ACS Sustainable Chemistry & Engineering
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2024
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IF 7.1
Zixiang Chen,Lihua Zhang,Yuanlong Guo,Jili Yuan,Tianlong He,Haibo Xie
With over 20 years of continued development of ionic liquids (ILs) for natural polymer processing and conversion, the design and facile preparation of ILs is still a hot research topic. In this study, a hydrogen bonding acceptor strengthening strategy was applied to design ether functionalized protic ILs, which were synthesized by a solvent-free neutralization reaction of methoxyacetic acid (Mea) and 1,5-diazabicyclo [4.3.0]-5-nonene (DBN). The ether-functionalized protic ILs ([DBNH][Mea]) were identified as a satisfactory solvent for the simultaneous dissolution of silk fibroin (SF) and cellulose at mild conditions, thus delivering a new dissolution processing platform toward value-added SF-based regenerated fiber materials. The strengthened simultaneous dissolution mechanism of SF and cellulose in [DBNH][Mea] by the introduction of an ether structure moiety in the anion was experimentally and computationally verified, and the results indicated that the ether structure moiety endowed it with more hydrogen-bonding acceptor sites, thus presenting stronger hydrogen-bonding disruption ability and outstanding solubility to SF and cellulose under mild conditions. Rheological study of the SF/cellulose/[DBNH][Mea]/DMSO solutions was conducted systematically, and the correlations between apparent viscosity (η), activation energy (Εη), overlap concentration (c*), structural viscosity index (Δη), storage modulus (G′) and loss modulus (G′′) of the solutions were highly correlated to the mass ratio of SF to cellulose. A series of SF/cellulose composite fibers were prepared by wet spinning using ethanol as the coagulation bath, and the obtained composite fibers were analyzed by Fourier transform infrared (FTIR), X-ray diffraction (XRD), elemental analysis, thermogravimetric analysis (TGA) and scanning electron microscopy (SEM) and mechanical tests. It was found that the composite fibers had high compatibility and the postdrafting technique is beneficial for enhancing the mechanical robustness.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Zongping Zhu,Yirong Luo,Liting Lin,Tianhui Gao,Qingsong Yang,Yunqiu Fan,Shuyi Wang,Chaomei Fu,Wan Liao
Turmeric, a traditional medicinal herb, is commonly used as a dietary and functional ingredient. This study aimed to investigate the effect of turmeric polysaccharides (TPs) on intestinal immunity and gut microbiota in cyclophosphamide (Cy)-induced immunosuppressed BALB/c mice. We verified that the oral administration of TPs-0 and TPs-3 (200 and 400 mg/kg, bw) improved thymus and spleen indexes, increased the whole blood immune cells (WBC) and lymph count index, and stimulated the secretion of serum immunoglobulin IgG. More importantly, TPs-0 and TPs-3 could repair intestinal immune damage and reduce intestinal inflammation. The specific mechanism is ameliorating the intestinal pathological damage, promoting CD4+ T cell secretion, regulating the expression of related cytokines, and reducing the level of critical proteins in the NF-κB/iNOS pathway. Interestingly, the intake of TPs-0 and TPs-3 significantly increased the content of short-chain fatty acids (SCFAs). Moreover, TPs-0 and TPs-3 relieved the intestinal microbiota disorder via the proliferation of the abundance of Lactobacillus and Bacteroides and the inhibition of Staphylococcus. Cumulatively, our study suggests that TPs-0 and TPs-3 can relieve intestinal immune damage by repairing the immune barrier and regulating intestinal flora disorders. TPs have potential applications for enhancing immunity as a functional food.
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Frontiers in Nutrition
·
2024
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IF 4
Jiang Long,Song Chen,Ai Chunqing,Wen Chengrong,Song Shuang
The present study demonstrated the digestion behavior and fermentation characteristics of a sulfated polysaccharide from Sargassum fusiforme (SFSP) in the simulated digestion tract environment. The results showed that the molecular weight of two components in SFSP could not be changed by simulated digestion, and no free monosaccharide was produced. This indicates that most of SFSP can reach the colon as prototypes. During the fermentation with human intestinal flora in vitro, the higher-molecular-weight component of SFSP was utilized, the total sugar content decreased by 16%, the reducing sugar content increased, and the galactose content in monosaccharide composition decreased relatively. This indicates that SFSP can be selectively utilized by human intestinal flora. At the same time, SFSP also changed the structure of intestinal flora. Compared with the blank group, SFSP significantly increased the abundance of Bacteroidetes and decreased the abundance of Firmicutes. At the genus level, the abundances of Bacteroides and Megamonas increased, while the abundances of Shigella, Klebsiella, and Collinsella decreased. Moreover, the concentrations of total short-chain fatty acids (SCFAs), acetic, propionic and n-butyric acids significantly increased compared to the blank group. SFSP could down-regulate the contents of trimethylamine, piperidone and secondary bile acid in fermentation broth. The contents of nicotinic acid, pantothenic acid and other organic acids were increased. Therefore, SFSP shows significant potential to regulate gut microbiota and promote human health.
