Biosensors-Basel
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2024
·Vol. 14
·期 9
·436
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IF 4.9
Ruixin Li,Jin Li,Xianbo Lu,Fanli Meng,Jiping Chen
Estrogenic chemicals are widely distributed and structurally diverse. They primarily disrupt estrogen-related metabolism in animals or humans by mimicking the agonistic receptor effects of natural estrogens, thereby influencing the transcription of estrogen receptors to regulate their quantity and sensitivity. This disruption of estrogen-related metabolism can lead to estrogen-related effects, posing risks to biological health, emphasizing the urgent need for simple and effective methods to screen compounds with estrogenic effects. Herein, a new electrochemical biological effect biosensor based on human estrogen receptor α (hERα) is developed, which uses hERα as the biorecognition element and employs the electroactive horseradish peroxidase (HRP) labeled 17β-estradiol (E2) multifunctional conjugate HRP-E2 as the signal-boosting element and ligand competition agent. Based on the specific ligand–receptor interaction principle between the target and nuclear receptor, by allowing the test compound to compete with HRP-E2 conjugate for binding to hERα and testing the electrocatalytic signal of the conjugate that fails to bind to the hERα estrogen receptor, rapid screening and quantitative detection of chemical substances with estrogenic effect have been achieved. The biosensor shows a wide linear range of 40 pM to 40 nM with a detection limit of 17 pM (S/N = 3) for E2, and the detection limit is 2 orders of magnitude better than that of the previously reported sensors. The biosensor based on ligand–receptor binding can not only quantitatively analyze the typical estrogen E2, but also evaluate the relative estrogen effect strength of other estrogen compounds, which has good stability and selectivity. This electrochemical sensing platform displays its promising potential for rapid screening and quantitative detection of chemicals with estrogenic effects.
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FOOD CHEMISTRY
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2025
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IF 9.8
Xiaoxiao Dong,Chang Lu,Shuaijie Guo,Siqi Zhang,Xuelian Hu,Wenliu Wang,Yiwei Tang,Shuo Wang,Xiuying Liu
A magnetic NiFe 2 O 4 @TiO 2 @Au composite was successfully synthesized via layer-by-layer assembly approach and exhibited excellent SERS performance. The composite was functionalized with an aptamer modified with Cy3, serving as the Raman signal reporter, and was hybridized with complementary DNA oligonucleotides (cDNA) to construct the NiFe 2 O 4 @TiO 2 @Au@ssDNA SERS aptasensor. This aptasensor enabled the development of a sensitive, specific, and straightforward SERS assay for acetamiprid detection, exhibiting good accuracy. Under optimized conditions, an inverse correlation was established between the acetamiprid concentration and the Raman intensity at the characteristic peak of 1132 cm −1 , spanning a range of 10 −1 -10 4 nmol/L with a LOD of 8.4 × 10 −1 pmol/L. Standard addition experiments to three types of leafy vegetables samples yielded recoveries ranging from 94.30 % to 111.83 %, with a relative standard deviation of <5.56 %. This method shows potential for detecting other hazardous substances in food and environmental samples by simply changing the corresponding aptamers and cDNA.
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ANALYTICA CHIMICA ACTA
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2024
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IF 5.7
Manting Li,Haikun Luo,Zhao Wang,Qian Mo,Shanshan Zhong,Yu-ang Mao,Shuting Li,Xinchun Li
Background Assembling framework nucleic acid (FNA) nanoarchitectures and tuning luminescent quantum dots (QDs) for fluorescence assays represent a versatile strategy in analytical territory. Rationally, FNA constructs could offer a preferential orientation to efficiently recognize the target and improve detection sensitivity, meanwhile, regulating size-dependent multicolor emissions of QDs in one analytical setting for ratiometric fluorescence assay would greatly simplify operation procedures. Nonetheless, such FNA/QDs-based ratiometric fluorescence nanoprobes remain rarely explored. Results We designed a sensitive and signal amplification-free fluorescence aptasensor for lead ions (Pb 2+ ) that potentially cause extensive contamination to environment, cosmetic, food and pharmaceuticals. Red and green emission CdTe quantum dots (rQDs and gQDs) were facilely prepared. Moreover, silica nanosphere encapsulating rQDs served as quantitative internal reference and scaffold to anchor a predesigned FNA and DNA sandwich containing Pb 2+ binding aptamer and gQD modified DNA signal reporter. On binding of Pb 2+ , the gQD-DNA signal reporter was set free, resulting in fluorescence quenching at graphene oxide (GO) interface. Owing to the rigid structure of FNA, the fluorescence signal reporter orderly arranged at the silica nanosphere could sensitively respond to Pb 2+ stimulation. The dose-dependent fluorescence signal-off mode enabled ratiometric analysis of Pb 2+ without cumbersome signal amplification. Linear relationship was established between fluorescence intensity ratio ( I 555 / I 720 ) and Pb 2+ concentration from 10 nM to 2 μM, with detection limit of 1.7 nM (0.43 ppb), well addressing the need for Pb 2+ routine monitoring. The designed nanoprobe was applied to detection of Pb 2+ in soil, cosmetic, milk, drug, and serum samples, with the sensitivity comparable to conventional ICP-MS technique. Significance Given the programmable design of FNA and efficient recognition of target, flexible tuning of QDs emission, and signal amplification-free strategy, the present fluorescence nanoprobe could be a technical criterion for other heavy metal ions detection in a straightforward manner.
