IONICS
·
2024
·Vol. 30
·期 4
·2375-2385
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IF 2.4
Cao Lin-an,Wei Min,Guo Xin,Wang Dailian,Chen Lu,Guo Jing
Ni 3 (HITP) 2 (HITP: 2,3,6,7,10,11-hexaiminotriphenylene) is a very typical 2D electrically conductive metal–organic framework (EC-MOF) material with great promising as active materials in electronic devices. Gas–liquid interface self-assembly is a common method of processing free-standing thin films for this EC-MOF. Owing to the different contact environment during growth process, Ni 3 (HITP) 2 film prepared by gas–liquid interface method has different morphology for up-side surface exposed to air and down-side surface infiltrated in solution. However, the asymmetrical morphology of Ni 3 (HITP) 2 film and its influence on sensing performance have never been implemented. In this work, gas–liquid interface self-assembly method is used to obtain an asymmetrical Ni 3 (HITP) 2 nanofilm in surface morphology with a flat up-side surface and an island-like down-side surface. The surface morphology of as-prepared film has a remarkable influence on the glucose sensing property. The island-like structure for down-side surface film exhibits more excellent glucose sensing performance because of its abundant crystal defect which play an important role in enhancing glucose catalytic oxidation capacity. Graphical abstract
研究领域:
材料科学
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纳米技术
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传感器
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电化学
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DOI
高影响因子
JOURNAL OF SUPERCRITICAL FLUIDS
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2019
·
IF 3.481
Lei Bao,Yang Chen,Liru Ma,Dongdong Hu,Yuan Zong,Ling Zhao,Weikang Yuan,Tao Liu
Three nonfluorinated co-surfactants, sodium bis (2-(isopropoxy)-ethanol) sulfonate (di-IOESS), sodium bis (3,5,5-trimethyl-hexanol) sulfonate (di-TMHSS) and sodium bis (2-(pivaloyloxy)-ethanol) sulfonate (di-POESS) were synthesized to replace partial sodium bis (3,3,4,4,5,5,6,6,6-nonafluoro-hexanol) sulfonate (4FS(EO) 2 ) to stabilize W/C microemulsions to decrease the fluorine content. The results showed that the stabilization ability of the co-surfactants at less than 55 °C was in the following order: di-TMHSS > di-POESS > di-IOESS. Results for MD simulations proved that the co-surfactants mainly changed the packing efficiency of the surfactant short chains. The flexible co-surfactant tails could maintain the bending fraction of the surfactant short tail at a low level and the appropriate length of co-surfactant tails helped to occupy more volume at the interface. Therefore, the nonfluorinated co-surfactants with flexible branched tails in an appropriate length relatively to the surfactant tails were conducive to replace partial fluorinated surfactants, which may help for designing nonfluorinated co-surfactants to decrease the fluorine content in W/C microemulsions.
研究领域:
化学
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材料科学
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环境科学
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DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2016
·
IF 2.336
Kun Liu,Kai-Kai Liu,Mu-Jeng Cheng,Ming-Han Han
A combined experimental and theoretical study was conducted to investigate the isomerization of 2-methyl-3-butenenitrile (2M3BN) to 3-pentenenitrile (3PN) and to 2-methyl-2-butenenitrile (2M2BN) catalyzed by nickel diphosphine complexes. Ni(1,4-bis(diphenylphosphino)butane) (dppb) was identified as the most reactive catalyst among the complexes that we examined experimentally. Quantum mechanics (density functional theory) was then used to study the two isomerization mechanisms catalyzed by this complex. We find that for the 2M3BN → 3PN isomerization, the reaction is initiated with C CN bond cleavage, followed by an allyl direct rotation and C CN bond reformation. For the 2M3BN → 2M2BN isomerization, the most energetically favorable pathway begins with C H bond activation, followed by a π-σ-σ-π allyl rearrangement and C H bond reformation. Our proposed mechanism for the 2M3BN → 2M2BN isomerization is slightly different (yet energetically more favorable) than that described in previous studies, where it has been suggested that 2M2BN is obtained through a π-σ-σ allyl rearrangement rather than a π-σ-σ-π type rearrangement. Additionally, we investigated the effect of Lewis acids in the 2M3BN → 3PN isomerization, which has been shown in most experiments to attenuate the reaction. Notably, our calculations indicated that ZnCl 2 , which is used as a model Lewis acid, actually reduces the barriers for all elementary steps. However, the effective kinetic barrier for the isomerization increases from 23.7 (without ZnCl 2 ) to 24.0 kcal/mol because of the formation of a very stable Ni(π-allyl) (CN ZnCl 2 ) intermediate, causing a decrease in the reaction rate. This theoretical result was further confirmed by our own experiments.