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Journal of Water Process Engineering
·
2025
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IF 6.7
Qingmuke Su,Yaguang Du,Dongyun Du,Tian C. Zhang
In recent years, the effective treatment of antibiotics and the rational resource utilization of high‑carbon industrial wastewater have become hot research in the industry. However, there is no research on combining the two together for efficient resource recycling. In this study, sulfamethoxazole (SMX) was added to distillery wastewater with high COD for anaerobic digestion (AD), and its effects on substrate metabolism and methane production in AD systems were investigated. The results show that SMX can be completely metabolized in the AD system of the winery. The methane yield is the highest (810.73 mL CH 4 /g·VS) when the concentration is 0.5 mg/L, which is increased by 55.09 %. Polysaccharides and proteins were more susceptible to SMX, accumulated in the extracellular area and then were used as carbon sources in the subsequent microbial activities. The microbial community and macrogenomic analyses showed that SMX regulated the microbial community and enriched the acetate-type methanogens, leading to more methane production. Meanwhile, the analysis of KEGG metabolic pathway showed that the abundance of functional genes of key enzymes synthesizing antioxidant amino acids was enhanced, which resisted the hydroxyl radicals generated by SMX, leading to the additional production of acetic acid under this metabolic pathway. In addition, functional genes related to glycolysis, amino acid metabolism, tricarboxylic acid (TCA) cycle, and methane metabolism were increased in abundance by 20–90 %, resulting in maximized methane production.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2018
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IF 3.909
Ang-Xin Song,Yu-Heng Mao,Ka-Chai Siu,Jian-Yong Wu
The bifidogenic effects of exopolysaccharide (EPS) of a medicinal fungus ( Cordyceps sinensis ) and a well-known food polysaccharide konjac glucomannan (KGM) with different molecular weight (MW) ranges were evaluated through in vitro experiments in liquid cultures of Bifidobacteria . Native EPS and KGM were partially degraded with power ultrasound (US) to improve the water solubility, and further hydrolysed with trifluoroacetic acid to much lower MW. The acid-hydrolysed fractions (EPS-AH and KGM-AH) supported the growth of all five tested bifidobacterial species, while the US-degraded high MW fractions, EPS-US and KGM-US, could only slightly support the growth of some species. All EPS fractions increased the acetic acid production of most bifidobacterial species. Most remarkably, the high MW EPS-US, EPS-AH and KGM-US fractions significantly enhanced the cell viability with much higher colony forming unit (CFU) counts, suggesting a protective effect of these high MW polysaccharides for the bacterial survival . The results have shown that MW was a significant factor on the bifidogenic properties of partially degraded EPS and KGM.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2018
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IF 3.412
Wangting Zhou,Yamei Yan,Jia Mi,Hongcheng Zhang,Lu Lu,Qing Luo,Xiaoying Li,Xiaoxiong Zeng,Youlong Cao
Digestion and fermentation in vitro of polysaccharides from bee collected pollen of Chinese wolfberry (WBPPS) were investigated in the present study. It was found that WBPPS mainly consisted of mannose, ribose, rhamnose, galacturonic acid, glucose, galactose, xylose, and arabinose in a molar ratio of 0.38:0.09:0.17:0.64:0.22:0.67:0.08:1.03, respectively. WBPPS was not affected by human saliva. The fraction A (molecular weight 1340 kDa) of WBPPS was not broken down in simulated gastric and small intestinal juices, while the small fraction B (molecular weight 523 kDa) of WBPPS was degraded. Moreover, fermentation in vitro revealed that WBPPS could significantly enhance the production of short-chain fatty acids and modulate gut microbiota composition via increasing the relative abundances of genera Prevotella, Dialister, Megamonas, Faecalibacterium, and Alloprevotella and decreasing the numbers of genera Bacteroides, Clostridium XlVa, Parabacteroides, Escherichia/Shigella, Phascolarctobacterium, Parasutterella, Clostridium sensu stricto, and Fusobacterium.