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Small Structures
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2024
·
IF 13.9
Zhenliang Li,Yujian Rao,Zhehan Wang,Tuo Zhang,Guodong Wu,Litao Sun,Yuan Ren,Li Tao
Two-dimensional (2D) transition metal dichalcogenides (TMDs) are widely used in interfacial reactions and electronic devices due to their tunable bandgap and high efficiency of carrier transport. However, the lack of fully exposed active sites in bulk samples or stacked nanosheets leads to limited performances. In this work, a general method is developed to construct ordered mesoporous TMDs/metal oxides (OM-TMDs/MOs) heterostructures, including WS 2 /WO 3 , WSe 2 /WO 3 , WTe 2 /WO 3 , MoS 2 /MoO 3 , and V 3 S 4 /V 2 O 3 , through one-step thermal sulfurization (selenidation/tellurization) of self-assembled amphiphilic block copolymer/polyoxometalates clusters nanocomposites with ordered mesostructures. The OM-TMDs/MOs possess highly OM structures with high specific surface area, large pore size, and rich active edge sites in the frameworks of heterostructures. The chemiresistive gas sensor based on OM-WS 2 /WO 3 shows excellent NO 2 -sensing performances at room temperature, with high sensitivity, ultrahigh selectivity ( S NO 2 $S_{\left(\text{NO}\right)_{2}}$ / S gas > 20), and fast response speed (6 s). Theoretical study reveals that the strong adsorption capacity of WS 2 /WO 3 heterostructure and edge sites of WS 2 for NO 2 molecules and the high charge transfer between them contribute to high selectivity and sensitivity of the sensor. This universal method provides novel strategy for synthesis of OM TMDs-based nanomaterials, showing great potential in various applications such as electronic devices, catalysis, energy storage, and conversions.
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MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Lianlian Wang,Yongfeng Cui,Yiduo Mi,Luyao Wang,Bing Han,Yadan Guo
Heavy metal ions pollution is one of the most threatened issues for human health and ecosystem balance. Herein, a promising microfluidic chip with microgel arrays for realizing the simultaneously point of care test to multiple pathogenic heavy metal ions was designed, which consisted of a sample perfusion area in the center (pipe width 200 μm), and four detection chambers (width 8000 μm, length 20000 μm) with microcolumn arrays (radius 100 μm, width 550 μm), all the heights were 100 μm. With simulation of the fluid flow, the flow rate of 5 mL/min made the microgel successfully patterning the precursor in microcolumn. By utilizing different kinds of quantum dots microgels, this chip could achieve specific and on-site quick detection for Pb 2+ , Co 2+ , Cu 2+ and Fe 3+ . Moreover, the gel composition had almost no effect on the performance of quantum dots and owned enough space after losing water to absorb the sample solution for reacting with the analytes. Furthermore, this POCT microfluidic chip was applied in the detection of actual water samples, and the fluorescence quenching of the chip was visible to naked eyes. It possessed the potential to achieve the ions quantitative determination. Therefore, this method realized the simultaneous detection of multiple pathogenic heavy meatal ions rapidly and availably and could further applied in actual water pollution samples with enormous advantages.
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Advanced Optical Materials
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2024
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IF 8
Zhongyuan Guan,Yang Huang,Zhaojin Wang,Jiayun Sun,Chengwei Shan,Yiguo Xu,Dan Wu,Aiwei Tang,Xiao Wei Sun,Kai Wang
The development of cadmium-free blue quantum dots (QDs) is of paramount importance to the display industry. In this study, high-quality ZnSeTe/ZnSe/ZnS blue QDs, followed by surface treatment with ZnI 2 are initially synthesized. The introduction of ZnI 2 passivated the surface defects, resulting in an increase in the fluorescence quantum yield. The time-resolved photoluminescence (TRPL) demonstrates a significant inhibition of non-radiative recombination associated with the surface defect state. The density functional theory (DFT) calculation reveals that the binding energy between iodine ions and zinc ions is higher than that between oleate ions and zinc ions, providing a theoretical basis for the effective passivation of the suspended bonds of zinc ions on QDs' surface by iodine ions. Moreover, quantum dot light-emitting diodes (QLEDs) are fabricated and UV photoelectron spectra (UPS) indicate the hole injection barrier between the hole transport layer and QDs decreases 0.12 eV after QDs being treated by ZnI 2 , facilitating hole injection. Finally, The ZnI 2 -treated QLED demonstrates a 1.57-fold and 1.82-fold improvement in L max and EQE max , respectively, reaching 6370 cd m −2 and 9.1%, compared to the pristine QLED. The work serves as a valuable reference for enhancing the performance of cadmium-free blue QLED.