研究领域:
有机化学
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理论化学
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DOI
高影响因子
Materials
·
2020
·Vol. 13
·期 24
·5733
·
IF 3.057
Tiancheng He,Caihuan Lv,Wenhao Li,Guohua Huang,Zhihui Hu,Jianmei Xu
The electronics related to the fifth generation mobile communication technology (5G) are projected to possess significant market potential. High dielectric constant microwave ceramics used as filters and resonators in 5G have thus attracted great attention. The Ba6−3x(Sm1−yNdy)8+2xTi18O54(x =2/3) ceramic system has aroused people’s interest due to its underlying excellent microwave dielectric properties. In this paper, the relationships between the dielectric constant, Nd-doped content, sintering temperature and the density of Ba6−3x(Sm1−yNdy)8+2xTi18O54(x =2/3) ceramics were studied. The linear regression equation was established by statistical product and service solution (SPSS) data analysis software, and the factors affecting the dielectric constant have been analyzed by using the enter and stepwise methods, respectively. It is found that the model established by the stepwise method is practically significant withY= −71.168 + 6.946x1+ 25.799x3, whereY,x1andx3represent the dielectric constant, Nd content and the density, respectively. According to this model, the influence of density on the dielectric constant is greater than that of Nd doping concentration. We bring the linear regression analysis method into the research field of microwave dielectric ceramics, hoping to provide an instructive for the optimization of ceramic technology.Keywords:microwave dielectric ceramics;Ba6−3x(Sm1−yNdy)8+2xTi18O54(x =2/3) system;dielectric constant;linear regression analysis
研究领域:
材料科学
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电子工程
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DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Shanshan Li,Hongxia Dai,Hui Chen,Jian Zhang,Xiaoning Shi,Haobo Zhang
Monitoring small amount of dopamine (DA) and acetaminophen (ACOP) in biological samples is of great significance for the early prevention of neurological diseases and safe use of medicines in clinical research. A novel electrochemical sensor based on conductive metal organic framework Cu 3 (HITP) 2 (HITP=2,3,6,7,10,11-hexaiminotriphenylene) and electrochemical reduced graphene oxide nanocomposite (denoted as Cu 3 (HITP) 2 /ERGO) was designed for simultaneous determination of DA and ACOP with enhanced sensitivity and selectivity. The Cu 3 (HITP) 2 /ERGO nanocomposite was characterized by scanning electron microcopy, energy dispersive spectroscopy and Fourier infrared spectroscopy. The oxidation potential separation of DA and ACOP achieved 226 mV. The Cu 3 (HITP) 2 /ERGO/GCE exhibited excellent electrochemical response towards the oxidation of DA and ACOP due to the superior conductivity and synergistic catalytic activity of Cu 3 (HITP) 2 /ERGO nanocomposite. The detection limits were 9 nM and 14 nM (S/N=3) for DA and ACOP with wide linear range of 0.05-150 μM and 0.1-100 μM, respectively. Furthermore, the proposed sensor has been successfully applied in the simultaneous detection of DA and ACOP in serum sample.
研究领域:
分析化学
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生物医学工程
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神经科学
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DOI
高影响因子
HISTOCHEMISTRY AND CELL BIOLOGY
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2023
·
IF 2.3
Jin Xin,Xu Hainan,Hu Qing,Yin Yitong,Qin Meiying,Xia Zhijun
Pelvic organ prolapse (POP) is a common disorder among women that negatively affects women’s quality of life. Early growth response 2 (EGR2) is a transcription factor that regulates cell growth. The present study aimed to explore the role of EGR2 in POP progression and provided a new target for the treatment and prevention of POP. Firstly, we extracted primary vaginal anterior wall fibroblasts from POP tissues and non-POP tissues and then constructed an EGR2-silencing lentivirus for further study. Immunoblotting, qPCR, TUNEL assay, CCK-8 assay, dual luciferase assay, and ELISA assay were carried out. EGR2 expression was much higher in POP tissues than in control tissues, and EGR2 expression positively correlated with cytokine signaling 3 (SOCS3) expression. Knockdown of EGR2 increased cell proliferation, upregulated PCNA expression, and reduced apoptosis in POP fibroblasts. Moreover, we found that the knockdown of EGR2 increased COL1A1 , COL3A1 , and Elastin expression and decreased MMP2 and MMP9 activities, and knockdown of EGR2 increased TGF-β/Smad pathway activity in POP fibroblasts. Interestingly, the results of dual luciferase assay demonstrated that EGR2 was able to increase SOCS3 transcriptional activity. EGR2 knockdown alleviated the apoptosis of POP fibroblasts by reducing SOCS3 expression and improving the proliferation and collagen synthesis of POP fibroblasts. Overall, our study illustrated that EGR2 was highly expressed in POP tissues, and knockdown of EGR2 alleviated apoptosis and reduced matrix degradation in POP fibroblasts. This study might provide a new insight into the pathogenesis of POP.