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CHEMISTRY-A EUROPEAN JOURNAL
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2018
·Vol. 24
·期 12
·2962-2970
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IF 5.16
Pengfei Yang,Fangxin Mao,Yongsheng Li,Qixin Zhuang,Jinlou Gu
Graphical Etch a sketch : A simple and efficient monocarboxylic acid etching (MAE) strategy was developed to prepare hierarchical porous UiO-66, which inherits excellent stability from its parent material and the pore parameters can be controlled by adjusting the monocarboxylic acid concentration and reaction temperature. A new monocarboxylic acid etching (MAE) strategy was developed for transforming chemically stable Zr-based metal-organic frameworks (MOFs) of UiO-66 to their hierarchical porous counterpart. The key design element was based on the incomplete replacement of bridging ligands in MOFs by monocarboxylic acids (MAs), leading to the departure of partial ligands and metal clusters to create mesopores in MOFs. A series of MAs with different acidity and carbon chain length were tested, and propionic acid (PA) was screened to be the suitable choice. The textural features including pore size distribution, specific surface area, and pore volume of the obtained products can be controlled by adjusting the MA concentration and reaction temperature. The obtained hierarchical porous MOFs inherited excellent stability from their parent materials. Additionally, the MAE strategy was universal to construct hierarchical porous Zr-based MOFs, and it was expanded to etch UiO-66 derivatives. The excellent adsorption behavior of the resultant hierarchical porous Zr-based MOFs over two enzymes with different size was also successfully exemplified, demonstrating their application potentials with bulky molecules involved.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
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IF 5.7
Tong Liu,Siqing Fan,Pengfei Meng,Mingxia Ma,Yanxin Wang,Jiaojiao Han,Yufei Wu,Xiao Li,Xiurong Su,Chenyang Lu
Gut microbiota provides an important insight into clarifying the mechanism of active substances with low bioavailability, but its specific action mechanism varied case by case and remained unclear. Dihydroquercetin (DHQ) is a bioactive flavonoid with low bioavailability, which showed beneficial effects on colitis alleviation and gut microbiota modulation. Herein, we aimed to explore the microbiota-dependent anticolitis mechanism of DHQ in sight of gut microbiota metabolites and their interactions with microRNAs (miRNAs). Dietary supplementation of DHQ alleviated dextran sulfate sodium-induced colitis phenotypes and improved gut microbiota dysbiosis. Fecal microbiota transplantation further revealed that the anticolitis activity of DHQ was mediated by gut microbiota. To clarify how the modulated gut microbiota alleviated colitis in mice, the tandem analyses of the microbiome and targeted metabolome were performed, and altered profiles of metabolite short-chain fatty acids (SCFAs) and bile acids and their producers were observed in DHQ-treated mice. In addition, SCFA treatment showed anticolitis activity compared to that of bile acids, along with the specific inhibition on the phosphoinositide-3-kinase (PI3K)-protein kinase B (Akt) pathway. Subsequently, the colonic miRNA profile of mice receiving SCFA treatment was sequenced, and a differentially expressed miR-10a-5p was identified. Both prediction analysis and dual-luciferase reporter assay indicated that miR-10a-5p directly bind to the 3′-untranslated regions of gene pik3ca, inhibit the PI3K-Akt pathway activation, and lead to colitis alleviation. Together, we proposed that gut microbiota mediated the anticolitis activity of DHQ through the SCFAs/miR-10a-5p/PI3K-Akt axis, and it provided a novel insight into clarifying the microbiota-dependent mechanism via the interaction between metabolites and miRNAs.
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Journal of Functional Foods
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2024
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IF 3.8
Zhenhua Yin,Juanjuan Zhang,Qingfeng Guo,Jiale Zhi,Xia Zhang,Wei Zhang,Lin Chen
Psoralea corylifolia polysaccharide (PPs) was the bioactive ingredient that conferred health benefits. In this study, simulated digestion and anaerobic fermentation models were employed to explore the digestion and fermentation characteristics of PPs and its effect on the intestinal microbiota. The results revealed that while the total and reducing sugar contents of PPs increased after simulated digestion, their molecular weight, monosaccharide composition, and overall structure remained unchanged, indicating that PPs was not degraded during digestion. On the other hand, during anaerobic fermentation, PPs was metabolized by intestinal microbiota, leading to the production of acetic acid and propionic acid, which subsequently reduced the pH of the fecal culture solution. Additionally, PPs modulated the composition of the intestinal flora, significantly decreasing the relative abundance of Proteobacteria while increasing the relative abundance of Bacteroidota and Firmicutes to varying degrees. This study highlighted the potential of PPs for development as functional foods and therapeutic agents.