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Science Advances
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2025
·Vol. 11
·期 29
·
IF 12.5
Ruihao Zhou,Muqing Cao,Yizheng Tan,Mark Neisser,Huaping Xu
Extreme ultraviolet (EUV) lithography has become the essence of advanced semiconductor manufacturing processes. While enabling smaller feature sizes, EUV lithography imposes increasingly stringent requirements on the comprehensive performance and stochastic defect suppression of photoresist. The widely recognized strategy to minimize these defects is a material that integrates high EUV absorption and energy utilization into a homogeneous system based on molecular building blocks—the ideal formulation for EUV photoresist. However, achieving these integrated characteristics within a single molecule has remained an unresolved challenge. Here, we address all these requirements by polytelluoxane using an organic telluride monomer polymerized via Te─O bonds. This polymeric photoresist, operating through a main chain scission mechanism, demonstrates high-performance positive-tone lithography. Attributed to this ideal formulation, our photoresist achieves a comprehensive 18-nm line width at a dose of 13.1 mJ/cm 2 with a line edge roughness of 1.97 nm. We believe that this strategy establishes a framework for the design of next-generation EUV photoresists.
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Journal of Materials Chemistry A
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2025
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IF 9.5
Hanqian Li,Bangzhi Ge,Wenqi Xie,Ruoyan Li,Chao Li,Wanqi Jie,Dongxu Zhang,Yi Qin,Yuan Yu,Chongjian Zhou
Liquid-like thermoelectric materials continuously draw significant attention because of their extraordinary performance. However, liquid-like Cu atoms usually aggregate into clusters, resulting in charge carrier concentration far above the optimized value. Herein, we demonstrate that the dynamic Cu atoms can be homogenized throughout the matrix by a phase-dependent diffusion process. We directly visulized that the typical equilibrium process periodically aggregates Cu atoms into clusters along the grain boundaries, leaving abundant vacancies within the dynamic cation sublattice and thereby causing carrier concentrations that are much higher than the optimal value. We developed a solid-state non-equilibrium quenching process to freeze the homogeneous Cu sublattice in the symmetry cubic phase to ambient environment and removed the unfavorable Cu segregation. This substantially decreases the hole concentration from 1.2 × 1022 cm−3 for the equilibrium sample to 0.8 × 1022 cm-3 for the quenched sample, approaching the calculated optimal value. Notably, the highly uniform Cu sublattice reduces the lattice thermal conductivity to predicted minima of 0.3 W·m−1·K−1 from 300 to 1000 K. The reduced hole concentration and lattice thermal conductivity collectively give rise to a high ZT value of 1.5 at 1000 K, lying in the ballpark of all previously reported stoichiometric copper chalcogenides.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yu-Lin Zhong,Bing-Bing Wang,Kai-Fei Chu,Ai-Jun Wang,Tiejun Zhao,Jiu-Ju Feng
Although nanozyme-mediated chemodynamic therapy (CDT) has been extensively investigated, its therapeutic efficacy is hindered by tumor microenvironment (TME), which features low endogenous H 2 O 2 level and high glutathione (GSH) concentration. In this work, PtFeCoMoMn high-entropy intermetallic alloy/N-doped carbon nanoflowers (HEIA/NCNFs) was synthesized by a one-step pyrolysis. The HEIA/NCNFs exhibited multiple peroxidase (POD)-, catalase (CAT)-, oxidase (OXD)-, glutathione oxidase (GSHOx)-, and NADPH oxidase (NOX)-like activities, which were integrated with glucose oxidase (GOx) and doxorubicin (DOX) to establish a cascade nanotherapeutic platform (termed HEIA/NCNFs-GOx/DOX). Shortly, GOx consumed glucose in tumor cells, generating H 2 O 2 to compensate for the TME's H 2 O 2 deficiency. Subsequently, the HEIA/NCNFs converted H 2 O 2 into reactive oxygen species (ROS) via the POD/CAT/OXD-like activity. Also, the HEIA/NCNFs depleted intracellular GSH via its GSHOx-like activity, and simultaneously suppress GSH regeneration by consuming NADPH via its NOX-like activity, thereby inactivating glutathione peroxidase 4 and inducing ferroptosis. By combining starvation therapy, CDT, ferroptosis, and chemotherapy, the established cascade nanozyme system significantly enhanced the therapeutic efficacy of breast cancer, validated by the in vitro and in vivo studies. This multifunctional nanodrug improves therapeutic precision, reduces off-target effect, and advances the development of safe, efficient cancer treatments.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2025