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Jiawen Wu,Xiaonan Sun,Junting Wu,Xue Yu
This study proposes a green and simple strategy for efficiently removing heavy metals from wastewater by activating biochar with eggshell and in-situ generating CaO/Ca(OH) 2 . Characterization results revealed that the composite carbon material (BCEg15) successfully incorporated CaO/Ca(OH) 2 active sites compared to the raw biochar (BC). Additionally, eggshell activation increased the specific surface area and pore volume of BCEg15 by 4.36 and 6.80 times, respectively, compared to BC. These structural enhancements increased the maximum adsorption capacity of BCEg15 for Pb 2+ and Cd 2+ by 20.68 and 42 times, respectively, compared to BC. Importantly, the loading of CaO and Ca(OH) 2 significantly enhanced the ion exchange and mineral precipitation capacities of the biochar. For instance, compared to BC, the adsorption capacities of BCEg15 attributed to ion exchange (Q e ) for Pb 2+ and Cd 2+ rose by 403.12 mg/g and 197.65 mg/g, respectively, while the adsorption capacities attributed to mineral precipitation (Q p ) increased by 19.60 times and 45.20 times, respectively. BCEg15 demonstrated excellent reusability, maintaining adsorption capacities of 461.18 mg/g for Pb 2+ and 265.26 mg/g for Cd 2+ after five cycles. Additionally, BCEg15 outperformed commercial activated carbon in treating heavy metals from desulfurization wastewater from coal-fired power plants, achieving a removal efficiency of 99.98 % compared to 48.22 %. The primary mechanisms by which BCEg15 removes Pb 2+ and Cd 2+ were identified as ion exchange, mineral precipitation, complexation with oxygen-containing functional groups, and interactions with π electrons. Density functional theory (DFT) was utilized to delve deeper into the microscopic mechanisms of adsorption. The findings showed that the O-top site of CaO exhibited the greatest stability for heavy metal adsorption. Electron density difference maps and partial density of states (PDOS) results revealed a denser electron cloud and greater orbital overlap between CaO and Pb 2+ compared to Cd 2+ , suggesting a higher affinity and adsorption capacity for Pb 2+ , consistent with the experimental findings. This study presents an effective method for preparing adsorbents capable of removing Pb 2+ and Cd 2+ from wastewater and offers theoretical insights into the adsorption mechanisms of metal oxide-incorporated biochar.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
MATERIALS & DESIGN
·
2022
·
IF 9.417
Yanfang Zhou,Mianrong Chen,Piaoyi Chen,Xiaotian Zhao,Hua Zhou,Jingmiao Wu,Xufeng Li,Qiuxia Li,Runxing Lin,Yugang Huang,Yingying Lun,Guodong Ye
Preparing polymers from allyl monomers without being hindered by degradative chain transfer (DCT) remains a challenge. Herein, we report the synthesis and characterization of embolic microspheres based on allyl monomers for transcatheter arterial embolization using a photodriven radical-mediated [3 + 2] cyclization reaction (PRMC) without metal catalysis. The mechanism of PRMC was validated by thermal and spectral experiments, indicating that PRMC overcomes the restrictions of DCT and makes it possible to synthesize a variety of well-defined polymers from inert allyl monomers. The embolization microspheres based on poly(sucrose allyl ether) were characterized by morphological determination, degradation and swelling tests. Cell experiments show that the microspheres have good biocompatibility. The complete arterial occlusion of the embolized kidneys was observed, indicating that microspheres have broad application prospects in embolization interventional therapy.