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Frontiers in Microbiology
·
2025
·
IF 4.5
Mengge Sun,Haotian Huang,Haibao Tang,Jiajie Chen,Wei Chen,Dongsheng Yang
Recent studies have highlighted the prebiotic potential of natural plant polysaccharides, demonstrating their role in promoting beneficial gut microbiota and improving health. However, research on the digestive properties and prebiotic activities of Imperatae Rhizoma Polysaccharides (IRPs) remains limited. This study investigated fresh Imperatae Rhizoma as the research object. After processing, dry Imperatae Rhizoma and carbonized Imperatae Rhizoma were prepared. Three polysaccharides from the fresh, dry, and carbonized Imperatae Rhizoma were extracted with traditional hot water. And another polysaccharide was obtained by cold water extraction from fresh Imperatae Rhizoma. Total four IRPs were extracted and named: IRPs-F, IRPs-D, IRPs-C, and IRPs-J. This study evaluated the prebiotic activity of four polysaccharides derived from the roots of thatch, demonstrating their resistance to digestion, their ability to promote probiotic growth, and their enhancement of short-chain fatty acid (SCFA) production. The final results show that four IRPs exhibit strong resistance to digestion and IRPs-F ability to promote the growth of beneficial probiotics, making it a promising candidate for functional foods aimed at improving intestinal health, immune regulation, and metabolic benefits. This research is highly relevant to food microbiology and holds significant potential for application in the functional food and gut health sectors.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
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IF 7.7
Zheng-Hao Chen,Xiao-hui Yuan,Ting-Ting Tu,Lei Wang,Yu-Heng Mao,You Luo,Shu-Yi Qiu,Ang-Xin Song
In this study, polysaccharides (RRTPs) were extracted from Rosa roxburghii Tratt pomace by hot water or ultrasound (US)-assisted extraction. The structural properties and potential prebiotic functions of RRTPs were investigated. Structural characterization was conducted through HPAEC, HPGPC, GC–MS, FT-IR and SEM. Chemical composition analysis revealed that RRTPs extracted by hot water (RRTP-HW) or US with shorter (RRTP-US-S) or longer duration (RRTP-US-L) all consisted of galacturonic acid , galactose , glucose, arabinose , rhamnose and glucuronic acid in various molar ratio. US extraction caused notable reduction in molecular weight of RRTPs but no significant changes in primary structures. Fecal fermentation showed RRTPs could reshape microbial composition toward a healthier balance, leading to a higher production of beneficial metabolites including total short-chain fatty acids, curcumin , noopept, spermidine , 3-feruloylquinic acid and citrulline . More beneficial shifts in bacterial population were observed in RRTP-HW group, while RRTP-US-S had stronger ability to stimulate bacterial short-chain fatty acids production . Additionally, metabolic profiles with the intervention of RRTP-HW, RRTP-US-S or RRTP-US-L were significantly different from each other. The results suggested RRTPs had potential prebiotic effects which could be modified by power US via molecular weight degradation.
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CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Huan Tian,Yi Liu,Feng-Lei Jiang
Perovskite nanocrystals attract growing interest owing to their unique optoelectronic properties. However, their chemical stability is relatively poor due to their ionic nature. In this work, we found that inorganic cations (e.g., Cs+) and ligands (e.g., didodecyldimethylammonium bromide, DDAB), used in the synthesis of CsPbBr3 nanocrystals (NCs) at ambient temperature, quickly converted CsPbBr3 NCs to Cs4PbBr6 NCs during the synthesis or postsynthetic treatment. These cations (Cs+, DDA+) were involved in both the chemical composition and dissociation of CsPbBr3 NCs. Nevertheless, DDA+ induced the generation of an impurity in addition to Cs4PbBr6 NCs due to its different nature from that of Cs+. The transformation process was observed by optical spectroscopy and transmission electron microscopy. The reverse transformation of Cs4PbBr6 NCs to CsPbBr3 NCs can be carried out completely by adding sufficient PbBr2 into Cs4PbBr6 NCs. Therefore, the forward and backward reactions were driven by Cs+ and Pb2+. With additional DDAB for passivation during the reverse transformation, the resulting product possessed a better photoluminescence quantum yield (PLQY, ∼90%) compared with that without the involvement of DDAB (∼69%). By considering the Cs4PbBr6 NCs as the Cs source, the reverse transformation can be analogized to the synthesis of CsPbBr3 NCs, providing a possible strategy for synthesizing luminescent perovskite NCs at room temperature with theoretical stoichiometry.
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