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IF 6.3
Wendan Wang,Xuhui Zhang,Huiyun Tang,Tianpeng Chen,Chao Luo,Tingling Huang,Di Mei,Qijun Liu,Xin Li,Hongliang Dong
The sintering behavior of polycrystalline diamond with a tellurium (Te) catalyst was studied at 10 GPa and 1750-1900 °C. CALYPSO software was used to find three crystal structures of carbon-tellurium (C-Te) compounds: CTe, CTe 2 , and C 3 Te 8 . The experimental results indicate that at 10 GPa, Te reacts with diamond only above 1850 °C. The C-Te compounds decompose into diamond and Te during cooling and pressure release. The Te from decomposition has a different crystal structure from those unreacted. Rapid cooling can retain some C-Te compounds at room temperature and pressure. By comparing the X-ray diffraction patterns of the C-Te compounds separated from the sample's spectrum with those of the three calculated crystal structures, it is suggested that the C-Te compounds in recovered sample are most likely orthorhombic CTe 2 . And computational results suggest that TeC may be the true catalyst in the diamond formation process. In samples sintered at 10 GPa, 1850 °C and 1900 °C, grain boundaries between diamond grains disappear. Hardness tests show these samples have an average Vickers hardness of about 61 GPa, similar to commercial polycrystalline diamond compacts.
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CERAMICS INTERNATIONAL
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2025
·
IF 5.6
Ying Wang,Shanze Liu,Fangbiao Wang,Xin Fan,Qi Chen,Youjin Zheng
The high-pressure effect can effectively regulate the bandgap width of thermoelectric materials, thus optimizing the material properties. In this study, the high temperature and high pressure (HPHT) technique was employed to synthesize In-filled, Te/S double-substituted skutterudite-based thermoelectric materials. The effects of synthesis pressures ranging from 2.0 to 3.5 GPa on their phase structure, microstructure, and thermoelectric properties were systematically investigated. XRD and EDS analyses confirm the phase-pure synthesis of In 0.05 Co 4 Sb 11.3 Te 0.6 S 0.1 . The experimental results combined with first-principles calculations indicate that the pressure-induced bandgap widens from 0.245 eV at 2.0 GPa to 0.270 eV at 3.0 GPa, resulting in not only an exponential decay of the conductivity but also a significant increase in the absolute value of the Seebeck coefficient. The analysis based on the Callaway model demonstrates that introducing In, Te, and S elements strengthens grain boundaries, increases point defects, and enhances resonance scattering, thereby effectively reducing lattice thermal conductivity. At 773 K, the 3.0 GPa sample exhibits the lowest thermal conductivity of 1.56 Wm −1 K −1 and a maximum zT value of 1.20, representing a 40.18 % increase over that of the sample synthesized at 2.0 GPa and an 11.02 % increase over that of the Co 4 Sb 11.3 Te 0.6 S 0.1 sample. In addition, the sample synthesized at 3.5 GPa demonstrates excellent mechanical performance, exhibiting a Vickers hardness of 11.12 GPa. New strategies have been provided for the development of materials with both high thermoelectric and mechanical properties.
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ACS Nano
·
2025
·
IF 16
Jicheng Wang,Shilei Ding,Bei Ding,Zhipeng Hou,Licong Peng,Yilan Jiang,Fengshan Zheng,Zhaochu Luo,Yu Ye,Jinbo Yang,Yanglong Hou,Rui Wu
Exchange bias (EB) effects play a crucial role in modern magnetic memory technology. Recently, the van der Waals heterostructures have shown potential for investigating mechanisms of the EB effect owing to their tunable physical properties and flexibility in fabrication. However, due to low magnetic ordering temperatures for most van der Waals magnets, establishing EB in van der Waals antiferromagnet/ferromagnet heterostructures at room temperature is challenging. In this study, we fabricate (Fe0.56Co0.44)5GeTe2 (FCGT)/Fe3GaTe2 (FGaT) heterostructures with magnetic ordering temperatures of each component well above room temperature to achieve a room-temperature EB effect. It is found that the sign and magnitude of the EB field can be efficiently controlled by manipulating the Néel order of FCGT. The manipulation of the Néel order shows significant magnetic field dependence. A strong preset field induces a switch in the Néel order of FCGT, which aligns the interfacial magnetization at the FCGT/FGaT interface, leading to robust EB, as revealed by both transport measurements and macrospin model calculations. Our findings demonstrate the intrinsic manipulation and switchability of room-temperature EB in all-van der Waals heterostructures and further emphasize the potential of two-dimensional spintronic devices.
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