ability, and enhanced its stability. Under the synergistic effect of CNTs and CD-MOF, the CNT@CD-MOF modified glassy carbon electrode exhibited a catalytic effect on BPA oxidation and significantly improved response signals, achieving detection of BPA in a fairly wide linear range of 1 nM ∼ 500 μM with a low detection limit of 0.5 nM. This study successfully applied functionalized CD-MOF for the electrochemical detection of BPA for the first time, greatly improving the electrochemical sensing performance of BPA and promoting the application of electrochemical sensing technology in BPA detection. In addition, the excellent properties of CNT@CD-MOF make it of great application value in the fields of BPA adsorption and removal.
研究领域:
环境科学
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材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
AICHE JOURNAL
·
2025
·
IF 4
Qinghua Liu,Guoxuan Li,Chengmin Gui,Minghao Song,Fei Zhao,Shengchao Yang,Zhigang Lei,Pan Xu
Deep eutectic solvents (DESs) were regarded as promising absorbents in many absorption processes. Here, we use randomly methylated β -cyclodextrin (RAMEB) to further improve the absorption capacity of DESs for aromatic VOCs. We found benzene and toluene vapor pressures obviously decreased after adding 2% RAMEB (molar fraction) to DESs. Dynamic absorption experiments also confirmed this enhancement effect; the dynamic absorption efficiency for benzene and toluene increased by 6.12% and 9.23%, respectively, at a 5 mL/min solvent rate. Water was used to reduce the viscosity of DESs; the humidity and regeneration stability were evaluated experimentally. At the molecular level, the strong host–guest interactions between RAMEB and aromatic VOCs were identified as the main reason for improving the absorption capacity of DESs. Additionally, the roles of hydrogen bond donor and acceptor molecules were analyzed. π–π stacking and CH–π interactions were also identified as significant contributors to the aromatic VOCs absorption process.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Food Biophysics
·
2022
·Vol. 17
·期 4
·598-611
·
IF 3.34
Yang Pan-pan,Shi Yu-gang,Li Dong-hui,Chen Ru-kang,Zheng Mei-zhi,Ma Kai-zhi,Xu Nuo,Dong Li-juan,Li Teng
To guarantee the safety and quality of food and prolong its shelf life, a novel multi-functionalized chitosan-based film with the outstanding antimicrobial property was prepared by incorporating with β -cyclodextrin ( β CD) and octyl gallate (OG). The OG encapsulation with β CD to form inclusion complexes ( β CD/OG-IC) endows OG with improved water-solubility and physicochemical stability. The formation of β CD/OG-IC has been proved through analytical techniques including FTIR, XRD, DSC and 1 H NMR. Then the chitosan (CS) films containing β CD/OG-IC were fabricated and their mechanical, physical properties and antimicrobial activities against four foodborne pathogens ( E. coli , S. aureus , L. monocytogenes and P. fluorescens ) were evaluated. The increased antibacterial activities of the CS film containing β CD/OG-IC were demonstrated by measuring the diameter of the inhibition zone. Meanwhile, the composite films showed higher tensile strength, more excellent water vapor resistance in contrast to pure CS films. Additionally, the composite films showed slow-release capacity and enhanced antibacterial efficacy to remarkably extend the shelf life of blueberry and asparagus. Our results substantially suggest that CS film containing β CD/OG-IC is a potential candidate for use as a multi-functionalized layer in the food-packaging system.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Jing Guo,Jianguo Jiang,Xiaolong Gu,Xia Li,Tianqing Liu
Multiple emulsions provide a facile route for particle preparation due to their ability to be used as liquid templates. Herein, biocompatible oil-in-water-in-oil (O 1 /W/O 2 ) double emulsions were fabricated using a two-step procedure and applied as templates for preparation of calcium alginate hydrogels with encapsulated β-carotene. The encapsulation efficiency ( EE ) of β-carotene showed a positive correlation to the outer-to-inner droplet size ratio of the O 1 /W/O 2 emulsion. The maximum EE , ∼50 wt%, could be achieved in the freshly prepared O 1 /W/O 2 emulsion when using aqueous alginate of 2 wt% as the intermediate phase and β-carotene-loaded R-(+)-limonene of 0.1 wt% as the inner oil phase. Gelation of the alginate phase was induced by addition of a small amount of aqueous CaCl 2 into the β-carotene-loaded O 1 /W/O 2 emulsion. The resulting hydrogels in water were characterized by laser diffraction and several microscopy measurements. The hydrogels showed good spherical shape and their average size was a little larger than that of the emulsion droplet templates. This work contributed to the understanding of encapsulation in O 1 /W/O 2 emulsion system and provided a novel methodology for encapsulation of carotenoids and other lipophilic bioactives.
研究领域:
食品科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）