研究领域:
高分子化学
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介入医学
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材料科学
✓ 已验证
DOI
高影响因子
Journal of Energy Storage
·
2022
·
IF 8.907
Zhiguo Bian,Yingjie Li,Feifei Wang,Yi Fang,Jianli Zhao,Jianhui Qi
CaO/Ca(OH) 2 heat storage system is one of the most promising candidates for large-scale thermochemical heat storage at temperature of 300–600 °C. In this work, the CaO/Ca(OH) 2 heat storage performances of the Ce- and Mn-doped CaO were investigated and the mechanisms of promoting hydration by Ce and Mn doping were determined via density functional theory (DFT) calculations. The Mn-doped CaO exhibits the higher hydration conversion than CaO and Ce-doped CaO. The structural parameters, partial density of states, electron differential densities and energy barriers during hydration stage on the CaO, Ce- and Mn-doped CaO surfaces were compared to clarify the effects of Ce and Mn on hydration of CaO. The results show the detailed hydration reaction pathways on the CaO, Ce- and Mn-doped CaO surfaces. During the H 2 O adsorption stage, H 2 O on the Ce-doped CaO surface approaches the Ca atom first, while H 2 O on the Mn-doped CaO surface approaches the O s atom first. The adsorption energy for Ce- and Mn-doped CaO are −1.612 and −0.896 eV, respectively, which are higher than that for CaO. The doping of Ce and Mn accelerates the H 2 O adsorption on the CaO surface. The Mn doping causes the 84.3 % reduction in the energy barrier for hydration of CaO and the reduction by Mn doping is larger than that by Ce doping. Thus, Mn-doped CaO exhibits the higher hydration reactivity and hydration conversion than CaO and Ce-doped CaO. The DFT calculations determined the promotion mechanism of Ce and Mn doping on the hydration of CaO in CaO/Ca(OH) 2 heat storage.
研究领域:
材料科学
·
热能储存
·
计算化学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 70
·44186-44198
·
IF 3.108
Qiqi Zhao,Aihua Zhang,Wenjing Zong,Na An,Huamin Zhang,Yihan Luan,Hui Sun,Xijun Wang,Hongxin Cao
Diabetes mellitus has imposed a huge burden on modern society and is a serious threat to human health globally. Obese people usually have a higher risk of developing T2DM, and this disease is often diagnosed in older persons, accompanied by hypertension, hyperlipidemia, arteriosclerosis and other diseases. In the early stages of T2DM, patients can have difficulties in identifying any symptoms or may only suffer from slight fatigue and thirst with no obvious hyperglycemia. The early detection of this disease may provide a means of preventing the development of this disease in a more timely way. The metabolic profiling of small molecules provides a snapshot of physiological processes. By using a metabolite profiling platform based on mass spectrometry coupled with pattern recognition analysis, outstanding biomarkers that can be used for forecasting disease may be identified. In this study, we attempted to investigate potential key metabolic pathways associated with T2DM and determine its metabolic mechanism. Using multivariate statistical analysis, 33 marker metabolites associated with the metabolism of lipids, amino acids, and carbohydrates were identified. Our experiment yielded substantial new insights into serum metabolism in type 2 diabetes mellitus patients, and these metabolites will be targets for future mechanistic research to help understand the clinical significance of these metabolic abnormalities.
研究领域:
医学
·
代谢研究
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DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2014
·
IF 3.816
Wang Liju,Keyume Ablajan,Feng Jun
A rapid and efficient ultrasound-promoted one-pot synthesis of spiro[indoline-3,4′-pyrano[2,3-c]pyrazole] derivatives is described here. The reaction of substituted phenylhydrazine and dialkyl acetylenedicarboxylate with substituted isatin and malononitrile is catalyzed by l -proline to give good-to-excellent yields in water/ethanol (v/v, 1:1) at room temperature.
研究领域:
有机化学
·
催化反应
✓ 已验证
DOI
PubMed
高影响因子
Green Processing and Synthesis
·
2019
·Vol. 8
·期 1
·568-576
·
IF 1.128
Yingna Cui,Changping Li,Ming Bao
Deep eutectic solvents (DESs) are successfully used as powerful and recyclable catalysts and solvents for the synthesis of 3,4-dihydropyrimidin-2(1 H )-ones/thiones (DHPMs). The acidity of DESs is the main factor that determines catalytic activity. DESs, based on p -toluene sulfonic acid (PTSA) and choline chloride (ChCl), exhibits the highest catalytic activity. ChCl/2PTSA is suitable for a vast variety of aromatic aldehydes with electron-donating and electron-withdrawing groups, different β-diketonates, and urea or thiourea to obtain the corresponding DHPMs. Furthermore, DESs can be recycled easily after synthesis. The reused DESs achieve catalytic efficiency six times without significant changes. This study will provide a new green catalyst and efficient process for the synthesis of DHPMs.
研究领域:
有机化学
·
绿色化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）